Topics created by haidut

Where do ppl buy it from?

@haidut Fantastic research. And great presentation of the pathogenicity of estrogen, once again.

@wester130 Niacin reduces inflammation and helps heal wounds. The flush is histamine release. It increases blood flow, which would logically be beneficial to hair growth. Have you ever taken it? I actually think the flush feels really good, and you have an extreme sense of well being and calmness after.

I do 'dead hangs'. Gripping a bar and supporting my weight seems to work for me.

https://www.youtube.com/results?search_query=dead+hang+benefits

@haidut Great post, I wonder if clonidine could potentially be useful here.

@haidut one such Vitamin D derived peptide is known as LL-37, and there are anecdotal reports of it curing persistent foot fungus, (the kind “nothing” seems to work on) and lifelong “gluten intolerance.”

I know peptides get thrown into the trash bin of “bro science,” (and understandably not without reason) but I wish there was more data on them. While many of them work in ways contrary to a bioenergetic approach, I believe others synergize, and the MOAs are not clearly understood.

@haidut So this isn’t something someone can run a test for?

It’s crazy how close to useless blood tests are the more we learn of this stuff

Very interesting, I’ve had issues with runaway inflammation for years, but it’s only been in the last few as I incorporated Peat’s ideas that I’ve been able to sense it. Recently I’ve had tons of success with aspirin and b vitamins, but on occasion, (for reasons I’m still not sure on) I will get a big inflammatory response the entire length of my alimentary canal. I can literally see the inflammation of my gums when this happens.

Recently on a whim I tried some Panquinone, and the inflammation abated immediately. I checked the old thread on Panquinone for information about it being an anti-inflammatory, but there was no such mention. Sure enough, today I come across this information, and I have my answer!

Many thanks for your work Haidut!

Thank you @oldchem That's the book - looking to see if there is a pdf somewhere.

@Buckian Ive had similar experiences. I now only use red light therapy before my last meal of the day and never after

Haidut what are your thoughts on PPAR gamma antagonists for diabetes and obesity? PPAR gamma knockout mice have no adipose tissue. Niacinamide seems to downregulate PPAR gamma while niacin seems to upregulate it.

This study (a bit biased on SFA) claims palmitate activates it through NNMT which depletes NAD plus and niacinamide can counter that. And since SAM is what is needed for NNMT would increasing homocysteine for a while through depleting methyl donors w niacinamide etc be a good trade off ?

https://pubmed.ncbi.nlm.nih.gov/37212549/

Niacin also increases PPAR gamma , Im wondering how the mechanism differs for niacinamide (Is it abrogating PPAR gamma transactivation only when palmitate induced or is NAD plus the deciding factor)

https://pubmed.ncbi.nlm.nih.gov/16386710/

@Kvothe yeah they are trying to kill us .... bastards lollllll

@haidut or anyone: I know a stage 4 cancer patient taking morphine sulphate 30 mg twice daily. What form of niacinamide to try and where to buy? Is a cheap brand like NOW foods ok? Extended release better? Is there an IdeaLabs supplement? SolBan looks good but dosage not high enough. I know the opoids are assisting the cancer but the pain would be intolerable without them. It started as colorectal cancer and aspirin with cyproheptadine upset his stomach. Thanks so very much for any help.