Posts made by Mauritio

How they created the oil:

One of the coolest studies I've seen in a long time.

They gave 12 depressed people a custom mix of certain oils (mostly lemon, but also orange and bergamot) and put it in their room, using a fan for circulation of the scent.
They were all on antidepressants.

They also had 8 depressed people who did not receive the scent as a control group, who were also on antidepressants.

At the end of the study 9/12 patients in the citrus scent group were off their antidepressants!
0 of the control people were able to do that.
The 3 remaining people in the citrus group were able to drastically reduce their antidepressant dosage.
It took 4-11 weeks for their depression to be in remission.

The patients inhaling citrus scent presented lower cortisol values, but also lower dopamine values. That speaks for increased GABAergic tone, since GABA reduces cortisol and dopamine.
Coincidentally lemon and orange oil consist of limonene to a large degree, which has been shown to lower cortisol and serotonin and increase GABA so that might be the active ingredient. Or at least one of them.

https://sci-hub.gg/https://pubmed.ncbi.nlm.nih.gov/8646568/

Some more interesting studies on butyrate:

• Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3×Tg-AD mice
  https://pmc.ncbi.nlm.nih.gov/articles/PMC11346541/

• butyrate improves metabolism and reduces muscle atrophy during aging
  https://pmc.ncbi.nlm.nih.gov/articles/PMC4693467/

• "Children with the highest levels of butyrate and propionate (≥95th percentile) in feces at the age of one year had significantly less atopic sensitization and were less likely to have asthma between 3 and 6 years. Children with the highest levels of butyrate were also less likely to have a reported diagnosis of food allergy or allergic rhinitis. Oral administration of SCFAs to mice significantly reduced the severity of allergic airway inflammation."
  https://pubmed.ncbi.nlm.nih.gov/30390309/

• Interesting human trial
  https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-022-06891-9

@LetTheRedeemed yes, I think this is pretty much what it is about.
Starch causes a higher insulin release and insulin causes glycogen synthesis.

@CrumblingCookie said in Random, interesting studies:

@Mauritio @cs3000 from my recent reading:
Treatment of intestinal cells with βHB or feeding mice with a ketogenic diet inhibits mTOR signaling in intestinal cells.

Butyrate stimulates catalase (no supraphysiological increase but rather recovery almost back to normal), SOD, PGF-1alpha, GPR109A. Lowers malondialdehyde, IL-1beta, TNF-alpha, leucotriene B4

Thanks for bringing this up again.
In the above study butyrate had some decent anti-oxidant effects, but where it really shone was at lowering inflammatory cytokines and increasing the expression of the butyrate receptor GPR109A also called HCA2

Even wikipedia admits that butyrate /its receptor helps with a lot of diseases.
Interestingly this receptor is also activated by niacin in supraphyiological amounts, so maybe the anti-vitamin A crowd is accidentally right about something.

"Studies, done mostly in animals and the cells taken from animals or humans, show or suggest that HCA2 functions to 1) inhibit lipolysis and 2) inhibit inflammation and thereby suppress the development of certain diseases in which inflammation contributes to their development and/or severity.[13][17][18] These diseases include: atherosclerosis,[19] stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, pathological pain (i.e. pain due to the abnormal activation of neurons),[13] mastitis,[20] hepatitis due to heavy alcohol consumption,[21] inflammatory bowel diseases, cancer of the colon,[22] and, possibly, psoriasis[23] and brain damage due to heavy alcohol consumption.[24]"

https://en.m.wikipedia.org/wiki/Hydroxycarboxylic_acid_receptor_2

@cs3000 that is interesting on T3!

Maybe that's what Peat was referring to when he said that it facilitated T3 entry In the quote above?

@Kvirion If you look at the whole picture I think butyrate is fantastic and definitely a net positive.

I made thread about it a few years ago:
https://lowtoxinforum.com/threads/sodium-butyrate-leads-to-weight-loss-and-less-inflammation-endotoxin.47498/

Butyrate increases CO2 in 3 different ways!(Uncoupling, carbonic anhydrase inhibition, as fuel for colonic cells)

It increases testosterone and lowers glutamate, ammonia and endotoxin .

Something that has these credentials, especially the endotoxin part, doesn't tend to increase serotonin.
I wrote about it in this post as there were people taking in-vitro high dosage studies out of context.

Post in thread 'Sodium Butyrate leads to weight loss and less inflammation/endotoxin' https://lowtoxinforum.com/threads/sodium-butyrate-leads-to-weight-loss-and-less-inflammation-endotoxin.47498/post-840441

In vitro studies with butyrate matter even
less than they usually do, since they don't take into account that colonic cells use butyrate as a main fuel,changing the whole gut environment.

Because you're quoting Peat, I want to mention that he has some rather favorable quotes on butyrate:
Post in thread 'Sodium Butyrate leads to weight loss and less inflammation/endotoxin' https://lowtoxinforum.com/threads/sodium-butyrate-leads-to-weight-loss-and-less-inflammation-endotoxin.47498/post-840681

@Corngold said in Favorite Peat Miracle story & Is potato protein really that good?:

@Mauritio

Did you cut starch entirely, or are you replacing it with carbs?

As my (liver) health has gotten better I naturally gravitated towards less starch. I used to crave starch for EVERY meal, now I go some days without it or minimal amounts.
I replaced starch mostly with dairy (yogurt, pudding, ice cream,...) so that should help the calcium/phosphorus as well.

Potatoes is as good as it gets for starch. But Im gravitating more and more towards no starch. Kind of happened organically , and it seems to be good for metabolism and digestion .

@cs3000 oh nice I didn't know they contained it.

https://bioenergetic.forum/post/40427

Inhalable spray-dried dry powders combining ivermectin and niclosamide to inhibit SARS-CoV-2 infection in vitro

https://www.sciencedirect.com/science/article/abs/pii/S0378517325001383

@Mauritio said in Niclosamide reduces serotonin and glutamate:

They're catching up! They're using A combo of niclosamide and acetazolamide to treat cancer.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10214212/

@cs3000 have you seen this one ?
If I understand correctly they created a new molecule containing both niclosamide and acetazolamide,which has potent anti-tumour effects .

Again it's the combination of an acetazolamide with an mTOR Inhibitor, in this case niclosamide, that has superior effects.
The same was seen in a other study I think you posted, with rapaymcin and acetazolamide.

This study shows that catalase and rapaymcin have an overlap in function.
Very interesting so low catalase might cause mTOR activation, reversed by rapa, an antioxidant or presumably catalase supplementation .
https://pubmed.ncbi.nlm.nih.gov/36474295/

@cs3000 said in Random, interesting studies:

Interestingly though feeding chickens catalase increased catalase in liver well along with the intestine, and some in blood

That's remarkable! I'm not sure what the HED is but if I'm right it's pretty low I think a few thousand units and most supplements have several 10k per pill.
Also: the trippling of catalase in organs might have drastic effects on health and longevity ,since those values are in line with that selegiline or ergothioneine achieve.

Check out this post: ergothioneine increased catalase by about 2.5 fold.
https://bioenergetic.forum/post/17948
So it's actually less effective at raising CAT than catalase supplementation in chickens , yet it still increases life span by 20% .

@cs3000 what do you think about a catalase supplement ?

Given that selegiline, ergothioneine and other successful anti-aging substance all leverage the antioxidant pathway, it seems like something worth trying.
Plus over expression of catalase to mitochondria lead to a 20% increase in life span in mice.

The supplements are very cheap. The only issue I see is that of absorption. Would there be a systemic effect , penetrating into the cells and mitochondria?
If that wasn't the case there wouldn't be douzens of success stories of people reversing grey hair with it , since h2o2 is produced inside the cells and mitochondria .

@CrumblingCookie interesting . Yeah it might have some messy hormonal effects.

@Hearthfire nice they used fresh basil in some studies so that's probably the best way to go!

@cs3000 said in Holy Basil: Phyto-TESTOSTERONE, Progesterone and thyro-mimetic ?:

@Mauritio
looks best trying close to sleep / or before last meal with carbs with the glucose effect, if theyre similar here maybe it wore off and caused lower gaba activity through the night? if dosed high the rebound could hit excessively looks potent

In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
https://pubmed.ncbi.nlm.nih.gov/36750371/
Although in this study it showed no effect on sleep.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

so shows 1g of dry plant powder is too low for effects. i have effective dose of dried leaves powder at 2.5g - 7.5g

Even the microdose (30mg) caused waking up to early for me. It felt like hypoglycemia, woke up with a pounding heart.

But maybe you're onto something with the GABA theory. GABA rebound is real.

I obtained dried powder of both basils and will continue experimenting.

"The biochemical parameters of hepatic function, renal function, glucose, triglyceride, and cholesterol level were significantly reduced in the treatment groups compared with the control group (p < 0.05)"

https://pubmed.ncbi.nlm.nih.gov/39555564/#&gid=article-figures&pid=figure-1-uid-0

Another reason to favor O. Basilicum !
Yeah it does have a glucose lowering effect. There's a few studies on basil as a diabetes treatment . I notice the hypoglycemic effect.

Interesting in that dosage it actually caused sleep issues for me . Although that was O. Sanctum and not O. Basilicum as in this study.

In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
https://pubmed.ncbi.nlm.nih.gov/36750371/

Although in this study it showed no effect on sleep.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/