Posts made by Mauritio

@CrumblingCookie Good point .
Well, sodium butyrate is widely available ...

@Luke nice I never shop at netto so I didn't know they had mandarine juice. Since REWE removed my beloved clementine juice I'm in need for a replacement. I'll check it out.

I have some mango stripes from my local market that are even better but DM is a close second.

This website has some good sweet stuff .

Organic orange marmalade that contains all the good polyphenols and limonene from the peel (hence it's important to get an organic one without pesticides)
https://www.memolife.de/laselva-bio-orangen-marmelade-220-g-h528c

Or some marshmallows with decent Ingredients
https://www.memolife.de/oekovital-bio-marshmellows-vanilla-mellows-90-g-h515p

Also a lot of guit fruit marmalades or dried fruit.

Besides that I want to mention Landliebe vanillapudding , which is 90% milk and very tasty. Great macros. High carb low protein.

Also Edeka has some good creme brulee without any bad ingredients.

REWE has some great vanilla, chocolate and caramel puddings in small glass containers , no bad ingredients as well.

The best OJ right now is Amecke milde orange IMO .

Oh and DM has some dried mango stripes that are absolutely delicious

Hope that helps.

Yesterday I did 1g of basil (O. Basilicum)powder.

I took it in the morning and it had a strong relaxing /anti cortisol effect on me.
Muscles looked very full and less water retention as well.
During the afternoon I became a bit irritable and serotonergic ,but not sure if related at all. Might be due to gut issues from the day before.
I also felt quite confident and masculine. Totally recommend. Will try again .

And the best part was it didn't mess with my sleep like in my previous experiments with holy basil.
It was a bit harder to fall asleep but I didn't wake up early.
Maybe that was because it was basil and not holy basil this time, but maybe it was me taking it so early that the GABA rebound was over when i went to sleep.
I also took some limonene in the evening which increases GABA so maybe that flatened the GABA issues.

Today I woke up weighing 500g less and muscles looking Big and full . I had no morning wood today which is unusual . But some androgenic substances do that to me.

I still want to try 500mg and 25mg to see how that feels in comparison.

@Gaston Well how about smelling citrus scent?:D

@jamezb46 good point. I love the smell of pine trees, too.

@Lejeboca said in Smelling citrus scent cures depression in 75% of study participants:

which not necessarily depended on the assessed depression levels.

What else would it depend on? The limiting factor for lowering your AD dose is if youre well enough to handle it. So if their depression didn't get better, they wouldn't have been able to reduce their dosage. As can be seen by the 3 individuals, that weren't well enough to completely come off AD's, so they didn't.

@Lejeboca said in Smelling citrus scent cures depression in 75% of study participants:

Also I could not find in the paper for how long the fragrance was applied. Post-assessments show only the number of weeks after the fragrance application.

It says it took 4-11 weeks to work, that's all I need to know.

@alfredoolivas yes you can look up my posts on the thread on the rpf on it.
And I still experience increased mood and energy on it. Im figuring out the dosage.
50mg seemed to be too much . 25 too little and today I took 35mg . Which seems to be a good mix.

So 35mg, 1-2/week might be a good protocol.

@Mauritio said in Niclosamide reduces serotonin and glutamate:

@bio3nergetic it's OTC in Germany. You can get 4 500mg pills for like 15€ ,which should be enough to try it out. For me that's like 40 dosages so will last quite a while.
It's called yomesan.

Inflation is real on this one.
In 2021: 5 tablets 6€
2025: 4 tablets 15€

Had to look up my old post on it lol
Post in thread 'Niclosamide for fat loss/ uncoupling' https://lowtoxinforum.com/threads/niclosamide-for-fat-loss-uncoupling.42781/post-718904

@bio3nergetic it's OTC in Germany. You can get 4 500mg pills for like 15€ ,which should be enough to try it out. For me that's like 40 dosages so will last quite a while.
It's called yomesan.

@cs3000 oh what were those side effects ?

Wow, niclosamide night be able to replace the low infrequent antibiotic dose peat recommend and the dosage wasn't even that high. Nice.

Niclosamide has excellent safety profile. They gave humans up to 1600mg daily and they observed no major side effects.
I'm taking about 50mg .

@sushi_is_cringe same. sometimes I put them on the heater which spreads the scent.

@Mauritio said in Smelling citrus scent cures depression in 75% of study participants:

Coincidentally lemon and orange oil consist of limonene to a large degree

Here's a short list of limonenes benefits:

D-Limonene ‍🟩:

• Increases brain GABA + lowers serotonin

• Reduces endotoxin and obesity in animal studies

• Increases UCP2

• Anti-viral, anti- bacterial, anti-fungal

• Anti-fibrotic

• Increases bile acids

• Increases vitamin C (up to 15 times in one study)

• Increases Testosterone (slightly) and increases androgen receptor expression

• Has Pregnancy supporting effects

How they created the oil:

One of the coolest studies I've seen in a long time.

They gave 12 depressed people a custom mix of certain oils (mostly lemon, but also orange and bergamot) and put it in their room, using a fan for circulation of the scent.
They were all on antidepressants.

They also had 8 depressed people who did not receive the scent as a control group, who were also on antidepressants.

At the end of the study 9/12 patients in the citrus scent group were off their antidepressants!
0 of the control people were able to do that.
The 3 remaining people in the citrus group were able to drastically reduce their antidepressant dosage.
It took 4-11 weeks for their depression to be in remission.

The patients inhaling citrus scent presented lower cortisol values, but also lower dopamine values. That speaks for increased GABAergic tone, since GABA reduces cortisol and dopamine.
Coincidentally lemon and orange oil consist of limonene to a large degree, which has been shown to lower cortisol and serotonin and increase GABA so that might be the active ingredient. Or at least one of them.

https://sci-hub.gg/https://pubmed.ncbi.nlm.nih.gov/8646568/

Some more interesting studies on butyrate:

• Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3×Tg-AD mice
  https://pmc.ncbi.nlm.nih.gov/articles/PMC11346541/

• butyrate improves metabolism and reduces muscle atrophy during aging
  https://pmc.ncbi.nlm.nih.gov/articles/PMC4693467/

• "Children with the highest levels of butyrate and propionate (≥95th percentile) in feces at the age of one year had significantly less atopic sensitization and were less likely to have asthma between 3 and 6 years. Children with the highest levels of butyrate were also less likely to have a reported diagnosis of food allergy or allergic rhinitis. Oral administration of SCFAs to mice significantly reduced the severity of allergic airway inflammation."
  https://pubmed.ncbi.nlm.nih.gov/30390309/

• Interesting human trial
  https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-022-06891-9

@LetTheRedeemed yes, I think this is pretty much what it is about.
Starch causes a higher insulin release and insulin causes glycogen synthesis.

@CrumblingCookie said in Random, interesting studies:

@Mauritio @cs3000 from my recent reading:
Treatment of intestinal cells with βHB or feeding mice with a ketogenic diet inhibits mTOR signaling in intestinal cells.

Butyrate stimulates catalase (no supraphysiological increase but rather recovery almost back to normal), SOD, PGF-1alpha, GPR109A. Lowers malondialdehyde, IL-1beta, TNF-alpha, leucotriene B4

Thanks for bringing this up again.
In the above study butyrate had some decent anti-oxidant effects, but where it really shone was at lowering inflammatory cytokines and increasing the expression of the butyrate receptor GPR109A also called HCA2

Even wikipedia admits that butyrate /its receptor helps with a lot of diseases.
Interestingly this receptor is also activated by niacin in supraphyiological amounts, so maybe the anti-vitamin A crowd is accidentally right about something.

"Studies, done mostly in animals and the cells taken from animals or humans, show or suggest that HCA2 functions to 1) inhibit lipolysis and 2) inhibit inflammation and thereby suppress the development of certain diseases in which inflammation contributes to their development and/or severity.[13][17][18] These diseases include: atherosclerosis,[19] stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, pathological pain (i.e. pain due to the abnormal activation of neurons),[13] mastitis,[20] hepatitis due to heavy alcohol consumption,[21] inflammatory bowel diseases, cancer of the colon,[22] and, possibly, psoriasis[23] and brain damage due to heavy alcohol consumption.[24]"

https://en.m.wikipedia.org/wiki/Hydroxycarboxylic_acid_receptor_2

@cs3000 that is interesting on T3!

Maybe that's what Peat was referring to when he said that it facilitated T3 entry In the quote above?