@yerrag said in Creatine and Ray Peat:
@mostlylurking I think (I have not been reading a lot lately so I could be wrong) that anaerobic glycolysis is wasteful of thiamine, and that thiamine mega dosing helps, but clearing the capillaries of obstruction to make oxygen available to the brain fully is the way to fixing Parkinson's. Thiamine megadosing helps by compensating for the inefficiency and wastefulness of anaerobic glycolysis.
Hi yerrag, thanks for the link; I always value your insight. I read through your post and immediately thought of a Ray Peat audio when he discusses vitamin K2 for removing calcium in the circulatory system.
I believe my own thiamine deficiency/functional blockage fall of 2020 derailed my calcium storage which usually means the calcium that is supposed to get stored in the bones gets stored in the soft tissue (including the blood vessels) instead. Peat related a story about a doctor he knew that used high dose K2 (40-50mgs?) to resolve his hypertension.
Thiamine is needed for good oxidative metabolism. When it is deficient, the end product of the process is lactic acid instead of carbon dioxide. If things are working right, the carbon dioxide drags the calcium inside the cell out when the carbon dioxide exits the cell (from memory - A Peat explanation from somewhere). So it makes sense that calcium storage would get derailed in a thiamine deficiency.
Here's a link or two:
https://bioenergetic.life/?q=k2
The one with the story about the doctor high dosing the K is in there somewhere....
also this:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926526/
Please note that vitamin D, needed for the immune system to work, also is responsible for making calcium get stored in the bones; in order to do this, there needs to be vitamin K available. So I think both D and K would be helpful.