Dandruff or scalp irritation? Try BLOO.
No sooner than I closed the previous post did I began to question my approach.
Considering I had not slept for 3 days, and that I survived the 3 x 32mg dosing for a day, and that the recommended treatment is a one time intake of 50mg or even 70mg (based on 1mg/kg),
why am I holding off on using a one time dose when it has already been used and recommended?
So, at lunchtime, I will take a 50mg dose, while accounting for the 16mg I tookat midnight.
I think that my struggles with sleeping will never go away unless my lungs are cleared of waterlogging or edema. That the edema is happening in the lungs does not mean it is confined to the lungs, as it can happen in the ankles and in the waist, but it is significant when it happens in the lungs especially that it powers the heart greatly and the lack of oxygen as a substrate has a great deal to do with heart failure.
Moreover, the lungs being waterlogged keeps it from deactivating serotonin, and when this happens, no amount of effort on my part is going to allow me to sleep. Already 3 days in without sleep, I take this issue as my job 1 before anything else.
Last night, I have no choice but to get back to mb treatment. I use s familiar dose at 16mb at midnight and spent the whole night monitoring for changes in spO2. It confirmed that mb did indeed increase my spO2 values greatly, confirming mb as an effective treatment.
However, despite using 3 drops of Cypro, I could not get myself to sleep. This means I have to find an mb dosage and frequency that would eventually result in dry lungs. Dry lungs would ensure serotonin is deactivated by the lungs. Not only can I sleep well, but my heart will pump much better.
Good that I have a tool to see if my lungs are dry- personal ECG that can graphically show a tall QRS wave.
I may be conservative and go with 3 x 16mg mb a day for now, and if I don't see much headway will increase dosage upward.
It's too bad I don't have the benefit of using doctors or even members here with the experience and insight I so need, but I will manage. It has happened to me before, so I am no stranger to it.
Thanks for your comments, advice, and support.
@Kilgore That was the exact same though process I had that led me to ask. Thanks
@CrumblingCookie said in Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin:
@yerrag
Sorry to read that you crashed into excessive MB MAO-inhibition and agitation, anxiety.
3x32mg = 96mg of MB in one day after already 48mg the day before and some the day before is really much.
Yes, two days since the 96mb day I get very hyper that lying down causes a hyper reaction. I'm hoping I could use the Cypro which I manage to find tucked between a nook and cranny. My sis gave me chamomile tea to calm me down
There's always a first time.
It'd be easiest if some of the caused anxiety and insomnia were caused by low-BG and some dextrose could help.
Not with me. My.blood sugar is top notch.
I know fresh ginger, ginger juice or oily ginger extract are anti-serotonine at high doses. They'll block CYP3A4, though, so not a sustainable thing to do.
Thanks. I hope I don't have to use them.
Not sure whether your CO hypothesis holds up after a trial with this much MB. Do you think your current extrapolations are becoming too far stretched? Perhaps very limited in their practical extent, even if theoretically true?
Except for the MB snafu, the theory is sound. It's no coincidence that my breathing became short and my neutrophils and macrophages got so active after I used the zapper with the lymphatics program chosen.
I'm not able to use fennel seeds to make me sleep. I may have to use a lower dose of mb to keep it from having a strong serotogenic effect.
Not getting enough good sleep will just make it hard for me to get energy to handle this project. As it demands flawless design and execution. And I find myself dozing off when I so research and plan next steps.
Last night, I was on the 2nd night of not being able to sleep.
I have a supply of fennel seeds, and tried chewing on a spoonful of seeds, on the strength of hasty online research, as I got the impression cheesing on it would me sleep.
To my surprise, it succeeded in making me sleep.
This afternoon, I wanted to verify further whether fennel seeds really is anti- serotonin.
And Gemini told me it has tryptophan, and has serotonin. The implication is it would not help me sleep.
So should I trust experience or Google's AI?
I really needed an honest answer, as my recovery after overdosing on methylene blue, so I can proceed to my goal of fixing my lungs from hardness of breathing, which is the first step I need to be able to rely on my innate immune system's phagocytes (neutrophils and macrophages) to destroy heavy metals (both iron and lead) with the aid of an effective chelator (Emeramide). Since phagocytes need respiratory burst to be able to produce ROS to eat up the heavy metals, and respiratory burst uses up a lot of oxygen, I would need to have a strong set of lungs to provide a good supply of oxygen to support the phagocytic respiratory burst action), otherwise the high demand for oxygen in respiratory burst action would cause me to run out of oxygen- and cause me to be sent to the ER.
Thanks. And if you have any info anti-serotonin substances other than Cyproheptadine, kindly pass on.
Some more info: MB destroys or neutralizes the carbon monoxide(CO) or counters it's action. CO and iron is released by the enzyme heme oxygenase from breaking down red blood cells.
@yerrag said in Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin:
@CrumblingCookie said in Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin:
@yerrag said:
After breakfast I'll decide on the dosage I likely would do a 3 x 20mg for the day.
The wanted benefits should be felt very quickly, IIRC within 1 hour. If 20mg in the morning works well, maybe 15mg 8hrs later is also already enough. I think MB is a very powerful and important instrument acutely.
Yes. Good thinking.
I don't think it generally changes chronic conditions once it's out of the system again (after a few days). Just don't take it without carbs or glucose / on an empty stomach to avoid a glucose drop.
If the source of carbon monoxide (dead red blood cells worked on by heme oxygenase) is depleted, there would be no chronic condition to deal with.
I also just remembered that Methylene Blue as a phenothiazine complexes with B2 and leads to higher excretion so it's important to not become deplete in B2 while "binging" MB. Vitamin B2 also acts as an important redox agent.
Thanks, I'll increase my B2 intake just to be sure.
The past two days I have become bloaty and serotogenic and couldn't sleep.
The first day on mb I got the dose right, at 3x16mg. I doubled it the next day to 3x32mb, which was a mistake as 70mb/day was my limit. And I had made a boo boo in my calculations.
Yesterday I felt terrible and ate little. Too much and the medicine becomes the disease itself.
Last night I chewed on a teaspoon of fennel seeds, and I caught some needed sleep, though short as it is.
I hope the meth blue wears out quickly. Will take a few days of rest to recover and the resume my original plan of detoxing the carbon monoxide, which may or may not have exhausted its source of dead read blood cells taking up space in my lymph.
When all is done, the CO will be gone and my breathing not be strained, and the free iron that uses to be in my hemoglobin would be sequestered chelated, and excreted. This will in turn lower my blood pressure.
@dapose You hit many right notes there. Usually there is an imbalance and that leads to a dominance that is seen as pathogenic. Perhaps we should see restoring balance as the goal. We never really kill or eliminate like genocides are natural, we only discourage dominance because uneven playing fields make it happen. Intentional or nor.
Glad that it worked for you the 2nd time around. It could be about cycling, as that is something I forget to do at times. It it could be that you changed that made your interior more conducive to being fixed.
Have you considered turpentine? It has been used to fight candida albicans in the gut suçcessfully by Dr. Daniels
I once discovered by live blood analysis I have candida residing inside my red blood cells. It was causing hemolysis but was not detectable by standard lab testing. I took turpentine daily for 2 weeks and I believe the candida was gone but it also helped that I made sure I had acid-base balance by having good mitochondrial metabolism with also help using carbogen while I slept. I could not really verify but my urine had turned into a golden fluorescent color where it had been beer amber that showed tinges of blood.
@CrumblingCookie said in Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin:
@yerrag said:
After breakfast I'll decide on the dosage I likely would do a 3 x 20mg for the day.
The wanted benefits should be felt very quickly, IIRC within 1 hour. If 20mg in the morning works well, maybe 15mg 8hrs later is also already enough. I think MB is a very powerful and important instrument acutely.
Yes. Good thinking.
I don't think it generally changes chronic conditions once it's out of the system again (after a few days). Just don't take it without carbs or glucose / on an empty stomach to avoid a glucose drop.
If the source of carbon monoxide (dead red blood cells worked on by heme oxygenase) is depleted, there would be no chronic condition to deal with.
I also just remembered that Methylene Blue as a phenothiazine complexes with B2 and leads to higher excretion so it's important to not become deplete in B2 while "binging" MB. Vitamin B2 also acts as an important redox agent.
Thanks, I'll increase my B2 intake just to be sure.
Thanks but I don't have a hydrogen machine, though I admit I also am skeptical of hydrogen machines.
Which leaves me with deciding what dosage to use for the mb.
After breakfast I'll decide on the dosage I likely would do a 3 x 20mg for the day.
I am dealing with shortness of breath as well as edema in my ankles and my waist that is reminiscent of last year's leadup to heart failure.
This time I know better on what causes it, and am taking things to my own hands rather than defer to the expertise of my cardiologist and my pulmologist. Although I will be forever thankful to my doctors for saving me from death from heart failure, I realize seeing them to solve this repeat issue is only going to lead to the same issue cropping up every now and then, with each time making me weaker. This rinse and repeat cycle only ends with me weaker and closer to death in a slow death spiral common to patients having been confined for heart issues.
I surmised by deductive reasoning that when I used zapper emf frequency to spur my lymphatic system to release dead red bloods that had congested in my lymph, it let loose a mass of RBCs into my lungs. The enzyme heme oxygenase began to produce carbon monoxide and iron from the heme in RBC. Free iron is toxic as well, but I shall concentrate in the interest of brevity on the harm being caused by the carbon monoxide.
The CO (carbon monoxide) causes the lungs to be watery and to restrict breathing. So much so that I experience hardness of breathing, and my spO2 levels would plunge 88, though this sporadic, and values of 75 would occasionally come up. This isn't good.
The doctors would never see this as a CO issue from dead red blood cells. the cardio would give me BP medication to lower BP and diuretics to get rid of water in my lungs. My pulmo would concur.
I did some research on how to deal with CO poisoning, and got a lot of hits, and all of these solutions involve the use of methylene blue at large amounta such as 50mg to 70mg to be taken in one sitting diluted in 100ml water. There is another option, using IV and using less water.
Well and good. But I would wonder why I can't find a protocol using MB for my situation. Further search only got me treatments using oxygen and hyperbaric oxygen. Personally, I think this is inane.They won't work. As how would more oxygen work when the lung is watery and can't take in oxygen in normal amounts.
I've taken lower amounts of mb to see if I could see mb effective at lower doses. But the doses I've taken are really low, just to be safe (although I'm aware that dosing is biphasic and lower doses can make it ineffective or even harmful).
I've done a day at 3 doses of 16mg (40 std drops of 400 mcg) and another at 3 doses of 32mg. Both are no good.
Am thinking of doing at a much higher one time dose of 35mg (which is half of the dose for CO poisoning common for CO inhalation in enclosed garages) and if this doesn't work I'll punch it up to 70mg.
I think 70mg is safe, but thought I'd run this by you guys here.
Incidentally, my case of CO poisoning via heme oxygenase may be more common but never diagnosed. I just happen to stumble upon it when my zapper emf treatment caused this issue. I think anytime the lungs suffer and is congested, the possibility of red blood cells dying en masse can result in the pooling of rbcs that are a ticking time bomb waiting to be released. What about the case of long CoVID also?
They are deserving of the nomination.
I hope though that this isn't a popularity contest.
While Joe Rogan deserves some recognition in other areas, health isn't one of them He is earnest though, and does not seek to mislead intentionally, but his love for a carnivore diet leads many to a lifestyle of stress and the consequences downstream. I may be late and Joe may have turned to accepting a well rounded bioenergetic view based on the research of Peat. But if not, he needs to get board.
Yeah, I hope I can get to find time learning they observing the microlife within me I now have to resign myself to simply accepting what labs tell us.
@cs3000 said in Thymus health:
Looks like a big health unlock , neutrophils are big players in autoimmune problems maybe the biggest, you see them showing up causing big damage in a wide range of health issues covid cystic fibrosis ulcerative colitis heart failure etc
and theyre highly destructive with different weapons, cytokine release, then they have proteases that degrade the structure surrounding the cell (if u inhibit neutrophil proteases in arthritis they dont develop arthritis at all https://pmc.ncbi.nlm.nih.gov/articles/PMC150852/ ), and they can form wild traps where they basically gut themselves & spill out strands of dna laced with proteins to form damaging webs like some kind of arsehole spiderman in the autoimmune situation
There is a lot I don't understand about the adaptive immune system and maybe it's this lack of understanding that betrays my view in seeing autoimmunity to be largely involved with B-cells.
In this regard, autoimmunity is not so much different from being very sensitive to stimulus that the immune system wrongly regards something that is endogenous as being foreign.
I have chronic high blood pressure and it is the result of my neutrophils and macrophages of the innate immune system trying to get rid of heavy metal toxins and periodontal infections with no success, given the persistency of these insults where they don't get permanently removed or killed. It is like Groundhog Day for my immune system where they keep repeating their efforts to get rid of persistent insults that keep bouncing back. Yet I do not consider the inflammatory effects of this endless effort to be an autoimmune condition. But I blame the tenacity of heavy metals refusing to be swallowed up and excreted out, and the ability of synergistic bacteria and fungi to defend against attack by phagocyte activity by neutrophils and macrophages.
But lately I have used techniques and substances to assist my immune system to successfully get rid of the hitherto unremovable toxins and immortal infection. But I had to employ medically unorthodox techniques to achieve these.
Seems to me medical complex is guilty of spreading misinformation and disinformation to label as autoimmune, on the strength of their vaunted research which are in many cases made up stories to lead trusting souls astray.
Yet I do not wish to throw the baby with the bathwater, for a large part of the body of research is valid, and a good filter is needed to separate wheat from chaff.
Thanks David. Looks interesting, but very deep and I wish my mind can ensure the onslaught of very unfamiliar words when reading on immunity down to deep levels.
I am reminded of what Peat had said before about T cells- that if you have a good T-cell response, you really won't need to rely on B-cells for immune protection as much. It is like saying a B-cell response is optional when T-cells are involved in the response. I remember him talking or writing about this at the start of the CoVID years. And in the ensuing two years marked with headlines about COVID, all I could hear was centered on B-cell immunity and ntibodies, centered on viral therapeutics.
The funny thing is that the elephant in the room was always being ignored, in the absence of the mention of the T-cells, such that its importance was being downplayed. It seemed to me the medical response is to trivialize the importance of T-cells to improving our body's response to the putative virus.
I think that beefing up the thymus gland should be the main topic of the COVID response.
@Johann2547 said in Thymus health:
And IIRC theanine is beneficial for the thymus.
interesting thread. makes me think the thymus, being where t cells mature, gets to have a sizable impact on how our immunity functions, or dysfunctions
For one, it dampens the inflammatory response of the innate immune system, characterized by the heavy involvement of neutrophils and macrophages where phagocytic activity can result in a large amount of collateral peripheral tissue damage from spillover ROS.
And given that the lack to T cells can result in B cells exerting more immune response, the tendency of B cells to generate autoimmune responses is also problematic.
Seems to me that ensuring we have a healthy thymus favoring the calming and moderating influenxe of T cells is not a small matter, and that metabolic health, where the stress hormone has to be kept to a minimum level of production and influence can never be stressed, pun not intended, enough.
I can't help but think of metabolic health being as impactful on our immunity, and this is is but just one example of Ray's dictum that metabolic health drives all other aspects of health in us.
I know I have a very rudimentary understanding of immunity, and I'm just giving an immaturely formed rambling of what I can gather from the musings of @mauritio and @cs3000 and @DavidPS
Please let me know how far off I am and what more you can detract and add to it