Posts made by yerrag

@gg12

It must be tough. I hope you find someone who's gone thru your initial experience and struggle and found a way to slowly get back to enjoying life with the drugged past being only a memory. One thstthat has cut his teeth the hard way would be able to help you avoid the difficult task of curing yourself on your own. Finding such a guide or coach is crucial, and healing on your own effort, while possible, can be very hard as you are not in the best position to think on your own. Hope you also have a supportive family or friends too.

That said, its good you have the desire to care enough to reach out for help. I pray and wish you the best in the coming years.

@gg12

Death is just a beginning to another plane of existence. I consider it a rite of passage not to be feared. But it doesn't meaning I'll do everything to hasten my death but on the contrary I want to live long in health, and continue to make myself useful. I hope I don't run out out of meaning and purpose as life becomes drudgery.

@Lejeboca said in Thymus health:

This got me thinking that, since our endogenous CORT is "naturally" elevated in the morning, if we have an LPS-prone breakfast, then any existing inflammation will spike.
So

• rule #1, breakfast that is easy on digestion (Ray-Peat-right-again!)
  At breakfast time consider
• charcoal or anything digestion-promoting
• getting red/sun light at breakfast time to to decrease NO and other inflammatory cascade factors.

Thanks. What would tou consider to be an LPS-prone breakfast? Is it a soluble fiber-rich breakfast, one that includes substances that kill bacteria and thus produce LPS remnants of bacteria? What are some noteworthy examples of such a breakfast?

@DavidPS You're welcome David. Thanks for bringing up the subject.

@DavidPS

My bad experience with using a potent dose of serrapeptidase just once was enough to cause my already high BP at 180/120 to increase further to as much as 240/160.

I was cautious. After just taking a capsule, I had a cbc done 4 days later and saw my wbc spike up to 11 from 8.

Since I don't believe in the existence of viruses, I just thought bacteria and fungi were released with the lysis of plaque.

For the next 4 years, I was busy using everything I could get my hands to bring my bp back to 180/120. It made me loathe antibiotics as ineffective, and hate using them for worsening my internal microbiome towards being more infected with fungal forms such that I had no choice but to use approaches like using turpentine with success. I followed up with using suppositories of essential oils and finally got my bp back to 180/120.

Getting rid of plaque opens up a Pandora's box and has unforeseen consequences. Sellers of serrapeptidase don't ever tell us to be cautious but their product is not without a dark underbelly. Plaque untouched by our unknowing interventions is a good thing when we know not to appreciate the adaptations our body employs to keep us from immediate harm.

@PranaDeva said in the main goal of humanity is to populate other solar systems:

Humans born on Earth may not be able to survive off planet. But when we die, we can incarnate onto other worlds as natives to a different planet or plane of existence.

Good. No need to worry.

We should be free as a bird is.

@TexugoDoMel said in Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer:

@yerrag

That general view of some peaters about lipolysis that you quoted in your reply probably stems from a misinterpretation of what Ray said about it. The emphasis he places on inhibiting lipolysis is in the context of too much PUFA stored in the tissues, which becomes less and less necessary as you become “PUFA depleted”. After that, inhibiting lipolysis becomes more of a therapeutic tool to be used in appropriate contexts, such as in some pathologies.

I agree with how you qualify the need for inhibition of lipolysis, in that it is only needed when there is too much PUFA stored in the tissues.

When that is the case, inhibiting lipolysis to such extent that fat stores don't undergo lipolysis except for a trickle isn't the solution, as when one takes too much niacinamide or when one increases insulin levels either by injection or by excreting a lot of it. As this keeps fat stores abundant and the person overweight or obese, and goes against the objective of becoming of normal weight again.

The answer lies in going cold turkey on further intakes of PUFA for a relatively long period of time, say about 4 years, during which time PUFA stores are allowed to slowly lipolyze. During this time, PUFA will be released from fat stores and so the stress it produces has to be minimized. Because the presence of PUFAs is expected to hinder sugar absorption and metabolism, there is no choice but to accept that as a transitionary evil to be dealt with. It would be helpful to take antioxidants such as vitamin E to minimize runaway lipid peroxidation reactions and to minimize blocks in the ETC arising from lipid peroxidation, and to modify food intake by eating carbs that have fiber that slow down the time and the rate by which carbs are assimilated into the blood stream. Instead of a quick sudden flood of glucose from eating white rice, eating brown rice would help slow the flow of blood sugar to a trickle that doesn't overwhelm the limited rate by which the body absorbs blood sugar. This keeps blood sugar from rising too much that triggers the release of insulin which often results in blood sugar being converted to fat in the liver and in blood sugar dropping to very low levels, which causes stress to increase from low blood sugar levels.

Accompanying the brown rice with plenty of meat protein and some fat in that meal would further slow down the rate of assimilation of sugar into the blood stream. In this way, blood sugar from a meal would trickle is slowly over a longer period of time. Ideally, the rate it trickles in would keep blood sugar maintained at normal healthy levels from that meal well into the next meal without blood sugar getting too high nor too low. Managing to achieve blood sugar stability between meals would keep the body from having to increasing insulin levels. Without high insulin levels, the body would be allowed to lose fat by lipolysis over this period while it is kept from making more fats via insulin signaling (with insulin being kept from being excreted excessively from minimizing high blood sugar levels).

This is not an easy task, as 4 years in a long time, and requires one to have the discipline to stick to the plan. With patience, over time the body will be rid of PUFAs, and this will open the way for blood sugar to be quickly absorbed and metabolized.

One can eat white rice once again, and as the ability to metabolize sugar optimally via the mitochondria is restored and strengthened, basal metabolism improves to such extent that internal metabolism increases, making the need for external metabolism less needed.

One can eat plenty of white rice with no need to do any tricks like intermittent fasting and have no need to walk the stupid 10,000 steps a day to be slim and normal weighted. Like I do.

Which is why I fail to see the wisdom in people saying one can bypass the 4-year cold turkey on PUFA intake by simply taking niacinamide and aspirin. This method just keeps PUFA in the fat stores and minimizes beta oxidation and the conversion of fatty acids into energy.

Moreover, relying on insulin excretion is only useful in lowering blood sugar st the cost of gaining weight. Which explains why following the dictates of the AMA and their doctors is a surefire way for the country to have an obesity epidemic and for the health of the population to keep getting worse.

For such a population, healthcare insurance companies can only make money by denying treatment as an insurance system where 100 percent of those insured will get sick and need costly treatment. When treatment is guaranteed for the sick, the healthcare insurance company will just go broke.

He even mentions that in healthy people (especially children) stress hormones are only produced in the amount needed because free saturated fatty acids serve as negative feedback, not allowing them to rise beyond what is necessary.

Good point. I must have missed reading this. Could you share the newsletter or where it is quoted?

In good health, especially in children, the stress hormones are produced only in the amount needed, because of negative feedback from the free saturated fatty acids, which inhibit the production of adrenalin and adrenal steroids, and eating protein and carbohydrate will quickly end the stress. But when the fat stores contain mainly PUFA, the free fatty acids in the serum will be mostly linoleic acid and arachidonic acid, and smaller amounts of other unsaturated fatty acids. These PUFA stimulate the stress hormones, ACTH, cortisol, adrenaline, glucagon, and prolactin, which increase lipolysis, producing more fatty acids in a vicious circle. In the relative absence of PUFA, the stress reaction is self limiting, but under the influence of PUFA, the stress response becomes self-amplifying.

This misinterpretation is probably one of the bases for the idea that moderately high insulin several times a day is beneficial (because it inhibits lipolysis and increases glucose oxidation). I don't particularly consider insulin to be a “stress hormone”, but high insulin several times a day and for long periods is obviously a bad sign; insulin plays an “enhancing” role and not the main role.

Keto diets, a very low fat and/or very low protein diet, exercise, ACV before meals, walking after meals, and other similar tools aimed at reducing insulin are only necessary if metabolic dysfunction is already present. Is it good to have these options available with the constant attacks on our health? Yes, but the more miraculous a therapeutic tool is, the more likely it is that your health isn't as good as you think.

If we peel away the layers of band aid we rely on, we realize that is the standard of care that only leads to the creation of more problems that require our experts in the medical establishment to guide us to the promised land.

@DavidPS

I've suspected for a long time that poor kidney function does not really require absurdly low levels of protein intake.

I think a lot of the medical myth has a lot to do with the perception that a higher protein intake increases creatinine levels, and because the eGFR formula used by rote and without question following the pied piper training of lemmingian doctor NPCs and transmitted to an uncritical base of miseducated people leads to the wrong think that eating less protein correlates to lower creatinine levels and a formulaic increase in the eGFR. An increase in calculated eGFR is assumed to indicate better kidney health.

But the e in eGFR means the eGFR is just an estimate, no better than a guess or a rule of thumb, and eGFR can be way off the mark when compared to actual GFR. And creatinine levels do not necessarily have a negative correlation to glomerular filtration rates (GFR).

This myth is a disservice to our health as it leads us to unnecessarily low levels of protein intake, which would severely rob us of key nutrients needed for our health upkeep.

Another association with protein intake has to do with protein being acidic, and because of this fact, protein avoidance or minimization is needed to keep the body ecf (extracellular fluid) from being acidic.

While it is true that we rely on our kidneys to maintain pH balance, and to keep us from being chronically acidic and to keep our organs from degenerating by calcification and fibrosis, it isn't by the fearful reduction of meat and protein intake that we keep ourselves from becoming chronically acidic and diseased, it starts with us knowing how to maintain a healthy lifestyle centered a lot on having the nutrients that keep our organs from degenerating and aging.

The kidneys that stay young and working well benefit greatly from keeping our ecf pH optimal such as calcification and fibrosis are avoided. Lessening protein intake may be needed when kidneys are already advanced in their degeneration, but with healthy kidneys that benefit from good acid balance protein restriction is not something to be of concern as healthy kidneys and a sound mitochondrial sugar-dominant metabolism provides us with a surplus of a pH buffer in the form of CO2 to keep us in a continual state of acid base balance.

@DavidPS

This is a sounder model, but that's all it is as it is only less sound.

How the medical system has put insulin at the apex of its medical malfeasance dogma is appalling, along with its many falsehoods. To name a few more equivalents of Nobel laureate level hoaxing such as the banshee worship of non-existent viruses, the bedevelling of CO2 within and without the body (downplaying its salutary role as an all important pH buffer within, and its regulatory role in providing earth with a green blanket of forests), the vilification of protective hormones such as progesterone with the false worship of estrogen in its altar of repose with western christian churches in an evil collaboration of promoting superstition and fear.

Even the bioenergetic community blathers on the term insulin resistance as it echoes in unison with the false reliance on insulin as it's savior, refusing to see insulin as just another stress hormone from the true Peatarian view of it. Instead of less insulin being seen as beneficial, insulin is viewed as needed and vital to blood sugar regulation.

To such extent that when the body refuses to lower blood sugar as the charlatans would have us believe, it is never called an acute phase biomarker but instead the body is considered stupid and unwise and in dysregulation.

Insulin does more than just lower blood sugar, and it only does so when the body's ability to absorb and metabolize sugar efficiently via the mitochondria. Only when the body fails in lowering blood sugar does insulin step in. And in corrective fashion, when it tells the liver to convert excess blood sugar to fat.

But when the body is doing well in absorbing and metabolizing sugar, with little or no help from insulin, there is just a minimum level of insulin around that is keeping insulin from inhibiting other metabolic pathways such as lipolysis (as well as other processes which space and the interest of brevity does not permit).

Lipolysis being uninhibited is wrongly viewed as evil from the false notion that there is forum consensus of fat or beta-metabolism as being unequivocally unsound. This is a mental block which keeps most Peatarians from really achieving metabolic health.

Why would inhibiting lipolysis be a bad idea, I ask? For one, how would you lose weight when you don't convert fat cells into fatty acids for these fatty acids to be used as a substrate for producing energy in the mitochondria?

Couple this with the inane idea that more insulin is needed as the solution to lowering your blood sugar, according to mainstream medical thought and experts, not on the strength of evidence but on the usual Nobel Prize-level of propaganda and hoaxing and insulting of our intelligence with Pied Pipers of long noses where we only see long noses as normal only because our de facto religion sanctifies long noses.

Without realizing that an overabundance of insulin not only keeps fat stores in stasis, as we keep our overweightness and obeseness fully intact; while at the same time our liver is told by insulin to tack on more weight by converting blood sugar to fat, and the obvious outcome would be weight gain and poor health.

And then we are mad at United Healthcare for being the proverbial hitman for the lying pharma complex for denying us treatment from being so sick from stupidly taking hook line and sinker pharma's obvious lies as we descend into metabolic hell.

@Kilgore

Thanks for the reminder. I've eaten carpaccio both in an Italian restaurant and at home. It was easy to make and there was no need to eat it at a restaurant. Especially when I could keep a piece of sirloin or beef nape (the meat by the neck with is marbled) cheap, have it frozen for 2 weeks to make it more safe to be eaten raw, then slice the meat across the grain thinly like Korean style using a manual slicer (Korean style) which makes short work of slicing fully frozen meat.

Preparation is almost non-existent as after slicing the meat you you lay the strips in a plate and drizzle with lemon juice and put capers to add some sourness and flavor and a bit of bumpiness into the adventure. Depending on your personal preference, you can add some salt and pepper or kick it up a notch with cayenne pepper.

If I'm having it with slices of french bread or baguette, then I can use the olive oil as a dip with the bread instead. Or I might open up a small can of liver spread, a poor man's paté, and spread it over the slice of bread and enjoy the carpaccio to my liking.

This meat slicer is simply indispensable. I was glad I could buy this for a song, as previously in looking for a meat slicer, it was the underpowered and unreliable electric meat slicers that have bad reviews due to their unreliable operation and short life, not mentioning they hog valuable counter space, or the pricey industrial and overkill and pricey meat slicer, both of them very unforgiving of careless mistakes involving our delicate fingers:

https://s.lazada.com.ph/s.LZCzn

@Njegos

May you go a long way in that quest.

My two cents says if we minimize stress, we would be producing energy efficiently and that energy would be used more productively. By that I mean that energy is not wasted on fighting small fires endlessly, and by avoiding such small fires we conserve our energy. Needless to say, large fires are even worse and use up our body stores of energy and nutrients and endogenous sources of helpful substances such as enzymes and hormones. But it is often the small fires that escape our attention as these constant small fires can be persistent and never go away and stay with us undetected throughout extended periods. If you added all the misspent energy our body has to allocate to keep defending itself from the wear and tear from these stresses, it would mean that our body would not have a net surplus of energy to use on non-essential improvements or appurtenances.

To be truly healthy we would have to bathe ourselves in the luxury of being nutritionally abundant through what we eat and breathe and drink and what energy the sun passes on to us. And then we have to convert and store and use this energy optimally through both oxidative and reductive forces.

Our understanding of bioenergetics should make us appreciate the wisdom of our body to know when and when not to use our oxidative potentials just as it knows when or when not to use reductive potentials, such that both potentials produce complementary sources that harmonize with each other. There is no other way I can describe this than by using the TCM concept of yin and yang. And Ray Peat would often cite the vitalism of Vernadsky et al who oppose the materialistic construct of modern medicine as based on the materialistic philosophical construct of Descartes, which forms very much a western christian divide distinct from the eastern christian approach of earlier Grecian philosophies.

Didn't we start off venturing into wholistic ideas based on the one-sided views of health where everything involving antioxidants is good and all that involves oxidation is bad? Such that when Ray talked of oxidative processes as good I was confused as hell in the beginning I encountered his ideas. It was hard to reconcile the idea that antioxidants can be just as bad as oxidants, and that they can each be as good as the other.

We are to learn that Linus Pauling and the field of orthomolecular medicine was rather incomplete in forming the initial concept of the benefits from antioxidants, in a Popeye and Brutus kindergarten view of antioxidants being all good and oxidants being all good. In the heyday of antioxidants being being king, when Pauling was alive, we were just beginning to form a rudimentary understanding of what is good and what is bad for the body.

If history serves me right, it was only in the 1970s that researchers started to find out about the beneficial role of oxidants to our health. And from then, the trickle would snowball into our current understanding of bioenergetics courtesy of Ray Peat sharing us his distillation and condensation of these ideas that made acceptance of oxidation as healthful and existential.

Not only that, we would later on learn of ROS - reactive oxygen species - and though they are the stuff that is misunderstood as "all evil," we would come to appreciate that our immune system uses these ROS in a way that benefits our health, by using them to fight pathogens and toxins.

Still, our understanding is not fully formed yet. And there are still many things we cannot agree on given that we are constantly being fed misrepresentations by so called experts from the mainstream school and from alternate channels, each with its own blend of sound and unsound ideas preying on gullible and impressionable minds. Worst of all, there are far too many experts who write books based on half-formed and wrong ideas, and become bestselling writers, based on the strength of book sales whose buyers can read but lack the ability to be critical enough who take wrong ideas hook line and sinker.

Still, as imperfect as all this is, we should still be able to get it right once we know the history of a patient, make theory into practice by really forming our ideas on Peat's research and writing, and make the dots connect.

If you begin to appreciate oxidative stress, and you also get to understand what reductive stress is, you would have come closer to untangling mysteries such as what this thread is about.

@Njegos Laudable of you. But first fix yourself so if you still have it in you, to change the world starting with those around you. The world and its inertia is not an easy project but one can still dream.

@CrumblingCookie said in Oxalobacter formigens after guts nuked by antibiotics. Sources? Possibilities?:

@yerrag said:

Use of natural substances available in nature that are known for their antifungal properties may help as a start. Taking turpentine orally, for example. This would help change the microbiome towards a dominance by bacteria instead of fungal forms.

When you said turpentine, did you only think of its antifungal properties or of more?

I've been harboring some aversion to turpentine and didn't try it as intended. A few days ago, however, I started 4-5 times daily 4-5 drops of aforementioned monoterpenes (from peppermint oil) and whilst it's ached a little inititally and especially when taken without any dextrose (it's recommened to be taken with sugar, just as turpentine) its effects are remarkably beneficial and remarkably quickly so.
I've tried to find associations of turpentines/terpenes with intestinal mucosa.

And couldn't find much, really. From a bit of crossreading, however, it appears to be the case that turpentine AT LOW DOSES, but not at large doses (opposite effects!), exhibits trophic effects on the intestinal mucosa and villous length and proliferation by releasing cytokines (and perhaps improved microcirculation).
It helps to maintain villous lenghts during a couple of days of starvation/fasting (I hadn't known that villous atrophy sets in so quickly from a "use it or lose it" point).

So overall, low but not high doses of turpentine seems to stimulate the intestinal mucosa, and sort of imitate a well-functioning microbiome--brush border interaction in the absence of a proper microbiome?
Or maybe it reinstates the proper microbiome by putting right the brush border functionings? It's difficult so say with these reciprocities.

I get little information from the medical literature about turpentine and that had been a problem for me, more so in the past as I was so tied to what the medical literature deletes constantly from past records of cures. Now I am not so dependent on what the pharma complex borne from the Flex or Report as commissioned by Rockefeller to destroy our health by making conventional pharma-based medicine practically like the only medicine we have been programmed to accept, with all its pretensions to being scientific but in reality has a lot of hokum and snake oil and charlatanry embedded in it. It's only real claim to legitimacy is that it intertwines some good juju with threads of poison and superstition and mask them as legitimate potions.

Luckily, there are some doctors that use turpentine and one of them is Dr. Jennifer Daniels. I went to her website and requested a free book and in that book she explains how turpentine can be used. I've used it for a treatment lasting 2 weeks where I would take a teaspoon of it poured over a teaspoon of sugar each night. She encourages it's use against candidiasis, and no doubt has antifungal properties. I don't have candidiasis but I went to have my blood examined using live blood analysis and discovered my red blood cells to harbor fungal species much like candida that would act like a parasite as it's life cycle revolves around feeding off my the blood in rbc's and making the red blood cells hemolyze, or breakdown and die. This process of hemolysis is hard to identify using standard blood tests, and the only visible indication is that my urine appears amber (like pale pilsen beer with a reddish tinge to it , the tinge being the tint given to it by hemolyzed blood. After taking turpentine, I would see my urine color turn more golden yellow or even like mountain yellow with a neon glow to it. I would later on observe that the wbc count in my CBC reduced to indicate a lower level of low-grade (meaning no fever) infection in my blood. Subsequently, with other efforts to lower infections with the use of suppositories with essential oils, I was able to lower the level of infection and inflammation to such effect that my blood pressure got lower, from 240/160 to 189/120. Still high, indicating the effect from remaining lead toxicity as well as a recently developed free iron toxicity.

Since I have come to employ substances more and more that do not conform to the standards used by standard conventional medicine, but align well with Peaty principles, my health has improved in many ways.

Use of turpentine is just one example. But I must warn that I don't just willy nilly use these substances without a lot of thought and consideration, and I dare only to treat myself. For making a mistake can have terrible consequences, one of which I experienced last year and continue to recover from (which involves heart failure where my heart stopped for 15 minutes). It is risky and that's why I can only risk myself. My consolation was that I was still careful, but careless enough that I didn't do enough of dotting my i's and crossing my t's. Lessons learned surviving it were invaluable though, as I learned so much about heart failure, and how easy it is for dead red blood cells in a mass die off from hypoxemia (from respiratory issues such as bronchitis in my case but in general from ARDS such as those involving COVID) could result in a long or even permanent case of hardness of breathing.

Dead red blood cells that aren't recycled but stay stuck in the a congested lymphatic system are not easily seen in the opacity of the lymphatic system, and a constant but slow release of these is toxic, as the enzyme heme oxygenase, which thankfully Ray has written a lot about, will cause the release of carbon monoxide and free iron, which would cause lungs to get wet and breathe poorly and contribute greatly to the development of heart failure. But this mechanism isn't acknowledged in medical circles, who would merely address the issue with prescription medicine that only address the symptoms while letting its true causes fester.

@Njegos

Your low temperature is enough to tell that your metabolism is low and that you are hypothyroid. But calling you hypothyroid is not the most helpful as it gives the idea that it is only your thyroid condition that is sub-optimal, and this condition, while applicable, gives the impression in many that taking thyroid supplementation would be the magic bullet to cure you of your condition. Too many thyroid supplementers are guilty of using the pharma medical model of taking pharma drugs regularly to alleviate the expression of a symptom, to simply stop any more attempt to permanently rid one of a pathology by identifying the root cause/s with the follow-up intention of eliminating the root cause.

Unfortunately, the medical system and it's doctors are woefully inadequately trained and equipped to to any semblance of root cause analysis, and this are unable to help you solve your impaired metabolism, which really is at the heart of your condition.

If the world were not dominated by a system where doctors serve as errand boys and drug distribution networks for the pharma cartel, and have the freedom to troubleshoot your body like mechanics would fix your car, with payment only necessary upon a repair fully done, you would find yourself being helped and not being told of the oft-repeated and used narrative that "our researchers have found no cure with all their research and that the only answer is to rely on expensive intervention with drugs and surgery and with implants if not transplants and toxic substances." It goes without saying that this level of intervention is very costly and this model of keeping people alive as zombies takes a lot out of our lives and leaves at best those remaining behind destitute to continue carrying the burden of the ones that have passed away.

Yet it is not impossible to learn of bioenergetics principles based on Ray Peat's research that would restore back to the body it's metabolic vigor without so much as costing us to lose out material possessions.

The problem is that there is no medical discipline srevolving around Peat research that has been formalized to compete against the AMA and it's sanctification by arbitrary nature as defined by the corrupt practices of the Nobel committees that honor snake oil and frauds as science and worthy of recognition while true discoveries are left unrecognized and unusable in contributing to a continuing and snowballing rate of advancement in medicine and health.

Not that there is no one to help you, but those that can help you exist as pockets and islands of isolation, and what effective solutions they offer are walled off in obscurity where only family members and self benefit from applying goods principles off Ray Peat's research. The rule of law favors bad juju, and good medicine is always persecuted by the the wrath of the law. In pursuit of the so-called aim of protecting the public.

But all the writings of Ray Peat of free. In it are kernel of truth that one can use, even at its very basic ideas it isn't hard to implement in one's own practices, lifestyle, and habits

Just know how to use the power of computers and search, and search thru his works, and distill it. If you are not so confounded and confused by competing arguments from the mainstream purveyors of science, and have a simpleton-like belief in Peat, and give him a chance, or the benefit of the doubt, you will be able to see your metabolic health improve. His ideas are foundational though they are hardly unique, and are mostly already in the public domain. Mostly they are based on earnest research. And truth always will hold water and substance, and healing powers. Some have been discarded for modern ideas where novelty carries a preium to produce profit for the modern snake oil salesmen, as they slither their way to rob both private and public health finances and community chests.

I can rattle off many Peat ideas I have adopted only to realize later how much my health has improved. It does not take a genius. It takes in reading him to recognize him as credible and to see how connected and coherent his ideas are after reading through enough of his articles to see how connected they are. And to see the body as a unity where internal systems synergistically operates in a virtuous fashion in a seemingly perpetual showering of vigor and robustness towards creating more structure, where intelligence and wisdom feeds off and enriches the mind and spirit.

If you want to improve, start reading so you can get
good ideas straight from Peat. Don't get carried away by too much dependence on drugs as well as supplements. Concentrate on getting nourishment from the clean upstream water source, and less on the polluted downstream.

@Insomniac

I've long considered the benefit or harm from mere increasing or lowering of bp to be dependent on context. People in relative good health worry about rising BP, only to realize they haven't yet experienced the other side of the coin in poor health, where low BP is what needs to be concerned about.

MB causing high BP is more s function of MB increasing metabolism, and when that happens, there isn't much to be concerned about.

@NNight said in Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin:

I don't know if it will be useful to you (you've already been there and done that), but TonEBP/NFAT5 activation could help deactivating HO-1:

We found that TonEBP is a potent suppressor of HO-1 in human and mouse macrophages.

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00850/full

The FXR might help too to rebuild heme:

FXR orchestrates the expression of multiple heme biosynthetic enzymes. Finally, human HepG2 cells and primary human hepatocytes treated with obeticholic acid, showed increased expression of several heme biosynthetic genes.

(In the liver...)

https://pubmed.ncbi.nlm.nih.gov/37695073/

Seems like the directions would be complicated, or materials not easily available. But thanks.

I could have gone at it at 1mg/kg of my bodyweight at 70 mg. Oh well.

I took in 50mg in100ml water yesterday in one sitting at 1pm. Gladly, nothing terrible happened. Expert for it causing my urine to trickle and mu urination became negligible. Fecal matter in small amounts.

My appetite was suppressed and desire to drink inhibited.

Because I had taken mb 2 and 3 days before I took this one time dose, I could not tell how different I would feel had I just taken this one-time dose.

But taking it in one dose seems the right way, as the strength seemed to have allowed mb to act as a diuretic, as I started to feel the effect it had on acting to dry the lungs. Still, my bloat remains, and my weight even increased by 3 kg I am hoping the diuretic effect would happen eventually. Will it take as long as a week?

The best part is my hardness of breath is gone, which one would expect when the lungs is drier. But not totally dry, as I could not see confirmation in my ECG's QRS wave, which is still depressed.

Will keep you posted.

Oh yes, I slept well last night. The drier lungs made the lungs get back it's work as a deactivate of serotonin.

@Samyo

If you're dependent on fiber primarily to drive motility having no fiber makes it hard to defecate and the body will find other ways to excrete toxins