@LucH Thank you for this!

@Kilgore @Kilgore said in 6+ cups of coffee a day cuts suicide risk by 80%.: @Ecstatic_Hamster said in 6+ cups of coffee a day cuts suicide risk by 80%.: I can drink only about 3 cups of very strong coffee daily. After that it starts affecting my sleep quality. I have read that if coffee impacts your sleep quality it is a sign of a glycogen depleted liver. Not sure about this. I can easily sleep with coffee, no problem. But sleep quality seems universally affected. https://www.sciencedirect.com/science/article/abs/pii/S1389945702000151 Methods: In the first part of the study, six volunteers drank either decaffeinated or regular coffee in a double-blind fashion on one day, and the alternate beverage 7 days later. Sleep parameters were assessed by actigraphy. In the second part of the study, the subjects again drank either decaffeinated or regular coffee, and they then collected urine every 3 h for quantitation of 6-sulphoxymelatonin (6-SMT), the main metabolite of melatonin in the urine. Results: We found that drinking regular caffeinated coffee, compared to decaffeinated coffee, caused a decrease in the total amount of sleep and quality of sleep, and an increase in the length of time of sleep induction. Caffeinated coffee caused a decrease in 6-SMT excretion throughout the following night. Conclusions: The results of our study confirm the widely held belief that coffee consumption interferes with sleep quantity and quality. In addition, we found that the consumption of caffeine decreases 6-SMT excretion. Individuals who suffer from sleep abnormalities should avoid caffeinated coffee during the evening hours. Also habitual coffee drinking shrinks pineal gland over lifetime https://academic.oup.com/sleep/article-abstract/41/10/zsy127/5053876?redirectedFrom=fulltext We found that smaller VPP was associated with higher cumulative lifetime coffee consumption. Participants who consumed more than 60 cup-years of coffee had VPPs that were smaller by about 20% than individuals who consumed less than 60 cup-years of coffee. The VPP mediated the association between lifetime coffee consumption and sleep efficiency and quality. Conclusions Our findings suggest that high lifetime coffee consumption may reduce VPP, and that this reduction in VPP may impair the quality of sleep in late life.

@Chud Did you get your labs back yet or just ordered?

@Sugarnotsnow I was fortunate to need little tweaking to fix my hypoglycemia, which was a 4yr cold turkey of PUFAs even before I heard of Ray Peat. So I didn't have to take thyroid to get my metabolism going at a fairly good clip. I did one year of therapeutic magnesium supplementation of 800 m elemental daily, and it was to prepare myself to end my lifestyle of relying on soluble fiber intake for good bowel movement. When I did stop soluble fiber intake, I continued to have good bowel movement with good peristalsis driven by having enough magnesium stores. Still, I have some Tyrone or T3 with me, when coming out of a sick state and my metabolism needed jumpstarting with a little T3.

@Tarzan17 I think peat recommends small frequent feedings that include all three macronutrients. Carbs, proteins, and fats in the right balance per meal.

@Sugarnotsnow Its fine to share info from others but please disclose it! "Vit E is great for lowering prolactin. I used 800IU of TocoVit vitamin E daily for 30 days and my prolactin dropped from 8.5 to 2.2. My prolactin wasn't elevated so it will work even better for someone with high prolactin. I like TocoVit as it contains lots of alpha-tocopherol, which is responsible for lowering prolactin. It's also a great source of policosinols. " https://x.com/HansAmato/status/1837529938074689968

The title is a bit misleading. Speaks little of beta oxidation but more of sugar mitochondrial oxidation. If we're relying too much in beta oxidation as an an energy source, it will deprive the sugar mitochondrial pathway of oxidative potential or energy to burn sugar mitochondrially, and the alternate sugar pathway of glycolysis will be used. This is where lactate is produced. This leads to lower CO2 production to a point where hypoxia occurs from poor tissue oxygenation, which further restricts sugar metabolism to the glycolytic pathway and less CO2 being produced. This causes blood sugar to be less absorbed and metabolized and for blood sugar to rise to higher levels, which causes it to be converted to fat and for blood sugar to drop excessively to the point of hypoglycemia. With low blood sugar, adrenaline is produced which causes glycogen to be converted to blood sugar. But if glycogen runs out or isn't available, then cortisol will cause body protein to be converted to sugar, and ammonia will be produced in this conversion.

@sphagnum Yea its hard to find them. They are starting to ban them in dtores. Especially ones that are bright enough

@dellamo

@sphagnum said in Vitamin K and constipation: what is considered to be a high dose of K? High dose Vit K can interfere with Vit E They are all fat-soluble vitamins and can compete with each other for absorption into the micelle. Vitamins A and E are antagonists of vitamin K because they interfere with its absorption and metabolism. Taking a high dose Vit K2 requires transporters that are in limited amount for transport in circulating lipoproteins for subsequent uptake by tissues. How much is too much is not clearly defined. By the way excess Vit E, K and Q10 leaves quinones but our liver has a limited capacity to deal with. I never take Vit A supplement at the same time as the other lipovitamins.

The dose makes the poison. [image: 1727191411597-12ebf431-7a12-4f72-a3c7-6def37f85c4f-image.png] Americans At Greater Risk Of Glyphosate Exposure than Europeans

you might want to cool off a little bit with posting a bunch of claims that are dangerous. Animal studies have shown a moderate overdose can cause liver cancer. 1mg per day safe dose. That's what Ray said. Not that hard to find out what Ray said about Biotin. He saw good things happen with it and then the animal studies in the 50's about liver cancer seemed to have spooked him. So the studies must have been pretty legit I am guessing.

@Sugarnotsnow Internal use of silver is anathema in the Peat sphere. Peat on silver: [image: 1727182000857-1000008187.jpg]