Getting to the correct and effective doses of T4 and T3 is quite tricky. I have yet to reach a ratio that works great.
I've been trying to gradually lower my T4 intake, as I didn't felt quite as energetic for a while and was suspecting that I have low conversion into active thyroid hormone from my gut issues.
Once I do that, and start increasing T3, I feel great for a day or two, then I crash again. Temps go lower too.
At that point, taking a large dose of T4 (75 mcg) quickly raises my baseline energy levels.
This is what happened this weekend.
If I take thyroid, I am functioning ok on a T4 amount that is at least 100mcg. I don't really understand why do I need such high doses.