Posts made by Mauritio

@DavidPS said in Beware of the Low Vitamin A Zealots- New Thorough Video by Mike Fave:

I have been wondering how low can you go. An the long term consequences of going too low. This study was an eye opener. Eggs are a source of vitamin A.
Consumption of eggs and the 15-year incidence of age-related
macular degeneration
Background and aims: A naturally rich source of lutein and zeaxanthin are eggs. There is scarce epidemiological data on the temporal association between total egg consumption and age-related macular
degeneration (AMD) incidence. We aimed to establish the prospective and independent association
between consumption of eggs with the incidence of AMD over a 15-year follow-up.
Methods: In this population-based cohort study of 3,654 participants aged 49 þ years examined at
baseline, 2034 participants had complete information on baseline egg consumption and AMD signs over
15 years. AMD was determined from retinal photographs. Egg consumption was assessed using a semiquantitative food-frequency questionnaire. Total egg intake was calculated through summing up intakes
in all forms e.g. boiled, poached, fried, scrambled and/or omelette. We summarized total egg consumption into the following categories: 1 egg/week; 2-4 eggs/week; 5-6 eggs/week; and 1 egg/day.
Results: At baseline, participants who consumed 2-4 eggs/week compared to those who consumed 1
egg/week (reference group) had reduced risk of incident late-stage AMD after 15 years: multivariableadjusted odds ratio, OR, 0.51 (95% confidence intervals, CI, 0.28e0.92).
Participants who consumed 2
-4 eggs/week versus 1 egg/week at baseline had 62% reduced risk of developing neovascular AMD.
Among those whose AMD onset was at or before the 10-year follow-up, consumption of 2-4 and 5-6
eggs/week was associated with 54% and 65% reduced risk of incident late AMD**, respectively. When
analyzed as a dichotomized variable, participants who consumed >1 egg/week versus 1 egg/week at
baseline, had 46% reduced risk of developing late-stage AMD 15 years later: multivariable-adjusted OR
0.54 (95% CI 0.3e0.90). Non-significant associations were observed between egg consumption and
incident early AMD.
Conclusions: Our findings suggest that moderate consumption of eggs significantly reduces the risk of
developing incident late-stage AMD over 15 years.

Interesting study.
It probably wasnt only the Vitamin A, but also (maybe even mainly) the B-Vitamins:

"One randomized controlled trial showed that a daily supplementation of folic acid and vitamins B6 and B12 reduced the risk of AMD by 40% [22]."

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318446/

T3 was a game changer for me.
I got similar results from a similar amount.

What I also noticed it that the amount of calories I can consume increased by about 30%, which is nice, because before taking T3 I really had to watch out for what to eat.

Almost everything got at least a little better. Liver function is a big one, less gut /endotoxin symptoms, too.
I feel more energetic, stress tolerant and positive.

A little T3 can go a long way. Thats why Ray was often saying: "the right dosage of thyroid can do xyz..." I really feel like this is key, because when I take too much I get depressed and bloated. For some reason I cant really increase my dose, but I am very happy with what I got so far.

The most prominent and fastest symptom of hypothyroidism to show up is water retention.
I get that when messing up the dosage or forgetting something to take it.

I have to watch out to take in enough b vitamins when taking T3.

@CreakyJoints Interesting. When I was a child I also couldnt stand the peel on apples. But good to know that it does not have to be the pesticides.

Yes, usually polyphenol content varies a lot. I have identified a band of apple juice that gives me a similar effect to the supplement so I buy this one a lot. But generally I dont stress about that too much.

@CreakyJoints said in The pro-metabolic effects of apple polyphenols:

Chocolate is also rich in procyanidin B-2, isn't it? I'm not sure if you'll remember this, but there was a user on RPF who claimed drinking store-bought chocolate milk did a lot to ameliorate his hair loss. I can't remember any further details, but perhaps this is another dot you've connected already?

Yes, apples and cocoa are basically the only foods that contain appreciable amounts of pro-B2.

@Kvothe said in Vitamin A increases T3 by more than 60% in humans!:

Some dude posted this study on RPF. In rats, an equivalent dose was enough increases TSH and suppress T3. I personally experienced that anything over an extra 5.000IU can be suppressive for a mildy hypothyroid person.

https://link.springer.com/content/pdf/10.1007/s00394-022-02945-5.pdf

Well that dude (sinatra) probably has the study from this thread here (https://bioenergetic.forum/post/12395) where I posted it a few days before him, it's interesting that he did not post the main study of this very thread or any of the other pro-vitamin A things I posted.
The HED of about 30k IU per day is still realtively high. And i agree that this can make you hypo, which peat has said for decades.
On the other hand the study, which this thread is about (human study, not rat) shows clear benefits in a similar dosage.

Thanks for sharing.

Activation of the PXR/SXR is an interesting thing in and of itself. It increases phase 1,2 and 3 detoxification in the liver and increases CYP3A4. Other ligands are for example: progesterone, 5aDHP or bile acids.

The authors of this study hypothesize that the liver-regenerating capabilites of Vitamin K2 were reliant on PXR-activation.

All the nucelar "X" receptors are really interesting, the FXR probably beeing my favorite.

PXR/SXR also upregulates a protein that takes up and excretes prostaglandins. So vitamin K leads to less PUFA/prostaglandin metabolites and damage.

I've been thinking about where heavy metals in my body might come from and I remembered that I read something about cigarrette smoke and heavy metals.
And two years ago I moved into an appartment which was contimaned with cigarrete smoke, so that might be a factor in this.

"We have recently shown that metals in
cigarette smoke are essential in the process leading to damage of the vascular endothelium (1)"

"Ciggarettes were fairly varied in their Cd content.
When the cigarette is smoked, Cd is transformed to cadmium oxide, which is then inhaled. Approximately 10% of the Cd is deposited in the lungs, and 20 – 50% is transferred to the circulation (9, 10). Mortada et al. (11) reported that the mean whole blood Cd content in smokers was 1.9 times higher that in non-smokers ..."

"Barany et al. (13) reported that
serum Cd values of young smokers was at least 3.1 fold increased in comparison to young non-smokers..."

"Mortada et al. (11) report blood Pb levels
(mean+SD) in non-smokers of 101.6 + 30.9 mg/l and in
smokers of 143.7 + 33.8, whereas Satarug et al. (12) report Pb serum levels of 4.2 + 5.4 mg/l in non-smokers and 9.0 +12 in smokers."

• https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/15216540500459667

Interesting that hair loss is associated with heavy metals.

"Moreover, hair loss was observed to be associated with Sb, Cd, and Ni as well as urinary DNA level, while age was associated only with lead and urinary DNA levels. The duration of smoking had a major impact on Pb and Sb levels. Finally, contamination with all six metals was significantly associated with DNA fragmentation."

• https://link.springer.com/article/10.1007/s11356-020-11633-y

@questforhealth said in The relationship between Candida infections and heavy metal toxicity:

@Mauritio

This is interesting. What dose are you using??

Do you think fixing the gut can help it too? Since the gut plays a role in detox

Also heard heavy metals make milk harder to digest for us??

I used 1 capsule per day for two days. Might take another one tomorrow.

You mean if fixing the gut can help heavy metal detox? Sure, probably less absorption into the blood stream. The gut bile axis also plays a big role! :

@Mauritio said in The relationship between Candida infections and heavy metal toxicity:

"One of the major issues with heavy metals, especially mercury, is the high percentage of reabsorption through the gut. While elemental mercury is poorly absorbed through the gut, its organic methylated form is highly absorbed (90–95% absorption). The non-organic elemental mercury excreted through the bile is often methylated by abnormal bacteria or yeast in the gut resulting in re-absorption of methylated mercury.

From what Ive read in germany at least two major supermarkets use Apeel (EDEKA and Netto). I actually buy my apples from EDEKA.

They are not required by law to declare Apeel usage, but on some fruits they added an apeel sticker, because they actually use this for advertising it as sustainable etc. (https://verbund.edeka/verantwortung/handlungsfelder/sortiment/apeel-produkte/)

Another way this can be spotted as the price, as apeel products should be a lot more expensive.

Acoording to this article (in german) from august 23, apeel is not beeing used in europe currently, at least on fruits where the peel is eaten, not so in the USA, here it is already beeing used on apples.

But theres more: apeel is not the only company there is a brithish company Agricoat which uses "Nature Seal" , known as E473 (german supermarket Rewe uses it), which seems to be more safe, but is also made from soy oil and potentially genetically modified.

E471 on health:

1. Effect on CVD:
   " Additionally, higher intakes of monoglycerides and diglycerides of fatty acids (E471 and E472) were associated with higher risks of all outcomes. Among these emulsifiers, lactic ester of monoglycerides and diglycerides of fatty acids (E472b) was associated with higher risks of CVD (1.06, 1.02 to 1.10, P=0.002) and cerebrovascular disease (1.11, 1.06 to 1.16, P<0.001), and citric acid ester of monoglycerides and diglycerides of fatty acids (E472c) was associated with higher risks of CVD (1.04, 1.02 to 1.07, P=0.004) and coronary heart disease (1.06, 1.03 to 1.09, P<0.001). "

2. Effect on cancer:
   "Higher intakes of mono- and diglycerides of fatty acids (FAs) (E471) were associated with higher risks of overall cancer (HR high vs. low category = 1.15; 95% CI [1.04, 1.27], p-trend = 0.01), breast cancer (HR = 1.24; 95% CI [1.03, 1.51], p-trend = 0.04), and prostate cancer (HR = 1.46; 95% CI [1.09, 1.97], p-trend = 0.02). In addition, associations with breast cancer risk were observed for higher intakes of total carrageenans (E407 and E407a) (HR = 1.32; 95% CI [1.09, 1.60], p-trend = 0.009) and carrageenan (E407) (HR = 1.28; 95% CI [1.06, 1.56], p-trend = 0.01). "

• https://pubmed.ncbi.nlm.nih.gov/38349899/

Only a correlation, but still worrying.

@DavidPS said in The pro-metabolic effects of apple polyphenols:

Returning to "to peel or not to peel" (that is the question), industrial distributed apples have a new fungical coating to extend their shelf life. The FDA designated it, known as Apeel, as organic and it does not have to be identified on the product. As always, let the buyer beware.

https://duckduckgo.com/?q=apeel+apples&ia=web

Thanks for sharing! A new rabbithole...it's wild how complicated the decision of peeling an apple (or not) can be, indeed an existential question.

Apeel contains mono and diglycerides of (vegetable) fatty acids, which is nothing new. This is E471 in Europe, which is contained in chocolate ,meat, cream bread and more. It shouldnt be too health concerning. I think it even occurs naturally during lypolisis.

But, most E471 is made from genetically modified soy beans, that already sounds more concering. And this article (in german) says it can cause allergic reactions in some people.

Wikipedia says this:
" A French study published in 2024 concluded that a higher intake of E471 increases the risk of cancer by 15%, particularly breast cancer (24%) and prostate cancer (46%).[7]"

--> coincidentally both breast and prostate cancer are highly estrogen-driven, so maybe there is an estrogenic activity here, which makes me lean more towards peeling my apples again.

If you want to look at it from a conspiratorial angle, it doesnt look good either. Bill Gates and the WEO both supported it.

Is there anyway of knowing if a company uses apeel? Maybe it's the glowing fatty layer on some apples that always seemed suspicious to me?

@questforhealth I had quite an interesting experience so far on MCP.

It increased my androgens as seen in bigger,fuller muscles and higher libodo. I've seen so many studies on how bad heavy metals are for testosterone and testicular health so this makes sense.

And i think it also increased my energy levels.

The issue was that it was bad for my sleep, thats why I stopped after 2 days. The benefits have remained since then. I also had a bit of headache and was a little moody but nothing crazy.

I've seen the metallic layer on my pee a few more times but it stopped, after I discontinued MCP. Maybe thats a poor man's heavy metal test lol

If all this is true then even weekly dosing should have substantial benefits. Going low and slow with a heavy metal detox is probably a good idea anyway.

@TheRealPeater

@TheRealPeater said in I have been banned on the RPF for posting this study on Vitamin A...:

@Mauritio

This is a shame. I enjoyed my conversations with you and @Jam on the iodine threads.

I think I'm OK posting in both places as I'm happy to give a generalised Low A approach a go...no different to how I gave SSKI a go...

I'm not looking for a Great Wise Old Sage to shape my life, but I am happy to run with thoughts that interest me.

I think thats totally fine. Many people have reported feeling better on a low A diet, although Im not sure how much of that is due to the absence of vitamin A and not the absence of all kinds of other things.

I think its good that people get a feeling for how certains vitamins affect them. As Vitamin A can be anti-thyroid in higher doses, which is not a controversial opinion at all, just as this is not news, but has been said by Peat for decades.

@CreakyJoints hey, sorry to hear you have been banned because of me. But maybe you're not missing out on much.
BTW it was not the thread you posted on that got me banned, the thread that got me banned was deleted.

@questforhealth
Started taking MCP yesterday.
Definitely increases BM frequency. Also my mind seems less foggy, but might have also been because of small amount of DHEA I took yesterday.
Yesterday night I forgot to flush after I peed and this morning there was a metallic /oily layer on top of my pee. Maybe coincidence, maybe not.

@Peatly said in Vitamin A quotes from Ray's favorite physiology book:

@Mauritio There are huge variations in results for vitamin A studies. I think Dr Peat’s recommendation, which is to be cautious if hypothyroid, seems reasonable. I would like to see that Iranian study replicated elsewhere – especially in regions where Billy Goat is blocking the sun.

Yes, I agree.
What does it have to do with the sun/ Vitamin D?

@Jaffe said in I have been banned on the RPF for posting this study on Vitamin A...:

Cross-posting probably didn’t help. Although, you have to ask yourself: Was anything lost?

The brain trust left. The forum is dying. Activity is being driven by 3-4 people.

Haidut is posting on both forums as well.

I agree, some of the brightest minds left and/or have been banned.
So If anything that low vitamin A cult will spread like a cancer on the forum, but eventually destroy its own host (the forum). Thats what cancer does.

@Kvirion said in I have been banned on the RPF for posting this study on Vitamin A...:

@Mauritio Yep, I can open it. BTW Thank you for the positive info about my favorite nuts

But you are still blocked, unfortunately...

Thanks.
Now I can see it too. Yesterday it wasnt there...

@Kvirion said in I have been banned on the RPF for posting this study on Vitamin A...:

@Mauritio said in I have been banned on the RPF for posting this study on Vitamin A...:

Wait so are you saying you can still see the macadamia post? Because I cant.

I can see this - screenshot taken just now

ok , thats weird. Can you also click on it and see the actual post?

@Mauritio said in The relationship between Candida infections and heavy metal toxicity:

Modified Citrus Pectin For Lead Poisoning

@questforhealth check out the thread with the above name on the rpf .
I have it here and will probably start taking it tomorrow.