Posts made by Mulloch94

@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:

Nice, ice cream has only about 2g of protein per 100g. So that is good thing to consider.

Yeah, at the time is was doing both low-protein and low-fat. But I have been wondering how well I might respond to a low-protein diet that doesn't emphasize low-fat as well. So I might give ice cream a try too. I'm interested to know whether my satiety is effected if I don't lower fat with my protein.

@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:

Did you notice any issues with libido or muscle strength?

I did notice I would get gassed quicker on my deadlifts and squats. I didn't notice much difference in sexual performance. I wasn't in a active relationship so I wasn't getting laid frequently. My guess is someone who has a more restricted refractory period between encounters might notice a difference. But I've also read higher-protein diets increase PRL (prolactin), so maybe a lower protein diet is actually beneficial in this regard?

@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:

I'm wondering about craving too. Im sure you were craving meat at some point , then wouldnt that be a sign that your body needs it ? Not sure, but that would speak for the intermitten approach as well.

This is something I've heavily considered as well. My personal opinion is if someone does heavy protein restriction for many years they may begin to slowly breakdown muscle tissue. You can look at some of those life-long vegans who eat starch based diets (like 80% carbs) and they're all small and bony. But, like you said, if you only eat that way intermittently this probably won't happen. Low-protein reduces the glucocorticoids you're already sparing your protein.

@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:

@Mulloch94 said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:

This is interesting research, I'm glad it's being discussed here. Anecdotally, when I was doing protein restriction a couple years ago I actually felt very good while doing it, and I wasn't even on thyroid during this period. I came to the conclusion that the "low-protein" aspect was more beneficial than the "low-fat" aspect of it. Though I'd imagine they both synergistically aid to some extent.

What set me on that path was stumbling upon some studies that suggested low-protein diets can reduce CRH and ACTH output, and thus quiet that negative feedback loop of stress hormones. I couldn't go long without eating because my liver was malfunctioning and not holding glycogen well.

The low protein diet seemed to stop (or slow down) the gluconeogenesis and subsequent stress response, as I wouldn't get the low blood-sugar "shakes" anymore, however I ran into a new problem of never seeming to get full. I was basically always thinking about food, even after eating. I guess because a almost pure carbohydrate diet doesn't really hit that satiety factor as much as a higher protein diet does, idk.

After successfully implementing thyroid into my regime I can handle higher protein much better, but I do believe a low-protein diet can partially alleviate many of the main issues associate with hypothyroidism if you can stick to it. I'm not really interested in going full low-protein again, but it would be nice to find a complete list of all the high methionine foods, because avoiding methionine and cysteine would be something I'd do, along with tryptophan.

If you dont want to go full low protein, maybe just 2 days a week is doable. If you look at image (a) in the post above, you can see that even 2 days a week at 5% protein caused FGF21 to more than double. And 5% might not even be necessary in rat and the human studies they mostly used 10% which is about 50-75g of protein for most people. Although that sounds more than it is.

How much protein and fat did you eat during those days?

I was hitting around 50 grams during my experiment. I ate mostly baked potatoes (around 2 pounds per day) with fresh salsa. I also made some rice pudding with skim milk, but kept it to one serving per day because I didn't want the milk to give me too much protein. I could probably do this diet again on a limited 2 day weekly basis with no issues at all.

Even now though, I do think I've managed to restrict methionine despite increasing total protein consumption. I didn't exactly plan it out that way (I was more focused on tryptophan), but my main sources of protein now are BCAA's in a morning smoothie with milk and fruit, casein in my afternoon oatbran, and something like hamburger or oxtail for dinner which might be high in methionine but it's got plenty of glycine in it too.

This is interesting research, I'm glad it's being discussed here. Anecdotally, when I was doing protein restriction a couple years ago I actually felt very good while doing it, and I wasn't even on thyroid during this period. I came to the conclusion that the "low-protein" aspect was more beneficial than the "low-fat" aspect of it. Though I'd imagine they both synergistically aid to some extent.

What set me on that path was stumbling upon some studies that suggested low-protein diets can reduce CRH and ACTH output, and thus quiet that negative feedback loop of stress hormones. I couldn't go long without eating because my liver was malfunctioning and not holding glycogen well.

The low protein diet seemed to stop (or slow down) the gluconeogenesis and subsequent stress response, as I wouldn't get the low blood-sugar "shakes" anymore, however I ran into a new problem of never seeming to get full. I was basically always thinking about food, even after eating. I guess because a almost pure carbohydrate diet doesn't really hit that satiety factor as much as a higher protein diet does, idk.

After successfully implementing thyroid into my regime I can handle higher protein much better, but I do believe a low-protein diet can partially alleviate many of the main issues associate with hypothyroidism if you can stick to it. I'm not really interested in going full low-protein again, but it would be nice to find a complete list of all the high methionine foods, because avoiding methionine and cysteine would be something I'd do, along with tryptophan.

I like squashes but whether or not they can be a reliable source of carbs depends on what type you eat. Stuff like Kabocha or Butternut can serve as carb sources. Pattypans, crooknecks, and zucchinis are too low in calories.They make good vegetables because they have a decent calcium/phosphate ratio, but you should probably eat some different starches or sugar with them.

@BeamsOfEnergy It's worth noting there is some disagreement about what the ideal temperature is. Ray has basically always settled on the 98.3-98.6 (36.8-37) zone. But Broda Barnes seemed to believe your thyroid was fine even if you were 97.5 (36.3). So perhaps you have a full degree, more or less, to play around with and see where you feel best at.

@Ismail Probably so, I think if any of them are expendable it's probably B2, or B7. Both thiamine and niacin seem to be the "heavy-hitters" of the B vitamins.

Hey, I hope you don't mind me posting this here. If you do I'm more than happy to post it in another more appropriate area. But I was actually trying to view the old forum's email exchange list with Ray and noticed the firewall was blocking a considerable number of IP addresses. It took the liberty of snapshooting the page and thought I'd share the link with everyone in case they need to view some of Peat's email replies too https://archive.ph/raPhe

*actually it's not my snap, someone else snapped it a few years ago as well.

I'm surprised Georgi didn't include B2 into the mix as well due to it's FNM/FAD qualities. The results are impressive nonetheless, but unless he's got a good reason for not including it I don't see why a human trying to replicate this couldn't do a B1/B2/B3/B7 + aspirin combo.

Are your normal temps (without progesterone) already euthyroid?

Progesterone can increase temperatures through a variety of mechanisms, most notably by countering estrogen's effects. But it will also increase GABA and thus antagonize adrenaline. It will also lower thyroid binding globulin (TBG) which increases more free T4 and T3.

@scamp At this point we can't even be sure your chest sensations are heart related, but you could always get an EKG if you wish to rule it out.

I would just focus on getting plenty of heart supporting nutrients in your diet. Potassium, magnesium, selenium, vitamins C, D, & E. Make sure you're keeping PTH suppressed with plenty of calcium and/or low phosphate. Those are the main supporters of general cardio health.

Endocrine issues, like estrogen dominance, can also be a problem, the "staircase effect" that Albert Szent-Gyorgyi talked about. Androgens and Progesterone stabilize the heart's rhythm, whereas estrogen promotes heart failure pathology by creating weaker faster beats. The heart begins to work twice as hard for smaller results.

Is this about health or social existence? Unless you can find a place on earth that isn't bombarded by EMF you're never going to detox "environmental toxins." Don't start going down this road, it's for your own good. You'll end up like FrankTufano and covering your whole house in silver fabric or whatever the fuck that shit is he's using. Dude was complaining he couldn't breathe at nights because his bed was covered in so many layers and he couldn't get enough oxygen...but at least he kept the EMF out, lmao. People like that are never the ones to live long healthy lives.

@Sugar said in What do you see as the most effective detox protocol for modern dietary and environmental toxins?:

How do we cleanse the human race

Get all this weird ass woke shit out of our universities. Even Marx would cringe at how far the left as sunk now days.

@scamp said in T3 causing weird feeling in chest at night:

I've been taking ~300mg magnesium every night before bed for years, and occasionally ~100-300mg during the day as well, so I would be surprised if not enough magnesium is the problem.

So 600mg total? Is it oral supplements, the oral magnesium can range drastically in terms of bioavailability. Just because you take 600mg doesn't mean you're getting anywhere near that amount.

@scamp said in T3 causing weird feeling in chest at night:

Would thyroid supplementation not have a similar effect? If not then can you speculate on what else might cause either/both of my symptoms?

No because thyroid works with cortisol, not against it. They're both important for maintaining the metabolic rate.

It's possible the T3 itself is causing the feeling. Ray said he would get arrhythmias from taking pure T3 without any T4.

@scamp said in T3 causing weird feeling in chest at night:

I should've said in the OP, I'm prescribed dexamphetamine for ADHD. I've been tapering down for a while but every time I stop completely I'm too dopey and tired to focus at work.

Taking amphetamines alongside thyroid will just cause additional adrenaline release, and will absolutely result in weird cardiac events. Sometimes minor shit, like "chest butterflies." Other times it can be more serious depending on your current state of health, preexisting conditions, etc.

If I were you I would slowly work on tapering that stuff down really low or coming off entirely. Have you tried pregnenolone? Pegnenolone will increase a lot of neurosteroids that can be beneficial for ADHD or other similar aliments.

@Crypt-Keeper said in T3 causing weird feeling in chest at night:

@Mulloch94 said in T3 causing weird feeling in chest at night:

I think it would be exceedingly hard to lower cortisol to dangerous levels with just natural stuff like emodin, DHEA, progesterone, etc.

Well, there's "dangerous levels" and then there's "sub-optimal levels". It's not a light switch, as if you're either on death's door or everything is sunshine and rainbows.

This is sort of my big grief with RPF. Unless you actually have a high cortisol condition (proven medically + symptoms), a person probably shouldn't be doing anything like taking progesterone to lower cortisol. Cortisol actually serves a (useful) purpose.

Now they've just moved on to Vitamin A. "Very high Vitamin A is bad, therefore you should completely eliminate Vitamin A from your body."

I didn't really express my view with the best choice of words. When I said dangerous I meant sub-optimal. I just said "dangerous" because cortisol is an important anti-inflammatory during acute stressors, without it we'd be in serious trouble.

I think lowering cortisol can be beneficial in certain situations. Sarcopenia for example, or immune deficiencies. Anyone wanting to increase glucose oxidation will be dependent on minimizing cortisol.

But I do find a lot of people complaining about "stress symptoms" who think it's a cortisol issue when it's actually an adrenaline issue.

@Crypt-Keeper said in How to esterize DHT at home? DIY:

If transdermal T aromatizes easily then maybe I should try taking it. I'm even doing straight transdermal estrogen and that isn't doing jack to help my low E symptoms. I guess I will have to revisit the transdermal T thread and learn the tricks.

Boron, d-aspartic acid, and saw palmetto would be a good (?) stack to raise estrogen. Also copper, so eat plenty of liver. Get your estrogen tested first, don't just assume based on symptoms alone. Raising estrogen would be too risky without knowing for sure. Edema, clots, stroke, cancer, erectile dysfunction are all a possibility from high estrogen.

@pannacottas said in How to esterize DHT at home? DIY:

Also Ray has recommended against applying substances there. Since the skin is so thin, whatever you put will be absorbed highly; though i think the problem has to do more with the carrier than the hormones.

Yeah it's the solvent/carrier that's typically the issue. Although I suppose if you get a batch of T with exceptionally high contaminants that would also be bad. But generally speaking it's a carrier issue. Fortunately normal T base dissolves well in most things.

@Crypt-Keeper said in T3 causing weird feeling in chest at night:

@Mulloch94 said in T3 causing weird feeling in chest at night:

But...a lot of people severely overestimate low cortisol, it's not common despite seeing several threads about it on RPF.

That doesn't surprise me because the common mantra on RPF is to do everything in the world to lower cortisol, so that's what people do.

People develop this weirdly cartoonish "bad guy / good guy" view of hormones, so...

I think it would be exceedingly hard to lower cortisol to dangerous levels with just natural stuff like emodin, DHEA, progesterone, etc. You would almost have to use something like mifepristone. But yeah, if someone did this, then that would also be bad.

My main point of contention is people who a) emphasize the fake disease "adrenal fatigue," and b) people who think saliva cortisol tests are reliable. An overwhelmingly large portion of people I've personally seen fit into this latter category.

@pannacottas said in How to esterize DHT at home? DIY:

Russian Star Peptides/Titan Chem seems to have finished DHT heptanoate (enanthate) oil but it's most likely bunk, since these guys are known scammers. Someone on RPF claimed their DHT gel contained caffeine and finasteride lmao. And someone on reddit actually tested it with Jano and it had no DHT.
But im a bit tempted to buy it and test it just out curiosity.

Do you mean this product? Looks kind of sus. Even if it's real I would never trust ordering controlled substances with my card or paypal. If they have a crypto option then fine, but they just mention card and paypal in their payment section.

Just to clarify, if you're wondering why I don't use the scrotal method and instead opt for normal dermal areas like shoulders, traps, forearms, etc. it's because I don't like waiting for it to dry on my balls before pulling up my pants. This is the only downside in my opinion, but if you have time to let it do it's thing, then this is the method I highly recommend.

I've seen very similar studies as well but using slightly higher dosages, like 25mg and 50mg. The 50mg might be getting kinda high if you're trying not to disturb your E2, but long-term usage at 25mg will likely not be an issue either.

@pannacottas said in How to esterize DHT at home? DIY:

Also i wouldn't use Test without DHT. Yes the skin has higher 5-AR expression bla bla, all i know is topical pansterone was very estrogenic for me. So i won't mess with aromatizable steroids, for now at least.

What's your diet like? Vitamin D, E, calcium, protein, salt, zinc, progesterone are all important to keep the right supply of androgens to estrogen. Lower more frequent dosing of T can prevent a rise in estrogen without the use of any aromatase inhibitors.

I actually take 100mg twice daily, but I also use an OTC aromatase inhibitor. But you probably wouldn't need this if you use the transscrotal method of delivery. As demonstrated in this study, physiological doses as small as 15mgs daily was enough to raise both T and DHT without effecting estradiol.

"The need for improved controlled delivery of testosterone to hypogonadal men stimulated the development of a self-adherent transscrotal testosterone system to provide programmed testosterone delivery through the uniquely permeable scrotal skin. In this short- and long-term efficacy trial, the responses of testosterone and its metabolites to the application of transscrotal testosterone systems of varying testosterone content were compared with the response to 200 mg of testosterone enanthate. Daily transscrotal testosterone system administration resulted in a rapid increase of testosterone and bioavailable, nonsex hormone binding globulin-bound testosterone levels to normal, peaking at two hours, followed by a slow decline over 23 hours, resembling the diurnal variation of endogenous testosterone. One year of daily transscrotal testosterone system therapy demonstrated continued reliable absorption of testosterone and suppression to normal of the luteinizing hormone in two of three patients. There was a greatly disproportionate increase of serum dihydrotestosterone over testosterone, suggesting 5-alpha reduction at the scrotal site. The subjects reported marked subjective improvement. Thus, the transscrotal testosterone system is a novel, effective, and well-tolerated method of delivering testosterone to hypogonadal patients."