Posts made by pannacottas

@Crypt-Keeper said in Experiments with transdermal hormones:

@pannacottas said in Experiments with transdermal hormones:

@Crypt-Keeper I've ordered dht base from QSC and had it tested at Janoshik, came back with 98%+ purity. Imo they are legit and they have better prices that PPL anyways.

Thank you. Have you tried DHT in DMSO? Do you feel anything? I also have some DHT from PPL (same shipment) which has slightly different characteristics to the T base so I might try it in DMSO to see if at least that is legit.

I have tried alphagels DHT in DMSO which gave me the most insane contact urticaria ive ever experienced. Like an allergic reaction that lasted for about an hour or two, made my skin lizard-like and stang like crazy. I dont know what quality DMSO he used but that reaction is enough for me to never try DMSO again.
So i couldnt really tell any effects from the DHT because of that reaction.
However QSC powder dissolved in 95 ethanol (managed about 35mg/ml, im getting anhydrous 100% ethanol soon which will give a better concentration) produced noticeable effects, like strong reduction in estrogenic libido, mental clarity, and a sense of calmness.
Also dry scooping 100-200mg powder and swishing/holding with some raki is probably very effective too because brought my strength back up to my previous peak after almost a month of no training, and definitely produces the same calmness effect.

@Crypt-Keeper I've ordered dht base from QSC and had it tested at Janoshik, came back with 98%+ purity. Imo they are legit and they have better prices that PPL anyways.

@Crypt-Keeper
Going off topic here but Ray didnt think there was such thing as "low estrogen". From what i've seen these symptoms can be low pregnenolone symptoms, among other things. Low blood estrogen can mean high tissue estrogen and high prolactin, btw.

@Mulloch94

As demonstrated in this study, physiological doses as small as 15mgs daily was enough to raise both T and DHT without effecting estradiol.

That's interesting, thanks.
Yeah i agree scrotal method is quite annoying. Also Ray has recommended against applying substances there. Since the skin is so thin, whatever you put will be absorbed highly; though i think the problem has to do more with the carrier than the hormones.

Do you mean this product? Looks kind of sus. Even if it's real I would never trust ordering controlled substances with my card or paypal. If they have a crypto option then fine, but they just mention card and paypal in their payment section.

Yes that one. I think he's in the UK where steroids are in a gray zone between legal and controlled, but yeah if they dont have crypto then im not buying anything

Russian Star Peptides/Titan Chem seems to have finished DHT heptanoate (enanthate) oil but it's most likely bunk, since these guys are known scammers. Someone on RPF claimed their DHT gel contained caffeine and finasteride lmao. And someone on reddit actually tested it with Jano and it had no DHT.
But im a bit tempted to buy it and test it just out curiosity.

@Mulloch94 I believe DHT is not popular not because "if it was effective people would use it", but simply because there was never supply to begin with. In a few years DHT years will gain popularity, vendors will start carrying it and people will be using it in place of any synthetic DHT.

Im not going to use any synthetic steroid when i can use bioidentical hormones. Yes there's no legit suppliers (i actually know a source but i dont trust it) but maybe there's a chance DHT esters can be sourced from china or sythesized (purpose of this thread).

Also i wouldn't use Test without DHT. Yes the skin has higher 5-AR expression bla bla, all i know is topical pansterone was very estrogenic for me. So i won't mess with aromatizable steroids, for now at least.

@Crypt-Keeper I am actually in a gc where ppl are taking big doses of DHT-E and report nothing but good effects from it, from mental clarity and improved cognitive performance, to pr's in the gym and lowered blood pressure. Ive already tried base DHT but only topically and the effects are good but not that impressive. That's why i want to try esterified DHT or for now another route of administration for base DHT, which im working on.

I would disagree about the general public's impression on DHT. Most normies i've talked to and i've seen talking about it in the internet, simply view it as nothing more than a trash hormone that causes hair loss and prostate cancer lol.

Yes i've read Haidut's posts. I know it is anxiolytic because i've tried it and its metabolites are potent GABA agonists. However androsterone had more of that effect i'd say.

How was your experience with Epistane? Some say it's the ultimate oral, but it causes joint pain similar to Winstrol, plus it's highly hepatotoxic...

@Crypt-Keeper It is indeed. Basically what op said, but to add more:

DHT is the ultimate male hormone; not testosterone. It is the most potent androgen receptor (AR) agonist, and is 2.5-10x more potent of an androgen than testosterone.
Unlike testosterone, DHT cannot be converted to estrogen, and is also an estrogen receptor (ER) antagonist. Interestingly, the anti-estrogenic effects of DHT are independent from its role as an androgen agonist.
DHT is thought to not have any significant effects on muscle growth. The reason for this is because DHT is metabolized primarily by 3a-hsd and 3b-hsd enzymes into "inactive" steroids (which are potent neurosteroids that have been shown to have various positive effects on mood and cognition).
So saying DHT isn't anabolic because it is metabolized quickly is not a valid argument, as you wouldn't inject base testosterone which would be metabolized even more quickly than DHT. In reality DHT it is more anabolic mg per mg than testosterone.
The reason we want an ester is why people use testosterone esters; to make the DHT stay in the blood as DHT for longer to exert its biological effects for an extended period of time.
Bodybuilders already use DHT derivatives like Masteron, Proviron, Anavar, Primo etc, which have some kind of structural modifications to make them resistant to metabolism by 3a-hsd and other enzymes. There are anecdotal reports on bodybuilding forums (though scarce) that claim DHT esters are better than any other DHT derivatives they have tried. Someone said 100mg DHT-E/week is stronger than 750mg Masteron/week. So, there is no reason not to use esterified DHT, a bioidentical hormone, instead of these DHT derivatives which can be quite toxic.
DHT has a number of beneficial effects on health and Haidut has made extensive posts for many of them, so im not going to post them here.
Lastly, DHT does NOT cause hair loss or prostate cancer, and can actually help treat the latter.

Like this tweet puts it, Exogenous DHT allows Men to experience how Life would be were soy and estrogen not pumped into anything and everything.

Also interested in this. Base DHT is not hard to find and with excellent purity too, but DHT enanthate seems impossible to find.
Here is a patent which discusses the synthesis of DHT-E: https://patentimages.storage.googleapis.com/3c/bc/8c/5511b97b572c0d/EP0197753A2.pdf

@kimbriel What does this have to do with what i said. I know vitamin e is derived from pufa oils, however it can then be purified. I want pure tocopherols.
Most vitamin e oils on the market, despite being advertized as pure tocopherol oil, or pure vitamin e oil, are either tocopherols DILUTED with some carrier oil (most commonly sunflower) with max conventration at around 70%, or at worst actual pufa oils like a mix of wheat germ, soy, sunflower, avocado etc oils, and advertized as vitamin e oil lmao.
I dont want either, just pure tocopherols.

Does anybody know the source of the vitamin e used by Kenogen in Progest-E?
I am trying to find some good quality one to make a DHT solution, but seems almost every tocopherol "oil" is diluted with some kind of pufa oil and is not pure tocopherols. I would assume the one in progest-e is pure tocopherols?

@Mulloch94 How did you like just dht in E orally vs the topical with ethanol?

@Mulloch94 I was actually thinking of making a transdermal/sublingual dht solution with ethanol and vitamin e. Probably dissolving the dht powder in ethanol first and then adding the tocopherols. I honestly think dht + tocopherols might be the new meta. Progest-e for males basically. Have you experimented with something like that?
Progest-e also has coconut triglycerides so these might be somewhat important to improving the absorption, and then theres also the sfa esters like ipm and ipp haidut uses that may help, but i think hormones in vit e are better absorbed in thin cell membranes such as gums in general, while the sfa esters would enhance absorption on regular skin.

nootropics depot scale is pretty good

@DonkeyDude +1 for citypharma, i ordered and it arrived in just 2 days

@milkgains_bro Im actually thinking from ordering from QSC, yeah for the most part they seem trustworthy based on the mesorx thread. Their prices are good too. They also have most of their stuff tested at Janoshik but if i buy from them ill have it tested again probably.
Are you in the EU by any chance? I wouldnt want 100$+ of dht to get seized lol

@CO3 I remember haidut saying on rpf that he doesnt like discussing the exact formulations of his products as other companies straight out copy them completely, even including the product description lol. Though eventually i think he did discuss the sfa esters/ethanol solvent which is what this company seems to have copied. Theres another one that has a liquid b complex with the same ingredients as energin

@Santosh did you have it tested at an independent lab like Janoshik?

@Mulloch94 nice, how much T did you put in? T and DHT have very similar solubility i think so it should work with micronized DHT at the same amount

Baffles me how someone can post something like this on a Ray Peat related forum.
Judging by the 80 iq doctor youtube video you linked, you probably arent familiar with Rays writings on NO.
Which begs the question, why are you asking a forum whats the consensus on it, like everyone here has a Phd in Biology, instead of actually reading Ray's articles and newsletters?

Anyways NO is not the molecule of life, its a pro-aging free radical that decreases mitochondrial energy production, and activates processes that lead to cell death, among other things.
The actual "molecule of life", or the non damaging, protective equivalent of NO, is CO2.