Allulose can foster the growth of beneficial bacteria and stimulate the production of short-chain fatty acids. THE ROLE OF ALLULOSE AND SUGAR ALCOHOLS IN GUT MICROBIOTA MODULATION AND METABOLIC HEALTH: A REVIEW 2025

@bio3nergetic thank you, I think it's okay to share the link. its in the name of science

@Ecstatic_Hamster pretty sure protein intake translation to increased muscle protein synthesis doesnt even begin topping out until 75-100g protein at one meal . irrespective of increased ammonia which maybe signals incomplete but not totally stopped protein utilization for better pathway

I try to remain within the ranges that Dr. Peat mentions in Gelatin, stress, longevity (2009) Gelatin (the cooked form of collagen) makes up about 50% of the protein in an animal, but a much smaller percentage in the more active tissues, such as brain, muscle, and liver. 35% of the amino acids in gelatin are glycine, 11% alanine, and 21% proline and hydroxyproline. The 1936 Cyclopedia of Medicine (G.M. Piersol, editor, volume 6) mentions the use of gelatin solution to quickly control nosebleeds, excessive menstrual bleeding, bleeding ulcers (using three doses of 18 grams as a 10% solution during one day), and bleeding from hemorrhoids and the lower bowel, and hemorrhage from the bladder. But since Selye's work relating the thrombohemorrhagic syndromes to stress wasn't known at that time, gelatin was thought of as a useful drug, rather than as having potentially far-reaching physiological effects, antagonizing some of the agents of stress-induced tissue damage. Although I pointed out a long time ago the antithyroid effects of excessive cysteine and tryptophan from eating only the muscle meats, and have been recommending gelatinous broth at bedtime to stop nocturnal stress, it took me many years to begin to experiment with large amounts of gelatin in my diet. Focusing on the various toxic effects of tryptophan and cysteine, I decided that using commercial gelatin, instead of broth, would be helpful for the experiment. For years I hadn't slept through a whole night without waking, and I was in the habit of having some juice or a little thyroid to help me go back to sleep. The first time I had several grams of gelatin just before bedtime, I slept without interruption for about 9 hours. I mentioned this effect to some friends, and later they told me that friends and relatives of theirs had recovered from long-standing pain problems (arthritic and rheumatic and possibly neurological) in just a few days after taking 10 or 15 grams of gelatin each day. In some of the older studies, therapeutic results improved when the daily gelatin was increased. Since 30 grams of glycine was commonly used for treating muscular dystrophy and myasthenia gravis, a daily intake of 100 grams of gelatin wouldn't seem unreasonable, and some people find that quantities in that range help to decrease fatigue. For a growing child, though, such a large amount of refined gelatin would tend to displace other important foods. The National Academy of Sciences recently reviewed the requirements for working adults (male and female soldiers, in particular), and suggested that 100 grams of balanced protein was needed for efficient work. For adults, a large part of that could be in the form of gelatin. If a person eats a large serving of meat, it's probably helpful to have 5 or 10 grams of gelatin at approximately the same time, so that the amino acids enter the blood stream in balance.

@Samyo the disconnect in pharma is the pill needs to do it all when in most realities it is a holistic effort. so whatever works has to work really well so that even the most normie goyslopped pufa eater gets at least some results

Well seen, for the impact of deiodination. When halogens take the place of iodine on thyroid receptors, it's hard to get the right amount of active hormones (T3). And the problem is all the more serious / harmful for women: fight between thyroid and breasts to capture circulating iodine. iodal would be then required; not just the RDA (150 mcg; much higher). A protocol must be followed. Halogens: Fl > Cl > Br> I. (stronger force of attraction for bromine). In iodine-sufficient areas, the adult thyroid traps about 60 μg of iodine/day, either from dietary iodine or from iodine released during thyroid hormone therapy. But much higher for iodine when there is inflammation or an immune reaction (mastocytose). Additional info Why does bromine displace iodine? The bromine displaces the iodine from sodium iodide as it is further up in group 7 and therefore more reactive than iodine. Iodine is lower down in group 7 and therefore less reactive than chlorine and bromine. Electronegative elements have the property to remove electrons form the elements to which, it is attached. Fluorine is an extremely powerful oxidizing agent. The oxidizing power of the halogens varies in the order: F2 > Cl2 > Br2 > I2 The order of reactivity is chlorine > bromine > iodine. This is because chlorine could displace bromine and iodine, bromine could only displace iodine, but iodine could not displace chlorine or bromine. Explaining the trend: When an element in group 7 takes part in a reaction, its atom's outer shells gain an electron and form negatively charged ions, called anions. The less easily these anions form, the less reactive the halogen. When the atoms become larger, the outer shell becomes further from the nucleus. The force of attraction between the nucleus and the outer shell decreases. An outer electron is gained less easily. The halogen becomes less reactive. Source: BBC - Halogen displacement reactions https://www.bbc.co.uk/bitesize/guides/zg337p3/revision/3#:~:text=The order of reactivity is,not displace chlorine or bromine.

@alfredoolivas said in The pro-thyroid effects of ethanol (lowered TSH & reverse T3, increased uptake and thyroid receptor expression): A possible mechanism for this effect is ethanol’s interaction with the thyroid system. Rather than increasing thyroid hormone secretion, ethanol appears to remove obstacles in the thyroid hormone pathway, allowing more of it to enter cells and activate its receptor. Firstly, in humans, ethanol appears to lower TSH without affecting circulating thyroid hormone levels. This suggests that it increases the thyroid gland’s sensitivity to TSH signals. Great thread. Just don't forget to pay the piper. There may be other ways to "remove obstacles" if and while a debt is paid. https://leadtheway.substack.com/p/thyroid-and-water-homeostasis

@DavidPS Would a "27% increase in fat oxidation" really be a good thing? Wouldn't that FAO increase in turn decrease OXPHOS, per the Randle cycle?

I have over the last year gotten a grip on superior health. I have religiously trained grip strength every Sunday a year straight and returning to moonkey has improved every major aspect of my life. Bitch, superior grip strength was an absolute game-changer. It’s one of those things you don’t realize you’re neglecting until you start pressing your fist around a woman's breast, and then suddenly, everything in life feels more erect. Grip strength is the key to superiority. It’s involved in every physical thing you do, and when you improve it, it’s like unlocking a cheat code for life. I feel like I’ve got lobster claws for hands. Pull-ups? Gavity is just a debunked theory now. I’m basically a human forklift. It’s insane how much my sex appeal has improved by having superior fists. Women completement my fists all the time. Being fisted by me is a bragging right at the town hall. My hands are no longer hands, they’re weapons of mass destruction. It’s like I’m investing in my own survival, one hand squeeze at a time. There’s something primal and satisfying about having a superior grip. It makes you powerful. I now walk into rooms knowing I could rip the door off its hinges if I wanted to. Handshakes aren’t just greetings anymore, they’re power moves. Grown adults wince when I grip their hand, and I’m not even trying. I am the alpha moonkey in all social situations, because my grip radiates dominance. People feel it. They know. They know. If you’re not working on your grip, you’re just mastrubating your life away. I am now a Swiss Army knife of human capability, and it’s all thanks to my relentless grip training. My forearms look like they were sculpted by Michelangelo himself. Veins popping, muscles rippling. I catch people staring at my forearms in public, and I don’t even blame them. They’re mesmerizing. But here’s the craziest part: grip strength has made me spiritually awakened. Every time I squeeze, I feel connected to my ancestors. Those ancient humans who had to climb trees, carry Pyramids, and wrestle saber-toothed tigers just to stay handsome. I’m tapping into primal sexual energy, channeling the raw (doggystyle), unbridled power of evolutionary design itself. I’m not just training my grip; I’m honoring the legacy of human moonkeys. So yeah bitches, grip strength is a spiritual revolution. It’s the key to unlocking your true potential and ascending to a higher plane of existence. If you’re not training your grip, you’re not just mastrubating, you’re sleeping on the greatest upgrade of your life.

@LucH Exactly; my first thoughts were it's completely theory-based and is designed to sound factual and kind of give hope, but I couldn't describe it in words; "buzz" is the perfect word thank you

@DavidPS Thanks, and as always thanks for the supplementary info, that's perfect.

@Ismail You're welcome

@CrumblingCookie sadly dopamine agonists are not usually prescribed to patients, even in Parkinsons, as they usually just prescribe Levodopa, so of course none of these drugs are commonly prescribed. Pramixepole is the new dopamine agonist and that increases noradrenaline, and as far as I know, Amantidine and especially memantine, are commonly prescribed off-label, for many conditions such as MS and depression. Why isn’t Bupropion a good DA reuptake inhibitor? It’s even combined with naltrexone, in a formula called Mysimba, which creates an anti-opioid, anti endotoxin, pro dopamine and noradrenaline effect

@William-Shat said in Effects of Maca on Physical Performance in Animals and Humans: flattered or baffled Humour in the middle.

https://www.sott.net/article/221013-Health-Benefits-of-Smoking-Tobacco https://www.sott.net/article/338885-A-comprehensive-review-of-the-many-health-benefits-of-smoking-Tobacco https://www.sott.net/article/139304-Lets-All-Light-Up https://www.sott.net/article/229156-Lies-Damned-Lies-400000-Smoking-related-Deaths-Cooking-the-Data-in-the-Fascists-Anti-Smoking-Crusade