Posts made by alfredoolivas

@risingfire Thank you!

@alfredoolivas I personally notice much higher temps, a faster resting heart rate and reduced stress when I start my day with 3 shots (75ml of vodka) mixed with orange juice. It greatly reduces the stress reaction to coffee. I do this every day, apart from when I am driving or operating machinery/doing labour that has health and safety risks.

A little-known fact about ethanol is that it acutely induces a hypermetabolic state.

"Effects of acute ethanol ingestion on liver include rapid increase in metabolic energy state, production and export of acetate, suppression of long chain fatty acid oxidation and synthesis, increased β-hydroxybutyrate/acetoacetate ratios, and under production of glucose by gluconeogenesis".
https://www.sciencedirect.com/science/article/pii/S0306987720300797

"An intriguing hypothesis is that the effect of prolonged ethanol ingestion has a similar effect to the action of thyroid hormone on the liver (16). A “hypermetabolic state” (1) (the effect of which is excess oxygen consumption) exists in such circumstances"
https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.1840030420

A possible mechanism for this effect is ethanol’s interaction with the thyroid system. Rather than increasing thyroid hormone secretion, ethanol appears to remove obstacles in the thyroid hormone pathway, allowing more of it to enter cells and activate its receptor.

Firstly, in humans, ethanol appears to lower TSH without affecting circulating thyroid hormone levels. This suggests that it increases the thyroid gland’s sensitivity to TSH signals.

"Ethanol 1.0 g/kg suppressed plasma TSH to 1.4 +/- 0.2 mU/L (P < 0.05 at 0100 h and P < 0.01 at 0200 h). According to the area under the curve analyses, the suppression in the nocturnal TSH was 32% in the 0.5 g/kg group and 45% in the 1.0 g/kg group (P < 0.05 for both cases)...In conclusion, small amounts of ethanol have unexpectedly great effects on nocturnal surges of TSH, and especially on those of GH, that are apparently mediated by suprapituitary mechanisms."
https://pubmed.ncbi.nlm.nih.gov/8675588/

In vitro study suggesting ethanol has stimulatory effects to the thyroid gland, acting as a TSH mimetic:
"Ethanol stimulated iodide uptake in a dose-response manner in TSH-free medium. Ethanol augmented the effect of TSH on iodide uptake, iodide organification, and thyroid hormone formation in the presence of 20-80 microU/ml TSH."
https://pubmed.ncbi.nlm.nih.gov/8380371/

Secondly, in rats, it decreases the production of reverse T3
"In the fed state, hepatic rT3 neogenesis in animals given ethanol declined relative to the levels observed in control fed rats; fasting restored the depressed rT3 neogenesis to the levels noted in the fed state. Because decreased rT3 production in ethanol-treated rats in the fed state could not be explained on the basis of a change in 5'-deiodinase activity, it is suggested that ethanol administered with a nutritionally adequate diet may inhibit hepatic rT3 generation by inhibiting T4(5)-deiodinase."

Thirdly, it increases the celluar uptake of thyroid hormones
In vitro:
"Acute administration of ethanol in doses of 4 and 6g/kg significantly increases the uptake of (131)I-labelled thyroxine by the liver."
https://europepmc.org/article/pmc/pmc1177839

In vivo:
"The ethanol-treated animals had higher levels of 131-I activity in the anterior pituitary, adrenal, kidney and liver as compared to the control animals. Also, the kidney and anterior pituitary of the ethanol-treated animals attained their maximal concentrations later than did comparable tissue from the control animals. "
https://www.sciencedirect.com/science/article/abs/pii/0024320569902768

Ethanol increases thyroid hormone expression in vitro:
"Chronic ethanol consumption increases the amount of mRNA for retinoic acid and triiodothyronine receptors in mouse brain"
https://pubmed.ncbi.nlm.nih.gov/8710190/

@risingfire said in DHT Enanthate:

To say DHT isn't as good as test is hilarious based on a study with mice. If you have high prolactin, take dht over test but you should take both.

That is genius thinking! If you want to disregard animal studies, show me a study showing the benefits of DHT in HUMANS, and I will show you the benefits of TESTOSTERONE in HUMANS.

You won't be able to find any studies on DHT in humans, and I will be able to show you dozens of studies of testosterone showing benefits of testosterone in humans. Therefore, according to your way of evidence based way of thinking, my research is far superior to yours, as it is actually tested in humans.

If you want to disregard animal studies, that is absolutely fine, but then you need to admit that testosterone is better than DHT, because testosterone is actually studied in humans, whereas DHT isn't.

Edit: Can you even show DHT lowers prolactin (especially in humans as mice studies are useless right?) or is this just a twitter rumour?

@Crypt-Keeper yes as DHT said, PPL offers domestic shipping of estradiol within the US. So it doesn't go through customs, and you can order estradiol and receive it in a week. If you are outside of US, PPL offers international shipping, which is a bit slower, but the stealth shipping is really good, I have ordered 4 times from them, no issue.

@sushi_is_cringe I was talking about cosmetic effects, not about DHT effect's on health issues. All those studies cover the latter

@Crypt-Keeper Well whether estrogen is good or not, is up for debate, but for certain, estrogen is responsible for the fat loss properties of androgens. Everyone, not just people on this forum say, "estrogen is the fattening, pregnancy hormone!". Well show me a study of an aromatase inhibitor reversing obesity? I will wait!

https://www.sciencedirect.com/science/article/abs/pii/0031938479900453

"Treatment of castrated male rats with low doses of testosterone propionate (TP; 0.2 mg/day) increases food intake and body weight gain, but long-term treatment with a higher dose of TP (1 mg/day) reduces body weight gain and carcass fat content. Concurrent treatment with androsta-1,4,6-triene-3, 17-dione (ATD), which blocks the aromatization of androgens to estrogens, prevents the weight-reducing effects of high doses of TP. "

So basically this studied showed that, if you allow T to only turn into DHT instead of E + DHT, via blocking the aromatase enzyme, fat is gained.

@dht DHT is pure hype when it comes to cosmetic purposes. If DHT had any cosmetic benefit, then at least one of the thousands of studies performed on DHT, would of shown it. But I have yet to see a single study showing any cosmetic benefit of DHT. I would stop showing interest in it, it's not a golden bullet, or a well-kept secret, but rather a hype train.

The guy behind the hype is also on testosterone as well.

https://academic.oup.com/endo/article/162/6/bqab045/6155679

"Testosterone Reduces Body Fat in Male Mice by Stimulation of Physical Activity Via Extrahypothalamic ERα Signaling...Testosterone but not dihydrotestosterone decreases fat mass in obese hypogonadal male mice

https://pubmed.ncbi.nlm.nih.gov/16741268/

"DHT treatment resulted in obesity, associated with reduced energy expenditure and fat oxidation. "

https://www.sciencedirect.com/science/article/abs/pii/S1344622399800194

"In respiratory parameters, expired CO2 gas decreased significantly in the hormone-treated rats"

If you are going to reply with some anecdotal something, please don't. Not trying to be rude, but we should skip the talk and share studies instead, in order to hopefully dismiss these studies showing DHT having negative cosmetic effects, as I want DHT to have cosmetic purposes as much as the next person.

@jamezb46 Most milligram scales aren't accurate when measuring single-digit milligram weights; and even then, the size of drops varies, therefore, a mean has to be taken to calculate the average size of a drop.

And if you use the mean value to say how much a drop is then it is automatically an approximate figure. So, unfortunately, using an approximate figure is the only way to guess how much you are taking based off of drops.

@Mauritio That might be how it inhibits LH and FSH, and is anti-androgenic, because the opioid receptor inhibits GnRH secretion when activated.

Steroids such as T and DHT, increase opioid receptor expression, which could be a mechanism of how they shut down the HPG axis.

@LucH Exactly; my first thoughts were it's completely theory-based and is designed to sound factual and kind of give hope, but I couldn't describe it in words; "buzz" is the perfect word thank you

@jamezb46 Just spoke to a friend that dissolved 10% DHT in a solution that was 51% tocopherol 49% olive oil( Vitamin E "Oil" from NOW. has 510mg of alpha-tocopherol per 1ml).

I might add since he was able to dissolve 100mg in per 510mg of alpha tocopherol, it is more like a 20% solution excluding the olive oil (which DHT is not soluble in)

@Mauritio Well progesterone does the same; inhibits LH and FSH, and is therefore anti-androgenic. Unless peppermint oil is estrogenic, it may be a good proxy for progesterone.

@Mauritio Peppermint oil is 30-50% menthol, 15-30% menthone and 5-10% eucalyptol. So peppermint oil could be a vehicle to deliver these substances.

@goniath Unsustainable and ineffective in my experience. His supplement SEA, doesn't work either, even when taken in massive doses repeatedly.

@Mauritio Menthol, Camphor, Menthone and Eucalyptus, all are terpenoids known for their "cooling" effect, and are completely saturated- Camphor and Eucalyptus are even saturated cages, similar to Adamantane. Very interesting to me.
I would love to see if their is some overlap in their origin, structure or effects

@jamezb46 The issue isn't that DHT is insoluble in tocopherol, but rather that people are either using the wrong solvent or brewing it incorrectly. I’ve successfully dissolved DHEA, progesterone, and exemestane at 300 mg/ml in a mixed tocopherol solution at a 30% concentration, multiple times, with ease. There was no undissolved particles when I looked through the glass, and shining a light through it exposed no further undissolved particles.

Tocopherol is likely the most effective solvent for dissolving unesterified steroids. However, it is also the most challenging to use. First, you need to determine the exact amount of tocopherol in milligrams and oil and use an appropriate amount of steroid. Second, it requires significant heating beforehand to properly mix the steroids. Additionally, you’ll need to reheat it during subsequent steps to ensure everything dissolves thoroughly.

Simply throwing a random amount of DHT powder in a "tocopherol" oil, which a lot of the time has a low amount of vitamin E inside it, and throwing it in the microwave until it gets hot, won't work.

@LetTheRedeemed Even though ethanol has it's own anti-microbial and drying effects, niacinamide can dissolve at 100% concentrations in water; e.g; 1g per ml of water or 10 g per 10 ml of water. Therefore, water can be used as a solvent to maximise the amount of niacinamide applied.

@risingfire It's not bad, DMSO tends to only causes irritation on dry skin, and testicles have no dry skin and are usually very sfot.

@CrumblingCookie sadly dopamine agonists are not usually prescribed to patients, even in Parkinsons, as they usually just prescribe Levodopa, so of course none of these drugs are commonly prescribed.

Pramixepole is the new dopamine agonist and that increases noradrenaline, and as far as I know, Amantidine and especially memantine, are commonly prescribed off-label, for many conditions such as MS and depression.

Why isn’t Bupropion a good DA reuptake inhibitor? It’s even combined with naltrexone, in a formula called Mysimba, which creates an anti-opioid, anti endotoxin, pro dopamine and noradrenaline effect