Posts made by brad

@tolstoy I changed the settings so this is the default globally.

@Norwegian-Mugabe Agreed. The yield should be higher if you're just using diosgenin though.

@pannacottas side effects from DHEA, that is. Be careful with DHEA, it can easily aromatize.

@ParthianCoconut Awesome post, thank you for sharing, and congratulations on your journey so far.

Progest E, available online or by emailing kenogen@gmail.com, is probably one of the most versatile compounds in the bioenergetic pharmacopeia. A deceptively simple combination of Vitamin E and bioidentical progesterone, it was patented by Dr. Peat in 1984.

I've found it to be a nearly miraculous compound. A friend of mine had neurological damage from a car crash. He described his toes as feeling like they were being constantly pounded by hammers and nails. I gave him a bottle of Progest-E, told him to smear as much of it on his foot as he wanted, and wait. About 20 minutes later, he said the pain was completely gone and replaced with a warm tingling sensation.

Making this thread to hear others' stories of successful applications of Progest-E.

I have a goal of being able to make most of the important bioenergetic substances from scratch. There's a process to make "thyroid" (-like substance) by boiling milk with iodine for a few hours. Something more impressive would be to fully synthesize progesterone from diosgenin, which is found in Mexican Yams.

There's a quote from Ray (can't find it now) that the process of synthesizing progesterone is well known and can be done on a local level. I haven't found any reliable source that actually explains how to do that in detail.

Russell Marker first accomplished this in 1942-1945. He was frustrated by the slow pace of progress. Remarkable and interesting story:

When Marker went to Mexico City in January 1942, the U.S. Embassy advised him to leave immediately because of widespread anti-American sentiment fueled by World War II. Instead, Marker took a bus to Orizaba, changed to the local bus to Cordoba, and, on the way, recognized the stream described in the botany text. By the stream, he found a country store owned by Alberto Moreno, a native Mexican who did not speak English. Despite the language barrier, Moreno was enlisted to find some cabeza de negro. Although Marker had no plant-collecting permit, two large roots in bags soon were loaded on top of the bus to Orizaba. When Marker got there, the bags were gone, but he recovered the larger 50-pound root by bribing a local policeman.

Back at Penn State, Marker isolated diosgenin in satisfactory yield from part of the smuggled tuber. Because his research had been funded by Parke-Davis, Marker took the rest of his root to its laboratories in Detroit. There, he repeated his process in an attempt to persuade the company to commercialize it. However, Parke-Davis's president refused, because he believed chemical work could not be done in Mexico. Marker's efforts to interest other pharmaceutical houses also failed, and, by the fall of 1942, he was convinced the only path to success "was for me to do it myself."

Marker returned to Veracruz and arranged with Moreno to collect and dry about 10 tons of cabeza de negro. In Mexico City, he found a man with a small-scale extractor, who extracted the roots with alcohol and evaporated the extract to a syrup. Next, in return for a third of the product, Marker arranged with a New York friend, Norman Applezweig, to use his laboratory to convert the syrup to progesterone. Marker finished with three kilos valued at $80 per gram, then the largest lot of progesterone ever produced.

The Marker Degradation diagram looks like this:

And here are links to his patents (1, 2).

At a high level, these are the steps involved in the Marker Degradation, from what I can tell (I'm no trained chemist):

1. Starting with Diosgenin: Diosgenin is a steroidal sapogenin and is the starting material in this synthetic pathway.

2. Acetylation: Diosgenin undergoes an acetylation reaction where the hydroxyl groups are protected by acetyl groups (AcO) using acetic anhydride (Ac2O) at high temperature (200°C). This step is important to prevent any unwanted reactions at these positions in the subsequent steps.

3. Ring Opening: The acetylated diosgenin undergoes a chemical reaction that opens the F ring of the steroid (highlighted in red in the diagram). This is done by heating with sodium hydroxide (NaOH) in alcohol.

4. Oxidation and Rearrangement: The open-ring compound is then treated with chromium trioxide (CrO3) in acetic acid (HOAc), which oxidizes the molecule and leads to a rearrangement of the structure to form a ketone at a specific position.

5. Conversion to Progesterone: The ketone undergoes further reactions, including bromination (Br2), another oxidation with chromium trioxide (CrO3), and finally treatment with zinc (Zn) in acetic acid (HOAc) to yield progesterone.

6. Synthesis of Other Steroid Hormones: The progesterone can then be converted into testosterone, estrone, and estradiol through additional chemical reactions. The diagram indicates a reduction step with hydrogen (H2) and a palladium catalyst (Pd), which is a common way to reduce ketones to alcohols, leading to the formation of these other steroids.

From here, the question would be how to modify this recipe to include ingredients and equipment that are widely available. Thanks for reading my post and please contribute if you have any expertise or opinions on the matter.

@Fructose Oh okay that makes sense now. @LaneswapSlides mentioned at one point that the forum language was localized so I thought maybe it translated posts as well.

@Fructose
Here's what I saw:

@skylark That sounds really interesting.

Luca Turin, perfume specialist, has very good videos on the internet. One on pharmacology. He's talking about antidepressant drugs in that case, but his main interest is in olfaction. I think that along with Heraclitus who talks about the "nose essences" as being at the center of consciousness, really the olfactory system is closely connected with our highest and best conceptual work.

• The Ray Peat quote from the video

@donovan

Doesn't look like there's much quality on the Toxinless page, which is what I'd check first.

If you can create an LLC or organize a group buy Sigma Aldrich seems to offer the raw material.

For someone more adventurous there's always China. This might actually be more risky than just getting something OTC regulated by the FDA unless you really know what you're doing.

@yeezy 100mg vitamin b1, coffee with lots of milk and sugar. T3 and orange juice. Have you tried it?

I believe Norway has the most tunnels per capita and Switzerland has the highest density of tunnels per unit of area.

@CO3 I understand what you're saying and broadly agree. Nibbler and I are running Bloo similarly to a benefit corporation to fund the creation and distribution of bioenergetic products. For example, the recipe is completely open and many people happily replicate it. Hopefully through our actions we can show it's not a purely profit-focused endeavor.

@Norwegian-Mugabe I have precognitive dreams regularly. They're either for heightened emotional experiences or something completely mundane. They also have a unique quality to them. A few specific incidences:

• My wife lost 20 boxes of her stuff when shipping her stuff across the country, including many sentimental items. I had a dream that she got an email that everything was found one night and the next morning I asked her to check her email and it was there.
• My espresso machine was broken in my dream (rarely happens) and the next day it was nonfunctional.
• Not a dream, but I gave a speech at my sister's wedding after "viewing it" in deep meditation. Many specific lines were just plagiarized from my future self. Depending on your perspective, this could be an imaginative exercise or remote viewing.

@adolfrizzler

It's well known that naked mole rats, who live in burrows with a CO2 concentration 10x atmospheric, live about 10 times longer than other species of rat. They also never get cancer. When taken out of their burrows living at normal atmospheric gas concentration of CO2 this longevity disappears. I think this has to do with the pro-metabolic effect of CO2.

@Fructose FYI your quotes are in Polish while I was typing in English. Interesting localization logic on the forum.

I agree that neither of those studies are conclusive on their own. If you listen to the Brent Wisner closing statement he does a more thorough review of the literature where there's adequate evidence to support genotoxicity, renotoxicity, and carcinogenicity. And he shows that the initial approval of glyphosate/Roundup was a sham.

Since there's no way to avoid it when in use as it becomes a ubiquitous environmental contaminant, I think following the precautionary principle and banning it outright would be the most healthful and environmentally sound option.

@arthyn This seems like a simpler fix than having a bot constantly running. If someone wants to write a plugin I'd be glad to install it.

@Norwegian-Mugabe Here you go: https://bioenergetic.forum/category/17/the-gym

@CO3 lol