Posts made by LucH

@haidut said in Parkinson’s may be due to B vitamin deficiencies, riboflavin (B2) and biotin (B7) may treat:

Yet another study, which not only points to the gut/endotoxin as a major cause of many chronic, degenerative diseases, but also corroborates again the role that energy production plays in pathologies such as Parkinson Disease (PD).

Very interesting. Thanks for sharing.
For the other readers:
I’d first deal with bacterial overgrowth (endotoxins LPS) and be sure to evacuate twice a day the stools (to avoid stagnation and proliferation of bacteria that have nothing to do in the second part of the colon, especially when eating starches, particularly potatoes). Thus, MMC must be optimal (motility of the intestines in the resting periods)
MMC= Migrating Motor Complex.
First calming before adding a layer.
Afterwards, we can manage to optimize useful nutrients.
More to say is needed but not now.

• Mummy, what's the difference between "excited" and "make me nervous"
• 20 years ago papy was exciting; today he makes me nervous.
  
  Comment: I take the lead: there is no more season.

@DavidPS
Hi,
If you want some more fuel / ideas, like these ones:
https://mirzoune-ciboulette.forumactif.org/t2043-blagues-et-funny-clips-13#29690
(jokes and funny clips)
Most comments are in French but the image is often speaking from itself…
At the end of the page (post) there are similar links:
“Histoires drôles et funny clips” (funny stories) + numbers 1-13 (13x).
Note: If desired, when needed, you can re-write the comments, with a image software. No problem for me.

@Kvirion said in Vitamin E safe for daily consumption?:

Raw veggies besides carrot salad are unhealthy, with many anti-nutrient, anit-thyroid substances...

Ray recommended a kale broth.

Hi,
If you want me to debate these points, open a new one, and leave a link here.
When I say "debate", it's to approve some points and how to avoid some others.
when you often eat the same kind of food, I agree we should take into account some disadvantages, for instance in a salad carrot

@SpaceManJim said in Vitamin E safe for daily consumption?:

So how about something like 100 iu daily, would that be safe? Mostly I'm interested in the anti-PUFA effects

I won't formulate it so.
There is no danger. 2 mechanisms exists to eliminate excess Vit E.
See Dr Traber from Linus Pauling Institute to go deeper into the process to understand why there had been a mess at some time. or I can give a link.
There is however one possible side effects: bleeding. Lack of K1. When I take essential oils or supplement (curcumin, aspirin), I take once a week a high-dose supplement of K1. It solves then the problem (anticipation 1x/wk; if problem 2x/wk, with a lot of fat, 35 gr needed).
K1 comes mainly from green raw veggies (=> smoothie).
Note: Not préjudiciable doesn't mean it's optimal. Too much of a good thing is bad, for me.
Chris Masterjohn says 20-25 UI is required per day.
I take a supplement 400 UI (mixed tocos) once a week, twice when problems (low-grade inflammation).
Never take only one source (add some gamma to alpha-tocopherols, e.g.).

@voldtzeig said in Thiamine hcl makes me smell.:

I'd love it if you could send a link btw!

B1 Thiamine protocol

Note: Most of the information is in French (You’ll need a translator) but the given sources (links) are most of the time in English. Here is a short summary. The video Of Allil Overton (nutritionist) below is in English, if you prefer the direct link (a bit too long for me).
Vaut le détour : *** It's worth the détour!

Mega-dose of thiamine: beyond the resolution of "deficiencies"

• By saturating the cell, you can bypass the low affinity and restore the enzymatic function in its normal state. (=> Justification for the use of megadoses). Some people do not suffer from what we call a nutrient deficiency but from a metabolic block (blocked enzymes)
  https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1#29728
  Active and passive diffusion. Capacity of certain forms to cross the encephalic barrier. Supra-physiological contribution. Interaction (diagram) and example of dosage.
  *) This could be a game changer!
  https://mirzoune-ciboulette.forumactif.org/t2016-this-could-be-a-game-changer#29423
• Pharmacological dosage of thiamine
  Target for high dosage:
  B1 300 - 350 mg 2x/dy
  B1 => Towards 750 mg 2x/dy (in 3 steps)
  B1 => then 1 gr 2x/dy according to Dr. Costantini
  His protocol (with potassium) :
  https://highdosethiamine.org/hdt-therapy/
  2 gr of B1 per day, before and after the lunch (Midday)
  NB: We do not increase the dose until the discomfort has regressed in the event of side effects.
• Read the references given in this post, particularly the references 10 - 11, notably Dr. Allil Overton.
• You will need Mg. 380 - 450 mg of Mg element to activate thiamine.
• Dosage of Thiamine HCL. Contraindication.
  *) Original text (source)
  How to Apply High-Dose Thiamine Protocols in Clinical Practice: Part 2
  Practical Guidance
  https://www.youtube.com/watch?v=RFZUzS_xP9A
  EONutrition – Elliot OVERTON speaking (nutritionist) (multiplex) – Part 2 – Video 2:04:02
  This is the second of two lectures I gave to a group of medical/health professionals on the clinical application of high-dose vitamin B1. In this video I outline the difference between nutritional deficiency and the concept of "functional dependence". I then discuss the practical aspects of forming a protocol including: - Which form to use and why - How to dose for different conditions - When to use this therapy and when not to use this therapy - Managing patient side effects.
  *) 10 hallmarks of the video

1. 07.059”: Basic Definitions
2. 08.21”: Nutritional Deficiency
3. 08.40”: High Calorie Malnutrition
4. 11.12”: Functional Dependency
5. 29.49”: Symptoms of B1 Deficiency
6. 32.22”: Therapeutic Use of B1
7. 34.40”: Forms of Thiamine Can You Use
8. 45.05”: Peripheral Neuropathy
9. 47.12”: Disulfide Derivatives
10. 49.47”: Heavy Metal Chelating Ability
11. --- X
    *) 1.45’’ Recap of last week (part 1)
    The Art and Science of Mega-Dose Thiamine Lecture: Part 1 – Video 1:34:21
    https://www.youtube.com/watch?v=-Uf1D2KdTn0
    EONutrition – Elliot Overton (nutritionist)

@voldtzeig said in Thiamine hcl makes me smell.:

Hey, I just bought a bag of thiamine hcl and after dosing 0.5g daily for a week or two I smell like urine.

B vitamins, like thiamine and choline, may impact the balance of chemicals in your urine. These extra chemicals and vitamins can change your urine’s smell.

Moreover, we shouldn't take high dose thiamine like you did.

• No thiamine without B2. Never do that. or the addition will be soon brought. Not necessary every day for B2. 2 or 3x a/wk.
• I would have begun with 100 mg thiamine HCL for one week, then upgrade to, 200-250 mg B1.
  A multi would be nice (co-enzymed), 2x/wk too. interaction.
  And there a protocol for taking high dose B1. See Dr Allil Overton. Or I can give a link.
  Note: If you want to reach 1500 mg B1, you won't see results with only B1 HCl.

Milk IS lightly acidifying.
Water IS more valuable for what it takes away than what it brings.
There are two kinds of water. Water as food and water as purifying agent (cleansing agent).
Perso I'd target to balance lactose with m'y capacity to assimilate it cause WE are enzyme-limited. Could ferment then.
Note: Most of thé milks are recombined when not spécified. Traficoted. Mind thé source.

@GreekDemiGod said in Liver/ gallbladder flush experiences?:

as someone does more flushes, the number of stones/ oil "balls" reduces?

Silly, if you consider the balls are mainly oil residues. Not only. Thus, partly true but not objective.

With a « cure » with olive oil, the amount of fat is so high that it enhances a flushy / contractile move because it’s laxative. In theory, very tiny crystals are going to be enrolled by bile and mostly by oily balls (amalgam). However, it’s a lottery: 2 or 3 tiny crystals could make a thicker sharp one. And if you encounter a narrow vessel / tunnel, especially near the liver or farther in the tubules of the kidneys, you are going to suffer a lot, calling for emergency 9.1.1
I’m not joking.
Use the soft way to dissolve the crystal stones. Be proactive (citrates) add fibers when eating meat, don’t take high supplement in calcium (higher than 200 – 250 mg Ca element). Target your oxalates supplement (cronometer.com) (spinach), combine A D3 K2 if required (according to your health state / locality = sun wavelength) to optimize healthy bones.

@Onza said in Liver/ gallbladder flush experiences?:

In your opinion, which nutrients?

Shortly said: choline (from taurine & glycine from foodstuff)
In details:
Useful nutrients for quality bile

• Minimum dietary protein: 0.8 gr /kg weight (functional membranes) (1)
• The quantity and quality of dietary lipid influence bile secretion: a few omega-3 from white fish and enhanced omega-3 eggs from free high grazing chickens (2x/wk for each kind).

• Dietary phospholipids are Nr one (eggs) when trying to influence bile secretion.

Or phospholipids coming from soybean lecithin if you can manage this kind of food (intolerance).

• Little is known over other interaction with dietary carbohydrates, fibers, minerals and vitamins on cholesterol and BA metabolism. But a restriction diet is not adviced. To advice a fast on several days is counterproductive since it’s going to heighten stagnation of the flux (thicker).
  BA = Bile acids.
  *) How to streamline bile naturally?
  It is advisable to work the digestive system to maintain a good fluidity of the viscous liquid. Consequently, following a low diet for several days requires a period of rehabilitation at the end of the "fast". Rosemary stimulates and decongestion the liver. It is often taken in combination with dandelion and artichoke. It promotes the production of bile. (20) Lemon juice also stimulates bile production and regenerates the purifying functions of the liver. 1 to 2 drops of HE from rosemary verbenone, on a base (1/2 sugar, 1 tsp yogurt / cream or 1 tsp of coconut oil) before breakfast. Or in a cream / oil to be applied to the liver region. In cure of 2 to 3 weeks. We need choline and inositol to make bile (250 mg). (20)
  *) Taurine and glycine to form choline (21)
  Bile acids are produced in the liver by oxidation of cholesterol. They are combined with taurine or glycine, or with a sulfate or a glucuronide, and are then stored in the gallbladder.

Sources and references
0. Bile & SIBO
Optimiser la bile & fluidifier le transit en cas de SIBO
https://mirzoune-ciboulette.forumactif.org/t2005-impact-de-la-bile-sur-le-microbiote-et-le-transit#29365

1. Nutrients needed to prevent cholestasis
   http://www.sciencedirect.com/science/article/pii/0271531796001042

@jhp said in Question about Cyproheptadine:

i'd be interested in hearing more about this.

I have no info in the form of a book or PDF for sophrology. But well to introduce the practice to people who do not really know EFT (Emotional Freedom Technique). For breathing technique see beneath but I’m not sure it’s going to help in asthma, except this pathology is quite bound to the nervous system. Without speaking about the inflamed lungs (selenium in nebulizer, not in a spray, could help, according to Dr. Klinghardt).
When your immune system reacts inappropriately, in front of an intruder (allergen, badly or indigestive macromolecule, for example) it sends the big artillery to neutralize the intruder, often accompanied by an inflammatory response, if so that there is an intruder to locate / to fight. Then we apply conventional techniques: medical imaging and painkillers, for example. (I simplify excessively for the clarity of the presentation).
You do not learn anything when I’m telling you that traditional European medicine and across the Atlantic, they focus mainly on symptoms. However, this medicine is especially effective in the event of a pathology with acute crisis (heart attack, fractured member, etc.). In the case of a PR or SPA "the conventional therapists" are often disarmed ... "Chinese medicine" is more efficient when it comes to rebalancing energy flows, homeostasis...
SPA = Syndrome de polyarthrite ankylosante: PR = polyarthrite rhumatismale.
*) Concrete example:
Take an image to view the problem:
1 ° Cause of the problem (causing pain or problem)
2 ° Zzzz… (=> disturbed energy system).
=> Image of a blurred TV making Zzzz (bad reception: fog).
3 ° Pathology (pain for example)
Traditional medicine will try to relieve pathology by "treating" the cause (stress for example). It will work quite often, but the evil will not be eradicated in a structural / deep way. It tapped / hided itself, will put itself on the backstil, until the next episode where you will have pulled too much on the rope ...
As long as you do not change the behavior and especially evacuate the Zzzz, a disturbing element, the problem will often persist ...
Otherwise expressed, if you only care about the phase 1 of the process (cause) and the phase 3 (pathology), you will not progress or not very well because the disturbing element will be still present (Zzzz).
*) Chinese medicine
“More than 5,000 years ago, the Chinese “people” discovered a system of energy circuits that crosses the body. Oriental medicine and acupuncture, acupressure and several other healing techniques are based on these energetically fluxes, or meridian circuits.
This energy circulates in the body and is invisible to the naked eye. We cannot see it without a high-tech equipment. By analogy, you do not see the energy broadcast in a television either. You know, however, that it exists, thanks to its effects. Sounds and images are proof that this energy flow exists”.
Source : Emotional Freedom Techniques TM (Technique de libération émotionnelle).
Manuel de Gary Craig, en PDF.
EFT – traitement énergétique de la douleur
https://mirzoune-ciboulette.forumactif.org/t550-eft-kes-ca-ko
Understand how and why EFT can help you (in French, translator needed)
https://mirzoune-ciboulette.forumactif.org/t347-comprendre-comment-et-pourquoi-l-eft-peut-vous-aider
=> Cardiac coherence - Relaxation session
We inspire on 5", rather slowly. Then we expire on 5".
Inspire by the nose and expires complete by the mouth. We do not inspire too quickly otherwise we will block / pause at the 4th time (1 - 2 - 3 - 4 - 5) (we do not count because we follow the sinusoidal graph). We expire well, thoroughly! If the head turns, you shorten the session and start again 3 hours later. 3 x 5’ a day. So it's a rhythm to take and it can be learned, it's like everything...
Examples of video if you need / if you want visual assistance:
https://youtu.be/fujdW6M3zcU (waterfall, with a ball that goes up and down).
https://youtu.be/6WV3BaOjoUo (seaside, waves on the beach, at sunset)
https://youtu.be/W3OVCOekcSk (full ocean)
Etc.

@Mallard6146 said in Bottom Range Vitamin D:

The range is 30 - 100.

minimum target: 35 ng/ml. Optimal above 45 ng/ml, for me. But everybody won't agree

• Excess magnesium can hinder the absorption of vitamin D. Neither too little nor too much magnesium (RDA Mg: 360 and 420 mg according to sex f / m) is favorable.
• If the ratio PUFA : MUFA > 1, you will have difficulty increasing the levels of 25(OH)D. This brings us directly to 18-20g and 12-15g of PUFA consumed daily by American men and women (Kris-Etheton, 2000) and their negative impact on the absorption of already low quantities of vitamin D in food. So beware of manufactured foods which often contain an addition of soy and corn oil.
  By the way, if your sun shadow exceeds your height, you will not make vitamin D. Question of wavelength.

Useful link (in French, translator needed, but with links in English):
Absorption de la vitamine D insuffisante ?
http://mirzoune-ciboulette.forumactif.org/t1664-absorption-de-la-vitamine-d-insuffisante#20619
Facteurs qui facilitent ou contrecarrent l’absorption de la vitamine D3

@Ilias-Ant

Caffeine has several interesting advantages, but we need to manage the possible side effects:
When drinking coffee too: coffee is diuretic and acidifying. So, we have to care for the acido-basic balance, as well. Caffeine is anxiogenic. So, not advised for sensitive people who are already stressed and sometimes anxious.
Try first to recover / to balance before taking coffee again. RP advices rather caffeine pills instead of coffee to avoid some problems. But you have to metabolize well xanthine (toxic metabolites) thanks to liver. Otherwise, no coffee nor caffeine for you, unless up to the moment your liver is functioning well. If you overload the chief engineer (liver), it’s like entering a no-way out.
Grounding is very good to get rid of some interferences. I would add some EFT or breathe technique and walking.
I can give a link if interested.
EFT = Emotional freedom Technique.
If you are stressed, you overload your adrenal glands (adrenaline and cortisol). You need 2 hours delay to recover a normal metabolism (glycolysis). You need to get the right fuel (glucose) to function well.
When recovering a peaceful state of mind, you’ll think about the thyroid and useful nutrients for thyroid. Attention: You need selenium before taking iodine. (…).

Magnesium bisglycinate, L-theanine, bone broth are very helpful when searching for a quiet mind. Not only.

For better sleep, I’ve already tested this combo of plants:
Roots of valerian (anxiety), hawthorn flowers (heart regulator) and flowers and branches of passiflore (light hypnotic). No notable side effects, except to have a little heavy legs when we abuse. A cup every 4 hours maximum (8 - 12 - 4 p.m. - 8 p.m.). Start with a cup (125 ml) 3 to 4 hours before bedtime and then adviced as needed. I would leave to infuse 10 to 15 'a good one in a percolator of 8 cups (125 ml x 8).
In French: valériane, aubépine et passiflore.
Note: Valerian doesn’t smell very well, but it’s fine with an extract of orange blossom (not really required). Don’t drink this the next day. Awful.

@Ilias-Ant said in Question about Cyproheptadine:

should i stop it?

Search with "Cyproheptadine and counter-effects and stress management"
Cyproheptadine can improve sleep architecture and REM (rapid eye movement) sleep pattern. It has been used to address distressing nightmares in post-traumatic stress disorder and dream anxiety disorder.
Counter-effects:
Cyproheptadine is an anti-histamine originally ... The main side effect of cyproheptadine is sedation, but excitation and restlessness may also occur.
Note: Other side-effects occur (on platelet aggregation e.g.).
Source: ScienceDirect.com and cyproheptadine toxicology

=> So I would listen to my symptoms.

First stop two days long. Cyproheptadine is well-absorbed following oral ingestion, with peak plasma levels occurring after 1 to 3 hours. Its terminal half-life when taken orally is approximately 8 hours. But by some people, the liver and kidneys no longer eliminate drugs on very optimal way (accumulation). It takes a longer time.
Afterwards I’d cut the dose by half and see how I can manage.
You probably need 300 mg magnesium bisglycinate too (2 – 3 times a day, after a meal, preferably).
Could you say more why you take cypro?

@GreekDemiGod said in Liver/ gallbladder flush experiences?:

e share your experience with liver/ gallbladder flushes

What you see is not crystal but oil balls.

• protect liver: curcumine and weak level of toxins (xanthines, rice from some countries, chocolate, etc.)
• try to stay in a fasting mode from 8 o'clock p.m. till 10 o' clock a.m. Only eat 2 fruits for breakfast till midday.
• eat useful nutrients for gallbladder to get quality bile + citrate to avoid oxalic stones.

@DavidPS said in Your top daily supplement? If you had to pick just 1:

I am interested. Please explain.

Why minimum 2 tocopherols?
Pharma-kinetics of tocopherols
There is no discrimination between the different forms of tocopherols (all forms are accepted) (1) but alpha-tocopherols are preferably absorbed by transporters (2-3), thus in higher concentration in plasma levels for RRR-alpha-tocopherols, via VLDL (transporters).
These results suggest the existence of a mechanism in the liver for assembling VLDL preferentially enriched in RRR- relative to SRR-alpha-tocopherol (natural vit E, versus synthetic one).
References (no need to read).
DOI: 10.1016/j.freeradbiomed.2021.10.016
PMID: 1431596
PMID: 2351872. (MG Traber)
=> We should not eat all the time the same source from food. Note that Vit E is present only for protecting the nuts.

Once ingested, we must renew the protection (half-life).

The half-life of γ-tocopherol in normal subjects has been estimated to be approximately 15 hours (Acuff et al., 1997). Suggested Citation:"6 Vitamin E." Institute of Medicine. 2000. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids.

Note: Vitamin E can be recycled by ascorbic acid when used. See & “Synergy”.
Most nuts brings some interesting amounts of alpha-tocopherols, especially almonds (25UI), hazelnuts (15 UI) and sunflower seeds (34 UI) (but I won’t take the last one, too rich in PUFA). UI given for 100 g. One portion = 30 g.
Pecans (24UI), walnuts (20 - 28 UI), pumpkin seeds (19 UI) and sesame seeds (28 UI) are rich in gamma-tocopherols. (I won’t take the last one, too rich in PUFA), or occasionally.
Source: Vit E toco alpha gamma in nuts and seeds
https://www.ars.usda.gov/ARSUserFiles/80400525/Articles/AICR06_NutSeed.pdf

*) English Corner: Liposoluble vitamins A D E & K – How much fat do we need to absorb them well?
http://suppversity.blogspot.be/2014/05/vitamin-d-e-k-how-much-and-what-type-of.html
Vitamin A (retinol) + bêta-caroten : 3 to 5 g.
Source: A Fat D-Ficiency
http://suppversity.blogspot.be/2011/12/fat-d-ficiency-do-you-really-need-more.html
Vitamin E: 3 g but a PUFA-diet exhausts toco- and trienols (latent inflammation).
Vitamin K (K1 and K2): 35 g
The quantity of phylloquinone (K1) which enters your blood circulation will be reduced by around 70% if you eat your spinach without a supply of fat (Gijsbers, 1996). The absorption of K2 is 3 times larger with 35 g of lipids in the meal than with 20 g. 6 x less with 8.8 g of FA. (Uematsu et al. 1996). However 18-20g and 12-15g of PUFA are consumed daily by the American man and woman (Kris-Eheton, 2000).
Vitamin D : It is the type of fat that will determine the degree of assimilation.

Oil-rich in PUFA inhibit the absorption of 25OHD vitamin.

(Niramitmahapanya et al. 2011). An oil with a ratio MUFA: PUFA > 1, like sunflower or soybeans, is deleterious.
Caution: If you have a high supply of PUFA (omega-3 supplementation or oilseed consumption, with the exception of macadamia nuts which are very rich in MUFA), the blood rate of Vit D and E will often be very low because these 2 vitamins also have an anti-inflammatory action and will therefore be hijacked / diverted from their use as hormones. Details on my forum (in French, but with links in in English):
http://mirzoune-ciboulette.forumactif.org/t1357-vitamines-liposolubles-et-matiere-grasse-ratio#15157

*) Synergy effect with vitamin E
“Vitamin C regenerates vitamin E and vitamin E protects β-carotene, helped in this by polyphenols. In the event of β-carotene supplementation, vitamin C regenerates vitamin E and β-carotene, and β-carotene seems to protect vitamin E without really explaining this phenomenon "(1)

Savings effect
Vitamin E is not just a vitamin. Vitamin C makes it possible to recycle oxidized vitamin E and thus prolong its lifespan. The same goes with glutathione which is thus saved for other more useful functions (detox). Glutathion is our antioxidant master. Vitamin E protects against the deleterious effects of polyunsaturated fatty acids when the latter are in excess. And it is quickly done!

1. John Libbey Eurotext - Anti-oxydants d’origine alimentaire : diversité, modes d’action anti-oxydante, interactions. Auteur : Claude Louis Léger.
2. Daniel Raederstorff et al. Br J Nutr. 2015. doi: 10.1017/S000711451500272X
   => 20 mg Vit E for 10 gr PUFA.

*) Factors that facilitate or counter the absorption of vitamin D3
http://mirzoune-ciboulette.forumactif.org/t1664-absorption-de-la-vitamine-d-insuffisante#20619

• A Magnesium intake neither too high nor too low (RDA Mg: 360 and 420 mg depending on the sex f / m) is favorable. An excess of Mg will thwart the absorption of vitamin D3.
• Mono-unsaturated fatty acids facilitate the absorption of vitamin D (olive, avocado, macadamia, for example). Saturated fatty acids (SFA) are probably neutral, at this level. But since these SFA’s contribute to the stability of the membranes, we should take care to have a 50/50 ratio between SFA and MUFA. And as few PUFA as what is necessary for metabolism (1 % = 22 gr. It is already calculated widely. 4 % is the level not to be over. 6 % is deleterious). (Perfect health diet. Jaminet).

@SpaceManJim said in Your top daily supplement? If you had to pick just 1:

I'm wondering what people value as their most important daily supplement (vitamin, mineral, hormone, etc). For your choice, why?

Hi,

• Collagen powder (hydrolyzed peptides) or bone froth for glycine.
  We no longer eat meat offal. Too much red meat brings a unbalance between excitatory amino acids (methionine, leucine) and amino acids that dampen / calm down (glycine)
• Vitamin E (20-25 mg), combined with K2 (not at the same time).
  To protect arteries from oxidation (20.25 UI mixed toco), against Corona SARS-CoV-2 (75 mg alpha tocopherol) (90 % virus load reduced).
  Note: two forms toco are required if prolonged use.
  I can give a link to explain how membranes should be protected from oxidation if interested and how liposoluble vitamins must be taken:
  Vitamin A, D, E & K - How Much and What Type of Fat Do You Need to Absorb These Fat Soluble Vitamins?

@Peatslop-enjoyer said in What Vitamin B cofactors should I supplement?:

Could you provide the link? Thank you.

Vitamin B6: How much is too much? Which kind, with staples.
https://mirzoune-ciboulette.forumactif.org/t2033-english-corner-vit-b6-how-much-is-too-much#29628
Excerpt:
The English Corner – Vit B6: How much is too much?
Main ideas

• Too much of a good thing is bad. Especially bad for neuro-sensitive people.
• Vitamin B6 is well documented for its role as a modulator of steroid hormones.
• No problem with food intake if not supplemented.
• Maximum RDA target is 25 mg B6.
• There are 6 vitamers and a way-out form through the urine.
• If we want a pharmacological effect, we have to take into account the form of the vitamers.
• The active form is B6 PLP.
• Look at the 6 vitamers form before continuing (figure):
  3 basic forms of vitamers B6:

•    PN= pyridoxine
  

•    PL = pyridoxal
  

•    PM = pyridoxamine
  

And their derivative, coupled with a phosphate molecule:

•    PNP = pyridoxine 5’-phosphate
  

•    PLP = Pyridoxal 5’-Phosphate (active form)
  

•    PMP = Pyridoxamine 5’-Phosphate
  

And the form used as a catabolite (excreted in the urine)

•    PA = 4-Pyridoxic acid.
  

• A tight regulation of the PLP concentration is necessary in the cell: The aldehydes are toxic. A self -regulation and a protective mechanism coexist. But there is a radical side effect: PLP will no longer passes the encephalic barrier. A withdrawal effect will soon take place, with an impact on neurotransmitters.

• PMP is a safer form: PMP is slightly increased in plasma, and rapidly converted into PLP and PL when needed.

• An excess of pyridoxine (PN) is deleterious. No pyridoxine supplement advised: PN has an inhibition effect on PLP, the active form.

• PL could be converted to PN by a PL reductase (side effects when too high supplementation).

• PM could be more suitable for supplementation because of the very low formation of PN by PM.

• If we suffer from a lack of enzymes, we must pay attention to the conversion pathway: PLP as a coenzyme factor has a pivotal role in catalysis of various enzymatic reactions.

• See the roles of PNP-dependent enzymes, namely kinase and oxidase (+ phosphatase).
  To be continued on the link. See above (my forum: Mirzoune et Ciboulette).

• A tight regulation of the PLP concentration is necessary in the cell: The aldehydes are toxic.
  We must not go beyond the absorption capacity of the body. We are not all equal. If you suffer from inflammation, if you need more antioxidants, you will probably burn more B6. What should be avoided is to approach the limit / the level of an overburdened of metabolism. A limit that will be different, depending on the individual.
  Why does an excess of B6 or an inadequate enzymatic metabolism cause a problem of neuro-sensitivity? An excess of Pyridoxal (PLP) will lead to the inhibition of the enzyme PLK (Pyridoxal Kinase). PLK is set out of function via the “Salvage pathway” process. Details on the link, with references.
  Useful link
  *) English corner: B6 leads to decrease of cytokines in neuropathy
  https://mirzoune-ciboulette.forumactif.org/t2041-english-corner-b6-leads-to-decrease-of-cytokines-in-neuropathy#29659
  Efficacy of Vitamin B1, B6, and B12 in Peripheral Neuropathy
  *) Useful nutrients in case of neuropathy
  https://mirzoune-ciboulette.forumactif.org/t2031-haute-dose-de-b6-p5p-contre-algodystrophie-et-scc#29618
  Mg bisglycinate, Zinc, Vit B6 PLP 20-25 mg, Vit C 500 mg, Vit D 5 000 UI (with K2).
  *) English Corner: Anti-Stress & Neuro-Protective Effects of Thiamine (B1)
  https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1

• See part 2 (in the same post): How much and which kind of thiamine?
  Excerpt from video of Dr. Allil OVERTON.
  => Practical example for beginner (patient N° 1): Basic protocol for thiamin insufficiency.
  https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1#29716
  With references.

Hi
I like the style but would it be possible to add one function when posting:

I’d like to be able to underline the main sentences.

H2 is for color (x2 size).
Thick dark black color is fine for one group words but is too aggressive when not necessary / required.
Explanation:
I use the underlined style when I want other readers to spare time. If not interested by the whole subject I posted, when the answer is a bit too long for most readers. I highlight in this way, less aggressive than thick dark black color.

@wester130 said in Thyroid Therapy for Chronic Digestive Issues:

I am not sure why thyroid hormone would magically solve digestion

Not magically but indirectly.
If nutrients are required for digestive enzymes (poor and long-lasting digestion), leaving metabolic enzymes not sufficient, from one hand, and if you suffer from low-grade inflammation, on the other hand (arthrosis or gluten 3 times a day which has an impact on zonulin and the tight junctions of the intestines) you can’t optimize the communication from the HPA axis and the central operator for energy (thyroid).
B6 is stolen with low-grade inflammation. B1 is stolen with rice and bread. Not enough. Energy metabolism requires appropriate levels of several B-vitamins. Not only.
So poor digestion impacts the energy level, directly and indirectly. Stress level too.
I can give a link for B1 and B6, in connection with the brain, if desired.
Expressed differently: Interconnection between the brain and the stomach, through steroid hormones.
Not directly but indirectly.

Additional info for the other readers:
Test for steroid hormone :

• adrenal: HPA axis + rt3 FT3 FT4
• sex hormones: testosterone, estrogen, cortisol
  Why is cortisol needed for other hormones to work properly? For some effects (e.g. libido, energy levels, thermoregulation) adequate levels of not just one but multiple or even all of the major hormones are needed.

Cortisol and thyroid hormones determine our energy levels

How much “energy” a person has, is to a large extent determined by someone’s levels of thyroid and adrenal hormones. Whereas thyroid hormones set the “idle” state for our system (i.e. the state of how much “background”-energy someone has), levels of cortisol are the “gas pedal” (i.e. they are one of the most important factors that determine moment-to-moment energy levels and wakefulness).
However, in order for thyroid hormones to exert their effects properly, adequate levels of cortisol are needed — and vice versa. Therefore, both hormones are needed in adequate levels for each other to work as they should and whenever one of these hormones is low, energy levels will be as well. In fact, replacement of thyroid hormones and/or adrenal hormones are often enough to “give people their life back”.
PS: And I haven't yet talked about the microbiota
70 % of our immune system.

@onliest said in Thyroid Therapy for Chronic Digestive Issues:

I've gone high thiamine HCL and subutiamine too with little effects. I want to try one of the other forms.

You won't reach passive absorption with High dose thiamine HCL. a combo between HCL and PLP, progressively and with staples are needed.
See Allil overtone for more information or I can give a link (with my summary) if someone finds it easier to understand / or have no time / no energy enough to spend
How to Apply High-Dose Thiamine Protocols in Clinical Practice: Part 2
Practical Guidance
https://www.youtube.com/watch?v=RFZUzS_xP9A
EONutrition – Elliot OVERTON (nutritionist) (Video multiplex)