Posts made by Mauritio

@DavidPS yeah that is the most convincing study i've seen so far the dosage also wasn't excessively high

@alfredoolivas yes. I'm just not sure about potential estrogenic or anti DHT effects. But I haven't seen anything conving, that would stop me from consuming it infrequently .

@alfredoolivas yeah very interesting!
Look at the progesterone like effect of the studies I just edited in.
If they are indeed saturated molecules that makes an estrogenic effect even less likely .

Btw trump just brought back menthol cigarettes , so that's good timing

"PO [Peppermint oil ]significantly promoted bile and bile acid secretion in rats. It also increased bile acid efflux and decreased cholesterol levels (P < 0.01) in bile. In HepG2 cells the mRNA levels of CYP7A1 and FXR were significantly upregulated after treatment with PO."
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1751-2980.2011.00513.x?utm_source=chatgpt.com

Menthol + Menthone seem to have a dopaminergic effect
https://pubmed.ncbi.nlm.nih.gov/18718482-/
https://pubmed.ncbi.nlm.nih.gov/12686756/

Menthol has some overlapping effects with progesterone as per this study
https://pubmed.ncbi.nlm.nih.gov/13819868/
It also acts as an anaesthetic like progesterone
https://pubmed.ncbi.nlm.nih.gov/11301871/

Mode of action of peppermint oil and (-)-menthol with respect to 5-HT3 receptor
https://pubmed.ncbi.nlm.nih.gov/21077259/

"...menthol acts as a noncompetitive antagonist of the 5-HT3 receptor..."
https://pubmed.ncbi.nlm.nih.gov/23965380/

Menthol decreased milk production ,which hints at an anti prolactin effect and it inhibits mTOR.
https://pubmed.ncbi.nlm.nih.gov/33188562/

Anti-leukemic effect of menthol, a peppermint compound, on induction of apoptosis and autophagy
https://pubmed.ncbi.nlm.nih.gov/36923503/

I'd say given these studies, it's worth to try peppermint oil, which can consist of up to 80% menthol + Menthone.

@Mauritio said in Random, interesting studies:

@Mauritio said in Random, interesting studies:

3,8-Dihydrodiligustilide
Strong phytoprogestogen.
https://en.m.wikipedia.org/wiki/3,8-Dihydrodiligustilide

It has almost the same potency as progesterone (80% of it). And it has no estrogenic or anti-androgenic effects.

"EtOH extracts of the dried rhizome of L. chuanxiong demonstrated strongest
progestogenic activity, reaching 80% of that observed with progesterone (100 nM) and had an EC50 of 8 lg/ml (Fig. 1b). The bioactivity of L. chuanxiong extract was spe-
cific to the PR, and the extract was at least 200-fold less active on other related members of the steroid receptor family like androgen, estrogen and glucocorticoid receptors."

https://www.sci-hub.wf/10.1016/j.phytochem.2006.01.024

The plant Ligusticum sinense chuanxiong from which it is extracted is traditionally used to treat uterus issues. It also has been studied to treat strokes and Parkinson's.

In this review they look at the anti inflammatory effect of it.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7591981/

HED about 20g of the extract.
"Effect-time studies indicate that injection of MPA and L. chuanxiong extract raised area-under-curve of progestogenic activity in sera by 8.2-fold (p<0.001) and 4.5-fold (p<0.01) respectively, compared to sera from rats administered vehicle only. Administration of MPA and L. chuanxiong extract by the oral route resulted in a 5.4 (p<0.001) and 2.3-fold (p=0.07) increase respectively. Our data suggest that PR-responsive reporter gene bioassays can measure bioavailability of compounds, known and unknown, of complex botanicals for hormone replacement therapy. L. chuanxiong extracts exert progestogenic activity in vivo, and may have utility for progesterone-replacement therapy."

https://pubmed.ncbi.nlm.nih.gov/16650443/

good review on it
https://www.tandfonline.com/doi/full/10.3109/13880209.2011.576346#d1e665

HED = 850mg of the extract.
L. Chuanxiong completely prevented weight gain on a high fat diet. It increases antioxidants and cholesterol conversion into bile acids. Genes related to steroid biosynthesis were also upregulated so I guess that was another way it lowered cholesterol.
https://iadns.onlinelibrary.wiley.com/doi/full/10.1002/fft2.249

Protective Effect of SFE-CO2 of Ligusticum chuanxiong Hort Against d-Galactose-Induced Injury in the Mouse Liver and Kidney
https://pubmed.ncbi.nlm.nih.gov/28056664/

Chuanxiong Rhizoma extracts prevent cholestatic liver injury by targeting H3K9ac-mediated
https://pubmed.ncbi.nlm.nih.gov/37777319/

Chuanxiong Rhizoma extracts prevent liver fibrosis via targeting CTCF-c-MYC-H19 pathway
https://pubmed.ncbi.nlm.nih.gov/38375042/

@tubert said in Olive leaf extract increases T3 + T4, lowers TSH:

@Mauritio how many mg a day are we talking about here to have those androgenic effects?

That was a high dose. 3-6g HED of the leave extract. It was in diabetic rats so its hard to convert to humans, probably best just to try it out.

Anti viral effects of olive leaf extract:

https://pubmed.ncbi.nlm.nih.gov/34839747/
https://pubmed.ncbi.nlm.nih.gov/38662719/
https://pubmed.ncbi.nlm.nih.gov/33541815/
https://pubmed.ncbi.nlm.nih.gov/15869811/
https://pubmed.ncbi.nlm.nih.gov/35496299/

@cs3000 Interesting. Peat right again I guess.
Unfortunately the other high dose study is circulating on X and people use it as an excuse to drink several cocktails a day and feel " fine".

Las time I took it it gave me bile flow issues , subjectively it was something which felt like choelstasis.

@Mauritio said in Random, interesting studies:

3,8-Dihydrodiligustilide
Strong phytoprogestogen.
https://en.m.wikipedia.org/wiki/3,8-Dihydrodiligustilide

It has almost the same potency as progesterone (80% of it). And it has no estrogenic or anti-androgenic effects.

"EtOH extracts of the dried rhizome of L. chuanxiong demonstrated strongest
progestogenic activity, reaching 80% of that observed with progesterone (100 nM) and had an EC50 of 8 lg/ml (Fig. 1b). The bioactivity of L. chuanxiong extract was spe-
cific to the PR, and the extract was at least 200-fold less active on other related members of the steroid receptor family like androgen, estrogen and glucocorticoid receptors."

https://www.sci-hub.wf/10.1016/j.phytochem.2006.01.024

The plant Ligusticum sinense chuanxiong from which it is extracted is traditionally used to treat uterus issues. It also has been studied to treat strokes and Parkinson's.

In this review they look at the anti inflammatory effect of it.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7591981/

Dates, olives and walnuts contain the highest amounts of the phytoprogestogen syringic acid.

http://phenol-explorer.eu/contents/polyphenol/420

https://pubmed.ncbi.nlm.nih.gov/9704030/

EDIT: Bloodroot might bin very well to the progesterone receptor but not agonize it.

https://journals.sagepub.com/doi/abs/10.3181/00379727-217-44247

3,8-Dihydrodiligustilide
Strong phytoprogestogen.
https://en.m.wikipedia.org/wiki/3,8-Dihydrodiligustilide

It has almost the same potency as progesterone (80% of it). And it has no estrogenic or anti-androgenic effects.

"EtOH extracts of the dried rhizome of L. chuanxiong demonstrated strongest
progestogenic activity, reaching 80% of that observed with progesterone (100 nM) and had an EC50 of 8 lg/ml (Fig. 1b). The bioactivity of L. chuanxiong extract was spe-
cific to the PR, and the extract was at least 200-fold less active on other related members of the steroid receptor family like androgen, estrogen and glucocorticoid receptors."

https://www.sci-hub.wf/10.1016/j.phytochem.2006.01.024

@TemetNosce how did you even get that stuff ?

@cs3000 yes me too.

I saw that too. Interesting.

Anecdotally i can say even small amount of alcohol seems to be very helpful when I have an incoming cold.

@cs3000 I saw one study with seven point five percent of ethanol, that did have negative outcomes.

So back to one tsp a day it is. I think a higher amount might be beneficial if it was spread out over the day as in the mice/ rats studies. That way you might get the continous anti­oxidant benefits. Maybe a few tsp's in your water bottle and then sip throughout the day.

Im a physical therapist and Ive never heard anybody having a cast for 6 months for a small fracture . That sounds ridiculous.
6 weeks maybe . I would need more info on the injury and operation to make a clearer statement .

Often the issues we face in rehab are more due to the long time of immobilization than the actual injury . Sometimes other healthy joints are immobilized for no reason whatsoever . Sometimes the damage is permanent.

I would make sure that the range of motion of the finger is stilk there and work on keeping it that way. If you don't move your finger for 6 months, it will stay that way.

@cs3000 interesting but what about the antioxidant effect and the increase in CO2？don't you think that in humans smaller those would have the same Effect. and by smaller those i mean more than a Tablespoon.

@Serotoninskeptic And muscle building isn't everything, maybe one can build a little more muscle on a way higher P-diet, but at what cost?

@Serotoninskeptic yes! He never gave out a recommendation to eat just 50g of protein. It's context specific.
For someone like you it might indeed be necessary to get more than 70g of protein.
I intuitively eat 60-80g if I don't restrict myself.
But I feel like the "threshold" is lower for me. I only feel the switch when I'm around 40-50g per day.

Update:
Mostly inspired by this thread I have bought an E-Ink tablet . The Boox note air 4c.

I had to become a mini expert on e inks but I think I made the right decision.

I've been using it for over a month and I like it so far. It's less taxing on the eyes.
And most importantly it doesn't feel weirdly stimulating, ADHD-inducing like LCD displays. It doesn't stress me as much.

There is still a little EMF:
On the front the values go up to 0.5uT averaging 0.1-0.3 uT. You can compare these values to other ones given in this thread.
On the back there is close to zero or zero measurable EMF, so if you touch it on the back you can reduce EMF exposure.

I can't use if for working I think it's too small for that. Typing also takes longer. So I'm using mostly the stylus to literally write what I want to post, which is fine. I'm also using text to speech which works surprisingly well. Still if I need to be quick, I don't use my E-Ink I go for my laptop or phone. If I only read, research do little typing it's a very good device.

Watching videos on it works as well and also feels less stimulating than on other devices.