Posts made by Mauritio

Update:
Mostly inspired by this thread I have bought an E-Ink tablet . The Boox note air 4c.

I had to become a mini expert on e inks but I think I made the right decision.

I've even using it for over a month and I like it so far. It's less taxing on the eyes.
And most importantly it doesn't feel weirdly stimulating, ADHD-inducing like LCD displays. It doesn't stress me as much.

There is still a little EMF:
On the front the values go up to 0.5uT averaging 0.1-0.3 uT.
On the back there is close to zero or zero measurable EMF, so if you touch it on the back you can reduce EMF exposure.

I can't use if for working I think it's too small for that. Typing also takes longer. So I'm using mostly the stylus to literally write what I want to post, which is fine. I'm also using text to speech which works surprisingly well. Still if I need to be quick, I don't use my E-Ink I go for my laptop or phone. If I only read, research do little typing it's a very good device.

Watching videos on it works as well and also feels less stimulating than on other devices.

Magnesium Sulphate for "stuck bile" I cholestasis

"Taken together, the results of this study suggest that MgSO4 treatment may be beneficial in cholestasis-induced hepatotoxicity."
https://pubmed.ncbi.nlm.nih.gov/25967882/

"Mg SO4 may increase bile secretion and relax the sphincter Of Oddi, resulting in emptying and consequently a reduction of Gallbladder volume"
https://journals.lww.com/ajg/fulltext/2004/10001/the_effect_of_magnesium_sulfate_on_the_human.140.aspx

It increases the discharge of bile
https://pubmed.ncbi.nlm.nih.gov/955499/

i was thinking maybe topical application of magnesium sulfate to relax the sphincter of oddi muscle and to increase bile discharge.

That's what I ve been suspecting. There is a threshold for the benefits. There is a subjective switch that I feel when Im on MR.
This implies that until the threshold there is no harm and after the threshold the harm increases disproportionetly from consuming excess methionine. That is the problem with the intermittent approach @Serotoninskeptic . I think it is a good idea to limit protein to one meal mostly, but overall protein intake shouldnt exceed 40-70g for most people. Thats at least my current opinion.

This is from Peats last Newsletter. His last gift to us.

"There is a threshold effect in exposure to
the harmful amino acids, and this involves a
very sensitive system for detecting their concentration, apparently involving the actin filament network throughout the body. Above
the threshold concentration, methionine
activates mTOR. Increased mTOR shortens
life-span and increases the processes of aging.
Increased fat in the diet increases mTOR,
adding to the effects of amino acids. "

"The way these regulators of energy and
aging interact is holistic, and it’s necessary to
understand that organisms make generaliza￾tions about their problems. Things that inhibit
mTOR will increase adaptation and organiza￾tion with expansion of the time horizon, while
things that activate it (methionine, estrogen,
radiation) will accelerate cell growth and
inflammation and activate terminal processes.
Progesterone and estrogen relate to the degree
of mTOR activity through the body as a
whole, not just through a series of receptor
intermediates."

@Mauritio said in God is the fire that does not consume you:

This is where Peat's research comes in, disproving the rate-of-living theory. The thyroid hormone produces uncoupling proteins that separate energy production from heat production, consuming harmful free radicals and old cells in the process. Overexpressing uncoupling proteins has been shown to treat chronic diseases and increase life span in animals.
So you're physically increa­sing the heat/fire and it makes you healthier. Not only that: it also consumes the parts of you that are bad or unhealthy.

Coincidently I just realized that Ray's last Newsletter was on that topic . May he rest in peace.

"The rate of living theory was gradually
being proven wrong in a variety of ways, as
animals with a higher metabolic rate turned
out to generally live longer than those with a
lower metabolic rate,..."

"The highly “wasteful” inefficient energy metabolism of
“uncoupled” mitochondria improves adaptabil￾ity to the environments, and extends longevity."

...and then can you add to that that alcohol might even be healthy in the right amount .
Check this out:
https://x.com/Metabolicmonstr/status/1876650999894434171

@Mossy I stopped using them topcically, because it was such a mess to apply. But looking backon it that was because of the apple juice i diluted it in.
So maybe I'll give the polyphenols another run mixed with niacinamide and glucose and water.

"OLE significantly induced testicular steroidogenesis in diabetic rat as evidenced by elevated P450 scc and 17β-HSD mRNA expression"
https://pmc.ncbi.nlm.nih.gov/articles/PMC6438850/

P450scc increases Pregnenolone
https://en.m.wikipedia.org/wiki/Cholesterol_side-chain_cleavage_enzyme

It increases mating success /fertility by 50% in diabetic rats in the above study.

@wester130 glucose + niacinamide + apple polyphenols

@cs3000 that's interesting. I might try ergo again, it start eating mushrooms again!

It's a no brainer if you look at the data...

@Serotoninskeptic
Wow, that is so interesting!

Looking at the macros, they ate a very, very good diet.

In the methionine thread I've written about high carb, low protein, low fat probably being the ideal diet (but restriction 2 macros is hard) and that is pretty much what the Okinawans ate !
That also gives credit to the low protein idea being sustainable long term. Around 10% protein is what they use in a lot of studies, so that seems to be a good goal.

"Key nutritional biomarkers for longevity among Okinawans include lower levels of homocysteine and higher levels of antioxidant vitamins, ..."
https://en.m.wikipedia.org/wiki/Okinawa_Centenarian_Study
--> both could result from a low protein diet

Iirc they also have/ had higher androgens and androgenic Features than other Japanese ethnicities.

This study shows Okinawan men have higher testosterone but also higher estrogen than American men.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8496353/

@dapose you're welcome.

Chlorogenic Acid Inhibits Lipid Deposition by Regulating the Enterohepatic FXR-FGF15 Pathway
https://pubmed.ncbi.nlm.nih.gov/35257010/

Chlorogenic acid fed mice increase less in weight than controls mice on a high fat diet. AND weigh less than animals on a normal control diet.
https://pubmed.ncbi.nlm.nih.gov/20064576/

Might inhibit Mao a+b
https://pubmed.ncbi.nlm.nih.gov/29893510/

@bio3nergetic said in Apigenin:

It really isn't even a matter of "black or white," but the lack of distinction. It is meaningless to throw around NOS without knowing what type in what context. Apigenin can increase eNOS and improve circulation. In a inflammatory context, it can inhibit iNOS, which is what we need to keep in check ultimately.

Yes, well said. It's the bigger picture that matters.

@LucH said in Apigenin:

@Mauritio said in Apigenin:

apigenin

Api activates BKCa and SKCa, leading to cell hyperpolarization that is followed by an influx of extracellular Ca2+; together with the release of Ca2+ from the ER, this rise in [Ca2+]i directly activates NOS; and the increased NO synthesis is then responsible for the inhibition of angiogenic endothelial cell functions by blocking Akt phosphorylation.
https://doi.org/10.1111/j.1538-7836.2007.02615.x

Nitric Oxide Induces Metabolic Shift from Glycolysis
"Nitric oxide, even in the presence of oxygen, causes a metabolic shift to glycolysis, wastefully producing lactate from glucose" RP

You're over focusing on one point from an in-vitro study, when in fact apigerin has been shown to do the opposite of what you suspect (inducing glycolisis).

Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging
https://pubmed.ncbi.nlm.nih.gov/34114892/

Apigenin Prevents Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway

https://pmc.ncbi.nlm.nih.gov/articles/PMC7212374/

Dates (polyphenols) activate FXR and modulate bile acids.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5749773/

It protects against cholestasis.
MoA: FXR modulation, TLR-4 inhibition,anti-oxidant

https://pubmed.ncbi.nlm.nih.gov/33620063/

Another study which also shows anti-fibrotic, anti cholestatic effects
https://pmc.ncbi.nlm.nih.gov/articles/PMC10967634/

High salt diet induces muscle loss via cortisol, if simultaneously given saline Solution, not if rats were given tap water.Maybe there's a Sweet Spot for Salt.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5409074/

@Serotoninskeptic thanks! That's basically what I've been doing for a while now. I posted a study showing benefts of MR after Just 6h! So if you only eat signifi­cant amounts of protein in the evening you have an18h window of "benefits". Intermittent protein fasting.

I feel bad for the normal person they've just adapted to high protein being healthy and now this...