Posts made by Mulloch94

@sharko said in Raypeatforum.com is down:

I can't live without it. (Mainly the old information that is there, the new information has already lost direction)

I am now collecting every possible Ray Peat information from the web and keeping a backup on my computer in case it is external factors. For some reason they also removed the entire backup of the forum from the Internet Archive. It is stressful.

I even started transcribing all his interviews from YouTube and everywhere.

This has already been accomplished. Someone else posted the link already...the "peatarchive." I think internet archive respects copyright law. But some of the other archive sites don't, lol. It's a dumbass law anyways, Charlie better recognize he's not in control of the information on that forum. We have it all already.

@Hando-Jin said in New "Mission" of RPF:

@Verdad said in New "Mission" of RPF:

No one has any idea why the ray peat forum is down i guess?

my voodoo doll must be working

lol, I don't know why but I can unironically believe someone has attempted this before . It's what happens when you piss off enough people across multiple different cultures. Hell there was people on that forum all the way in Russia!

There's definitely something wrong with the forum. Which is why I never purchased a subscription. Dude could cut and run any time. You buy subs from people that are reliable....Charlie is everything opposite of reliable.

But I guess we shouldn't assume things. For all we know he's doing server maintenance. Shouldn't take long though, and usually you don't have to pull the entire site offline for that, it's just a little slow and laggy.

Was anybody on the site right before it went dark? I wonder if it was getting DDoSed or something, and he freaked the fuck out and pulled it offline, lol. One can only hope, lol. But he has pissed off a lot of people, what are the odds one of the people he did dirty was a hacker.

I've always found my diet to be financially reasonable. The trick is not worrying about organic stuff. It's a scam. Unless you're buying from a local market just get conventional.

You should be more concerned with ingredients in your products anyways, not so much the labeling on stuff. For example, Daisy brand (conventional) cottage cheese is the only acceptable product I've seen. Organic Valley's (organic) cottage cheese has gums in it.

Just because something is organic doesn't mean it's better, it could in fact be worse. So just avoiding organic produce will be a big saver on your grocery bills.

Another thing you can do is bulk buy some items. It'll cost more upfront, but if you can spare it, you will be saving money in the long run.

@evan-hinkle said in Doxycycline has antidepressant effects by lowering nitric oxide in mice:

@Mulloch94 thanks for posting this. I’m curious as to whether or not the benefit came from blocking or eliminating the endotoxin the mice were injected with, or if doxy itself lowered the iNOS that was upregulated due to the endotoxin?

Haidut had an old post talking about endotoxin being a typical cause of back pain. I’ve had unexplained back pain for a few years now that hits every morning but goes away as the day progresses. I assume it’s endotoxin related as I’ve had endotoxin issues in the past. I have used doxy, but never at the dose suggested here, (HED would be about 4mg/kg I believe). May give this a shot.

Thanks!

No problem! I'm sure there's some synergy between lowering the endotoxin and blocking nitric oxide. But if I had to guess, at least according to this study, the main mechanism is behind the nitric oxide suppressing effects. Because when they administered sodium nitroprusside the antidepressant action of doxy was inhibited.

@basebolt said in High salt intake:

Salt is significantly improving my quality of life. Every hour I take about a gram and a half. No negative effect on BP. The chloride can have an acidifying effect on the body so to bring more balance I sometimes take baking soda instead.

I'm two weeks into this.

Salt, whether it be sodium chloride or sodium bicarbonate, is the number one mineral for suppressing the sympathetic nervous system. Too much sympathetic activity can ruin just about every aspect about one's life. Emotionally, intellectually, physically, etc. Shooting for around 9-10 grams of salt a day, or roughly 3,500-4,000 milligrams of sodium a day is good. Of course there some people who eat more than this, even upwards of 17 grams of salt daily, like the Chinese. But generally speaking, if you find yourself needing extra salt all the time you're likely hypothyroid.

https://www.sciencedirect.com/science/article/abs/pii/S0166432823004825

"Doxycycline is an antibiotic that has shown neuroprotective, anti-inflammatory, and antidepressant-like effects. Low doses of doxycycline revert the behavioral and neuroinflammatory responses induced by lipopolysaccharide treatment in a mice model of depression. However, the molecular mechanisms involved in the antidepressant action of doxycycline are not yet understood. Doxycycline inhibits the synthesis of nitric oxide (NO), which increases after stress exposure. Inducible NO synthase (iNOS) inhibition also causes antidepressant-like effects in animal models sensitive to antidepressant-like effects such as the forced swimming test (FST). However, no direct study has yet investigated if the antidepressant-like effects of doxycycline could involve changes in NO-mediated neurotransmission. Therefore, this study aimed at investigating: i) the behavioral effects induced by doxycycline alone or in association with ineffective doses of a NO donor (sodium nitroprusside, SNP) or an iNOS inhibitor (1400 W) in mice subjected to the FST; and ii) doxycycline effects in NO metabolite levels in the prefrontal cortex and hippocampus these animals. Male mice (8 weeks) received i.p. injection of saline or doxycycline (10, 30, and 50 mg/kg), alone or combined with SNP (0.1, 0.5, and 1 mg/kg) or 1400 W (1, 3, and 10 µg/kg), and 30 min later were submitted to the FST. Animals were sacrificed immediately after, and NO metabolites nitrate/nitrite (NOx) were measured in the prefrontal cortex and hippocampus. Doxycycline (50 mg/kg) reduced both the immobility time in the FST and NOx levels in the prefrontal cortex of mice compared to the saline group. The antidepressant-like effect of doxycycline in the FST was prevented by SNP (1 mg/kg) pretreatment. Additionally, sub-effective doses of doxycycline (30 mg/kg) associated with 1400 W (1 µg/kg) induced an antidepressant-like effect in the FST. Altogether, our data suggest that the reducing NO levels in the prefrontal cortex through inhibition of iNOS could be related to acute doxycycline treatment resulting in rapid antidepressant-like effects in mice."

@yerrag Yeah that's a pretty serious BP at 240/160. Definitely not the "slightly elevated" adaptive BP of old age. Are you sure you've eliminated any possible hypothyroidism? Checking the QT interval is very hit and miss, simply because there's so many things that can distort that (not just hypothyroidism). And the symptom itself may not show in everyone who is hypothyroid. What about your blood lactate levels? Which will indicate a metabolic dysfunction if elevated. In my experience hypothyroidism, or TSH (more specifically TRH), is a big cause of hypertension. My BP wasn't the greatest until I got on thyroid replacement. TRH can act a lot like adrenaline, pushing the heart rate up while inducing vasoconstriction. Of course all sort of downstream abnormalities will manifest themselves, like altered calcium metabolism. And why magnesium might help this (albeit only acutely until thyroid is corrected).

Doesn't look too bad. Oregano isn't something people take regularly, so I assume you're taking it for an infection of some sort? I see nothing wrong with that product if it's being used on a limited basis.

Everyday is a little different. I'm sure the amounts of PUFA in that is microscopic by comparison to what you find even in "low-PUFA" foods.

But cutting back wherever is ideal. For future reference, I find Barlowe and Hawaii Pharm to have the most pure botanicals on the market. I don't know if either has oregano, but their the vendors I'd check first just due to their clean product standards.

Probably just a rise in metabolism. Same thing can happen when taking thyroid, however you eventually adjust to the effects of thyroid. Not sure about "high-dose" thiamine. Thiamine as opposed to thyroid will carry the additional risk of lower potassium levels.

In regards to the adrenaline issue just eat more carbs and salt. If that doesn't cut it you could try also adding taurine, niacinamide, inosine, or progesterone. Basically anything that will blunt adrenaline until your metabolic "set-points" adjust to the new normal.

You might would be interested in following this thread as well. If you restrict your protein intake your gelatin requirement won't be all that high.

Probably about 1/3rd of your protein should come from gelatinous sources. I don't really know how much this would translate over into pure gelatin packets. I get most of my glycine from oxtail or hamburger, or pressure cooking chicken carcasses. I usually have oxtail daily in my fridge to heat up for dinner, and if I don't I just turn to hamburger, or drink chicken broth with dinner. I don't feel the need to track my glycine intake because I just intuitively know I'm getting enough. I basically never eat muscle meats anymore, bidenomics has made it too expensive

In terms of pure gelatin, it seems like the 3-6 tbsp recommendations is probably pretty accurate. Unless you're just eating a ton of protein daily. Or milk. For peaters the milk is probably the biggest source of tryptophan. The calcium does help some, Ray mentioned it helps convert the tryptophan to niacin.

Inosine - I've used this product before. It's the only inosine product I've found that either wasn't encapsulated already or didn't have junk in it. Not cheap, but considering insoine isn't something you'd take long-term everyday it should last a while.

@CO3 We come from different roots I suppose. Nevertheless, I feel I should state while some may put aesthetics over health, and therefore take a turn to the "dark side" (i.e gear use, "death wish," what have you), to just generalize and say all bodybuilders have a death wish is preposterous. Have greater lean mass is correlated to overall longer life. Lifting heavy weights is generally the best exercise one can do...if they're going to exercise. Long slow walks are good, but I'm not sure I'd classify that as exercise per se. Marathon runners, different story. Most of them age worse than cigarette smokers. I digress, but you get my point.

@CO3 Eating it as a "vegetable" means I eat it for it's micronutrients, fiber, good Ca/P ratio, and, in general, as good filler food. Most vegetables, or fruits eaten like vegetables (i.e squash), are superior to grains, bread, and legumes for these reasons. If I have a choice to eat meat with bread, or meat with zucchini, I'd choose the latter and just add a mexicoke or something for my carbohydrate.

Contrarily I used "fuel source" as slang for anything (vegetable or fruit) that provides substantial net carbs (non-fiber carbs). Starchy tubers, winter squash, and most fruits come to mind.

You must not have a lot of experience talking to bodybuilders, me asking how much food you eat is softcore compared to what those dudes would ask you. Regardless, you clearly got anger issues over nothing. Take a aspirin or something, chill the fuck out.

https://www.nature.com/articles/s41416-023-02506-5

A couple sections of this I found particularly interesting, after correcting for publication bias, the benefits of aspirin were still "significant." Also despite the lack of randomized trials, the few early reports also suggest a 9% reduction in cancer related deaths. And finally, gastrointestinal bleeding has been, by far and large, fearmongering.

"Publication bias, arising from the selective publication of positive findings for an intervention such as aspirin, is a most important issue in meta-analyses such as the above. A ‘trim and fill’ testing procedure to restore symmetry in forest plots was therefore applied extensively to the data, and although the benefits of aspirin were reduced, significance of almost all the reductions remained.

In their report the authors identified 23 publications which had focused upon fifteen less studied cancers (naso- and oropharyngeal, oesophagus, gastrointestinal, gastric, rectal, liver, gallbladder, bladder, pancreas, bladder, endometrium, ovary, glioma, head and neck, lung, melanoma). Meta-analysis of these gave pooled reductions of around 30% in deaths associated with aspirin taking (HR 0.67; 0.60, 0.75 in 21 studies, and OR 0.47; 0.26, 0.83 in five studies) [30]. Together with the evidence of favourable effects of aspirin upon a wide range of biological mechanisms relevant to cancer mortality [3], these clinical outcomes suggest that aspirin is likely to be of benefit to patients within a very wide range of different cancers...

...The pooled results of four early trials based upon a total of 722 patients with cancer gave a suggestive pooled reduction associated with aspirin of about 9% in cancer deaths. Currently, a number of randomised trials which test aspirin and mortality are in progress. These focus upon the common cancers: colon, breast, prostate and one in lung cancer."

"In a systematic literature search eleven randomised trials which included data on fatal bleeding were identified . These 11 RCTs included together a total of 121,094 subjects, followed for an average of 2.8 years...

...These data confirm the usual excess risk of all ‘major’ bleeds for aspirin (RR 1.55), equivalent to about one per bleed per 1000 persons per year. Note however that the 50% increase above the background risk of bleeding from a peptic ulcer, stomach infection or other pathology, means that amongst patients who are taking aspirin the risk of a GI bleed being truly attributable to aspirin is only one in every three bleeds.

However, the proportion of ‘major’ bleeds in subjects who had been randomised to aspirin that led to death was 4% in those who had been randomised to aspirin while 8% of bleeds in subjects randomised to placebo were fatal. Clearly, this implies that overall, the bleeds truly attributable to aspirin must be of a much lower severity than other bleeds attributable to stomach pathology. This is further confirmed by the absence of any increased risk of a fatal bleed associated with aspirin taking, as shown in the third cell in the above table (RR 0.77), and this final conclusion has been confirmed in overviews of bleeding reported by other authors.

It is unfortunate however that the scientific literature on the issue of aspirin and bleeding appears to have been swamped by a host of statements about serious dangers of aspirin, most unsupported by any evidence while some are total misinterpretations. Probably the most misleading and most influential item on the web was a report issued by Reuters on the 14th June 2017, stating: ‘daily aspirin causes 3000 deaths from bleeding in Britain every year’. This claim was taken up and very widely and repeatedly publicised in the web and the media across the world. The report by Reuters was however a totally invalid, having been based on a prospective study of 3166 older patients, all of whom (93–97%) were taking aspirin. There were therefore no control subjects and no valid estimate of the independent contribution of aspirin to the fatal bleeds can be made."

Also, I can't really leave without posting this things of beauty. Straight from the belly of the beast itself, the oldie but goldie, the good old Harvard finding that pissed everyone off.

It appears that, like all too often, Ray was right again. Aspirin appears to be a useful addition for cancer patients.

@yerrag How high of a BP are we talking about? I remember Ray saying high blood pressure as we age is an adaptive protective mechanism. Although I assume this has limits. I guess it would greatly depend on your age as well.

Have you tried ACE inhibitors instead of CCBs? The swelling sounds more like a RAAS aldosterone issue to me. Most ACE inhibitors are a little "softer" on the side-effect spectrum as well. A high-potassium diet can also help flush excessive fluids out. I say "high," but in reality just shooting for the RDA of 4 grams will likely be a big aid. You'd be surprised just how many people fall short of K's RDA on a daily basis.

As for the PTH-magnesium thing the only reason I mentioned that was based on the limited data I've seen on CCB's they seem to stimulate PTH. Or some of them do at least (the dihydropyridine class). And since magnesium helps modulate PTH similar to how dietary calcium does, you may be responding well to magnesium because it's helping to slow down the extracellular Ca concentration.

Not to get too far off topic myself, but this could have possibly been set in motion by unresolved hypothyroidism, which has been shown to decrease calcium excretion via renal impairment in humans. Once on thyroid replacement the problem should resolve itself, or at least get substantially better.

But in the event kidney's have reduced ability to get rid of calcium, and CCB's increase the extracellular Ca from PTH stimulation, you might be left in precarious situation where you actually feel better not taking the CCBs despite higher BP. And it would explain why you respond well to magnesium too, as it's ability to modulate PTH independent of calcium networks.

Lots of speculation though, would be nice to see some tests specifically measuring the TSH, PTH, 1,25-D, and calcium for a better understanding. If any (or all) are elevated it would be a little more clear of what's happening.

This guy's content is great

Wikipedia is controlled by some really woke people. I wouldn't recommend creating a Peat page unless you're willing to deal with a smear piece.

Surprised the smear piece doesn't already exist tbh.

There is a wiki on Glibert Ling, although it's not terribly bad. Likely because he's kind of esoteric outside his micro-electrode invention. I believe I remember them disparaging him though on the membrane pump stuff (which is unironically his most fascinating stuff!).

@Jakeandpace Probably, or maybe they just remove problematic foods from their diet. Big thing about "peaters" (I've never liked that word, lol) is the dairy/milk. There's a shit ton of people that don't tolerate milk, so when they remove it they feel better. That doesn't mean vitamin A is bad, or calcium, or lactose, or whatever else they can think of. It means they continued to try and force a food that wasn't agreeing with them due to some misconception that a "way of life" (in this case peating) necessitates that they do so.