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  • Place to discuss the work of Ray Peat, Otto Warburg, Albert Szent-Györgyi and the interdependence of energy and structure

    4k Topics
    34k Posts
    B
    This picture of VDR knockout mice being "lean" and "obesity resistant" is taking some of the trees for the forest and claiming it's the whole forest. If you are insulin resistant, generally force-feeding a lot of carbohydrate substrate without any other measures is probably not a good idea. Are carbohydrates bad? No. Vitamin D has been skewed, I am sure intentionally, as a general calcified public is also "paradoxically" calcium deficient, or more aptly on a very low calcium:phosphate ratio, focusing on inflammatory, active D (1,25) paints the perfect, evil picture of vitamin D overall and is frankly wrong. Hydroxylases tightly regulate local conversions to 1,25 from 25. What interrupts this regulation? Calcium deficiency, estrogens, PUFA. In other words pre-inflammatory state. Knockout mice, barring all other factors of health - which is usually the game here in these worthless studies - will not experience this inflammatory, dysregulated system. And looking only at this narrowly through a lens, you derive your conclusion you are looking for: manipulating the meaning and function of things. In reality, in the real world, the better method in avoiding these inflammatory responses is, you guessed it, sufficient calcium, low PUFA, in turn keeping estrogen in check, and being careful of other inflammatory things. Much like the knockout mice scenario, removing some apparatus to prove something is bad, when that something itself is hijacked and fed into a detrimental cycle is a sleight of hand, not proof. Vitamin D is not the problem, and VDR knockout doesn't prove it is, only in that if 25 is converted via inflammation. Lipopolysaccharide derived MKP-1, inhibition by inactive D already shows vitamin D is an anti-inflammatory, but not 1,25. And 1,25 is one of the resident experts of inflammation, when conditions of health are not met. Get tho9se conditions met and D does what it does that is good for us. By the way, progesterone and methylene blue also help Also, "constant milk intake" is an absurd, hyperbolic suggestion. I am certain nobody here has an IV of milk coursing through their veins 24-7. You have some milk throughout the day, then we all fast whether we know or not: it's called sleep.
  • Discussion of individual human or animal cases. "There is no foreseeable limit to the qualitative development of the economy." - Ray Peat, Generative Energy

    233 Topics
    2k Posts
    alfredoolivasA
    @sunsunsun Great find sushi I think it was reffering to this study It used a HED of 70mg a week for an 80kg man, which is a very low dose. They measured protein synthesis by measuring the concentration of RNA in muscle, which usually increases during AAS administration, but fell during trenbolone treatment. The tren rats had less amino acids in their muscle, indicating less muscle breakdown and more nitrogen per kg of bodyweights and normal organ sizes (actually less as a percent of bodyweight) it's interesting. to see its' unique effects
  • 184 Topics
    4k Posts
    ThinPickingT
    https://youtube.com/watch?v=2KPTiSYuzwg
  • Conversations about Bioenergetic Forum

    86 Topics
    1k Posts
    M
    @ThinPicking , Definitely. But I would like to talk with the administrator.
  • Off-topic or unclear threads sent here. But dig around and you might find some gems.

    512 Topics
    15k Posts
    BrunusB
    @maplesyrupbro Good to know. Did you use idealab's DHT? Tell us the important details. @bio3nergetic @gg12 I'm not cut, and this is not purely about size. The increase in size would come from better vascularization, also increasing sensitivity which I lack.