@brad peat bot really helped me out when I first started Peating properly. It answered all my insane questions.
I have warm feelings towards Peatbot.
I hope all of this stuff stays safe no matter what the future holds.
Thankyou.

@DavidPS what's funny is that I started back on glycine recently (was heavy at the beginning of the year and fell off) and have had more energy as well, so it may be a combination of things...

@smok said in Over-methylation:

On the subreddits r/Nootropics and r/Supplements there's hundreds of posts on the cholinergics Choline, Alpha-Gpc causing serious depression in their users.

Possibility when in excess.
After a search with LucH pendulum 😉 , here is what I've fund:
Too much choline ?
Can too much acetylcholine cause depression?
Acetylcholine normally enhances cortical sensitivity to external stimuli and decreases corticocortical communication, increasing focused attention. However, increases in ACh signaling can lead to symptoms related to anxiety and depression.
What about prescribing a supplement of αGPC?
Alpha-glycerylphosphorylcholine (αGPC) is a precursor of acetylcholine and can increase acetylcholine concentration in the brain.
=> Neuromodulation by Acetylcholine.
Side effects:
Alpha-GPC seems to be safe when used appropriately. It can cause side effects in some people including heartburn, headache, insomnia, dizziness, skin rash, and confusion. Possibly excess choline (20 g) can also include depression and heart rhythm problems. Choline may cause depression in some people.
Can you take choline and Alpha-GPC together?
These two choline supplements work well together. The synthesis of acetylcholine (ACh) is largely dependent on the choline provided by phosphatidylcholine (PC). Alpha GPC is a byproduct of phosphatidylcholine (PC). And supplemental CDP-Choline provides the uridine needed for PC synthesis.
Does Alpha-GPC affect dopamine?
Treatment with αGPC increases dopamine levels as well as dopamine active transporter expression in the frontal cortex and cerebellum [10]. It also increases serotonin levels in the frontal cortex and striatum of rat brains [10].
10. doi: 10.2174/1871527311312010015
Does choline affect estrogen?
Estrogen stimulates the breakdown of phosphatidylcholine (cell membrane) so those with low estrogen (postmenopausal women) require more choline. Detoxify excess estrogen via the methylation pathway.
Does choline affect your mood?
Low levels of choline are also associated with depressive symptoms — likely because choline is a precursor to the nutrient known as betaine. Betaine reduces homocysteine levels in the body, and high homocysteine has been linked to depression (particularly in men). 2023
Note from Luc on side effects on High Dose PLP (B6)
See “English Corner – Vit B6: How much is too much?”
https://mirzoune-ciboulette.forumactif.org/t2033-english-corner-vit-b6-how-much-is-too-much#29628
An excess of B6 could induce choline-like effects of deprivation. PLP encounters a barrier when in excess.
An excess of Pyridoxal will lead to the inhibition of the enzyme PLK (Pyridoxal Kinase). PLK is set out of function via the “Salvage pathway” process. Note that this observation has been “recorded” only in 2021. It was not rigorously established up to then. But, it already seemed logical / acceptable to me.
Attempted explanation by researchers:
In case of supplementation with a high dose of Vit B PLP – activated vitamin B6 – or in the event of upstream malfunction (coupling / decoupling process for the transfer to the cell), a protective mechanism occurs in order to control the cell levels of PLP. (6-7)
Pyridoxal (PL) is inhibited by Pyridoxal Kinase (PLK) during a regulating process related to the B6 metabolism. The inactivation process (inhibition of Vit B6 PLP) is a protective mechanism when there is too much PLP in circulation. The cause remains uncertain; the possibilities would include aldehyde stress from the degraded / neutralized PLP molecule. Pathology mimics then the symptoms of a lack of vitamin B6.

@Sunniva

Thank you.

@GRay
library genesis
look it up

@Lejeboca Thanks a lot!

@DavidPS wow, thank you so much for the info. That PeatBot is amazing.

@Lizb Nice

Archive search is very bad! Go to the forum in incognito mode and search. When it says you've reached the maximum searches, simply copy the url, close the window, open a new incognito, and paste it.

@Lothric

If you're coming from a liberal arts background, I hope you have at least a good foundation from high school biology and chemistry.

Stuff like balancing equations and a bit or lf understanding on both organic and inorganic chemistry.

If you don't, check the syllabus of an engineering major program and you will still see some chemistry units needed.

You can then go to Khan’s Academy to take lectures from there.

I would not have you go down the road of reading Warburg, St-Georgyi, Long but you can get straight to reading Peat’s books and articles. And then every time you encounter something new, go into your own sidebar and study that topic before going back to finish reading that article or section (if it's a book).

But that is going to still be overwhelming. As Ray has written so much and you can't possibly read everything even if you were so determined (if you're like me).

It would be better to do a search on a topic that is relevant to you at that moment and search thru a database that contains all his written works.

I currently just have his 4 books, and his newsletters, but have yet to gather his other writings as well as transcripts from interviews, and don't see myself having enough time to do these.

Still, I do a search on my phone with a paid search program on what I got so far.

It has helped me a lot in understanding his principles very well. It allows me to form my own knowledge base that I draw from in problem solving my own pathology, and help others.

And it helps me too when I post answers to questions from members, as formulating answers in sharing ideas further helps me develop connections informing coherent answers to problems. And for me, that is the best way to learn. Especially when you are questioned as if a panel of advisers are questioning and interrogating you on your answers.

@Mauritio such a simple concept with such radical implications for how we live and what society values

@jgs130 nice. Thanks

@psi
yeah everyone else is a zombie and bugman but you are the woken one especially after you took a psychoactive cactus

come on man

@oj Can't resist, sorry not sorry 😬
c74727f7-f369-4b67-b8bd-8619d9759a76-image.png

You have all the needed sources within reach https://bioenergetic.forum/topic/4/ray-peat-resource-thread

Seems like an interesting project. Can I ask why it's so expensive for you to run?

@RealNeat

Yes, has to do with my bp. But in an unexpected twist of fate, in my continuing effort to lower my bp, I took a substance (cinnamon bark oil) in the wrong way (in a sugar cube instead of in a capsule). This led to my lungs becoming irritated and losing its ability to expel phlegm. Developed COPD in the form of bronchitis. Realized too late the lower spO2 levels was something to take more seriously. This condition cascaded into my heart failure last year. The heart was effected, so was my nervous system as I developed ataxia, which is about the same thing as Parkinson's. Heart and lungs fully recovered now, with an improven nervous system but crossing my fingers my neurons did not die but only time will tell.