@dapose said in More writings from people who influenced Ray Peat: Something about the way Ray passed Georgi and Danny breaking up and the old forum caving in just doesn’t feel organic to me. Has anything in the distance since 2020. And before depending on the somnolence of an observer. It's all connected. I know Georgi still posts stuff, but it could be in AI generated post I can tell you for a fact that's Georgi. Only telling though so there's humour in it, can't "prove" it rn. He's just busy, and what really is there to yell off a platform. like all *Mr Mercola‘s podcast now are all AI generated Guy's view counts are in the tank. I wonder how the inc "entity" is doing.

@Zachs Looking forward to updates, experiments can be fun, and walking (lots) is awesome too

@lobotomize-me I believe by body mass he meant the bone structure and not tissues/fats. That being said I'm not certain, I do hear this planets best and brightest essentially live in MacDonalds. Also worth noting this is something that applies across all mammals on Earth not just humans, pretty sure it wasn't "his" and it's not a "theory".

@herenow when snake juice started in the packaged form cole didnt even take a cut of the product sales, idk if he does now he literally tells people how to make it themselves cole is not the kinda guy you are implying

*Will make a separate thread.

Thank you

@JayFisher fair enough, seems like you are a man of your word

@Corngold Oh sorry it's 36:00... Dr. Ray Peek, is that your name? Mm-hmm. How do you spell that, please? P-E-A-T. P-E-A-T? P-E-A-T. T-A-T? Okay. Earlier I heard you talking about productive cholesterol is important for connective tissue. Did you say something like that? Yes. Now, I was born with a rare disease where I don't have any connective tissue over my whole body. ... Have you heard of such a thing? ... Is your tissue very elastic? cont'd: Have you tried increased amounts of vitamin E? Yeah, I did when I was younger and that made me very horny, very horny, and I couldn't control it hardly. Lmao, this guy. Look, ok, maybe it's real, but it sounds like a comedy routine. Jerky Boys or Tim and Eric. That's one of the best things about this archive of radio shows. Some of the callers are unhinged! Un-ironically makes for great entertainment. P, E, A, T. PEAT.

You’re welcome, @secondkelping. I’m so happy to hear you figured out the cause. It makes sense that your NDT stopped working for you because Forefront’s isn’t standardized so there’s no way of knowing how much hormones it actually contains from batch to batch. With synthetics like Tyronene and TyroMix, you know what you’re getting but with NDT, you don’t if it’s not standardized/USP like Armour, Nature-Throid, NP Thyroid, ADTHYZA, TyroMax etc.

@Kilgore wow, that is pretty amazing. Thank you!

Good stuff some may not like it, but it's a good way to get some Ray Peat knowledge while working out

@Uncover In fairness his thyroid would still be there just severely damaged so it could probably regain function again but likely hard without supplementing thyroid

@wikipeatiaadmin The name is perfect. There are several repositories on Peat currently. That's not to say yours should not exist, just sharing what is already out there: https://wiki.chadnet.org/ray-peat https://archive.is/OJZkW https://expulsia.com/health

@smok said in Over-methylation: On the subreddits r/Nootropics and r/Supplements there's hundreds of posts on the cholinergics Choline, Alpha-Gpc causing serious depression in their users. Possibility when in excess. After a search with LucH pendulum , here is what I've fund: Too much choline ? Can too much acetylcholine cause depression? Acetylcholine normally enhances cortical sensitivity to external stimuli and decreases corticocortical communication, increasing focused attention. However, increases in ACh signaling can lead to symptoms related to anxiety and depression. What about prescribing a supplement of αGPC? Alpha-glycerylphosphorylcholine (αGPC) is a precursor of acetylcholine and can increase acetylcholine concentration in the brain. => Neuromodulation by Acetylcholine. Side effects: Alpha-GPC seems to be safe when used appropriately. It can cause side effects in some people including heartburn, headache, insomnia, dizziness, skin rash, and confusion. Possibly excess choline (20 g) can also include depression and heart rhythm problems. Choline may cause depression in some people. Can you take choline and Alpha-GPC together? These two choline supplements work well together. The synthesis of acetylcholine (ACh) is largely dependent on the choline provided by phosphatidylcholine (PC). Alpha GPC is a byproduct of phosphatidylcholine (PC). And supplemental CDP-Choline provides the uridine needed for PC synthesis. Does Alpha-GPC affect dopamine? Treatment with αGPC increases dopamine levels as well as dopamine active transporter expression in the frontal cortex and cerebellum [10]. It also increases serotonin levels in the frontal cortex and striatum of rat brains [10]. 10. doi: 10.2174/1871527311312010015 Does choline affect estrogen? Estrogen stimulates the breakdown of phosphatidylcholine (cell membrane) so those with low estrogen (postmenopausal women) require more choline. Detoxify excess estrogen via the methylation pathway. Does choline affect your mood? Low levels of choline are also associated with depressive symptoms — likely because choline is a precursor to the nutrient known as betaine. Betaine reduces homocysteine levels in the body, and high homocysteine has been linked to depression (particularly in men). 2023 Note from Luc on side effects on High Dose PLP (B6) See “English Corner – Vit B6: How much is too much?” https://mirzoune-ciboulette.forumactif.org/t2033-english-corner-vit-b6-how-much-is-too-much#29628 An excess of B6 could induce choline-like effects of deprivation. PLP encounters a barrier when in excess. An excess of Pyridoxal will lead to the inhibition of the enzyme PLK (Pyridoxal Kinase). PLK is set out of function via the “Salvage pathway” process. Note that this observation has been “recorded” only in 2021. It was not rigorously established up to then. But, it already seemed logical / acceptable to me. Attempted explanation by researchers: In case of supplementation with a high dose of Vit B PLP – activated vitamin B6 – or in the event of upstream malfunction (coupling / decoupling process for the transfer to the cell), a protective mechanism occurs in order to control the cell levels of PLP. (6-7) Pyridoxal (PL) is inhibited by Pyridoxal Kinase (PLK) during a regulating process related to the B6 metabolism. The inactivation process (inhibition of Vit B6 PLP) is a protective mechanism when there is too much PLP in circulation. The cause remains uncertain; the possibilities would include aldehyde stress from the degraded / neutralized PLP molecule. Pathology mimics then the symptoms of a lack of vitamin B6.

@Sunniva Thank you.

@GRay library genesis look it up

@Lejeboca Thanks a lot!

@DavidPS wow, thank you so much for the info. That PeatBot is amazing.