@questforhealth the problem seems to be that you’ll never approach 1mg of vitamin K2 from most foods. The most concentrated source is natto and even though it does have about 600mcg per the most common serving size, most people here won’t touch it because it’s a soybean food containing significant PUFA; also the form is MK-7 not MK-4, which is viewed as a disadvantage by most

@Kvothe said in Vitamin A increases T3 by more than 60% in humans!:

Some dude posted this study on RPF. In rats, an equivalent dose was enough increases TSH and suppress T3. I personally experienced that anything over an extra 5.000IU can be suppressive for a mildy hypothyroid person.

https://link.springer.com/content/pdf/10.1007/s00394-022-02945-5.pdf

0db5dde3-7db7-4cfb-8447-a8fe77b96aba-grafik.png

Well that dude (sinatra) probably has the study from this thread here (https://bioenergetic.forum/post/12395) where I posted it a few days before him, it's interesting that he did not post the main study of this very thread or any of the other pro-vitamin A things I posted.
The HED of about 30k IU per day is still realtively high. And i agree that this can make you hypo, which peat has said for decades.
On the other hand the study, which this thread is about (human study, not rat) shows clear benefits in a similar dosage.

Thanks for sharing.

Activation of the PXR/SXR is an interesting thing in and of itself. It increases phase 1,2 and 3 detoxification in the liver and increases CYP3A4. Other ligands are for example: progesterone, 5aDHP or bile acids.

The authors of this study hypothesize that the liver-regenerating capabilites of Vitamin K2 were reliant on PXR-activation.

All the nucelar "X" receptors are really interesting, the FXR probably beeing my favorite.

PXR/SXR also upregulates a protein that takes up and excretes prostaglandins. So vitamin K leads to less PUFA/prostaglandin metabolites and damage.

@Master Too bad but thanks anyway Master.

How's your thyroid, what's your waking up temp? It's probably not good since your sleep is bad.

@GreekDemiGod Are you trolling?

@Mauritio said in Vitamin A quotes from Ray's favorite physiology book:

@Peatly said in Vitamin A quotes from Ray's favorite physiology book:

@Mauritio There are huge variations in results for vitamin A studies. I think Dr Peat’s recommendation, which is to be cautious if hypothyroid, seems reasonable. I would like to see that Iranian study replicated elsewhere – especially in regions where Billy Goat is blocking the sun.

Yes, I agree.
What does it have to do with the sun/ Vitamin D?

I was under the impression that being exposed to sunlight, for extended periods, increases your vitamin A requirements. I was thinking that if the sun is being blocked this might lower need?

Dr Peat talking about light exposure and vitamin A

This is the dentist Dr Peat mentions in that clip
Emanuel Cheraskin, M.D., D.M.D., late Professor of Oral Medicine at the University of Birmingham, AL.

The "ideal" daily vitamin A intake

Relationship of vitamin A and oral leukoplakia

@banquos-ghost I originally started taking NDT by the Life Giving Store, around four years ago. When I first started taking it, it worked for me but stopped working about a year after I started it (my TSH went up to 3.0 and I still had all of my hypo symptoms). What ended up working the best for me and what I take now is Cynomel (I break up one pill into four pieces and take it throughout the day with meals). Then starting around 6:00 PM, I take one drop of Tyromix. I take one drop of that every 1.5 hours until I go to bed. So, I end up taking 5 drops total of Tyromix (orally) and spread out. That amount of Tyromix is what helps me sleep throughout the entire night without waking up, and that is the marker that I use to decide the dosage of the Tyromix.

https://pubmed.ncbi.nlm.nih.gov/27565891/#affiliation-4

Agmatine is very peaty? I think Dr Peat mentioned agmatine somewhere?

I'm currently dealing with rabid insomnia. I pray this helps.

@Amazoniac said in Vitamin C in the prevention of cellular respiration (CcO) inhibition by sulfide:

200 mg ascorbic acid per day

Practical application: that's roughly the amount in 500ml of orange juice, less if it's fresh.

No wonder that we seem to be on a never ending decline when it comes to young people's mental health. What chance do kids have when before they're even born they are exposed to even more and more chemicals that mean they are more likely to be dumb and sick.

One upside I guess is if you're aware of this and you and your partner don't eat PUFA you're going to have a child with an automatic leg up compared to everyone else.

@Buckian Ive had similar experiences. I now only use red light therapy before my last meal of the day and never after

This is not a new study. We have discussed this study several times. You can follow John himself on Twitter. He had a very interesting series of tweets when the study was published.

@sphenoid said in Vitamin A deficiency impairs gonadal steroid synthesis:

Screenshot 2024-02-18 085932.png

The vitamin A movement could be a possible pop control psyop

Disturbing! I'm not too concerned about the fertility of older people who go low A, but the young people and children who have to eat what their low A moms prepare. I sure hope this is reversible.