Topics created by DavidPS

@Razvan said in Bioenergetic Cardiology & the Awesome Foursome:

L carnitine can cause heart attacks due to the pro fatty acid oxidation effect, raises cortisol also.

Thanks, I generally think that dose makes the poison. L-carnitine is part of many healthy diets and may be deficient in elderly with heart issues who do not eat enough meat.

6 Foods High in L-Carnitine That Are Really Good for You

Strangely, the delivery method also matters. Eating foods containing L-carnitine will have a different effect than injecting it.
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L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis (2013)

Conclusion: Compared with placebo or control, L-carnitine is associated with a 27% reduction in all-cause mortality, a 65% reduction in VAs, and a 40% reduction in anginal symptoms in patients experiencing an acute myocardial infarction. Further study with large randomized controlled trials of this inexpensive and safe therapy in the modern era is warranted.

@DavidPS said in Anabolic Sensitivity in Healthy, Lean, Older Men:

Staying lean and fit fights aging

Hi,
just to make a up, and contribute ...
Nothing to do with insulin insensitivity but as overfat, insulin insensitivity and inflammation are members of the same trilogy, we could add one more point: lack of potassium, preventing adequate cleansing. I explain (context needed):

Oxidized Cholesterol, Macrophages and Potassium
Potassium to dampen high tension and prevent AVC. Atherosclerosis begins with macrophage engulfment of oxidized LDL C-foam cells (process to clean / get rid of Ox-LDL.
=> 2 g K+ more makes a difference (3 g as middle take). So 3 + 2 = 5 000 mg.

Excerpt (translated)
Macrophages are cells that infiltrate tissues and have a cleaning role. They are notably responsible for purifying LDL cholesterol (the wrongly-called “bad” cholesterol). But when this cholesterol is oxidized, macrophages store it in the arterial walls and become the raw material for atherosclerotic plaque. They are then called “foam cells”. By preventing macrophages to adhere to arterial walls, potassium could slow down cardiovascular disease.
Translated from the book “Potassium: Mode d’Emploi”. Dr. Philippe VEROLI.
Chapitre 5 – Prévenir et Traiter les maladies Cardio-Vasculaires.
Sources and References

The role of macrophage ion channels in the progression of atherosclerosis
&3. Ion channels in macrophages
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1225178/full
Potassium channels are crucial regulators of macrophage membrane potential and ion homeostasis. Human macrophages contain a stretch-sensitive potassium channel that is activated by adherence and cytokines
https://pubmed.ncbi.nlm.nih.gov/8558596/
We have identified an outwardly rectifying K+ channel that appeared to be involved in cytokine and adherence-mediated macrophage activation, and in the maintenance of cytoskeletal integrity and cell shape. Inverse relationship between potassium intake and coronary artery disease in the cholesterol-fed rabbit
American Journal of Hypertension, 1999, https://doi.org/10.1016/S0895-7061(99)00039-4 Atherosclerosis begins with macrophage engulfment of oxidized LDL C-foam cells (process to clean / get rid of Ox-LDL.
Researchgate (access denied with VPN)

@yerrag

That general view of some peaters about lipolysis that you quoted in your reply probably stems from a misinterpretation of what Ray said about it. The emphasis he places on inhibiting lipolysis is in the context of too much PUFA stored in the tissues, which becomes less and less necessary as you become “PUFA depleted”. After that, inhibiting lipolysis becomes more of a therapeutic tool to be used in appropriate contexts, such as in some pathologies.

He even mentions that in healthy people (especially children) stress hormones are only produced in the amount needed because free saturated fatty acids serve as negative feedback, not allowing them to rise beyond what is necessary.

In good health, especially in children, the stress hormones are produced only in the amount needed, because of negative feedback from the free saturated fatty acids, which inhibit the production of adrenalin and adrenal steroids, and eating protein and carbohydrate will quickly end the stress. But when the fat stores contain mainly PUFA, the free fatty acids in the serum will be mostly linoleic acid and arachidonic acid, and smaller amounts of other unsaturated fatty acids. These PUFA stimulate the stress hormones, ACTH, cortisol, adrenaline, glucagon, and prolactin, which increase lipolysis, producing more fatty acids in a vicious circle. In the relative absence of PUFA, the stress reaction is self limiting, but under the influence of PUFA, the stress response becomes self-amplifying.

This misinterpretation is probably one of the bases for the idea that moderately high insulin several times a day is beneficial (because it inhibits lipolysis and increases glucose oxidation). I don't particularly consider insulin to be a “stress hormone”, but high insulin several times a day and for long periods is obviously a bad sign; insulin plays an “enhancing” role and not the main role.

Keto diets, a very low fat and/or very low protein diet, exercise, ACV before meals, walking after meals, and other similar tools aimed at reducing insulin are only necessary if metabolic dysfunction is already present. Is it good to have these options available with the constant attacks on our health? Yes, but the more miraculous a therapeutic tool is, the more likely it is that your health isn't as good as you think.

Olive polyphenols are pretty underrated IMO.

https://bioenergetic.forum/topic/3624/olive-leaf-extract-increases-t3-t4-lowers-tsh

Thanks @DavidPS I am some how not surprised! Arginine anything is a major risk.

Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals (2024)

@DavidPS Holymoly

Another article related to cardiac fibrous.

The Influence of IL-11 on Cardiac Fibrosis in Experimental Models: A Systematic Review

Fibrosis is one of the main factors that impair the function of many organs. In the heart, fibrosis leads to contractile dysfunction and arrhythmias, which are important in the development of heart failure. Interleukin (IL)-11 is regulated in various heart diseases and has recently been reported to be an important cytokine in fibrosis in this organ. However, this topic has been little explored, and many questions persist. Thus, this systematic review aimed to report on possible IL-11 therapies evaluated in rodent model-induced cardiac fibrosis.

@Lejeboca - I did not know that one could search Sci-Hub by ISBN. Thanks.

How are people still making long-form podcasts with no time stamps😩

@Lejeboca Thanks a lot!

@Sunniva Also, these things are very specific, mk4 is not the same molecule as mk2, so even if it is approved he might still be able to continue selling Kuinone (plus mk2 supplements are very popular)

@DavidPS great, thanks. so boiling the mushrooms removes the bads while keeping the benefits

What many people don't know is why inhale far more micro plastics than we ingest. The size of a credit card every week.
Frequently airing a room is important to let less poluted new air come in.

Useful info
Interaction between fat-soluble vitamins A D K
Key ideas
Nutritionists talk about vitamin K as if there were only one type!
We know the role of vitamin K1 (phytomenadione) for its role in coagulation. It is mainly found in green vegetables.
Vitamin K2 (menaquinone) is less well known and has no RDA recommended by health authorities!
We can convert K1 into K2 but it is random and notoriously insufficient.
K2 plays a key role in the activation of hormones that regulate calcium metabolism: osteocalcin, which is involved in the mineralization of bone matrix, and matrix Gla protein (MGP), which protects soft tissues against calcification.
The role of vitamin K2 is not limited to these functions alone. Here, it is much more than a co-factor because vitamin K2 is the substance that allows dependent proteins A and D to activate/come to life. While vitamins A and D act as signaling molecules, telling cells to produce certain proteins, vitamin K2 activates these proteins, giving them the physical ability to bind calcium.
If more details wanted:
https://mirzoune-ciboulette.forumactif.org/t127-interaction-entre-les-vitamines-liposolubles#889
See second post for the original article in English.