Well, if you want to try supplements you could try those that are carbonic anhydrase inhibitors such as acetazolamide.
Posts made by jamezb46
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RE: Ideas for getting more CO2 into your everyday routine
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RE: Seborrheic Dermatitis (SD) cured by Topical Caprylic Acid (C8:0)Triglycerides
Wonderful. Glad to see my solution seems to be of general utility.
Of additional interest is the androgenicity of caprylic acid. Perhaps that is another mechanism by which it opposes the inflammatory response that is SD. Namely, by opposing estrogen.
I’m currently researching p5p, the active form of vitamin b6 for this skin disorder as well. I’ll report back in a few months. It may be that SD is really a micronutrient deficiency, of some combination of zinc, b6, selenium, etc.
Since people in the RP community don’t eat a lot of PUFA, their metabolic rate is higher and thus the need for these micronutrients, as demonstrated in the PUFA-deficient mice who developed scaly skin on their paws.
The fact that one study gave them b6 and saw no improvement doesn’t really show much, since they didn’t control for other micronutrients such as those above mentioned.
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RE: Seborrheic Dermatitis (SD) cured by Topical Caprylic Acid (C8:0)Triglycerides
That’s awesome to hear. Did you recommend it based on this post?
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RE: Seborrheic Dermatitis (SD) cured by Topical Caprylic Acid (C8:0)Triglycerides
So the caprylic acid worked for you?
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Negative Feedback Mechanism of steroids on Gonadotropin Releasing Hormone
The standard picture of the HPTA in males is: Hypothalamus releases GnRH, which induces the pituitary to release LH and FSH, which induces the leydig cells in the tests to produce testosterone.
Now, I want to get clear on what the negative feedback mechanism is between the hypothalamus and sex hormones.
I am well aware that there are other signals the triggering of which will induce a negative feedback mechanism on the hypothalamus, such as decreased dopamine levels, increased CRH levels, increased leptin levels, and so on. I am for my present purpose not interested in those processes.
From some surface level research, it seems as though the primary negative feedback mechanism is with estrogen, as regards the negative feedback mechanism the hypothalamus has with sex hormones. So, in men this would presumably be with estradiol (E2).
Although, there is some discussion of how very high androgen levels can also have a negative feedback mechanism with the hypothalamus.
So, how exactly does the hypothalamus detect this estradiol? Are there estrogen receptors in the specialized neurons in the hypothalamus the binding of which constitutes the negative feedback mechanism?
And (assuming there is a negative feedback mechanism with androgens, which I think is probably true at a sufficiently high level of androgens), how exactly does that work? Are there androgen receptors in some of the neurons in the hypothalamus that when activated decrease the output of GnRH?
I ask because depending on what the mechanism is, it might be interesting to design a drug that influences the binding of androgens or estrogens to these receptors in the hypothalamus, which could potentially increase the "natural" testosterone levels (i.e the testosterone produced by the testicles)
Drugs that limit estrogen synthesis like exemestane are known to work on this mechanism, but I want to know what the full story is.
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RE: Homemade Vanilla Ice Cream
Yes, it can be done with two stainless steel bowls, some salt to help the one containing ice to stick to the one containing the ice cream, and a good amount of time. It's called Philadelphia ice cream.
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RE: Cure for chronic burnout?
Perhaps. You could try Haidut’s energin and oxidal. Coffee of course is also great.
But I would need to know your context. Working a job you hate for absurd hours is never going to be healthy. With that said, if you could provide more details I could give a better answer.
If the burnout is mostly because you hate what you’re doing and find it meaningless, but you imagine that if what you were doing were more meaningful, things would be better, I would look into substances that can shift the neurotransmitter dominance from serotonin to dopamine, such as cyproheptadine. With that said, I’m not sure that such a pharmacological intervention would help you put up with your situation better. Rather, it might make you more assertive, and thus more motivated to get out of whatever led you to burnout.
If the burnout is more “physical” then you could try red light therapy, or anything to help you sleep better, such as anything that decreases the effects of cortisol, such as 6-keto p4, emodin, progesterone, DHEA.
Lastly, if the burnout is making you feel “on edge” at work or wherever it is coming from, you could try taking some DHT boosting supps such as androsterone, methylated SFA, testosterone, or DHT itself to help you keep a level head and not suffer the potential negative cardiovascular or psychological effects of feeling like you went to rip people’s heads off.
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RE: Homemade Vanilla Ice Cream
Lovely. I LOVED when I made ice cream with rum and raisins. It was only a small amount of rum lol. Plus I think it was Jamaican which may have a significant amount of policosanols.
I really want to try a coffee ice cream. Could be great as a desert.
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RE: Revisiting Oral Testosterone
@Crypt-Keeper that was my experience also. It dissolves very well in DMSO + Ethanol, however. Transdermal is the way I think.
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RE: Any experiences with DHT?
Do you think using Pansterone + kuinone topically on scrotum at a few drops/day is a sustainable way to get a boost of androgens?
And what could you recommend for an acute boost pre workout for increase aggression and power? It would likely be sublingual/buccal, right? But what androgen in particular would you think would be best 1-2x/wk? DHT? Anadrol? Var? Tren?
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RE: The Testosterone/DHT Conspiracy
Hairdut provided studies showing that transdermal DHEA, P4, and K2 applied to testicles (dissolved in DMSO/ethanol) is very effective at raising androgens. There’s even an individual on the RP forum who got his test into the 1000+ ng/dL range using that combo.
You could also look into the combination of oral DHEA and androsterone which again Haidut provides evidence for completely revitalizing castrated rats.
If you want to do an experiment with straight T/DHT, that will most likely work too and be very effective. I myself am going to do an experiment with t dissolved in tocopherols and taken orally. I think 5-10 mg/day dissolved in the vitamin E should have a very powerful effect, together with p4 since supplemental androgens can down regulate the enzymes that produce/convert other hormones into the precursor steroids.
If you don’t want to dissolve in tocopherols, I found a study showing that 200 mg T given as free crystals 2x/day was able to raise the T levels of Eunuchs to full normal levels for the entire day, and that was in the 70’s.
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RE: DHT powder dissolve
Ok. I plan on dissolving T in vitamin E; your claim of being able to dissolve 20 mg DHT/mL is encouraging.
Please let me know what effects you have noticed from taking it, and please include dose and route of administration.
Also, if possible I would like to know what the concentration of tocopherols is in your solution in mg/mL.
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RE: Revisiting Oral Testosterone
I could not get vitamin E to mix with DMSO, I would not recommend this. Unless you’re talking about dissolving d-alpha tocopherol acetate in DMSO. That may well work, but according to Ray the acetate ester is about 50% as effective as the nonesterified tocopherols.
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RE: Revisiting Oral Testosterone
@RFC32 for the love of God why would you essentially tease the success you had with sublingual T and not disclose the formulation
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RE: Topical Steroid Solubility and Absorbtion
Still waiting on my shipment from PPL. Will update this thread after I dissolve the powder and again after a few weeks of using it.
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RE: Revisiting Oral Testosterone
I read a study where they gave 400 mg per day in 4 divided doses of 100mg to Eunuchs. There were no detrimental effects on the liver.
Given that Peat recommended 10-20 mg P4 when dissolved in vit E and taken orally, I cannot think of any reason why a low dose of 10mg T orally dissolved in vitamin E would not be massively effective at “supplementing” testosterone levels in healthy men.
I myself am going to get to the bottom of this. T powder is on the way, vitamin E is on hand. Hopefully I can get the T to dissolve in the tocopherols and I can present some solid results after a few weeks of use and we can all get on the same page about the exciting idea of homebrewing the “male version” of progest-e.
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RE: Topical Steroid Solubility and Absorbtion
@Lothric I decided on dissolving T in vitamin E. Similar to progest-e except I will use T instead of P4.
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RE: Whats worth knowing about structured water / magnetized water?
I think that one of the benefits of the bioenergetic perspective is that there are certain unifying principles that explain why certain substances or effects are beneficial and others are not. Among those principles is that whatever can afford the cell increased stability is of benefit to it. Thus, saturated fats, gelatin, niacinamide, etc. can be thought to be of benefit partly because they simply make the cell more lipophilic and less hydrophilic.
So, when it comes to liquid vs structured water, it should be clear that the structured water is the more beneficial, because it increases the stability of the cell.
You can even do this experiment at home: Dissolve a tablespoon or so of collagen protein and niacinamide in a few oz of water and compare that to water without anything extra dissolved in it. The one with the protein and niacinamide will be much more gel-like than the other.
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RE: DHT powder dissolve
The reason why we dissolve in tocopherols is because according to Ray and also current research the tocopherols allow the steroid to travel through the body on chylomicrons that are not metabolized in the first pass by the liver.
In addition to that, there is the lymphatic system effect whereby the steroid when dissolved in a fat of chain length 12 or greater is absorbed through the thoracic duct and enters the lymphatic circulation, thus bypassing the liver on the first pass.
To be completely frank, I do not know what relationship exists between these two mechanisms. I don’t know if they are two different mechanisms or if one is the effect of the other. Perhaps @Santosh or @haidut can chime in here.
It does seem that the steroid would have to be dissolved in either the tocopherols or the longer chain fat (or both) for either effect to take place, but I don’t know for sure.