Posts made by Kvirion

Kaboom!

Finally...

More indirect evidence:
A natural MAO-B inhibitor eugenol also inhibits GABA-A

• Eugenol Inhibits the GABAA Current in Trigeminal Ganglion Neurons
• Pharmacological Properties and Health Benefits of Eugenol: A Comprehensive Review

In practical terms:

• Ashwagandha enhances GABA-A
• Emodin (Cascara) and eugenol are MAO-B inhibitors...
• L-Theanine work on GABA-B

According to ChatGPT

A little midfuck about MAO-B inhibitors...
It seems it is more about GABA than dopamine...
What do you think about it?

Monoamine oxidase (MAO) is believed to mediate the degradation of monoamine neurotransmitters, including dopamine, in the brain. Between the two types of MAO, MAO-B has been believed to be involved in dopamine degradation, which supports the idea that the therapeutic efficacy of MAO-B inhibitors in Parkinson’s disease can be attributed to an increase in extracellular dopamine concentration. However, this belief has been controversial. Here, by utilizing in vivo phasic and basal electrochemical monitoring of extracellular dopamine with fast-scan cyclic voltammetry and multiple-cyclic square wave voltammetry and ex vivo fluorescence imaging of dopamine with GRABDA2m, we demonstrate that MAO-A, but not MAO-B, mainly contributes to striatal dopamine degradation. In contrast, our whole-cell patch-clamp results demonstrated that MAO-B, but not MAO-A, was responsible for astrocytic GABA-mediated tonic inhibitory currents in the rat striatum. We conclude that, in contrast to the traditional belief, MAO-A and MAO-B have profoundly different roles: MAO-A regulates dopamine levels, whereas MAO-B controls tonic GABA levels.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333267/

Second study

GABA is the major inhibitory transmitter in the brain and is released not only from a subset of neurons but also from glia. Although neuronal GABA is well known to be synthesized by glutamic acid decarboxylase (GAD), the source of glial GABA is unknown. After estimating the concentration of GABA in Bergmann glia to be around 5–10 mm by immunogold electron microscopy, we demonstrate that GABA production in glia requires MAOB, a key enzyme in the putrescine degradation pathway. In cultured cerebellar glia, both Ca2+-induced and tonic GABA release are significantly reduced by both gene silencing of MAOB and the MAOB inhibitor selegiline. In the cerebellum and striatum of adult mice, general gene silencing, knock out of MAOB or selegiline treatment resulted in elimination of tonic GABA currents recorded from granule neurons and medium spiny neurons. Glial-specific rescue of MAOB resulted in complete rescue of tonic GABA currents. Our results identify MAOB as a key synthesizing enzyme of glial GABA, which is released via bestrophin 1 (Best1) channel to mediate tonic inhibition in the brain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259537/

BTW

High throughput Screening to Identify Natural Human Monoamine Oxidase B Inhibitors
Of the 905 natural extracts tested, the lowest IC50s [<0.07 mg/ml] were obtained with extracts of Amur Corktree (Phellodendron amurense), Bakuchi Seed(Cyamopsis psoralioides), Licorice Root (Glycyrrhiza glabra/uralensis), Babchi (Psoralea corylifolia seed). The data also show, albeit to a lesser extent, inhibitory properties of herbs originating from the mint family (Lamiaceae) and Turmeric, Comfrey, Bringraj, Skullcap, Kava-kava, Wild Indigo, Gentian and Green Tea. In conclusion, the data reflect relative potency information by rank of commonly used herbs and plants that contain human MAO-B inhibitory properties in their natural form.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521852/

@Melora Manufacturer is legit; it has certificates and positive reviews. The product should be pure.
I plan to buy it soon. I also saw good reviews of it from fellow peaters on Twitter.

BTW
You can buy it directly https://sklep.biomus.eu/de/acetylsalicylsaeure/477-kwas-acetylosalicylowy-250g-5902409416220.html

@Butter-Girl said in Tucker Carlson Red Pills the population about the medical industry:

The majority is brainwashed. But I don’t see the majority (on all sides) wanting to become “un” brainwashed.

Yeah. Most people like to behave like majority (imitation). Change require people to use some extra energy. In the current energy-scarce society it's hard...
And usually people change because of desperation or inspiration... And current environment (elites) are trying to inspire people to stay the same dummy consumers... and also is keeping most people (usually one step away) from desperation...
In short practical terms anthropology says that people choose good if it require less energy than doing evil...

If you want to know more there is an excellent text/podcast about it, but in pretty heavy language... https://medium.com/@brixen/dave-snowden-how-leaders-change-culture-though-small-actions-766cd2bf5128

Hmn...

@oj Can't resist, sorry not sorry

You have all the needed sources within reach https://bioenergetic.forum/topic/4/ray-peat-resource-thread

@mavuue If your cortisol is elevated (probably is) it would be helpful to lower it too (together with estrogen).
https://testonation.com/2019/06/09/43-ways-to-lower-cortisol-that-work/

In general, the best approach is to focus on improving your overall health, especially metabolism with thyroid optimization (as others already mentioned).
https://www.youtube.com/watch?v=-FTOVRcUqTs

Stay away from reductionistic desperate steps like partially estrogenic Clomid or inconvenient HCG...

@StreamOfWater said in High DHEA, Cortisol, Prolactin and Cholesterol:

and I feel like it's damaging my body as a whole.

Yep, low thyroid / high cortisol may cause muscle wasting, fat accumulation, etc.

also looks like that my liver has a problem storing glycogen

RAY PEAT: “Thyroid acting partly through the liver helps to lower prolactin production"

https://raypeat.com/articles/articles/hot-flashes-energy-aging.shtml "One of the things progesterone does is to stabilize blood sugar. In one experiment, hot flashes were found to be increased by lowering blood sugar and decreased by moderately increasing blood sugar (Dormire and Reame, 2003). Hypoglycemia increases brain hormones, corticotropin releases hormones, CRH (Widmaier, et al., 1988), which increases ACTH and cortisol. CRH causes vasodilation (Clifton, et al., 2005), and is more active in the presence of estrogen. Menopausal women are more responsive to its effects, and those with the most severe hot flushes are the most responsive (Yakubo, et al., 1990). | The first reaction to a decrease of blood glucose, at least in healthy individuals, is to increase the activity of the sympathetic nervous system, with an increase of adrenaline, which causes the liver to release glucose from its glycogen stores. The effect of adrenaline on the liver is very quick, but adrenaline also acts on the brain, stimulating CRH, which causes the pituitary to secrete ACTH, which stimulates the adrenal cortex to release cortisol, which by various means causes blood sugar to increase, consequently causing the sympathetic nervous activity to decrease. Even when the liver's glycogen stores are adequate, the system cycles rhythmically, usually repeating about every 90 minutes throughout the day."

Haidut: The methods for increasing glycogen storage depend very much on the specific organism/person, but if you are interested in trying some new things the first option I would suggest is to get some pure fructose (or fruit juices like apples that contain mostly fructose) and use that as your primary source of sugar for several days. Fructose is supposed to be particularly good at building up glycogen storage. | On the supplement side, taurine is supposed to help with that, but the dose varies wildly from person to person for optimal effects. So, you have to try to find out what works for you. Typically, effective doses are 2g-5g a day. | Another supplement that Peat wrote about is uridine. Read The Problem of Alzheimer's Disease as a clue to Immortality Part 1 | Finally, if you are interested in trying drugs (after consulting with your doctor of course) an older antihistamine and anti-acid drug famotidine (Pepcid) is exceptionally good at inhibiting glycogen breakdown and promoting the synthesis of new glycogen. It is worth noting that famotidine is unique in its glycogen effects among the anti-acid drugs and unlike other drugs it has no known interaction with any other drug or any known effects on liver health or metabolizing abilities. So, you could use that while loading up on sugar. Famotidine is helpful for several conditions completely unrelated to stomach acid such as schizophrenia and PTSD. A probable explanation of those benefits would be due to the drug improving glycogen storage/usage and thus improving brain energetic profile.

I'm very happy for you that you are doing better. Did you dig yourself out of it?

I spent a lot of time researching and healing my soul/psyche and body. I'm almost at the right spot, but the legal availability of some drugs (prescription only) is the thing I still need to overcome...

@yerrag said in Bioenergetic AI Labs: The future of Ray Peat's legacy is already set:

I have for now only my own thought processes to guide me in my own expectations from AI. I can only think of it as extremely useful as uncovering concealed dots which I have overlooked, leaving me to spend more time connecting the dots in search of solutions where cause and effect is brought back from exile in the current orthodoxy of academia and science.

I'm with you. I often use peatbot to find extra info. However, it is worth emphasizing that LLM can also serve us faulty dots...

@existence said in Help with EU Sources:

Does someone have a source for Novothyral without the need of a prescription that ships from within the EU?

I would like to know this too...

My thyroid package from https://pharmapct.to/ has been recently seized by customs in Poland

Permanent surveillance... I hate this fucking authoritarian paternalistic rigid culture/state...
(Sorry guys, I needed to vent...)

@Amazoniac Thank you for the comprehensive information!!

And Hail Satan! i.e. Hail Phosphorus I meant...

@sharko said in Bioenergetic AI Labs: The future of Ray Peat's legacy is already set:

A few examples out of maybe 100: for a year I would wake up every day after exactly 5 hours with massive chest pains and crazy sweating, along with hand tremors for 15 years, tingling all over my body and head, tics, neurological problems, manic depression, vision problems, severe stomach pains , 0 energy, crops and that's just the tip of the iceberg.

It doesn't prove anything, some issues may be easier to fix, some are more difficult, and sometimes it's just luck... or confabulation...

Will you take responsibility, that someone asking your "favorite toy" for advice may die because your "AI" miscalculated a statistic between words...?

@sharko said in Bioenergetic AI Labs: The future of Ray Peat's legacy is already set:

I don't ask AI a question, get an answer and say thank you. I check everything 100 times, fix it and improve its understanding as I go. In the end, I'm still learning at a speed 100 times more than it would have taken me through Google (as someone who has been an expert in Google search for over 25 years and of which 15 years as an seo expert who knows exactly what to choose from all the top false results and how to find the more correct answers).

Will your "AI" do that? Will ask a user to check different sources, think about different approaches, ask a user to experiment, ask a user to think of the context of an unhealthy condition and what preceded it?

And a key question: what is the chance that your ego is bigger than your knowledge?

@sharko said in Bioenergetic AI Labs: The future of Ray Peat's legacy is already set:

I will ask you a question:

Suppose you are researching according to the knowledge of Ray Peat but you do not have a basic understanding of human physiology and biology, how long would it take you to understand the picture if you were to read all of Ray Peat's information and at the same time learn basic things about human physiology and biology through Google, Pubmed, etc. and how long would it take you if you used an AI that contained all the knowledge that Ray Peat published, along with a lot of additional knowledge and unlimited access to research?

Sorry, but with all the respect, you are making the same mistake over and over...

The theory of cognitive Predictive Processing claims that "People don't see, what they do not expect to see". You seem to be a great example of it...

Wisdom isn't about (the speed of) information processing.
It is about the process of continuous sense-making... (learning, exploration, probing, understanding/framing, analyzing chunks, synthesizing contradictions, contextualizing, refining, questioning assumptions, epistemic humility, etc.)

If one does not have a basic understanding of human physiology and biology (not to mention ontology, epistemology, phenomenology, and axiology) then one shouldn't even approach this field, or one may get seriously hurt...

Moreover, you seem to assume that all knowledge sources are equal and rational. And that a person is asking the right question...

Knowledge is like a forest - each component (trees, fungi/Mycorrhiza, insects, soil, rain, sun, prey/predators, season) and their relationships are important! But you seem to be only interested in counting kilograms of wood...

One should know [before] that a body is an ecosystem of interrelated components with synergistic effects, feedforward/feedback loops, allostatic/homeostatic mechanisms, etc. That most substances/substrates and their effects are context- and path-dependent. Also, understand what is the current problem with peer-reviewed publications. How to differentiate between a paper written with a reductionistic approach or a systemic (holistic one). What is the problem with p-values... And this is only level one...

Have you ever heard about Popper, Kuhn, and Lakatos, and how they define a theory, a paradigm (change), and the process of gaining understanding in general?

And all the points above are just the tip of the iceberg of scientific Knowledge Management...

You want to offer definitive answers in a non-definitive universe... This will not end well...

What you propose is a reductionistic point-based (not systemic) information stripped from all dependencies - we already have it in the mainstream and this is a key problem! What you propose is the opposite of what Ray was for...

If you were to ask an AI agent that is capable of performing several processes one after the other in response to a prompt, connected to a Vector DB containing chunks of 3,000 words and structured so that it is possible to quickly retrieve the 5 chunks most relevant to the user's prompt, after being filtered and improved by gpt-4o and returning An answer after analyzing 15,000 words with the most relevant content of all the knowledge Ray Peat published in a clear language of your choice, checking it against relevant external information and information he was trained on by gpt-4o

It's just soulless/blind information mining...

Where is Perceive-Think-Act?

@yerrag said in Bioenergetic AI Labs: The future of Ray Peat's legacy is already set:

Thanks for sharing these ideas. Did you learn these concepts by self-study? Or did these come from a liberal arts education that are similar to Peat's that give such a perspective?

A mix of... partial education in liberal arts plus self-study thanks to some wise people sharing their insights online/books... Plus recently reading/learning from Ray's works (I miss him so much...) helped me to add another dimension... but I'm still learning and I'm open to dialogue

BTW I also received professional training in advanced sense-making and Complex Adaptive Systems.

Can you be more constructive rather than talk down then as if you want to give a lecture more than help Sharko make his efforts of using AI to help us gain a better understanding of Ray Peat's work?

Yeah, you're right, my bad. I may try... but both sides need to be more open-minded...
Honestly, I'm pretty frustrated with the IT guys claiming unfoundedly that they have a panacea or they are helping the world... When in reality they are unaware (WEF/neoliberal?) agents of destruction/idiocracy (i.e. Moloch)...

In my imagination I'm with John Connor, Morpheus, and Butlerian Jihad - fighting the machines!

BTW I tried to be nice to Sharko at first...

Full disclosure - in the ancient past I also worked in roles of IT database developer/Analyst or IT project manager and I was a technology fanboy.

But I may be wrong in not giving you and T-3 enough credit as really I can see some effort to be constructive, and that Sharko's responses to you may not hit the right notes with you, though I get the sense that he is more about explaining the possibilities and potentials if AI, than in addressing the points you raised.

Right, it's good to use/explore possibilities and potentials, BUT one also must be aware of (many) limitations...

LLM can help us find something, but such info must not be seen as a conclusion, but only as an input for further conscious processing with the help of the scientific method and creativity...

But let's continue the diacussion giving Sharko a chance to answer Kvirion's points, and if Kvirion's points are not sufficiently addressed in the current prototypical stage, then we have to consider the likelihood of improving the AI model instead of prejudice it based on previous attempts of AI thst failed.

Golden advice, I'm for it.

@StreamOfWater said in High DHEA, Cortisol, Prolactin and Cholesterol:

I conducted the blood test myself so I could select the markers based on recommendations from Ray and Danny. I took my blood at 8:30 AM, and based on my symptoms, my cortisol and adrenaline levels are often high. My vitamin D levels were indeed low, but I took 300,000 IU within a month, so that should be fine now.

This is good, maybe next time try morning and evening cortisol as this may be a useful diagnostic tool.

Wikipedia: "Studies on people show that the HPA axis is activated in different ways during chronic stress depending on the type of stressor, the person's response to the stressor, and other factors. Stressors that are uncontrollable, threaten physical integrity, or involve trauma tend to have a high, flat diurnal profile of cortisol release (with lower-than-normal levels of cortisol in the morning and higher-than-normal levels in the evening) resulting in a high overall level of daily cortisol release. On the other hand, controllable stressors tend to produce higher-than-normal morning cortisol. Stress hormone release tends to decline gradually after a stressor occurs. In post-traumatic stress disorder there appears to be lower-than-normal cortisol release, and it is thought that a blunted hormonal response to stress may predispose a person to develop PTSD.["

@StreamOfWater said

I previously researched the HPA axis; it's quite complex. I ordered Cabergoline a few weeks ago (it still needs to arrive) and will try it to lower my prolactin levels. Perhaps it will help steer my health in the right direction.

High prolactin is usually a symptom, not a cause. Cabergoline may offer some temporary relief, but most probably will not solve the key issues.

It would be good to consider that you may have some genetic sensitivity/proclivity for high stress (hormones). Plus you probably experienced some prenatal/childhood/adolescent (chronic/mild?) stress, which created mutually upregulating feedback loops... i.e. you may be in a permanent state of fight or flight mode... It may be hard to get out of it...

An optimal solution would be to address simultaneously biological, environmental, and psychological negative factors step-by-step.
You may start with a careful analysis of the following Wiki article, it's pretty
comprehensive and helpful... https://en.wikipedia.org/wiki/Hypothalamic–pituitary–adrenal_axis

@StreamOfWater said

If you want to know more about me you can just ask me. I appreciate your knowledge and assistance.

Happy to help, I dealt with somewhat similar issues in the past. I know the hell/maze of doctors telling you that you're ok, but you are obviously not feeling right...

@sharko You really don't get what @T-3, @Peatful, me, and others are trying to explain to you, do you?

Maybe because you don't know what you don't know i.e. you're probably affected by Dunning–Kruger effect...

Your convictions/claims are mostly false, because of

1. Epistemology:
   LLMs are only capable of partial deductive and inductive reasoning in statistical ways.
   They are unable to perform Creative (innovative/inventive) thinking i.e. abductive reasoning (e.g. "logic of hunches") - this is a scientific fact.
2. Ontology:
   LLM's algorithms are linear and statistical, limited by datasets i.e. closed IT systems. But the human mind is a nonlinear, interrelated, adaptive, partially quantum open complex ecosystem. This is a big difference.
3. Phenomenology:
   A human mind operates with a sense of self-awareness and intentionality, we perceive, think, and act, etc.
   LLMs lack consciousness and intentionality. They generate responses based on patterns in the data they were trained on, without any subjective experience or self-awareness. Their outputs have no underlying intention or purpose; they just produce statistically probable text.
   Moreover, human cognition is deeply embodied. Our thoughts and experiences are influenced by our physical bodies and sensory inputs. Emotions, physical sensations, and the environment play critical roles in shaping our mental states.
   We are emotional and adaptable - continuous/dynamic improvement (or regress); can also reflect, and see things from different angles (at least some of us). LLMs do not.
4. Axiology: LLM doesn't get ethics...

Plus basics of Knowledge management: people can think more than they can say, and they can say more, they can write...

So, "AI" can help us find some useful info, but can not bring new ideas.

@StreamOfWater Yeah, family doctors are usually simply trained to follow procedures and not "overthink".

I wouldn't trust the normal ranges on blood tests, they are just averages of results done by usually sick people...
There is a fascinating book about it https://drgabormate.com/book/the-myth-of-normal/

BTW Regarding the cortisol test - a proper one should have morning and evening values... your doc screwed this up...
Vitamin D3 levels are also below optimal values...

If I may suggest, it would be good to analyze your whole Hypothalamic–pituitary–adrenal axis - i.e. the main conductor of stress hormone synthesis...

Maybe you will discover which part of this axis makes trouble itself or is influenced by other parts of your body.
Your microbiota may also be problematic...

Maybe such systemic analysis may help you get unstuck...

You may also look for Ray Peat's interviews about cortisol.
Moreover, also check Haidut's interviews about it https://www.youtube.com/results?search_query=georgi+dinkov+cortisol - he struggled with high cortisol himself and has excellent knowledge about it.

You may also check this https://drgabormate.com/book/when-the-body-says-no/

@sharko said in Bioenergetic AI Labs The future of Ray Peat's legacy is already set:

also a little afraid that other people will acquire this knowledge and even more, in 1/1,000 of the time

LOL! This advertisement is getting embarrassing...

A living person can add context to a situation to reinterpret it, synthesize opposing views, etc. LLMs can't.

BTW