Posts made by Kvirion

@alfredoolivas Yeah, I see your point.

I guess it would be better to exchange the category name for "mediators" - ones who don't like their friends fighting each other and try to establish consensus or mutual understanding. This will fit more with empathy.

But this is one of my reservations about this study - categories seem to be too broad... too generalized.

Or maybe this study should be seen just as a study of dating sites'' members nothing more...

I tend to see noticable kindness as a bad first impression when I meet someone.

This may be highly context/culture-dependent...

@alfredoolivas Yes, this is a good one!

But for example, I doubt the estrogen category, the study would do probably much better with progesterone instead.
I would probably also exchange Testosterone type with the T to DHT ratio... etc.

@lobotomize-me Nice find, thanks!
So, some next experiments before me...

@jamezb46 said in Estrogenic, Androgenic and Progestogenic People:

I actually think that there are some observable characteristics that can give some indication of at least some of those hormones. For example, the 2D/4D digit ratio test for pre-natal testosterone exposure.

There was a (quasi-?) scientific attempt to approach a similar topic: https://helenfisher.com/personality/ - I may have some/many doubts about the methodology, but still I think the author at least tried to do her best...

@Mauritio said in Holy Basil: Phyto-TESTOSTERONE, Progesterone and thyro-mimetic ?:

@Kvirion you do you . For me it certainly didn't feel like it raised prolactin , quite the opposite.

Yep, right. Context matters
Therefore Perceive. Think. Act. is a bit different for everyone.

@Mauritio said in Holy Basil: Phyto-TESTOSTERONE, Progesterone and thyro-mimetic ?:

@Kvirion do you have any reference for it increasing prolactin in vivo ?

Sweeti basil is a galactagogue and galactagogues increase prolactin...

Some of the studies I posted above used sweet basil and it drastically increased testosterone which is unlikely if it increases prolactin...

Maybe an increase in progesterone overcomes prolactin, or maybe the antiinflammatory actions of basil help with the production of testosterone.

This is too complicated and unreliable mode of action for me. Therefore not worth trying - at least for me..

@wester130 said in Estrogenic, Androgenic and Progestogenic People:

nothing I said was scientific, they are observations.

Science is simply about how to better observe and how to draw better conclusions...

And yes, there is no science in your initial conclusion/categorization - just poor judgment...

This forum is devoted to Ray Peat, who was very wise, scientific, and prudent in his conclusions. Please behave accordingly.

@Mauritio said in Holy Basil: Phyto-TESTOSTERONE, Progesterone and thyro-mimetic ?:

sweet basil

Sweet basil seems to be a galactagogue, i.e., it promotes lactation in humans and other animals, i.e., increases prolactin—therefore, I wouldn't touch it with a proverbial stick.

Just a field report...
I tried Holy Basil today. I didn't notice much effect.
Probably, some anti-inflammatory (maybe TSH lowering one?) and a bit cortisol/adrenaline lowering one, but since I have my cortisol pretty under control this wasn't any significant change.
No change in body temperature or libido.

@bigdeuce Take all the good advice provided in this thread, just start small and don't stop.

Maybe just start with doing some meal/food experiments, finding/reading interesting books, going to new places, etc. Then learn how to get more CO2 with bag/Buteyko breathing

Also, read/learn how to lower stress in peaty ways:
https://www.functionalps.com/blog/2014/05/25/stress-a-shifting-of-resources/
https://raypeatexplained.com/ray-peat-on-stress/
https://raypeat.com/articles/articles/gelatin.shtml
etc.

"To live is to suffer, to survive is to find meaning in suffering" - Friedrich Nietzsche

@wester130 Let's be a bit scientific...

• What's your background/CV?
• What are the scientific premises for this list?
• How have you been verifying/testing your hypothesis?
• Why do you think that your observations can be universal?
• What is the difference between typology and taxonomy
• What about ratios between those hormones?
• What about adding cortisol to the mix?
• What about the neurotransmitters?
• Finally, what about the thyroid hormones?

Please provide answers without looking at google/chatgpt/etc.

@Corngold said in Donald Trump defies the laws of aging. An obese, garbage food eating insomniac conquered the world at 78 (politics aside):

Humanity is about humanity in the literal sense of the word "about." But language is not about language. We have to understand that people are using language and thought, and that is what is shaping language and thought, which makes language "about" language.

It's rather about a discourse.
"Discourse determines how knowledge is formed, legitimized, and applied in society. It limits what is thinkable and unthinkable, visible and invisible, normal and deviant."

Moreover, tamed people most often reinforce certain discourses and build tools (e.g. Facebook or cryptocurrencies) that support them. And then they tame people even more... I.e. there is a constant interaction between people (culture), tools, and narratives with various feedback loops between them...

In other words, Heidegger is writing for a particular time and place. He should be read more like a novel or a painting.

Yep. BTW Why are these ancient German old farts still being squeezed?
Currently, we have far better interpreters of reality like for example Mexican Miguel DeLanda or Korean-German Byung-chul Han...

@Mauritio said in Random, interesting studies:

Estrogen seems to be necessary to some degree.

“Estrogen’s name, derived from the gadfly, accurately suggests its role as an excitant, getting things started. Progesterone’s name, relating to pregnancy, is compatible with thinking of it as an agent of calming and fulfillment. But these properties show up in every aspect of physiology, and the special cases of female estrus and pregnancy can be properly understood only in the larger context, in which, for example, progesterone is a brain hormone in both sexes and at all ages, and estrogen is an essential male hormone involved in the sperm cell’s function and male libido.” ~Ray Peat, PhD

https://www.functionalps.com/blog/2012/07/05/menstrual-cycle/

From https://raypeat.com/articles/articles/milk.shtml

"Milk with reduced fat content is required by US law to have vitamins D and A added. The vehicle used in the vitamin preparation, and the industrial contaminants in the “pure” vitamins themselves, are possible sources of allergens in commercial milk, so whole milk is the most likely to be free of allergens.
A thickening agent commonly used in milk products, carrageenan, is a powerful allergen that can cause a “pseudo-latex allergy” (Tarlo, et al., 1995). It is a sulfated polysaccharide, structurally similar to heparin. There are good reasons to think that its toxic effects are the result of disturbance of calcium metabolism (see for example Abdullahi, et al., 1975; Halici, et al., 2008; Janaswamy and Chandrasekaran, 2008)."

Plus: https://raypeatexplained.com/ray-peat-on-milk/

@LinDaiyu wrote:

The more Skim milk I drink the more thirsty I become. What's going on there? Why can't Skim milk quench thirst like it should?

@LinDaiyu, maybe you don't drink enough of it, e.g. maybe your diet lacks enough fat (most people thrive on 15-20% fat in diet), or maybe your body wants more carbohydrates or more calcium, etc. Or there may be many other factors. Hard to say without knowing all details/context. Therefore, there is a job for you: Perceive. Think. Act.

@herenow

LA TIMES
"Cheese really is crack. Study reveals cheese is as addictive as drugs"
...During digestion, casein releases opiates called casomorphins

LOL! What a BS...

1. Casomorphins' content in milk/dairy is minimal
2. Only found in A1 cows' milk
3. Can be easily counteracted by coffee and OJ...

@jamezb46 said in High-Fat Diet Triggers Memory Decline Within Days:

I usually get about 2-3g per day for context. You will find the same gaslighting when it comes to studies "showing" that high saturated fatty acid diets cause inflammation. All of those "high SFA" diets are confounded by PUFA.

Good point. But only a few look under the hood of such studies...

@Corngold

gotta wonder what the result would be if it was 90% saturated fat instead of 36%.

It should look better, but it is still far from perfect. 60% fat is not a healthy amount... I guess.

@ThinPicking said in High-Fat Diet Triggers Memory Decline Within Days:

This may be the therapeutic they're actually after.

Yeah, right - to some extend, if fats were all saturated.

@teenus Good point

So, high-fat diet: 18.3% calories from protein, 21.4% from carbohydrates, and 60.3% from fat (36% SFAs, 41% MUFAs, 23% PUFAs)

Full research paper https://immunityageing.biomedcentral.com/articles/10.1186/s12979-024-00496-3

Via Neuroscience News - in your face ketards

High-Fat Diet Triggers Memory Decline Within Days

A new study reveals that just three days of consuming a high-fat diet can trigger memory problems and brain inflammation in older adults, independent of obesity.

Researchers observed that aged rats fed a diet with 60% of calories from fat exhibited rapid cognitive decline, while younger rats remained unaffected.

Metabolic issues and gut health changes took longer to develop, suggesting that diet-related brain inflammation occurs before other health effects.

The memory deficits were linked to increased inflammatory markers in the hippocampus and amygdala, two key brain regions for memory and emotion.

This study challenges the assumption that diet-induced brain inflammation is primarily driven by obesity.

The findings highlight the vulnerability of aging brains to unhealthy diets and underscore the importance of nutrition in maintaining cognitive health.

Source: https://neurosciencenews.com/high-fat-diet-memory-aging-28469/ + https://x.com/NeuroscienceNew/status/1897761324693852345

@alfredoolivas said in Pro Metabolic Substances Tier List:

There were 7 medications on this list, that I recommended SOLEY based off of personal experience. 7. None are patented. I clearly said the others had drawbacks that I had experienced, and I don’t recommend them.

If you don't have an in-depth systemic understanding of how those products work, your recommendation can be harmful to others.

Pure scientism huh?

I'm just asking you to look deeper/different and question your assumptions.

And with all the respect, you @alfredoolivas still seem to focus on a single or a few variables instead of looking at the whole equation/calculus.

So my suggestion is: to look at how to facilitate the organism's phase-shift to a new better dynamic homeostatic state, than wrongly seeing single "receptors" as linear levers.

Your view on semaglutide is missing the secondary/tertiary effects of what it is doing and what it is not doing.
(in for example comparison to thyroid hormones)

BTW you may want to better look from the perspectives like those:

Ray Peat’s approach distilled to the key core: “energy and structure are interdependent at every level”;

Health issues are not meant to be addressed directly. You heal by simply out-nourishing the issue. Until it feels like all aspects of your life are improving in unison, you are not adequately nourished. It should feel like nothing can break your stride. The bioenergetic symphony. ~@natelawrence_

Martin Picard: Pharma is about suppressing. Healing needs nourishing and stimulating the right processes. We need a new Healing Science to understand how and when to stimulate endogenous forces that will sustainably promote healing in each person…

Let me be a peacemaker here

Both sides of the dispute in this thread are doing their best to prove their point honestly and diligently. Still, unfortunately, one side's arguments (I'm talking to you @alfredoolivas) are based on a deprecated limited paradigm or simply reductionism (AKA scientism or logical positivism).

However, Ray Peat's research was based on a different broader/deeper, i.e. holistic approach as described for example here https://raypeat2.com/articles/articles/adaptive-substance.shtml
Modern medicine is also starting to understand this fact/difference in its ways as described here https://pmc.ncbi.nlm.nih.gov/articles/PMC3498395/

The current discourse on clinical medicine is dominated by a mechanistic, deterministic, and reductionist world view and has much to gain by embracing the concepts in complexity science (CS).

BTW holism = complexity (CS)

So guys, please first embrace the differences between your paradigms, then fight...