Posts made by LucH

@GreekDemiGod said in How to restore glucose oxidation/ insulin sensitivity?:

I do know I have low bile output. Pale stools is probably because of that.

I'll take Betaine HCl at the evening meal (if with protein). Eat main meat at midday.
=> in order to optimize protein digestion.
If your stools are not uniform and contain undigested fats , I'll take Enzymedica Lypo Gold (with high fat enzymes). When the stools contain excess fat, they are light, soft, bulky, oily and have an abnormally smelly appearance
Fats between 15 - 30 %. Optimal at 20 % if problem.
Note: Coconut oil is easier to digest than other fats. Progressively, otherwise it will be laxative.

Crohn disease
The main clinical signs are abdominal pain, prolonged diarrhea, the emission of bloody mucus, a possible palpable mass in the right iliac pit, moderate fever, asthenia and weight loss. Biologically, there is an accelerated ESR, increased CRP (reactive Protein-C), light anemia, leukocytosis with polynucleosis and hypo-albuminemia.
Note: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are two markers in the blood that measure levels of inflammation.
For JS, Crohn's disease has a mechanism similar to that of colitis. The severity of the Crohn’s would be due to a difference in the waste to be eliminated, perhaps a stronger quantity, often a more complex structure. The activation of several varieties of leukocytes and the secretion of multiple pro-inflammatory cytokines cause the release and activation of matrix metaloproteinases which degrade tissues, which can generate fistulas, cracks, large abscesses and fibrous strenosis (Shanahan 2002).
The proportion of various cells and cytokines in the infiltrate suggests a much more inflammatory than immune response (Mac Dermott et al. 1993), which is corroborated by the absence of association between Crohn and HLA and the ineffectiveness of the Ciclosporin which reduces the immune response in vain (Sandborn 1995). Crohn’s is related to the pathology of elimination and not to autoimmunity. Crohn’s is for Seignalet a giant colitis, a multifactorial pathology (bacteria and food).
In Crohn's disease, certain foods have awakened certain symptoms (diarrhea, pain), even a simple exclusion diet would have put these symptoms under the nod: it is interesting to note that cereals, milk and some cooked products appear frequently challenging for patients. And JS cites case studies carried out on his patients.
The results
The hypotoxic diet has been implemented in 99 cases of Crohn’s, but he will only retain the 72 patients for whom the decline is more than one year. The results are 62 frank success, with complete or almost complete remission, 9 more nuanced results and one single true failure. JS comment
Nutritional change can remove ulcers, micro-abscess and inflammatory granulomas; in short, the inflammatory process characteristic of the Crohn’s. But it can do nothing against certain definitive lesions, such as cracks, fistulas, macro-abscess and fibrous stenosis.

@yeehawyinzer said in Crohn's Disease Drugs:

What are some alternatives to consider from a Bioenergetic lense?

Crohn's disease or irritable colon (IBS): how to soothe and get out of it?

Crohn’s is related to the pathology of elimination and not to autoimmunity. Crohn's disease has a mechanism similar to that of colitis, with high levels of inflammatory cytokines, but not correlated with HLA failure (genetic reaction).
Jean Seignalet (deceased in 2002, immunologist) has treated several Crohn’s: The results are 62 frank success, with complete or almost complete remission, 9 more nuanced results and one single true failure.
In this article, we’ll see that exclusion diets were effective to improve leaky gut (intestinal permeability), what kinds of food are beneficial and which substances to optimize homeostasis.
See original post (in French):
https://mirzoune-ciboulette.forumactif.org/t2023-maladie-de-crohn-ou-colon-irritable-ibs-comment-apaiser-et-sen-sortir#29501
Irritable colon syndrome is a functional gastrointestinal system disease. Thus, unlike Crohn's disease, no change in the structural level is present, it is rather the function of the digestive system that is altered.
Jean Seignalet (immunologist) talked about colitis, also called spasmodic colopathy, irritable colon (IBS) or functional colopathy. With an IBS we often meet an abdominal bloating, transit disorders: constipation, diarrhea or alternation of both. The colopath is often tired, sometimes even anxious or depressed, prey to various discomforts (…).
In this type of colopathy Nanda and Coll. (1989) found that exclusion diets were effective in 47 % of patients, and that many subjects were able to identify dangerous foods. With a decline of one year, the benefit is maintained. I quote Jean Seignalet, in L’Alimentation ou la 3ème Médecine – &28 : Pathologie d’élimination – - 5th edition book:
“Certainly foods have a major responsibility in colitis, but not by an allergy or intolerance mechanism. The disease is not due to the assault of the colic mucosa by a poorly tolerated food. Raws and fruits are only triggers of crises. They are only dangerous because the colic wall is the seat of permanent inflammation. It is therefore we must find the root cause of the inflammation in order to treat it. Only an etiological treatment can be able to cure a colitis.”

Inflammation of the colon wall (inner lining)
Some patients have often been offered a treatment oriented towards psychopathy – it happens in the head at first time – by modulating the diet with a few common sense prescriptions (eating homemade, Mediterranean style), as soon as the inflammation of the intestinal walls will allow it ...
Inflammation – not an autoimmune reaction – is due to the assault of the mucosa by one or more poorly tolerated food, not by an allergy or intolerance mechanism. The disease is not of psychic origin, either. The fatigue and signs of anxiety are only the consequence of a mined ground. The motility is altered and the sensitivity of the colon is exacerbated. Otherwise expressed, these are symptoms of the colitis we have there.
For Jean Seignalet, this is the most likely observation, confirmed by the following analyzes: this inflammation is demonstrated by the excessive presence in the colic wall of various varieties of leukocytes, in particular mastocytes, macrophages and T lymphocytes (Fioramonti et al. 2001) (Barbara et al. 2002).
Similarity with Crohn: intestines hypermeability (leaky gut)
The attack on the mucosa of the intestines through modern diet and certain dangerous bacteria it promotes, the leaky gut with passage of bacterial and food macromolecules, this causes a permanent blood infiltrate. Drugs should not be given to slow down digestive transit, but on the contrary let this flow expurgate the body of its waste.
It is therefore logical to propose an original type diet, by promoting raw products and not cooked products, unlike certain conventional medical practices, as soon as a lull of inflammation of the intestinal walls will allow it. The patient will have to adapt in a 1st step and select what is most easily passed. It is a question here of adopting a coordinated approach: to calm the exacerbated sensitivity, then orient the type of food at the 1st stage of the remission to then gradually increase the tolerance of the intestinal walls.
X
Intestinal permeability (leaky gut)
In Crohn's disease there is a mechanism similar to that of colitis, but more complex. The Crohn’s evolves frequently by successive thrusts, separated by sometimes complete, often incomplete remissions.
Before speaking in more details of Crohn's disease, I need to highlight a common point between Crohn and IBS: leaky gut.
Zonulin, a marker of intestinal permeability
Zonulin is a protein that regulates the permeability of the intestinal wall by acting on the tight junctions between the cells. (1) Its role is to allow the passage of certain molecules necessary for the body, but to block undesirable substances such as bacteria or toxins. However, zonulin can be disturbed by genetic, environmental or food factors, which leads to an increase in intestinal permeability and stimulation of the immune system.

Among the foods that can increase zonulin production and therefore promote intestinal hyperpermeability, we find in particular (2):

• Casein (milk protein)
• Gliadin (gluten)
• Potatoes, especially young potatoes, or potatoes in shirts.
• Peppers
• Tomatoes
• Lectins (proteins present in legumes, cereals, shell fruits, etc.)
It is therefore advisable to avoid or limit these foods if one suffers from excessive intestinal permeability. There are also zeolite-based food supplements that can help restore the balance of the intestinal wall and eliminate harmful substances.
Beneficial foods and substances

• The butyrate
  The butyrate, a short chain fatty acid, has beneficial effects on the health of the colon, strengthening the intestinal barrier, modulating the immune system and preventing inflammation. The indicated dosage of butyric acid is on average 300 to 600 mg / day in a 3-month cure. Butyrate is found in appropriate quantities (> 3 mg / 100 gr) in the butter / ghee. See julienvenesson.fr later to deepen "sensitivity" to gluten, endocrine disruptors and associated pathologies, such as neurodegenerative diseases (MS, depression, autism, hyperactivity, etc.). + an overview of nutraceutics.
  Practical question
  In the event of inflamed intestinal walls (IBD), apart from the curcumin and lemon balm (Melissa officinalis), what could calm the irritation of the intestinal walls to make it possible to ingest mixed sweet fibers (shaker) with cooked foods? And not a classic NSAID, which will not extend the taking, if necessary.
• Zeolite
  Zeolite is a natural mineral that has detoxifying and anti-inflammatory properties. It can help strengthen the intestinal wall and reduce intestinal hyperpermeability, which is linked to many chronic diseases (3).
• Homeopathy
  There are several homeopathic remedies that can relieve abdominal pain, diarrhea, bloody stools or spasms related to MICI. Note that we are not trying to stop the transit but to modulate it because it is necessary to let out the circulating toxins. For example, in case of cramps with spasms, Colocynthis 4 hp (if the pain improves by being folded in half or with a hot water bottle) or Dioscorea villosa 5 hp (if the pain is improving while hiding back, improved pain in extension and walking, or leaning back).
  Sources et Références

1. Zonuline – définition & rôle
   fr.wikipedia.org
2. Aliments favorisant la production de zonuline
   santedigestion.com
   labo-barla.eu
   carolinenaturopathe.ca
3. La zéolithe
   https://www.biogena.com/fr-FR/savoir/zeolithe.html

To be continued on next page

Hi
I would track Chrome (a tiny amount, otherwise it’s counterproductive) and add some inositol too (sensibility improved).
We lack magnesium. 450 mg. Magnesium bisglycinate.

When eating carbs, potassium would be helpful for managing insulin response.

As RP said, sugars only count for 8 % in the insulin reaction. Typed food as Mediterranean is advised, or similar (blue zone).
Need 20-25 mg vitamin E to neutralize PUFA. 1% maximum targeted for Jaminet (Perfect health diet.) but it’s too high for me (22 gr). 6-10 gr is enough, if you balance with SFA (coconut oil).
To optimize insulin response (often too high), I’d read the book of Jessie Inaupsché (JI) (Glucose revolution).
According to JI the first meal is the more important to help regulating insulin. Proved.
=> Fibers first, then protein with fat, and carbs at last.

You said your insulin response is not optimal: It needs to be more precise:

• Muscles are overburden by fat and more insulin is needed to do the same job. Probably not by what I’ve read.
• What about the low-grade inflammation? (HbA1c must be under 7, optimal at 5 if you’re over 50 years old) (Glycated hemoglobin).
• How is your pancreas? Enough bile to digest fat well? Enough insulin secreted?

One of the main coffee polyphenols is chlorogenic aid, which improves insulin sensitivity and blood sugar control. (Pr. van Dam). No more than 3-4 cups 125 ml (400 mg caffein). 3-4 hours between each cup (5 hours maximum for managing impact on stress).
These polyphenols also help reduce inflammation and increase the production of proteins involved in the repair and protection of cells, especially in the liver.
Some cinnamon powder could help to but too much of a good thing is bad (powerful polyphenols), but not if you lack insulin (hypoglycemic).
Walking 20’ after a meal help managing glycemia, in case of excess carbs (> 50% calories).

If dysbiosis, unbalanced microbiota counteracts the glycemia gestion.

Gut microbiota modulates neurobehavior through changes in brain insulin sensitivity and metabolism. (Soto M, Herzog C et al. doi: 10.1038/s41380-018-0086-5).
Probiotics, L-Gasseri in particular, make it possible to restore an intestinal flora, with better management and metabolization of fats and sugars, and fight against the transformation of choline into trimethylamine then TMAO which is a pro-inflammatory and atherogenic molecule, particularly dangerous for people predisposed to cardiovascular disease and atherosclerosis.

It’s not because your BMI is under control (< 25), you don’t suffer from poor arterial state. I’d take some K2 MK4 twice a day, with b-caroten from vegetable (pumpkin soup and carrot salad), with fat added to optimize assimilation.

Useful info (translator needed but with study links in English)

• Role of Vit K in the calcification of tissues. How much vit D?
  https://mirzoune-ciboulette.forumactif.org/t661-calcification-des-arteres#5876
• Vitamin E and peroxidation of membranes
  https://mirzoune-ciboulette.forumactif.org/t642-vitamine-e-et-peroxydation-des-membranes#5645
  Membranes protection (see figure)
  Beta-carotene, astaxanthine and vitamin E protect the membrane against the aggressions of radicals free of oxygen (AO on the diagram). They have a lipophilic tail and can therefore penetrate the membrane. Vitamin C is not lipophilic and only protects the outside membrane, in addition to having a savings effect on other antioxidants.

@noodlecat59
If your can't read between the lines, I"ll say it in another way.
Yes, there is a problem if you do what I told.
Too much toco.
You can't take k2 without a full meal with enough fat.
Bye, see you in another life.

I hope there is ten least 2 tocopherols; otherwise it's a problem.
No need to take 400 UI vit E every day. Too much of a good thing is bad.
K2 must be taken with a lot of fat: 35 g to optimize the assimilation, with some MUFA.
And if you take K2 without appropriate Ca (850 mg /day) you'll get problems with PTH.

Hi,
What about your vitamin D intake, there is interaction between the liposoluble vitamins.
And PTH in influenced by ca absorption. 850 mg Ca is optimal (depending on the acido-basic balance).
Here is some info to optimize assimilation.
*) Vitamins A, D, E & K – How much lipids do we need to absorb vitamins A D E?
http://suppversity.blogspot.be/2014/05/vitamin-d-e-k-how-much-and-what-type-of.html
Vitamin A (retinol) + beta-carotene : 3 to 5 g.
Source: A Fat D-Ficiency
http://suppversity.blogspot.be/2011/12/fat-d-ficiency-do-you-really-need-more.html
Vitamin E: 3 g but a PUFA-diet exhausts toco- and trienols (latent inflammation).
Vitamin K (K1 and K2): 35 g
The quantity of phylloquinone (K1) which enters your blood circulation will be reduced by around 70% if you eat your spinach without a supply of fat (Gijsbers, 1996). The absorption of K2 is 3 times larger with 35 g of lipids in the meal than with 20 g. 6 x less with 8.8 g of FA. (Uematsu et al. 1996). However 18-20g and 12-15g of PUFA are consumed daily by the American man and woman (Kris-Eheton, 2000).
Vitamin D : It is the type of fat that will determine the degree of assimilation. Oil-rich in PUFA inhibit the absorption of 25oHD vitamin. (Niramitmahapanya et al. 2011). An oil with an AGMI ratio: AGPI > 1, like sunflower or soybeans, is deleterious.
Caution: If you have a high supply of PUFA (omega-3 supplementation or oilseed consumption, with the exception of macadamia nuts which are very rich in MUFA), the blood rate of Vit D and E will often be very low because these 2 vitamins also have an anti-inflammatory action and will therefore be hijacked / diverted from their use as hormones. Details on my forum (in French, but with links in in English):
http://mirzoune-ciboulette.forumactif.org/t1357-vitamines-liposolubles-et-matiere-grasse-ratio#15157
*) Synergy effect with vitamin E
“Vitamin C regenerates vitamin E and vitamin E protects β-carotene, helped in this by polyphenols. In the event of β-carotene supplementation, vitamin C regenerates vitamin E and β-carotene, and β-carotene seems to protect vitamin E without really explaining this phenomenon "(1)
Savings effect
Vitamin E is not just a vitamin. Vitamin C makes it possible to recycle oxidized vitamin E and thus prolong its lifespan. The same goes with glutathione which is thus saved for other more useful functions (detox). Glutathion is our antioxidant master. Vitamin E protects against the deleterious effects of polyunsaturated fatty acids when the latter are in excess. And it is quickly done!

1. John Libbey Eurotext - Anti-oxydants d’origine alimentaire : diversité, modes d’action anti-oxydante, interactions. Auteur : Claude Louis Léger.
2. Daniel Raederstorff et al. Br J Nutr. 2015. doi: 10.1017/S000711451500272X
   => 20 mg Vit E for 10 gr PUFA.

Factors that facilitate or counter the absorption of vitamin D3
http://mirzoune-ciboulette.forumactif.org/t1664-absorption-de-la-vitamine-d-insuffisante#20619

• A Magnesium intake neither too high nor too low (RDA Mg: 360 and 420 mg depending on the sex f / m) is favorable. An excess of Mg will thwart the absorption of vitamin D3.
• Mono-unsaturated fatty acids facilitate the absorption of vitamin D (olive, avocado, macadamia, for example). Saturated fatty acids (SFA) are probably neutral, at this level. But since these SFA’s contribute to the stability of the membranes, we should take care to have a 50/50 ratio between SFA and MUFA. And as few PUFA as what is necessary for metabolism (1 % = 22 gr. It is already calculated widely. 4 % is the level not to be over. 6 % is deleterious). (Perfect health diet. Jaminet).

Targeting Dysbiosis (and leaky gut)
Two things:

• avoid fermentation and bacterial overgrowth
• Tight junctions are no longer operational. Low-grade inflammation and lack of glutamine (1/4 tsp glutamine 2x/d in a shake). Some B6 PLP would be helpful. Mind overdose. I’d take only 20-25 mg B6 PLP if brain sensitive.
  If bacterial overgrowth is suspected, I’d follow a strict protocol if you want to avoid a hide and seek game. It is illusory to want to kill all bacteria. We will strengthen the presence of certain resistant bacteria. Some bacteria will take refuge behind a biofilm.
  Tactic: we weaken, we ration, we estourbit / hammer and then we kill. Then we occupy the place. Nature hates an empty place.

Mind stagnation in the second part of the intestines when eating starches. Get informed on MMC (migrating Motor Complex):

The migrating motor complex (MMC) is an electrical and contractile activity of digestive motility which takes place in the inter-digestive periods (between two meals), and interrupted by food intake. Each MMC is accompanied by an increase in gastric, pancreatic and duodenal secretions. They are thought to serve to evacuate contents in the small intestine between meals, and also to transport bacteria from the small intestine into the colon. An alteration of this phase notably favors the development of chronic bacterial colonization of the small intestine, a source in particular of bloating, diarrhea, or even steatorrhea, of the majority of food intolerances. When contractile activity is low, we then speak of lazy intestines. Support and rehabilitation is often necessary, with a prokinetic (I took Resolor 0.5 mg), initially.
Mostlylurking thinks B1 could help too, in this case. Indeed.

Some target points to deal with

• B1 is needed for communication between the brain and the stomach (vagal innervation).
  High dose B1 is needed for passive assimilation, with staples. I’d take Mg bisglycinate every day (300 mg x 2 or x3, according to stress); and B2 50 mg (every other day, thrice a week). B2 is needed when taking B1.
• B1 for gut motility
  Dr Costantini and bacterial overgrowth
  SIBO, IBS, and Constipation: Unrecognized Thiamine Deficiency? – June 2020
  https://www.hormonesmatter.com/sibo-ibs-constipation-thiamine-deficiency/
  To understand how thiamine impacts gut function we have to understand the GI tract. The GI tract possesses its own individual enteric nervous system (ENS), often referred to as the second brain. (vagal innervation). Enteric neurons also use acetylcholine to initiate peristaltic contractions necessary for proper gut motility. Thiamine is necessary for the synthesis of acetylcholine and low levels produce an acetylcholine deficit, which leads to reduced vagal tone and impaired motility in the stomach and small intestine.
  => choline or glycine needed.
  For Dr. Constantini, a chronic thiamine deficiency can indirectly produce an inability to digest and absorb foods, and therefore produce a deficiency in most of the other vitamins and minerals. In fact, this is indeed something I see frequently. And sadly, as thiamine is notoriously difficult to identify through ordinary testing methods, it is mostly missed by doctors and nutritionists. To summarize, B1 is necessary in the gut for:
   Stomach acid secretion and gastric emptying
   Pancreatic digestive enzyme secretion
   Intestinal brush border enzymes
   Intestinal contractions and motility
   Vagal nerve function
  If I have problem to digest protein, Betaine HCL, at the evening meal. Digestion is optimal at midday.
  If I have problem to digest fats: Enzymedica Lypo Gold for fat digestion.
  Note: you’re not going to solve this kind of problem with 100 mg B1. Passive assimilation is needed when targeting High dose B1, in several staples, not only with B1 HCl. I can give a link for the protocol of Dr. Allil Overton, on my forum, if wanted (“mirzoune et ciboulette”)
  Dr. Overton says, when talking about Thiamine (nod need to listen to):
  https://www.hormonesmatter.com/talking-about-thiamine/
  “Thiamine (vitamin B1) is critical for the metabolism of food into cellular energy or ATP. Without sufficient thiamine, cellular energy wanes, and with it, the capacity to maintain the energy to function declines. Chronic, unrelenting fatigue is a common characteristic of insufficient thiamine. At its root, fatigue is the physical manifestation of poor energy metabolism.
  Why is this nutrient such a problem? Two reasons. First, B1 is the gatekeeper to energy metabolism and so if it is low, everything downstream gums up and does not work well. Second, modern diets, medicines, and other chemical exposures contain numerous anti-thiamine factors that derail thiamine absorption and metabolism. This pushes many people into states of chronic deficiency, one that is simple to correct if identified. Unfortunately, however, patients can go years before the deficiency is recognized.”
  Additional info
  Thiamine Deficiency - A Potential Cause of SIBO and other Gut Dysfunction?
  Elliot Overton – Nutrition and Functional Medicine – 2019
  https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo
• Thiamine deficiency - A consequence or cause of SIBO?
• How can thiamine deficiency cause gut dysfunction?
  Key points:
  Thiamine's key role in energy metabolism of the brain regions responsible for controlling autonomic balance, coupled with its role in acetylcholine synthesis, indicate that a deficiency could easily cause the symptoms which we associate with SIBO.
  The autonomic nervous system is involved in:
   Secretion of stomach acid, pancreatic enzymes, and brush border enzymes
   Release of bile from the liver
   Maintaining regular intestinal peristalsis (motility)
   Reducing intestinal permeability (leaky gut)
   Reducing inflammation

@wrl said in Endotoxin Inflammation Stack:

@LucH
Wouldn't it mainly be about promoting good digestion(rapide!)/stomach HCL/bile/enzymes, which would help minimise bacteria.

yes of course, but not at first time. The liver is overloaded with residues of endotoxines.
First relieve (and help to get rid of), then assist digestion, and afterwards optimize metabolism to find energy back.
That's how I would phase out.

LDL in excess is often the sign of a problem: oxidized arteries.
Need for Vit E (mixed toco 20-25 mg), b-carotenes (orange vegetables & fruits) + K2 MK4
In details
Cardiologist Stephen Sinatra says that to blame cholesterol because he causes calcification (plaque), it's like blaming firefighters, accusing them of being responsible for fires, just because they are still present on the stage. (It's stupid, editor's note). The number one indicator to induce inflammation is insulin, followed by an excess of polyunsaturated fatty acids.
Note: Vitamin K2 is critical for avoiding calcification when you take high amounts of supplemental vitamin D (5000 UI)
When you take oral vitamin D, you increase your need for vitamin K2. The biological role of vitamin K2 is to help move calcium into the proper areas in your body, such as your bones and teeth. It also helps remove calcium from areas where it shouldn't be, such as in your arteries and soft tissues. Symptoms of vitamin D toxicity are actually produced by vitamin K2 deficiency, including the inappropriate calcification that can lead to hardening of your arteries.

Hi,
How did you manage to drive LPS away? need details.

How much riboflavin?
The gut can only absorb a limited amount of riboflavin at one time, and an excess is quickly excreted in the urine. Therefore, No Upper Intake Level for riboflavin has not been established.
=> Light yellow urine = excretion of unused B2. However, riboflavin does not cause any side effects.
No need to take B2 every day.
Every other day for maximal intake. But I take it twice a week when I make a cure with thiamine (B1).
When consumption exceeds the ability to absorb (37 mg), riboflavin passes into the large intestine, where it is catabolized by bacteria to various metabolites that can be detected in feces.[5] There is speculation that unabsorbed riboflavin could affect the large intestine microbiome.[42]
But taking into account that riboflavin is used immediately, thus not stored in the body, excess amounts would be excreted, mainly in the urine (90% in 24H).
The biological half-life of riboflavin in the liver of rats was 6.5 days.

I use Swanson riboflavin 100 mg 2x/wk.

50 mg would be enough if no worrying excipient.
(Here: rice four, gelatin, magnesium stearate). Not every day Mg stearate and not too much.
I didn’t find a better form. But it’s OK for me.
42. https://en.wikipedia.org/wiki/Riboflavin#cite_note-42

Mind heavy metal toxicity (especially with mercury)

Heavy metals are likely to take the place of ALA in the chain and to block the enzymatic reactions of metabolism.
ALA = alpha-lipoic acid.
ALA has the ability to trap circulating toxic metals, such as arsenic, cadmium (Cd) and Mercury (Hg). If there is mercury, some enzymes are blocked and homeostasis (return to health) will not be able to take place naturally. The SOD enzyme is found at the mitochondria and cytoplasmic level. Its role is to destroy superoxide anions.
SOD cofactors are trace elements Mn-Zn and Cu.
SOD = Superoxide Dismutase. Its role is to neutralize hyperoxidant free radicals (superpowing reducing role)

Heavy metals such as Cd and Hg move these trace elements away and inhibit the activity of superoxide dismutase.

We repeat: if there is mercury, there will be blocking certain enzymes and homeostasis cannot be set up in this case.
*) Appreciable elements to improve the ground:
Selenium
Vitamins C and E and flavonoids
Co-enzymed vitamins complex

• Zn and Mg which are often lacking. Take Mn-Zn and Cu, after chelation (8/1 intake for the Zn and the Cu). 15 to 30 mg of Zn. (=> Contribution necessary for metalo-enzymes).
  NB: You must follow a strict protocol in case of detoxification with heavy metals, with recovery breaks.

Formes d'ALA : Acide lipoïque, acide R-alpha-lipoïque, et sodium R-lipoate
Pour les autres pathologies, la forme R-ALA est mieux métabolisée par l'organisme car c'est la forme naturelle de l'acide lipoïque. On parle alors de biodisponibilité améliorée.
Une étude a démontré que la stabilité et la biodisponibilité étaient encore améliorées en convertissant l'acide R-alpha-lipoïque en son sel de sodium, le NaRALA (sodium R-lipoate).
Le sodium R-lipoate atteint des niveaux plasmatiques plus élevés plus rapidement que l'acide R-alpha-lipoïque pur. Il peut permettre d'obtenir une concentration plasmatique dix à trente fois plus élevée que l'acide R-alpha-lipoïque pur8.

8. Zhang W.J. et al., Dietary alpha-lipoic acid supplementation inhibits atherosclerosis lesion development in apolipoprotein E-deficient mide, Circulation, Jan 22 2008,

@Sippy said in Vitamin B6 supplement makes me feel great, why? Safe for long-term use?:

Sippy
about an hour ago

Can neuropathy be caused by B6 deficiency or just toxicity?

=> Both can cause damage.
If lack of communication (with problem of electrical or chemistry exchanges), it will affect the brain-stomach axis through the vagus nerve. Toxicity can affect enzyme functions.

But I’d rather say that an optimal amount of B6 PLP and thiamine (with other cofactors) are susceptible to optimize homeostasis and to help recovering.

*) Dr. Lonsdale says:
Thiamine Deficiency and Sympathetic – Parasympathetic Regulation
“The hypothalamus is in the center of the brain computer and it presides over the ANS (Autonomic nervous System), as well as the endocrine (hormone) system. The ANS has two channels of communication known as sympathetic (governs action) and parasympathetic (governs the body mechanisms that can be performed when we are in a safe environment: e.g. bowel activity, sleep, etc.).
When the ANS system is damaged, sometimes by genetic influence, but more commonly by poor diet (fuel), our adaptive ability is impaired.”
Source: Thiamine & the Nervous System
How Can Something As Simple as Thiamine Cause So Many Problems?
By Derrick LONSDALE MD, FACN, CNS. 2023
Understanding Thiamine’s Role in Complex Adverse Reactions – The Limbic System
*) B6 relieving neuropathy
Administration of VitB1, B6, and B12 forte relieved symptoms of moderate peripheral neuropathy with improvement of VAS and TSS scores
VAS score: Visual Analogue Scale (VAS) for pain
TSS score: Total Symptom Score.

• B6 modulates the activity of GABA
• B6 reduces inflammation and modulates neuro-mediators
• Additional K2 MK4 could help in case of “Complex regional pain syndrome”
  Ref.: Complex regional pain syndrome: A vitamin K dependent entity?
  DOI: 10.1016/j.mehy.2010.03.012 2010

@Mostlylurling says:
Got links to corroborate this statement about thiamine hcl "safe up to 200-250mgs"?
=> The two links given are about reducing cancer cell proliferation or stimulation.
I didn’t find back my source. But after reading my PC sources, I think I interchange the cheapest form of B1 and B6. I made a mistake. It’s B6 pyridoxine (PN) which is a problem on high dose.

• An excess of pyridoxine (PN) is deleterious. No pyridoxine supplement advised: PN has an inhibition effect on PLP, the active form. A tight regulation of the PLP concentration is necessary in the cell: The aldehyde derivatives are toxic. A self-regulation and a protective mechanism coexist. Indeed, there is a radical side effect: PLP will no longer passes the encephalic barrier. A withdrawal effect will soon take place, with a bad impact on neurotransmitters (Gaba).
• B6 HCl (PN) is safe but Allil Overtone advices to begin slowly with PN and afterwards to add PLP, by adapting the dose to the ground, with staples, to avoid side effects from metabolites when in excess (brain protection).
  For other readers:
• B1 HCl is safe:
  https://www.medscape.com/viewarticle/760242_5?form=fpf
• The vitamin B6 paradox
  Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function.
  https://www.orthofyto.com/wp-content-orthofyto/uploads/2018/01/192123-Vitamin-B6-paradoxMisja-Vrolijk2017.pdf
  The neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to pyridoxine. The inactive form pyridoxine competitively inhibits the active pyridoxal-5′-phosphate. Consequently, symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency.

Basebolt said:
He states neuropathy can happen with pyridoxine and P5P. That it may get worse for weeks after stopping but usually will resolve.
=> It happens when the liver can’t evacuate the excess of B6 residues: metabolites become toxic when we overtake what the body needs. The brain protects itself. Lack of glycine will soon take place, with a lot of side-effects. This warning gets applied to pyridoxal phosphate (PLP).
Note: P5P = PLP or PMP
3 forms

• PNP = Pyridoxine HCL (nor more that 200-250 gr, gradually).
• PLP = pyridoxal phosphate (active form).
• PMP = pyridoxamine phosphate
  When taking high supplement of Vit B6, the type and the way must be taken into account. Otherwise, do not take into account the warning (applied to high dose).
  No Pyridoxine high dose (PN / PNP). PN is then toxic. So, no Pyridoxine HCl, with high dose.
• PLP is the active form (pyridoxal 5’-phosphate) but too much of a good thing is bad: metabolites in excess from PLP are not well evacuated and are toxic because of aldehydes. The brain will block the passage. Problems will then happen because of a lack of GABA.
• Half-life of PLP and PMP (pyridoxamine) must be taken into account. Let’s say 30 days.
  -The dose needed can highly vary. With neuro-sensitive persons, 25 mg B6 every day could be too high after one week reload. Adapt yourself with posology, according to the symptoms (level of inflammation and antioxidant required). Make breaks. E.g. take 20 mg 5 days, the weekend off, during 3 weeks. Then stop for one month (half-life).
• PMP (pyridoxamine) could be a better choice for avoiding side-effects of high dose (> 25 mg) but I haven’t seen such supplements at a lower dose (12 - 20 mg).
  Zn status may be important in the regulation of vitamin B6 metabolism
  Zinc will be needed in the process. If deficient, it won't function...
  Source and references
  B6 leads to decrease of cytokines in neuropathy
  Pyridoxine PLP as pain inhibitor in peripheral neuropathy
  Efficacy of Vitamin B1, B6, and B12 in Peripheral Neuropathy
  https://mirzoune-ciboulette.forumactif.org/t2041-english-corner-b6-leads-to-decrease-of-cytokines-in-pn#29659
  Useful link (in French, translator needed):
  Effets de la Vitamine B6 sur les Neurotransmetteurs
  https://mirzoune-ciboulette.forumactif.org/t2032-effets-de-la-vitamine-b6-sur-les-neurotransmetteurs#29621

SpaceManJim says
1) I actually have a full genetics panel, what genes/mutations should I look for, and at what values, to determine if I have some methylation issues?
=> MTHFR gene mutation and test required
The MTHFR gene mutation inhibits the body's processing of folic acid (B9) and other important B vitamins.

Some of the best multivitamins for MTHFR mutation are methyl folate (B9), methyl cobalamin (B12) and B6 (PLP), vitamin D3, and glutathione.

And choline (to help recycling homocysteine into methionine).
MTHFR gene = The methylenetetrahydrofolate reductase gene contains the DNA code to produce the MTHFR enzyme.
Note: Not simply acid folic or folate but methyl folate. B9 and B12 have to be methylated.
The MTHFR gene codes for an enzyme that helps your body convert homocysteine in excess when eating proteins. People with high homocysteine levels suffer from low-grade inflammation (not perceived); they typically respond well to supplementation with vitamins such as B6, B12, and folate (B9). The form of vitamin and the posology must be taken into account.
Test price for gene test: +/ 150 $. Most insurance companies do not cover this type of MTHFR gene test, and may leave you with an $800-$1,000 bill.
Home test for 677 and 1298 MTHFR Gene Variants (C677T and A1298C).
See customer review here on amazon (I have no personal background) for the manufacturer ‏: “MTHFR Doctors”. It seems OK.
https://www.amazon.com/Comes-Physician-Recommendations-Results-Interpretation/dp/B07DMVV76W
An MTHFR gene test is used to look for the two most common MTHFR changes called C677T and A1298C. It's possible to have one or both of these gene changes without having any health problems. An MTHFR gene test may be done alone or as part of a group of genetic tests.
Personal advice: useful test but not obliged to if you consider you can manage the problem by adapting the treatment, acting as if you were deficient.
Note that a methylation defect has an impact on thyroid and the whole metabolism.
Useful info (in French, translator needed): Méthylation définition
What is methylation? Very few people know it, when it is the keystone of a multitude of vital actions within our organization (metabolism).
https://www.nutriting.com/experts/methylation/

2) And secondly, do you have any further practical recommendations regarding my supplement usage?
=> Get informed on the side effects when taking high dose of a supplement.
Situation: Restore communication between the brain and the thyroid. Get rid of toxic derivatives resulting from a methylation defect. Find out about the why of how when you take pyridoxine (B6) (form and dosage, errors not to be committed).

1st step:

• Get rid of excess of homocysteine
• help methylation process
  => I can make suggestion on products if desired.
  Mind excess oxalates. It interferes with sulfur and at the end with methylation. I take potassium citrates to neutralize oxalates from spinach or when I eat rhubarb or combine several sources like chocolate, coffee or one of the twelve bastards.
  Figure: Aliments riches en Oxalates : 12 Salopards
  

3) Btw, prolactin is probably an issue for sure, I had minor childhood gyno, maybe even still a little bit now as an adult though much less so. I notice that I feel flabby on bloated in the torso region specifically after sexual activity, but reliably I can pop a B6 afterwards and reverse it.
=> I would take B1 to help to get rid of lactic acid and high level of No when having sexual activity. See beneath too.
Need to be anticipated or it will take 2 or 3 days to get rid of excess. Especially if you eat refined carbs. B2 B3 and particularly B1 are required to assimilate sugars.
B6 can help here to relax.
PLP is required for the synthesis of the neurotransmitters serotonin, norepinephrine, epinephrine, and GABA, and as such is involved in both neuronal excitation and inhibition. (1)
Administration of VitB1, B6, and B12 forte relieved symptoms of moderate peripheral neuropathy. (2)
Tips to relax and lower excess lactic acid:
 Breathing in co2 (bag) slightly lowered it, nothing significant.
 Walking around actually lowers it. 30’ low exercise levels.
 Biotin 50 milligrams would lower it.

1. doi: 10.3945/an.113.005207 2015 (no need to read further).
2. https://doi.org/10.14710/dimj.v2i1.9549 M. Silviana, D. et al. 2021. “Therapy in Peripheral Neuropathy Patients” (no need to read further).
   Note: I’d add some glycine and magnesium bisglycinate after a sexual event.
   A shake with:

• Orange juice 150 ml
• ½ scope of bisglycinate of magnesium (a scope = 2.5 gr)
• 1 scope potassium citrate (2 ml = 1.25 gr)

• 50-100 m PLP (20-25 mg if brain-sensible, at the beginning). I took 100 mg PLP with TMG (tri-methyl-glycine).
  Explanation:

• Collagen could help (glycine). 1 tsp with the meal or a snack with dark chocolate (if appreciated).
• B6 modulates the activity of GABA.
  PLP is used as a cofactor to synthesize and degrade GABA and modulate its activity. In this way pyridoxine administration facilitates GABA turnover.
  PLP is the cofactor for the enzyme glutamate decarboxylase, which converts glutamate (the main excitatory neurotransmitter) into GABA (the main inhibitory neurotransmitter).
• B6 can help increase progesterone and decrease estrogen, with adapted proportions. Mind this last point (with adapted proportions). Too much of a good thing is bad.
  Source: B6 abaisse-t-il le niveau de dopamine?
  Does B6 lower the level of dopamine? Pyridoxine has both dopamine improvement properties and dopamine blocking: on the one hand, pyridoxine (as dopamine) depresses the prolactin release of the pituitary gland; on the other hand, in oral doses of 10 to 20 mg, it quickly reverses the therapeutic effect of dopamine.
  Source: Pyridoxine
  https://www.sciencedirect.com/science/article/pii/B9780444537171013706
  In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016
  https://www.sciencedirect.com/referencework/9780444537164/meylers-side-effects-of-drugs
  Comment: Vitamin B6 is well documented for its role as a modulator of steroid hormones. Pyridoxal phosphate (PLP), the active form of Vitamin B6, may interfere with the action of the estrogen receptor (ER) by blocking the hormone-binding and/or DNA-binding site of the ER.
  Source: PLP as Modulator of Steroid Hormones
  PLP decreases estrogens and modulates DNA synthesis
  Vitamin B6 Decreases Proliferation and DNA Synthesis of Human Mammary Carcinoma Cell Lines in Vitro. By Brandy Ellen Cowing.
  *) Additional info 1:
  B6 and molybdenum deficiency could both contribute to anxiety or insomnia. B6 lacks if excess sulfites or low-grade inflammation. When more vitamin B6 is consumed, for instance with arthrosis (anti-inflammation effect), this situation could lead to vitamin B6 deficiency. Deficiency of vitamin B6 blocks the metabolic pathway and leads to accumulation of kynurenine pathway intermediates.
  See Chris Masterjohn for reference.
  Excerpt (from CM):
  B6 is needed to make melatonin and GABA, and to maximally suppress quinolinate. Molybdenum is needed to maximally suppress sulfite. Quinolinate stimulates excitatory glutamate receptors, and sulfite drives the generation of S-sulfocysteine, which does the same. Thus, B6 and molybdenum deficiency could both contribute to anxiety or insomnia.
  *) Additional info 2:
  Thiamine (B1) has also neuro-protective effects: Brain & Digestive System. There is a connection between the brain, the digestive system and the vagus nerve. Dr. Derrick Lonsdale calls this “dysautonomia and adaptation to the stress environment” when fuel is re-loaded.
  Full post on this link (my forum), with explanations, figures, studies links and case reports if you want details and see how to manage in practice with high dose thiamin (B1) (How much and which kind of thiamine?).
  https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1#29712
  => Neuroprotective Effects of Thiamine
  Thiamine (vitamin B1) is essential for brain function because of the coenzyme role of thiamine diphosphate (ThDP) in glucose and energy metabolism.

Thiamine possesses “universal” anti-stress properties: B1 is mobilized in response to cellular stressors.

Mostlylurking has commented, on a previous post (in High-dose thiamine troubleshooting):
https://bioenergetic.forum/post/18941
“I think that the optimized cellular energy level that thiamine facilitates when working as a co-factor for several enzymes in the Krebs cycle restores the body's balance on the cellular level. Getting the body's energy level working on the cellular level as it is intended is neuro-protective. Think of it as restoring the electrical current that connects the body's cells so that they work in harmony.”
Note: There is a strict protocol when using high dose thiamine (B1).
Additional info (David Nazarian, M.D.)
Thiamine and Hormonal Balance: The Vital Connection
https://www.myconciergemd.com/blog/thiamine-and-hormonal-balance-the-vital-connection/
Excerpt: There is evidence that thiamine aids in maintaining normal thyroid function by lowering oxidative stress and enhancing energy metabolism. Additionally, thiamine is vital for maintaining correct nerve and muscle function, which can also aid in supporting healthy thyroid function.
A balanced diet with thiamine and other critical vitamins and minerals supports thyroid function.
Reminder: Do not take high dose thiamine without B2 (not necessarily every day).
*) To lower lactic acid:
Breathing in co2 slightly lowered it, nothing significant.
Walking around actually lowers it. 30’ low exercise levels.
Biotin 50 milligrams would lower it.

Hi,
Thiamine HCL is safe up to 200-250 mg, according to studies but you need to take into account some parameters, in order not to suffer from side-effects (the brain protects itself. No passata => lack of glycine). Too much of a good thing is bad.
Apart from effectively reducing homocysteine levels, when targeting the right dose of B6 (in association with folate, vitamin B12, not necessarily every day),

we should take into account a right window for the degradation of the pyridoxal metabolites to 4-pyridoxic acid.

Otherwise, there will be a return of the crank with UL of B6. Expressed in a different way, we need to take breaks to optimize profits. More details will be given on the way to adapt the levels when taking high doses of B6 and the kind of B6 you could manage with.
Vocabulary. UL = Upper Limit.
See my post on this link:
English corner: B6 leads to decrease of cytokines in neuropathy
https://mirzoune-ciboulette.forumactif.org/t2041-english-corner-b6-leads-to-decrease-of-cytokines-in-neuropathy#29659
Note: If other readers wants details about the kind of B1, why B2 with B1, why niacinamide (not niacin), why supplementing with TMG (tri-methyl-glycine) if taking high B3, managing high B6 and what to care for to avoid backdraft.
Note: Make a search on my forum with “English corner” + …

Note2: @bio3nergic
Well seen for methylation. It could also explain many problems coming from the thyroid.
Useful info:
Methylation, MTHFR and Thyroid Dysfunction. By Benjamin Lynch, ND.
https://mirzoune-ciboulette.forumactif.org/t119-the-thyroid-madness#1333
Since 1 in 2 people have some form of MTHFR defect, folic acid is not the best form of folate to use. Defectuosity depends much on your ethnicity. Chinese, Italian, Hispanics or Mexican ethnic groups have nearly a 50% likelihood of being heterozygous for the MTHFR C677T defect and 20% to 30% are homozygous. 'This means that nearly 1 in 2 of these individuals will have a MTHFR enzyme functioning at 65% and 1 in 4 will have a MTHFR enzyme functioning at only 30%.10
In a nutshell, it’s very common.
=> One in 2 person has a partial impairment at genes coding for the MTHFR enzyme. The handicap ranges from 20 - 35 % to 70 % (reduction in function). 10% suffers from a severe (almost total) handicap.
Methylation in short:
https://mirzoune-ciboulette.forumactif.org/t2028-the-english-corner-fix-the-gut#29593
=> What is methylation?
Excerpt:
This process (methylation), apparently simple, alone ensures a multitude of functions in the human body, such as the production and regulation of a large number of molecules including neurotransmitters and hormones in the brain, the detoxification of the body via the production of glutathione (which is none other than the most powerful antioxidant in the human body), the breakdown of histamine in the intestine, but also and above all, according to one of the great discoveries of recent years, it allows the modulation of the expression of certain genes in our DNA via epigenetic processes.

Methylation is therefore essential for the maintenance, repair and manufacturing of our cells, intracellular communication, and more particularly, the inheritance of epigenetic information from a mother cell to daughter cells during cell division (which is the way cells reproduce). (1)

Note:
These nutrients are often too short for a correct methylation:
Vit C B6 (P-5-P) Mg

• Other nutrients for recycling high levels of homocysteine. (2)

=> See half-life of biotin. You don't burn B7 at every step.
Chris Masterjohn says 150 mcg is required when eating 100 gr meat (non-collagen)
35 mcg gr every 50 gr supplement meat.