Posts made by skylark

@MB gang

Do you know what condition the SSRIs were prescribed for? Any OCD tendencies? What did the Docs think?

Obviously thc, metergoline & cyproheptadine have strong neurological effects and can be abused. SSRIs can leave long-lasting effects and are known for unpredictable interactions with other drugs that modulate serotonin function.

Additionally, if the diet is not sufficient, increasing metabolic rate, especially through the use of drugs, can lead to deficiencies of regulatory nutrients such as magnesium & vitamin D, leading to sudden disturbance in glucose metabolism and effecting energy systems in the brain.

Supplementing milk, fruit & vitamin D usually has a stabilising effect.

concentration/name/source of thc gummies? Any other previous pathologies, particularly neurological & endocrine related? Any previous medications? Use of other recreational drugs? Any known allergies or adverse drug reactions? What were the results of blood panel? Any brain/ glandular scans?

…yes

Béla Bartók - Romanian Folk Dances Sz 56: III. Pe-loc - Andante

https://youtu.be/unm48hM4pgw?si=mPl-TBOmN9Iod-BV

This piece is about the night, cannibalism, dance between beast and prey… be careful!

@C-Mex surely there’s a case for Ray’s next-of-kin, Charlie is clearly profiting off of Ray’s reputation - and there’s written evidence of Ray’s disapproval

When consumed, PUFA are preferentially stored whereas SFA/ MUFA are preferentially oxidised to provide energy. In context of a typically modern diet this would mean that the fat stores of most people will consist of predominantly PUFA. There have be recent studies to suggest that when fats are liberated through lipolysis (e.g. in a starved state), PUFA is preferentially released, which carries with it inflammatory and anti-metabolic activities. Whether PUFA is preferentially released due to a high concentration in the fat stores of most people or whether it’s due to another mechanism idk. @haidut talked about these studies on RPF. Generally Ray advocated for slow re-comp instead of caloric restriction, which is made more effective by the pro-hormonal effects of he’s dietary & metabolic recommendations. But he did recommend a person to take Vitamin E when dieting to protect themselves from the effects of FFA.

@Charlie

Ray’s work attracts a lot of sick people, unsurprisingly. It was just unfortunate that one of them instated themselves as “The Law” over the community for so long lmao. Best not looking back now…

@ThinPicking jinxies ;))
@lactose rtfm http://raypeat.com/articles/

Vet Rec. 2010 Jan 30;166(5):133-6. Effect of diet on plasma tryptophan and serotonin in trained mares and geldings. Alberghina D, Giannetto C, Visser EK, Ellis AD.

Bull Exp Biol Med. 2005 Jan;139(1):64-7. Effect of serotonin on respiration, cerebral circulation, and blood pressure in rats. Aleksandrin VV, Tarasova NN, Tarakanov IA. V. V. "Serotonin rapidly decreased local cerebral blood flow (by almost 30%) and blood pressure."

Aust N Z J Med. 1984 Dec;14(6):888-95. Serotonin antagonists. Anthony M. "The realisation that serotonin plays a role not only in the carcinoid syndrome but also in migraine, nociception, dumping syndrome, vascular disease and hypertension, has led to an enormous amount of activity in search of serotonin antagonists."

Biull Eksp Biol Med 1976, 82(10): 1181-3, Role of the biological activity of serotonin in the productin of the "shock lung" syndrome, Bazarevich GIa, Deviataev AM, Likhtenshtein AO, Natsvlishvili BP, Sadeko MKh. Headache. 2006 Sep;46(8):1230-45. Serotonin in trigeminal ganglia of female rodents: relevance to menstrual migraine.Berman NE, Puri V, Chandrala S, Puri S, Macgregor R, Liverman CS, Klein RM.

Biol Psychiatry. 2000 Mar 15;47(6):562-76. Steroid regulation of tryptophan hydroxylase protein in the dorsal raphe of macaques. Bethea CL, Mirkes SJ, Shively CA, Adams MR.
Bowman, WC & Rand MJ, Textbook of Pharmacology, Second ediction. Oxford: Blackwell Scientific Publications, 1980.

Arch Int Pharmacodyn Ther. 1962 Jan 1;135:142-51. Blockade of depressor responses to serotonin and tryptamine by lysergic acid derivatives in the chicken. Bunag RD, Walaszek EJ.

J. Theor. Biol. 169:391-402.(1994). Rethinking "shape space": evidence from simulated docking suggests that steric shape complementarity is not limiting for antibody-antigen recognition and idiotypic interactions. Carneiro, J. and Stewart, J. Psychol Neuropsychiatr Vieil. 2010 Dec;8(4):243-54. [Personality and risk of dementia]. [Article in French] Clément JP, Teissier MP.

Nature Medicine 1995, 1:623-625. The psychobiological regulation of social cooperation, Cloninger CR. JAMA. 1962 Jul 28;181:318-21. On migraine headache: serotonin and serotonin antagonism. Dalessio DJ.

Int Clin Psychopharmacol. 1991 Dec;6 Suppl 3:23-8; discussion 29-31. Depression and 5HT. Deakin JF. "Much evidence is compatible with the idea that 5HT systems reduce the impact of impending or actual aversive events. Anticipation of an aversive event is associated with anxiety and this motivates avoidance behaviour--a normal adaptive response. There is evidence that this is mediated by projections of the dorsal raphe nucleus and associated 5HT2 and 5HT3 receptors."

Exp Brain Res. 1983;51(1):73-6. Effect of acute and chronic 17 beta-estradiol treatment on serotonin and 5-hydroxyindole acetic acid content of discrete brain nuclei of ovariectomized rat. Di Paolo T, Diagle M, Picard V, Barden N. "Increased serotonin content of the dorsal raphe nucleus and of the substantia nigra were seen following acute (12 h or 24 h) administration of 17 beta-estradiol to ovariectomized rats."

Neuroscience. 2009 Oct 6;163(2):705-18. Epub 2009 Jun 23. Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei. Donner N, Handa RJ.

Br Med J. 1962 May 19;1(5289):1390-1. Carcinoid syndrome: alleviation of diarrhoea and flushing with "Deseril" and Ro 5-1025. Dubach UC, Gsell OR.

Br. J. Pharmacol Chemother. 1954; 9(1):31-6. Identification of the stable antidiuretic substance (stable ADS) of serum with 5-hydroxytryptamine, Erspamer V, Sala G.

Brain Res. 1996 Mar 4;711(1-2):84-92. In vivo evidence for progesterone dependent decreases in serotonin release in the hypothalamus and midbrain central grey: relation to the induction of lordosis. Farmer CJ, Isakson TR, Coy DJ, Renner KJ. "The rapid decrease in extracellular 5HT in the MCG suggests that this effect may represent a non-genomic action of P."

Am J Physiol Endocrinol Metab, 2007;292(4): E1173-E1182, Estrogen potentiates adrenocortical responses to stress in female rats, Figueiredo HF, Ulrich-Lai YM, Choi DC, Herman JP.

Mechanisms of LSD: a glimpse into the serotonergic system, Anne Frederickson, 1998,serendip.brynmawr .edu/bb/neuro/neuro98/202s98-paper3/Frederickson3.html.

Exp Gerontol. 1984;19(4):217-25. Enterosorption in prolonging old animal lifespan. Frolkis VV, Nikolaev VG, Bogatskaya LN, Stupina AS, Shcherbitskaya EV, Kovtun AI, Paramonova GI, Sabko VE, Shaposhnikov VM, Rushkevich YuE , et al.

Biomater Artif Cells Artif Organs. 1989;17(3):341-51. Effect of enterosorption on animal lifespan. Frolkis VV, Nikolaev VG, Paramonova GI, Shchorbitskaya EV, Bogatskaya LN, Stupina AS, Kovtun AI, Sabko VE, Shaposhnikov VM, Muradian KK, et al.

Brit. J. Pharmacol. 1954, 9, 240, Drugs which antagonize 5-hydroxytryptamine, Gaddum JH, Hameed KA.

Quart J exp Physiol 1953, 121, 15P, Antagonism between lysergic acid diethylamide and 5- hydroxytryptamine, Gaddum JH.

J Clin Invest. 1983 Jun;71(6):1806-21. Effects of parathyroid hormone on skeletal muscle protein and amino acid metabolism in the rat. Garber AJ.

Synapse. 2011 Mar;65(3):249-56. The microtubule cytoskeleton acts as a key downstream effector of neurotransmitter signaling. Gardiner J, Overall R, Marc J.

Psychoneuroendocrinology 25: 479-496, 2000. Neuroendocrine correlates of temperamental traits in humans, Gerra G, Zaimovic A, Timpano M, Zambelli U, Delsignore R, Brambilla F.

Br. J. Pharmacol Chemother 1957 Dec;12(4):498-503. The antagonism of the vaxcular effects of 50hydroxytryptamine by BOL 148 and sodium salicylate in the human subject. Glover WE, Marchall RJ, Whelan RF. "Sodium salicylate is also a specific antagonist of 5-hydroxytryptamine....."

J. of Psychoactive Drugs 2002, 34(3), p. 266, The serotonergic system and mysticism: Could LSD and the nondrug-induced mystical experience share common neural mechanism? Goodman N.

Pharmacol Biochem Behav. 1996 May;54(1):129-41. Role of 5-HT in stress, anxiety, and depression. Graeff FG, Guimarães FS, De Andrade TG, Deakin JF.

Med Hypotheses. 2004;62(2):169-72. Biophotons, microtubules and CNS, is our brain a "holographic computer"? Grass F, Klima H, Kasper S.

Pharmacotherapy, 1995; 15(3):357-60. Treatment of depression with cyproheptadine, Greenway SE, Pack AT, Greenway FL.

J Am Soc Nephrol. 2000 Jun;11(6):1002-7. Effect of serotonin receptor antagonist on phosphate excretion. Gross JM, Berndt TJ, Knox FG.

Biochem J. 1996 Dec 1;320 ( Pt 2):615-21. Locally formed 5-hydroxytryptamine stimulates phosphate transport in cultured opossum kidney cells and in rat kidney. Hafdi Z, Couette S, Comoy E, Prie D, Amiel C, Friedlander G.

Biological Psychology Volume 51, Issue 1, October 1999, Pages 77-81. Harm avoidance and serotonin. Hansenne M, Ansseau M.

Physiol Behav. 2004 Sep 15;82(2-3):357-68. Anxiety and aggression associated with the fermentation of carbohydrates in the hindgut of rats. Hanstock TL, Clayton EH, Li KM, Mallet PE.

Endocr Rev. 1980 Fall;1(4):319-38. Biogenic amines and the secretion of parathyroid hormone and calcitonin. Heath H 3rd. Rev Neurosci. 2000;11 Spec No:213-328. A unifying hypothesis of Alzheimer's disease. IV. Causation and sequence of events. Heininger K.

Can J Physiol Pharmacol 1998 Dec;76(12):1120-31. Bulbospinal serotonergic activity during changes in thyroid status. Henley WN, Bellush LL, Tressler M

Biol Psychiatry. 2006 Aug 1;60(3):288-95. Estrogen selectively increases tryptophan hydroxylase- 2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between gene expression and anxiety behavior in the open field. Hiroi R, McDevitt RA, Neumaier JF.

European Journal of Pharmacology. 1985; 111(2):211-220. Maternal aggression in mice: Effects of treatments with PCPA, 5-HTP and 5-HT receptor antagonists. Ieni JR and Thurmond JB.

European J. Pharmacology 1983, 90:275-78, Raphe neurons-firing rate correlates with size of drug response, Jacobs BL. American Scientist 1987, 75:386-91, How hallucinogenic drugs work, Jacobs BL.

Arch Gen Psychiatry. 2005 May;62(5):529-35. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B.

Pharmacol Biochem Behav. 1977 Sep;7(3):245-52. Fatty acid and tryptophan changes on disturbing groups of rats and caging them singly. Knott PJ, Hutson PH, Curzon G. Life Sci. 1991;48(2):175-81. State-dependent variation in the inhibitory effect of [D-Ala2, D- Leu5]-enkephalin on hippocampal serotonin release in ground squirrels. Kramarova LI, Lee TF, Cui Y, Wang LC.

Metabolism. 1978 May;27(5):511-20. Serotoninergic activation and inhibition: effects on carbohydrate tolerance and plasma insulin and glucagon. de Leiva A, Tanenberg RJ, Anderson G, Greenberg B, Senske B, Goetz FC. (In Garattini, Adv in Pharmacol 6, pages 131-2, McCullough and Myers, 1965.)

J Psychiatr Res. 2009 Mar;43(6):656-63. Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. McNamara RK, Able J, Liu Y, Jandacek R, Rider T, Tso P, Lipton JW.

Pharmacol Biochem Behav. 1976 Jul;5(1):55-61. The role of serotonergic pathways in isolation- induced aggression in mice.Malick JB, Barnett A. "All of the antiserotonergic drugs selectively antagonized the fighting behavior of the isolated mice...."

Curr Dev Psychopharmacol. 1979;5:1-27. The pharmacology of isolation-induced aggressive behavior in mice. Malick JB.

J Geriatr Psychiatry Neurol. 1997 Jan;10(1):29-32. Neurodegeneration, sleep, and cerebral energy metabolism: a testable hypothesis. Mamelak M.

Vopr Med Khim. 1991 Sep-Oct;37(5):2-6. [The role of monoamine oxidase in the regulation of mitochondrial energy functions]. Medvedev AE, Gorkin VZ.

Vopr Med Khim. 1990 Sep-Oct;36(5):18-21. [Regulation by biogenic amines of energy functions of mitochondria]. [Article in Russian] Medvedev AE.

Diabetes. 2004 Jan;53(1):14-20. Portal serotonin infusion and glucose disposal in conscious dogs. Moore MC, Geho WB, Lautz M, Farmer B, Neal DW, Cherrington AD.

Neuropsychobiology 1996; 34:155-165, Serotonin and dopamine as mediators of sensation seeking behavior, Netter P, Henning J, Roed IS. Comp Biochem Physiol C Toxicol Pharmacol. 2002 Dec;133(4):507-13.

Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. Perry G, Taddeo MA, Nunomura A, Zhu X, Zenteno-Savin T, Drew KL, Shimohama S, Avila J, Castellani RJ, Smith MA.

Pharmacol Biochem Behav. 1993 Sep;46(1):9-13. Involvement of brain tryptophan hydroxylase in the mechanism of hibernation. Popova NK, Voronova IP, Kulikov AV.

Pharmacol Biochem Behav. 1981 Jun;14(6):773-7. Brain serotonin metabolism in hibernation. Popova NK, Voitenko NN. Biol Psychiatry 42: 1123-1129, 1997, Clomipramine challenge responses covary with Tridimensional Personality Questionnaire scores in healthy subjects, Ruegg RG, Gilmore J, Ekstrom RD, Corrigin M, Knight B, et al.

J Psychopharmacol. 2010 May;24(5):725-31. Epub 2009 Nov 25. Social separation and diazepam withdrawal increase anxiety in the elevated plus-maze and serotonin turnover in the median raphe and hippocampus. dos Santos L, de Andrade TG, Graeff FG.

Res Commun Chem Pathol Pharmacol 1975 Jan;10(1):37-50. Thyroid hormone control of serotonin in developing rat brain.Schwark WS, Keesey RR. "Experimental cretinism, induced by daily propylthiouracil treatment starting at birth, caused increased serotonin levels in all brain regions studied."

Neurology. 2006 Jun 27;66(12):1920-2. Cluster headache research, Sewell RA, Halpern JH, Pope HG. Cerebral Cortex 2010 Nov;20(11):2560-7. Estrogen promotes stress sensitivity in a prefrontal cortex-amygdala pathway,Shansky RM, Hamo C, Hof PR, Lou W, McEwen BS, Morrison JH.

Scand J Clin Lab Invest. 2004;64(1):3-8. Platelet serotonin 5-HT2A receptor binding in patients with carcinoid tumor. Spigset O, Kristoffersson A, Mjörndal T.

Science 1979, 205:515-18, Dissociations between the effects of LSD on behavior and raphe unit activity in freely moving cats, Trulson ME & Jacobs BL.

Neurobiol Aging. 1985 Summer;6(2):107-11. Synergistic effects of estrogen and serotonin- receptor agonists on the development of pituitary tumors in aging rats. Walker RF, Cooper RL.

Biosci Biotechnol Biochem. 1998 Apr;62(4):816-7. Theanine-induced reduction of brain serotonin concentration in rats.Yokogoshi H, Mochizuki M, Saitoh K.

Biosci Biotechnol Biochem. 1995 Apr;59(4):615-8. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Yokogoshi H, Kato Y, Sagesaka YM, Takihara-Matsuura T, Kakuda T, Takeuchi N.

J Clin Endocrinol Metab. 1980 Dec;51(6):1274-8. Serotonin stimulates adenosine 3',5'- monophosphate accumulation in parathyroid adenoma. Zimmerman D, Abboud HE, George LE, Edis AJ, Dousa TP.

Neurosci Biobehav Rev. 1990 Winter;14(4):507-10. 5-HT-related drugs and human experimental anxiety. Zuardi AW.

Antonio Recalcati

@ATP By taking testosterone?

I'm same age and I need about around 3000kcal for maintainance depending on my activity level, I can easily burn 4000kcal + if I'm out walking all day. I think Ray said he used to eat 5000kcal/ day when he was younger & working for forestry commission. He did mention that when he took T3 for the first time, it actually lowered his overall metabolic rate, shifting from a wasteful metabolism driven by adrenaline/cortisol over to a more efficient metabolism driven by thyroid - and he found he's caloric requirement dropped. He's said that he's met a lot of young men who experience this with T3. I tried it but I don't think I need it, just makes me hot and out of breath easily. If you already feel good, I wouldn't bother. How tall are you?

@CheesedToPeatYou nice, I’ll get some

Ray describes tanning as a reaction to injury here, it’s in the context of melanoma but he relates the two. Not being able to tan is related to Vitamin D deficiency though.

@eric I get this if I take a break from the gym & then overtrain upon returning, especially if I'm not eating enough. Are you eating regularly throughout the day, not letting yourself get hungry? It's not just before bed but frequent meals all day that keep glycogen supply stable. Dehydration can lead to overheating during the night. Too much protein before bed can cause a sudden drop in blood sugar a few hours later. Sometimes any meal too close to bed time will disturb sleep.

@sztrapacska best yoghurt imo, less acidic than any greek yoghurt i've tried

Oh yeah and Azithromycin, Doxycycline, Acetazolamide and other prescription medicines can be aquired through online pharmacies like DrFox by filling out a quick form, they don't even check with your GP.

Very nice

I use Premier Research D3, Haidut's K2 , Regency Organics makes good superpure DMSO, Cynoplus & Cynomel through farmaciasdelnino, Hexeal Magensium Chloride, Magnesium Hydroxide can be mixed with carbonated water to create a potant Mg Bicarbonate tonic, Jarrow Formulas theanine, flowers of sulpher, Athrovite Equi Gel Collagen Hydroslate (it's sold for horses but it seems pure & dirt cheap) masa from mexgrocer, Stoats sell flour without mandated additives.

The only good OJ I've found here is sometimes Morrison's fresh squeeze but a lot of the time it's shite, clementine juice from Tesco is always ok. Lots of good finds in Costco, cheeses, french jams, californian dates... Skyr I find to be the least acidic yoghurt, fresh oysters from Waitrose, Sainsbury's organic mink is the best tasting but Tesco's isn't bad, Cocio choccy mink...

Currently looking for a source for reasonably priced, authentic olive oil and pure aspirin.

@Atlas He had a preference for Agaricus Bisporus, and was under the impression that the agaritine was mitigated by thorough cooking - enough so that he was comfortable with it anyway.
https://www.bioenergetic.life/clips/78123?t=3639&c=75