@dapose said in Exercise, the Only Known “Medicine” for Maintaining and Improving Mitochondrial Function: If I have particularly lazy days laying around, my legs will be so stiff and I will generally have a low grade ache everywhere. Absence of exercise impacts Short answer Thiamine deficiency leads to excess lactate [image: 1763381066695-fig-1.thiamine-deficiency-leads-to-excess-lactate.png] Source: Lactic Acidosis: A Lesser Known Side Effect of Thiamine Carol Rees Parrish, M.S., R.D. In Nutrition Issues in Gastroenterology, Series #161 You miss thiamine (B1) from conventional food sources Our typical diet covers approximately 45 to 53% of your daily vitamin B1 requirements. And I don’t mean eating fast-food but a conventional one. B1 from food = ~50% of needs → supplement provides the remaining ~50%. A B50 2x/wk. brings 14–16 mg/day on average. I won’t take a B50 complex every day. => Probably.0.5 mg per additional 1000 K/cal. So, RDA 1.2 mg + 0.5 mg = 1.7 mg for 3 000 K/cal. A target intake around 1.6–1.8 mg/day of thiamine is a reasonable nutritional estimate, but not a medical prescription. Magnesium helps to a certain extent. What vitamins help with acidosis? Which proportion as a prevention? Useful info and links Muscle pain, lactic acid and thiamine B1 – A myth? No so far, for my personal case. Average deficiency in vitamin status High deficit for B1 (70-80%), B2 (60%), B9 (90%), C (60%), A (15%), E (75% W – 40% M), D (90%), iron (90% W – 5% M) and magnesium (80% W – 60% M). (ESVITAF, 1986). Impact of a moderate amount of alcohol (2 glass wine or 2 beers), as an extra precaution: ~0.3–0.5 mg/day more. Extra info on my forum if you want details: https://mirzoune-ciboulette.forumactif.org/t2147-english-corner-how-to-avoid-excess-lactic-acid#30449

the thing with red light is wtf is the dose . it is apparently biphasic so too much is as bad as too little. they did 15 min here with lights right up against the skin , probably not very powerful. these niggas are measuring joules. I guess u gotta do some maths and know the intensity of your device at which distance.

And from Thailand: Association Between Vitamin D Levels and Long COVID Signs and Symptoms (2025) Results: The study results indicated a female-to-male ratio of 1.1:1 and a mean age of 45.87 ± 8.65 years; of these, 62.4% received three doses of the COVID-19 vaccine, and 64.7% developed long COVID. The most prevalent signs and symptoms were respiratory (55.3%), skin (50.6%), and general (39.4%). The median blood vitamin D level was 22.96 ng/mL, with 41.2% of subjects having insufficient levels, 30.6% having deficient levels, and 28.2% having sufficient levels. Patients with long COVID had significantly lower vitamin D levels compared with those without long COVID (21.52 ng/mL vs. 25.46 ng/mL; p < 0.05). Multivariable analysis found that vitamin D deficiency was significantly associated with overall long COVID signs and symptoms (Adj. OR, 5.80 [95% CI: 2.10, 16.13]). Additionally, vitamin D deficiency significantly increased the number of long COVID systemic signs and symptoms (Adj. IRR, 3.30 [2.12, 5.12]). Conclusion: Assessing and maintaining vitamin D levels, vitamin D supplementation, and sunlight exposure in COVID-19 patients can reduce the risk and severity of long-term COVID-19 signs and symptoms. [image: 1762787830708-1a25b4b4-9c29-4aec-81ef-c1cf58f7b626-image-resized.png]

@lobotomize - Okay, this is not my first misunderstanding.

I agree with Dr. Peat about melatonin, especially since the usual supplements often come in absurd doses. However, I'm a bit sceptical about that study. Did they control for other variables? Who takes melatonin long-term? People with chronic insomnia. Who has a higher risk of all sorts of health problems including heart disease? Chronic insomniacs. It's one of the worst things that can happen to the body. So I wouldn't be surprised if studies like that just find that insomniacs have more health problems, which is logical. Having said that, it's not worth it to take melatonin. For me personally it had no effect at all on my sleep when I tried it on two occasions many years ago. For people who are desperate, an sleep-inducing anti histamine drug is likely the safer option. Although these can be hard on the liver if used longer term.

@DavidPS probably because less fat person has more vitamin d stores in relative to if they are fat

@dapose said in Evidence for a connection between coronavirus disease-19 and exposure to radiofrequency radiation from wireless communications including 5G: Millimeter wavelength 5 g waves have some punch. The actual footprint of this rollout is practically microscopic and the airtime is worse. Five gee is practically 3GHz, FM and AM coding changes on existing spectrum, and marketing. LTE is just all talk. How did you become aware the p word was a happening and get berated if you failed to stand in a marked box like a flamingo. How did hospitals receive protocol updates with variable interpretation. In fact what tends to precede everything generally bad. Right? Ok then. Yes.

@Mauritio really cool

@evan-hinkle said in Inosine directly binds and blocks the endotoxin/LPS receptor (TLR4): @Ecstatic_Hamster this is actually what I do now, but the day after my dose of charcoal typically slows my transit time, and for whatever reason I just can’t feel optimal without daily consistency, (I assume due to years of unchecked, and totally undiagnosed low-grade sepsis). My hope is to be able to antagonize TLR4 while maintaining fast, complete, and regular transit. Otherwise forward progress for me tends to be a bit like sprinting on a treadmill, (I don’t move forward, just keep-up so to speak). doing the honey diet with intermittent reset days, bowel movements are loose enough and fast enough so the charcoal is absolutely beneficial to me, and not a problem at all, quite the opposite.

@Acephale So this would explain why I feel super fragile/emotional taking 100mg oral prometium and can barely function (due to fatigue) after 7 days of consistent nightly use? Would not taking it orally reduce this issue?

@LucH, thank you for the post and reference to your site. Luckily, I read in French :). Didn't know this concentration-dependent action of LPB protein. Will have to study more.