@Sunniva said in Bile can serve as a reservoir for funghi, making them harder to treat:

(DMSO) inhibits the germination of Candida albicans

That is so interesting . You just helped me to connect the dots.
Several times when I used Melanon topically on the area above my liver/gallbladder I experienced fungal die off. I attributed it to apigenin or naringenin, but it might as well be the DMSO.
Apigenin and naringenib are also anti-fungal. They're also small molecules, but not hydrophilic. But still Melanon should be a very effective anti fungal applied topically.
https://pubmed.ncbi.nlm.nih.gov/29346565/
https://pubmed.ncbi.nlm.nih.gov/33934490/

If the gallbladder is so hard to reach for anti-fungals maybe topical is the way to go.
Maybe using some anti-fungal IdeaLabs supplements over the gallbladder would be good, ideally one that uses DMSO as a solvent.

Alternatively dissolving MSM in DMSO should help. It is a small, hydrophobic molecule and it dissolves in MSM so it might be very potent if delivered directly to the gallbladder via topical application.

I find this a classic example of misinterpretation of scientific studies.
And there are way too many to discuss each one of those in their wrong conclusions.

D3 metabolism in rodents is known to be crucially different from D3 metabolism in humans.
It's beyond poor science to even directly convert these rodent findings to human equivalent doses.

This just feels like science-spam.
The findings themselves and the priorly known implications of hypothyroidism may be valid.
The conclusions (and motives for funding such studies) with regard to "vitamin D prevents it" are not.

Histological and biochemical study of the superficial abdominal fascia and its implication in obesity
Abstract
The advancement of liposculpturing and fascial flaps in reconstructive surgery has renewed interest in the superficial fascia of abdomen. Its histological and biochemical composition may play a vital role in maintaining strength and elasticity of the fascia. Hence, study of abdominal fascia for the elastic, collagen, and hydroxyproline contents is desirable to understand asymmetrical bulges and skin folds and in improving surgical treatment of obesity. Samples of superficial fascia were collected from of upper and lower abdomen from 21 fresh cadavers (15 males and 6 females). Samples were stained using Verhoeff–Van Gieson stain. Digital images of superficial fascia were analyzed using TissueQuant software. The samples were also subjected to hydroxyproline estimation. The superficial fascia was formed by loosely packed collagen fibers mixed with abundant elastic fibers and adipose tissue. Elastic contents and collagen contents of superficial fascia were significantly more in the upper abdomen than that in the lower abdomen in males. Hydroxyproline content of superficial fascia of upper abdomen was significantly more than that of lower abdomen in both males and females. The elastic, collagen and hydroxyproline contents of superficial fascia of upper abdomen were higher compared to the lower abdomen. This may be a reason for asymmetric bulging over abdomen and more sagging fold of skin in the lower abdomen than in the upper abdomen. This study may therefore be helpful in finding new ways to manage obesity and other body contour deformities.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5052227/

Muscle Pain: It May Actually Be Your Fascia
Ways to Relieve Fascia Pain
There are various strategies that work to loosen up painful knots, such as:

Heat therapy: Apply a heating pad to the affected area or take a warm shower or bath.
Yoga therapy: See a highly trained yoga therapist to get a regimen of yoga poses targeted to treat your area of pain. (Yoga therapy works in the same manner as physical therapy — the therapist creates a routine and you practice it at home between visits.)
Foam rolling: Try a foam roller, a cylinder of hard foam that you roll your body over to release tension. It’s a form of self-massage. You can also do this with a lacrosse ball.
Massage therapy: Schedule multiple therapeutic massage sessions with an experienced therapist who can find and apply pressure to release knots.
Acupuncture: The insertion of acupuncture needles into trigger points can cause tense tissue fibers to relax.
https://www.hopkinsmedicine.org/health/wellness-and-prevention/muscle-pain-it-may-actually-be-your-fascia

Yoga Poses for Myofascial Release | 5 Poses to Try
https://www.acefitness.org/resources/everyone/blog/5667/yoga-poses-for-myofascial-release-5-poses-to-try/

@Insomniac

I wasn't clear...

Do you agree with his conclusions about proper nutrition and excellent health?

@haidut

Yeah.

I ask about Georgi a few hours ago, and BOOM. He posts!

@Lejeboca - thank you for taking the time to respond. I got things twisted around in my mind and it is embarrassing.

I think of the relationship between the eNOS and iNOS isoforms of nitric oxide synthase as being analogous to Dr. Jekyll and Mr. Hyde. The "i" in iNOS is related to inflammation, ischemia and intoxication all of which are generally bad. Whereas the "e" is related to the endothelium and is very healthy to have on board. Caldwell Esselstyn had his cardiac patients eat greens all day to maintain high levels of eNOS as part of his successful plan to reverse heart disease.

In 1998, the Noble Prize in Medicine was awarded to 3 people for their work on NO (see press release). This encouraged people to supplement with L-arginine to lower their blood pressure. The excessive iNOS from the supplementation had long term consequences that were not good.

Incidentally, aspirin releases eNOS.
Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action (2009)

The role of melatonin in bone regeneration: A review of involved signaling pathways
Abstract
Increasing bone resorption followed by decreasing bone mineralization are hallmarks of bone degeneration, which mostly occurs in the elderly population and post-menopausal women. The use of mesenchymal stem cells (MSCs) has raised many promises in the field of bone regeneration due to their high osteoblastic differentiation capacity and easy availability from abundant sources. A variety of compounds, including growth factors, cytokines, and other internal factors, have been combined with MSCs to increase their osteoblastic differentiation capacity. One of these factors is melatonin, whose possible regulatory role in bone metabolism and formation has recently been suggested by many studies. Melatonin also is a potential signaling molecule and can affect many of the signaling pathways involved in MSCs osteoblastic differentiation, such as activation of PI3K/AKT, BMP/Smad, MAPK, NFkB, Nrf2/HO-1, Wnt, SIRT/SOD, PERK/ATF4. Furthermore, melatonin in combination with other components such as strontium, vitamin D3, and vitamin K2 has a synergistic effect on bone microstructure and improves bone mineral density (BMD). In this review article, we aim to summarize the regulatory mechanisms of melatonin in osteoblastic differentiation of MSCs and underling involved signaling pathways as well as the clinical potential of using melatonin in bone degenerative disorders.
https://www.sciencedirect.com/science/article/abs/pii/S0300908422002127

Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures
https://pubmed.ncbi.nlm.nih.gov/28130552/

tea is very high in fluoride. The more expensive teas are harvested from young shoots, which are much lower in fluoride due to less time growing to accumulate it. But that is the issue, the cheaper assam teas can have 2mg per cup.

@Lejeboca - I did not know that one could search Sci-Hub by ISBN. Thanks.

Pantethine
Because of pantothenic acid’s role in triglyceride synthesis and lipoprotein metabolism, experts have hypothesized that pantothenic acid supplementation might reduce lipid levels in patients with hyperlipidemia [19].

Several clinical trials have shown that the form of pantothenic acid known as pantethine reduces lipid levels when taken in large amounts [20], but pantothenic acid itself does not appear to have the same effects [1]. A 2005 review included 28 small clinical trials (average sample size of 22 participants) that examined the effect of pantethine supplements (median daily dose of 900 mg for an average of 12.7 weeks) on serum lipid levels in a total of 646 adults with hyperlipidemia [20]. On average, the supplements were associated with triglyceride declines of 14.2% at 1 month and 32.9% at 4 months. The corresponding declines in total cholesterol were 8.7% and 15.1%, and for low-density lipoprotein (LDL) cholesterol were 10.4% and 20.1%. The corresponding increases in high-density lipoprotein (HDL) cholesterol were 6.1% and 8.4%.

A few additional clinical trials have assessed pantethine’s effects on lipid levels since the publication of the 2005 review. A double-blind trial in China randomly assigned 216 adults with hypertriglyceridemia (204–576 mg/dl) to supplementation with 400 U/day CoA or 600 mg/day pantethine [21]. All participants also received dietary counseling. Triglyceride levels dropped by a significant 16.5% with pantethine compared with baseline after 8 weeks. Concentrations of total cholesterol and non-HDL cholesterol also declined modestly but significantly from baseline. However, these declines might have been due, at least in part, to the dietary counseling that the participants received.

Two randomized, blinded, placebo-controlled studies by the same research group in a total of 152 adults with low to moderate cardiovascular disease risk found that 600 mg/day pantethine for 8 weeks followed by 900 mg/day for 8 weeks plus a therapeutic lifestyle change diet resulted in small but significant reductions in total cholesterol, LDL cholesterol, and non-HDL cholesterol compared with placebo after 16 weeks [19,22]. Increasing the amount of pantethine from 600 to 900 mg/day did not increase the magnitude of reduction in the lipid measures.

Additional studies are needed to determine whether pantethine supplementation has a beneficial effect on hyperlipidemia independently of, and together with, eating a heart-healthy diet. Research is also needed to determine the mechanisms of pantethine’s effects on lipid levels.
https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/#h9

@Mauritio said in Glycine is an anti-biotic, restores sensitivity to antibiotics:

In light of this thread, the findings of this old thread by haidut are even more interesting.

https://lowtoxinforum.com/threads/gut-bacteria-overgrowth-drives-cocaine-addiction-glycine-can-reverse-it.48285/

I'm puzzled. How can glycine be helpful if it feeds the bacteria? Aren't we supposed to deprive the bacteria of its food source to have an antibiotic effect such that the bacteria would just not be able to multiply and become a thriving colony by being deprived of its food source? How is providing more gelatin going to help?

@yerrag
Yes, although this study shows rapamycin has thymus weight lowering effect in mice. Although there was clearly a dose dependant effect and the HEDs were like 15-60mg per day which is really high, so I'm not sure if there would be any such effect if you were to take just 1-5mg / week .
So the weekly dose of this study was about 30-100 times higher than what most humans take.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9360838/

@sneedful said in vitamin k2 mk4 levels elevated in covid patients, k2 mk7 and k1 depleted:

is it because k2 mk7 and k1 are being rapidly converted into k2 mk4 which is then detected at high levels in blood?

No, I don't think so. K2 MK7 is preferably used for clotting problems. More soluble and also "reactive". Reactive to ox-agression.
But mind the peremption of K2 MK7: very fragile (3 months) if not well encapsulated and protected by e.g. rosmarinus.

Source: Chris Masterjohn
There is reason to think MK-7 would be better at supporting blood clotting.
“MK-7 is not just three times better than K1 at reaching bone; it’s also five times better at supporting blood clotting (Schurgers, 2007). This may be because the greater fat-solubility of MK-7 makes it hold on more tightly to the membranes within liver cells, making it stay active in the liver much longer rather than being released and broken down (Shearer, 2008). The liver is where clotting proteins are made, so more extended activity in the liver would explain why MK-7 could better support blood clotting. If this is correct, other long-chain MKs such as MK-8 and MK-9 probably share this property as well.”
https://chrismasterjohnphd.com/blog/2016/12/09/the-ultimate-vitamin-k2-resource/

It's advised not to take vitamin E at the same time as vitamin K when taking high dose.
Since I take 1 mg (1 000) K2 MK4 at breakfast, I never take vit E at the same time. 2x/wk for 400 UI mix toco.

Where do ppl buy it from?