Posts made by jamezb46

@sushi_is_cringe

Dbol + DHTE makes my mouth water

@Hussle1738

There is just enough truth in the argument from the genetic determinist camp as to make their position appealing.

For those who think that race is tied in some fixed way to race, I wonder if they’ve read the studies about inheritable traits being passed on for multiple generations in mice.

So, in a sense they are right that there is a genetic “difference” but that is simply a reflection of the past. Genes are the way an organism estimates the environment. If your last 5 generations had no time nor nutrition to engage in higher cognition, why is it a surprise that the current generation can not either?

@wester130 maybe you should try ammonia detox with calcium alpha keto glutarate and Ornithine

@Sugar I have thought extensively about this question and I am inclined to say that there are differences, and these differences are as a result of "imprinting" that has occurred over many generations.

We know that T3 correlates highly with intelligence. Stress destroys the thyroid and metabolism. So my argument would be that intelligence is lower in certain races because of chronic generational stress.

On a more societal level, I also think that people tend to follow what the expectations are for them, and again creativity requires strong metabolism so it's not a surprise that if you live in a culture where you are expected to not achieve anything, that will become your fate if you don't do anything about it.

I do think it can be changed metabolically, but there is probably some "hard coding" in the genome which is just to say that the weighted average over the past dozen or so generations is difficult but not impossible to reverse.

@lamb

Maybe you would do better with raw ginger, 5g or so daily. It does similar things to aspirin including thinning the blood, reducing prostaglandin, raising temps, mildly increase T, drop cortisol, increase insulin sensitivity. Will have more of a laxative effect.

@alfredoolivas

Yes that’s true, but it can be an average of averages.

For example: trial 1 is the average weight of 10 drops,

Trial 2 is the average weight of 10 new drops,

etc. then the final estimate for average is the average of each n trials.

Although this obviously isn’t perfect, it’s the best we can do without lab equipment

@BeamsOfEnergy From my experience, you need to weigh the drop on a milligram scale while knowing the mass stoichiometry of the solution and calculate like that. Using approximate volume of a drop is not accurate.

@Mauritio

Do you still take Policosanol?

@evan-hinkle

Well, it's more complicated than that. For one, the benefits of protein restriction are probably due to decreased methionine, cysteine, and tryptophan, or more specifically, poor ratios of Glycine/Cysteine, and Tyrosine,Phenylalanine/Tryptophan.

Also, the randle cycle is not as simple as fat vs carbs. Certain fats are more permissive of glucose oxidation than others. For example, Palmitic acid encourages glucose oxidation.

Hi all,

I'm currently a graduate student studying biostatistics. In Fall 2025, I'm going to have the opportunity to work with some other master's students to design a study.

What experiment from the 20th century should I try to replicate that will really expose contemporary scientific "knowledge" in biology?

The one I'm thinking of is randomizing mice to groups where the sum of PUFA + SFA + Sugar(or starch) is equal in calories for all groups but the ratios of PUFA, SFA, Sugar are varied across groups. I might even introduce an arm in which I see how high I can get the metabolic rate in the low PUFA groups by supplementing small amounts of liver.

I remember Peat reporting that the high PUFA groups were all fat whereas the low PUFA were all lean.

@wester130 increase sodium

@Serotoninskeptic

Well, whether it’s a good idea depends heavily on whether relatively constant protein consumption throughout the day has enough benefits that restricting protein intake outside a specific time window does more harm than good.

One of the best ways to increase metabolic rate is by building muscle. And I don’t know of any bodybuilders who have countenanced the idea of not eating protein at breakfast and lunch.

@samson

Interesting. So your numbers in the gym stayed the same? I wonder if you could actually get stronger on such a diet? Perhaps adding in some AAS (oral, mild) would help to answer the question as to whether with AAS you need more or less protein to build muscle.

I think that the idea we ate meat later in the day and fruit earlier is also plausible for a number of reasons. One, fruit would have been easier to find to start the day (literally just hangs there lol).

Two, animals humans like to hunt like deer and others are more active later in the day.

Three, if we got a kill, we would have to travel back to camp to cook it and share it with others. Or, if we were traveling, we would probably have waited until we stopped for the night to eat it.

I also agree that just because something is adaptive, that doesn’t mean it should be avoided. For example, caffeine is probably there as a natural fungicide and a toxin to insects or whatever else wants to eat the part of the plant that contains it. There’s some discussion about how the plant might use caffeine to give bugs an “energy boost” but I think that’s the wrong way of thinking about it. It’s probably for self-defense and that’s all from the plants POV.

But obviously caffeine has known benefits.

@samson I also wonder if it’s not wiser to follow some widely established dietary principles rather than hyper focusing on FGF 21.

I also wonder whether FGF 21 is up-regulated when protein (or whatever the body uses as a proxy thereof, perhaps isoleucine) is scarce in the diet because the body is trying to get the organism to eat more to satisfy its needs for isoleucine.

I think we can therefore try to distinguish between permissive increases in metabolism and the body not permitting the metabolism to decrease.

The former would be an increase in metabolism because the body senses that it can “afford” to do so because of a plenitude of resources and a feeling of safety or dominance.

The latter would be when the body recognizes some kind of danger, necessity, or need, the response to which must be an increased metabolism.

For example, good sleep, caloric surplus, warm temperatures, would all create permissive increases in metabolism.

Whereas danger (increased adrenaline) would cause the body to not let the metabolic rate drop because of some need it thinks it must fulfill.

When it comes to restricting isoleucine, I’m inclined to say that the body increases the metabolic rate in an effort to eat more isoleucine-poor food (the food you have been eating) in order to get enough protein.

@Serotoninskeptic

Well if you read the original thread, he did get a metabolism increase from cypro + BCAA + tyrosine (no gelatin or goat milk)

So, my claim here is not that BCAA is necessarily metabolism boosting (though @haidut has evidence they increase maximum lifespan) but that it’s not metabolism hindering, which I thought is a refutation to @anabology ’s point.

@Serotoninskeptic

Why do you think @haidut 's BCAA + Tyrosine 2013 experiment worked then?

He claimed that his BPM reached over 100 and body temp of 39 C by consuming 2mg cypro +3500 mg BCAA and 1500 mg Tyrosine + Goat milk protein + Gelatin.

If BCAA were truly anti-metabolic, what can explain that?

@PeatPerspective Ever heard of Fenclonine?

@alfredoolivas

The butter oil seems interesting, though. From some research I did, shea butter from the warmest parts of Africa can have as much as 40% stearic acid.

So, maybe thats a natural alternative.

@Crypt-Keeper

DHT is not very orally bioavailable. I guess you could dissolve it in tocopherols or DMSO but the former can be difficult. It's not very soluble in tocopherols. A few forum members have had difficulties with dissolving it in vitamin E.

Maybe sublingual in DMSO is the best bet.

@anonymous1

People in the know have known about it for a while. There are reviews of people saying it’s amazing, as good as any AAS. However, it’s very hard if not impossible to source.

There are pharma esters of DHT such as Pesomax and Anaboleen depot, but I don’t know where to find them.

With that said, I do feel as if, should someone open up a supply chain of the stuff, it could explode. When you think about it it’s not even that hard to do. Just get about 500 grams of the raw stuff from china, synthesize the ester, and get the word out.