Posts made by jamezb46

@metabolicmilk

I could not get vitamin E to mix with DMSO, I would not recommend this. Unless you’re talking about dissolving d-alpha tocopherol acetate in DMSO. That may well work, but according to Ray the acetate ester is about 50% as effective as the nonesterified tocopherols.

@metabolicmilk

Hey that’s my ratio

@RFC32 for the love of God why would you essentially tease the success you had with sublingual T and not disclose the formulation

@metabolicmilk

Still waiting on my shipment from PPL. Will update this thread after I dissolve the powder and again after a few weeks of using it.

@RFC32

I read a study where they gave 400 mg per day in 4 divided doses of 100mg to Eunuchs. There were no detrimental effects on the liver.

Given that Peat recommended 10-20 mg P4 when dissolved in vit E and taken orally, I cannot think of any reason why a low dose of 10mg T orally dissolved in vitamin E would not be massively effective at “supplementing” testosterone levels in healthy men.

I myself am going to get to the bottom of this. T powder is on the way, vitamin E is on hand. Hopefully I can get the T to dissolve in the tocopherols and I can present some solid results after a few weeks of use and we can all get on the same page about the exciting idea of homebrewing the “male version” of progest-e.

@Lothric I decided on dissolving T in vitamin E. Similar to progest-e except I will use T instead of P4.

I think that one of the benefits of the bioenergetic perspective is that there are certain unifying principles that explain why certain substances or effects are beneficial and others are not. Among those principles is that whatever can afford the cell increased stability is of benefit to it. Thus, saturated fats, gelatin, niacinamide, etc. can be thought to be of benefit partly because they simply make the cell more lipophilic and less hydrophilic.

So, when it comes to liquid vs structured water, it should be clear that the structured water is the more beneficial, because it increases the stability of the cell.

You can even do this experiment at home: Dissolve a tablespoon or so of collagen protein and niacinamide in a few oz of water and compare that to water without anything extra dissolved in it. The one with the protein and niacinamide will be much more gel-like than the other.

@madmac

The reason why we dissolve in tocopherols is because according to Ray and also current research the tocopherols allow the steroid to travel through the body on chylomicrons that are not metabolized in the first pass by the liver.

In addition to that, there is the lymphatic system effect whereby the steroid when dissolved in a fat of chain length 12 or greater is absorbed through the thoracic duct and enters the lymphatic circulation, thus bypassing the liver on the first pass.

To be completely frank, I do not know what relationship exists between these two mechanisms. I don’t know if they are two different mechanisms or if one is the effect of the other. Perhaps @Santosh or @haidut can chime in here.

It does seem that the steroid would have to be dissolved in either the tocopherols or the longer chain fat (or both) for either effect to take place, but I don’t know for sure.

@madmac

How much DHT in how much vitamin E? According to a post on RP forum, each drop of progest-e contains 4-22 mg tocopherols. If we estimate each drop to be 1/20 mL, and we know 100mg P4 is in 1/4 tsp of progest-e, we know that 81 mg p4 is soluble in 1 mL of a solution containing 80-440 mg tocopherols.

So, to be conservative, I would think that 40 mg DHT should be soluble in 1mL of a solution containing 80-440mg tocopherols.

For reference, the vitamin E product I have has 10mg tocopherols per drop ~ 1/20 mL. So, I would expect to be able to dissolve at least 20-40 mg DHT per mL in my solution.

@wester130

Why on earth would it be pointless?

@Santosh

On the RP forum you mentioned dissolving T in 50% ethanol 50% tocopherols. I mixed tocopherols with ethanol at home, and they do not mix well at all.

Did I understand you correctly that you mixed vitamin E with ethanol and dissolved T powder in it?

@SpaceManJim

For me it has to be Creatine or Emoxypine. Methylene blue is up there too. Creatine makes my muscles look bigger and perform better and emoxypine keeps my mind clear after workouts. Methylene blue is amazing. Gives me great energy, and synergizes with the emoxypine.

I’m planning on doing an experiment with the Russian actoprotector Bemethyl soon as well as the Russian drug Cytoflavin. Perhaps one of them will prove to be even better than the ones I mentioned.

@secondkelping sounds good. I probably should have wrote that when I applied the C8:0, I didn’t wipe it off, just left it on.

@Hearthfire Correct. Here is the link to the one I bought.

@Andrewㅤ FYI I dissolved mine in Glycerin for increased viscosity and all the actives dissolved well in 1-2 oz

@Hearthfire but it needs to be applied to the skin as I wrote. The oral capsules will not work.

@Hearthfire I do think mct oil would work

@yerrag

1. I used it every day for about 10 days after which I did not need to use it any more to maintain the benefits. I saw visual benefits within the first day and benefits as regards itchiness/irritation of the skin within hours.

2. I was using a pure C8:0 triglyceride product

3. I do not know which/if any yeast were present or were causing the condition. If you go on PubMed, and search for Seborrheic Dermatitis, you will find some studies claiming that there is a spectrum between Seb Derm and other inflammatory skin conditions such as psoriasis meaning that there is no clear distinction. My present thinking is that the saturated fatty acids themselves improve epidermal function or outcompete the unsaturated fatty acids and thereby decrease inflammation for reasons described by Haidut in the thread I linked.

Since about the age of 20, I've suffered from seborrheic dermatitis on the nasolabial folds, chin, eyebrows, neck, and scalp. After doing much research, I found a couple of treatments that seemed plausible to try.

Protocol
The one that worked was topical application of C8:0 triglycerides to the affected area. Within days, symptoms began to abate. After about a week of consistent daily application to the skin, I no longer needed to apply it at all and my skin remains clear.

Mechanism of Action
While the exact MOA is difficult to know for sure, based on the research that I've done, I have a theory.

According to this study,

"Malassezia utilizes human sebum triglycerides as food, and the metabolites such as oleic acid and arachidonic acid cause aberrant epidermal differentiation, barrier defects, and inflammatory response"

So, the yeast Malassezia consumes triglycerides found in the sebum and leaves behind the inflammatory unsaturated fatty acids which then destroy the epidermis.

The C8:0, I think, when applied topically is absorbed by the skin and is used by the skin cells to rebuild and combat the effects of the unsaturated fatty acids. In addition, C8:0 has anti-fungal effects, which may simply be due to the fact that the saturated fat is absorbed by the host and is used to mount an effective immune response and restore barrier integrity.

For an in-depth explanation as to the benefits of saturated fats for decreasing inflammation, read Haidut's post on methylated SFA

Conclusion
I think that you can take this as very strong evidence of just how harmful the unsaturated fatty acids are for us and how healthy the saturated fats are, as replacing one with the other is able to restore even fairly seriously compromised skin barriers.

@Androsclerozat Let's get a nice purple color, the color of royalty