Posts made by jamezb46

@alfredoolivas

I know of females who have run it for months with only mild liver enzyme elevation, not over the reference range. I don’t think it’s seriously liver toxic at 20-30 mg/day.

I’m not aware of any kidney toxicity issues, but who really knows for sure. There aren’t studies available that investigate this. It is known to decrease aldosterone though I think by about 50%.

Because people report keeping their gains, I don’t think it’s highly suppressive.

People report getting an improvement in mood from it similar to Dbol. They also say it increases metabolic rate significantly and temperature.

@sushi_is_cringe

Based on the studies I've read on Anavar, Dbol, and the one you just posted, they all do the same thing.

While the synthetic androgen is present in meaningful concentrations

LH, FSH do not decrease significantly,

Testosterone decreases by around half but is NOT zero

After discontinuing the synthetic androgen

Testosterone production rebounds relatively quickly (days) to baseline WHERE IT REMAINS, and there may even be supercompensation

So, what's problematic about this? While you're on it, who cares if endogenous production goes down? The net effect is a supraphysiological amount of androgens.

After you come off your own production comes back, so as far as I'm concerned, this is all we were ever hoping for.

@sushi_is_cringe

Well the thing is there aren't any studies to read about tbol, for example. Nor are there any coming because pharma companies are no longer interested (if they ever were) in producing AAS that are ergogenic.

So, all we can do is go off the limited information we do know from studies (ex. Dbol and Anavar have shown to be minimially suppressive) and look at people's experiences.

Based on my reading of people's reports with Tbol, I would say that they generally report that its less problematic than Dbol, and the gains they make on it they report as being more "keepable" than those with Dbol.

One of the few scientific studies I was able to find on the specific effects of Dbol on skeletal muscle was that it did in fact hypertrophy it, but the muscle that was grown on Dbol was not the same as the "dry" muscle that is usually built: It had different amount of potassium and it is indeed accurate to characterize as the bodybuilders do as "water weight" or "muscle fullness" and not dry tissue.

Although there aren't studies on Tbol (or if there are I have no idea how to get them - it was developed in secrecy by the East Germans ffs), based on people's reports, it does seem that Tbol specifically avoids the issue of gaining only "water weight" in the muscle as opposed to real dry tissue.

That's why I would go with the Tbol personally but it Dbol works for you go for it.

@sushi_is_cringe

Yes, I think this is right regarding dbol and halo, but there’s some complications. Because halo is expensive to make, you have to be quite sure that what you’re getting is real halo because there’s a higher chance it’s being faked.

And dbol is probably good at 10-20 mg day but there’s the risk of increased BP and the methyl estradiol it produces is known to be harmful. It might not be an issue at a low dose but something to keep in mind.

There are also studies showing that Anavar is non-suppressive at 20mg/day. The same pattern with Dbol in the study I posted before: LH, FSH slightly decrease, testosterone decreases slightly, liver enzymes not significant affected.

Also, if dbol has this safety profile then why use it instead of tbol, which is basically the same thing but with zero estrogen conversion. I guess price if that’s an issue because dbol is generally cheaper but I’d just rather go with tbol.

@thyroidchor27

Maybe cyproheptadine could help you out if apetite remains an issue

@alfredoolivas Pretty sure that fluoxymesterone (Halotestin) increases cortisol fairly strongly despite being a strong androgen.

@sushi_is_cringe Where do you buy? I usually get it from whole foods, Tubes and Tentacles, Town Dock brand. Says its wild caught.

If the "flesh meat" of the squid has that much copper, imagine a squid liver xD

I'm also interested in the heart and brain of it. Idk why but I wanna eat it

@sushi_is_cringe

Yes, this is why I like squid. It's also low PUFA and high in cholesterol.

@bioenergetical DMSO

@sushi_is_cringe

Yes, the 5 mg, 3x per day sounds right. 15 mg/day is where some of the clinical trials start with mental illness sufferers like depression.

@Corngold

Respectfully, my friend, On the Fourfold Roof of the Principle of Sufficient Reason has nothing to do with Buddhism. It’s a thorough analysis of causation and it has implications for free will, mathematics, physics, and logic. It’s metaphysics.

Sure, you could claim that it’s not “original”, but so what? That doesn’t mean it’s not valuable. Is it “original” to build a house from pre-existing materials, or is that a worthless endeavor? Besides all our perception is from nature and so is again not “original”. So what’s the point in insisting on “originality”. Do you mean to suggest he wasn’t an original thinker in the common sense? He most certainly was.

@alfredoolivas yes that’s where I got the idea. But maybe it’s true at low doses and not high. In other words maybe the potentiation is 10x at very low doses of caffeine like 1 mg but approaches 1x as the amount increases toward some value like maybe 10mg caffeine.

@Corngold

Have you read Schopenhauer? Have you read his On the four-fold root of sufficient reason? Have you read his critique of Kant? Or are you just parroting what others who don’t actually read the source material say about it?

@sushi_is_cringe

I don’t think he was an “incel”

He was highly intelligent, and is actually famous for having a high sex drive that influenced his philosophy. He probably had extramarital sex, though.

@sushi_is_cringe

If you want to understand Western philosophy

The World as Will and Representation - Schopenhauer (written when he was about 26)

@happyhanneke It potentiates the effect of the caffeine meaning any caffeine co-adminstered with the MB makes the effect of the caffeine as if you had taken approx a 10x dose of caffeine. So, if you take MB with 10 mg caffeine, you get an effect from the caffeine as if you had taken 100mg caffeine.

@CO3 Lactoferrin probably

@CO3 Do you have any actual evidence that 7mg (likely 0.1 mg/kg) is "high dose"? It's used at 15-60 mg per diem for all sorts of mental health disorders and was used at doses far beyond that in world war I for months.

@alfredoolivas

Well since most of the pregnenalone that is taken orally is converted to progesterone derivatives, I'm not sure if that would confound the calculation.

If 10-15x pregnenalone in circulation is what is needed to prevent testicular atrophy, then you're probably never going to be able to get there with oral supplementation since most of it is converted to progesterones. But, maybe that's fine because progesterone can also save the testes.

Why not just do transdermal pregnenalone or testosterone to the testes (or both) together with an AI like androsterone? If someone wants to try this, it would be very useful.

@alfredoolivas

Yes, but its downstream effects are inhibiting T production.

I wonder if Ray’s suggestion to use Pregnenalone to safeguard the gonads would work to preserve their steroidogenic potential even in the presence of high levels of circulating androgens?

And if that did work, perhaps using topical Pregnenalone, k2, and caffeine on the scrotal skin would be even more effective.