@samson I also wonder if it’s not wiser to follow some widely established dietary principles rather than hyper focusing on FGF 21.
I also wonder whether FGF 21 is up-regulated when protein (or whatever the body uses as a proxy thereof, perhaps isoleucine) is scarce in the diet because the body is trying to get the organism to eat more to satisfy its needs for isoleucine.
I think we can therefore try to distinguish between permissive increases in metabolism and the body not permitting the metabolism to decrease.
The former would be an increase in metabolism because the body senses that it can “afford” to do so because of a plenitude of resources and a feeling of safety or dominance.
The latter would be when the body recognizes some kind of danger, necessity, or need, the response to which must be an increased metabolism.
For example, good sleep, caloric surplus, warm temperatures, would all create permissive increases in metabolism.
Whereas danger (increased adrenaline) would cause the body to not let the metabolic rate drop because of some need it thinks it must fulfill.
When it comes to restricting isoleucine, I’m inclined to say that the body increases the metabolic rate in an effort to eat more isoleucine-poor food (the food you have been eating) in order to get enough protein.