A lot of us are interested in using transdermal/oral/sublingual steroids to get performance enhancing effects or pro-libido and pro-masculinizing effects.
So, what do you think about a methylated androsterone formulation? In theory it would convert to methyl-DHT, which would stay in the body longer than would its base metabolite, bioidentical DHT. It should also convert to methyl-androstanediol, which shares many of the calming effects of allopregnenalone and would again remain in the body for longer due to the methylation.
I don’t think any of the metabolites of methyl-androsterone would be hepatotoxic, either. That is because the hepatotoxicity of the methylated androgens is likely due to the methylated estrogens that the androgens are metabolized into. But since neither Androsterone nor its metabolites can be easily turned into estrogen, I don’t think this is a concern.
Lastly, I recall that Haidut posted a study showing that androsterone and DHEA in a 50-50 to 25-75 ratio were capable of completely re-masculinizing castrated rats. So, if the methylated androsterone ever gets produced, perhaps running it with IdeaLabs Pansterone would be the ultimate pro-masculinizing stack.