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  • Humorous musings

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    DavidPSD
    [image: 1772102331525-47ba56e8-1e11-47ae-b195-65dfeb9c7f70-image.png]
  • Is heterosexuality a health marker?

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    Milk DestroyerM
    I've seen a couple of gay peaters that seem to be relatively healthy. Nathan Hatch on fuckportioncontrol.com comes to mind as being gay but seemingly healthy. Though I think he's always been gay and did have cancer and digestive problems in the past. I do think it's more likely that someone is predispositioned to being gay if their mother has high stress or thyroid problems though.
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    LucHL
    Here's a concrete example of where the information came from and how I used AI, in relation to microglia and inflammation. I don't master everything https://mirzoune-ciboulette.forumactif.org/t2174-neuropathologie-comment-attenuer-la-fibrose-en-cas-d-algodystrophie-et-de-fibromyalgie#30632 Excerpt Neuropathology & how to mitigate fibrosis in complex regional pain syndrome (CRPS) and fibromyalgia. Key ideas • Improve nerve conduction and limit hyperalgesia. • Limit fibrosis (dermal sclerosis) by modulating TGF-β1 stimulation. • Combined approach to fibrogenesis, the extracellular matrix (ECM), and inflammation. • Tactics to counteract fibrosis & optimize conduction – Practical aspects. Antifibrotic action of curcumin & dexamethasone. Anti-excitotoxic action of magnesium bisglycinate Neurotropic mechanism of action of thiamine (B1), pyridoxine (B6), and vitamin B12 in cases of heightened neurosensitivity and as modulators of inflammation PEA to stabilize mast cells and limit microglial activation. By stabilizing mast cells, PEA reduces the sensitization of peripheral and central nerves.
  • ELITE DIETS

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    bradB
    @ThinPicking yes - no glorifying violence or illegal behavior. Thank you.
  • PC choline to stabilize membranes

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    LucHL
    I'm going to end up with useful nutrients to protect lipid directly 1. Antioxidants That Protect Lipids Directly Vitamin E (tocopherols + tocotrienols) • Acts as the primary lipid-phase antioxidant, protecting membrane phospholipids from peroxidation. • Gamma-tocotrienols add stronger chain-breaking antioxidant activity in membranes. Dose: 400 IU mixed tocopherols (with gamma tocotrienols) 2–3×/week, or 20–25 mg/day. Note: More is not better; excess can disrupt redox balance. Beta-carotene (from food) • Quenches singlet oxygen and supports antioxidant recycling. • Best obtained from diet (carrots, sweet potatoes, leafy greens). Astaxanthin • A potent carotenoid that embeds across the lipid bilayer and protects both sides of the membrane from ROS. • Particularly effective in mitochondrial membranes. 2. Water-Soluble Antioxidants and Cofactors Vitamin C • Regenerates oxidized vitamin E. • Supports collagen, immune function, and general redox balance. Magnesium • Key mechanism: Magnesium inhibits PLA₂, the enzyme that releases arachidonic acid (AA) from membrane phospholipids. • Mg²⁺ stabilizes phospholipid bilayers, reduces Ca²⁺-dependent PLA₂ activation, and lowers eicosanoid production. Dose: 350–420 mg/day elemental magnesium. Form: Magnesium bisglycinate (≈2.5 g/day split into 2–3 doses to reach ~450 mg). Note: Higher needs after stress; do not “preload” before stress. Zinc • Protects thiol groups and stabilizes membrane proteins. • Inhibits NADPH oxidase–induced lipid peroxidation, reducing the arachidonic acid cascade. Dose: 10–15 mg/day. Mechanism: o ↓ membrane peroxidation o ↓ PLA₂ activation o ↓ free AA release o ↓ PGE₂ formation (independent of COX inhibition) Key references: • Prasad, Am J Clin Nutr, 2009 • Ho et al., Free Radic Biol Med, 2008 Selenium • Required for GPx4, the enzyme that repairs lipid hydroperoxides directly in membranes. • GPx4 is the only enzyme that can detoxify oxidized phospholipids inside the bilayer. Dose: 100 mcg 2–3×/week; more if inflammation is present. Note: Excess selenium causes fatigue and organ stress — more is not better. 3. Structural Lipid Support Phosphatidylcholine (PC) • The primary phospholipid of cell membranes. • Essential for maintaining bilayer structure, fluidity, and repair. • Supports ER–mitochondria lipid exchange, which is required for cardiolipin remodeling. Stearic Acid • A saturated fatty acid that “solidifies” and stabilizes membranes without promoting peroxidation. • Helps maintain the optimal balance between membrane fluidity and rigidity. Sources: Cocoa butter, dark chocolate, beef tallow. Why This Matters for Mitochondria • PC stabilizes the outer mitochondrial membrane and supports lipid trafficking. • PE (phosphatidylethanolamine) shapes the inner membrane and allows cardiolipin to organize respiratory complexes. • Cardiolipin anchors the electron transport chain and is extremely sensitive to oxidation. • GPx4, vitamin E, astaxanthin, zinc, and magnesium protect cardiolipin and PC from peroxidation and enzymatic degradation. • Stearic acid and low-PUFA intake prevent fragile, oxidation-prone lipids from entering mitochondrial membranes. Together, these nutrients maintain membrane integrity, mitochondrial efficiency, and resistance to oxidative stress.
  • Unbelievable Reddit thread

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    ThinPickingT
    @Corngold said in Unbelievable Reddit thread: I think male hair has been sexualized by the non-committing hypergamous modern female and baldness was always the norm for at least 50% of dudes after like 25-30. "Unconsciously" they probably know what actually causes it. I don't, so I can't say anything more about this. They're all adorable. Also the shape of a Hamilton-Norwood is not suspicious at all.
  • Vitamin C Role in Blocking Nitrosamine

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    LucHL
    @sunsunsun said in Vitamin C Role in Blocking Nitrosamine: u eat seed oil chips??? Yes, I eat Lays’ pepper and salt chips, only when I “crave” for, not as a snack. I know they use sunflower oil, rich in PUFAs, which I shouldn't be using. It’s rather once a month, and even less. Nothing is forbidden if you limit the impact (quantity and frequency). Because we only "need" a tiny amount of Omega-6 (around 1-2% of calories) for essential functions, our modern intake (often 10-20%) sends a constant signal of "inflammation and storage" to the body. The Bottom Line: You can't just "burn off" a bad type of fat the next day. It stays in your system, influencing your inflammatory markers for years. This is why a small amount of "bad" fat is more disruptive long-term than a large amount of "good" fat. I know. By keeping the chips to once a month, I ensure that these "fragile" fats never become the primary building blocks of my cells. This is where the quantity vs. type debate is settled. I know fat isn't just stored energy; it’s a signaling molecule. Nobody is perfect Useful info (in French, translator needed, but with English links): Les besoins réels en AG polyinsaturés surestimés ? (Are the actual needs for polyunsaturated fatty acids overestimated?) https://mirzoune-ciboulette.forumactif.org/t1581-les-besoins-reels-en-ag-polyinsatures-surestimes#18738
  • Epic Drink Recommendations For Starting Alcoholics

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    sunsunsunS
    a teaspoon of grain alcohol in a 355ml coca cola
  • I want to bully danny roddy

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    EPSTEINE
    #BIOENERGETICFRIDAY[image: 1769807397165-img_2571.jpeg]
  • A Treatise on the Neumale

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    L
    @Corngold ah so I wasn't referencing the video I was sharing when I said I didn't think women were at fault, I was referencing your comment, that part I disagree with I think women get blame kinda like a child is to be blamed for their bad decision. Yes, they made the choice, but who built the environment. And that's why I'll forever be a masculinist in my assessment of the dynamics of the sexes -- it's always man's responsibility at the end of the day, women have cunning and deception, but like a child trying to trick a parent with even clever lies, a parent's best guard is to be unwavering in stable and wise conduct, and they will weather conflict well -- this requires a discipline, most parents, indeed men, don't have. On to the point of the types of feminine, I'm always one for some classical skull calipers and their categorizations, but I feel like it's back seat to man with huge balls going apeshit on the opp. I think women (and men) have changing charactar traits according to circumstance/environment. I don't believe it's set in stone... For instance, which came first: Hitler, or WW1 and it's consequences?
  • A Survey of Dietary Liver and Oyster, and Their Impacts

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  • How to get Vit C from potatoes milk and meat

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    U
    @LucH said in How to get Vit C from potatoes milk and meat: @sunsunsun said in How to get Vit C from potatoes milk and meat: have you considered an orange? I suppose you're asking for "histamine problems". If you want to know if there is some DHA in orange juice or in the fruit, it's not pertinent. Mostly AA in the fruit. DHA is present in fresh and processed orange juice, where the enzyme ascorbate oxidase can catalyze its formation, especially at temperatures above 30°C. Stability: The total ascorbic acid (AA) content (ascorbic acid + DHA) decreases over time and with exposure to air/oxygen. Histamine Orange is H3, like most citrus fruits. Clementine is H2. I do not eat H3 nor L3 at breakfast (histamine). No orange when in crisis. Now under control. Ok for one orange a day, but still with 1 000 0000 unit DAO enzyme every other day. Naturdao. No need to take the one with useful nutrients (Mg & B6) as I already follow them with cronometer.com Note: When leaving fresh orange juice for 2-3 days in a frigde with some "peel", there is a fermentation, and we got new DHA. So drop after 36 hours, then higher at 72 hours. All that commun claim that oranges/citrus fruits inherently increase histamine therefore it can be bad or is bad isnt true, most oranges simply arnt optimally ripe so it wont make people feel optimal, if a person eat enough optimally ripe oranges, it would increase relaxation significantly, more than most foods
  • Costco PUFA shakes?

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    engineerE
    One month later: I'm using more protein powder and whenever I don't, the Nurri shakes take its place, along with Super Coffee in the morning.
  • I will teach you to grow taller

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    alfredoolivasA
    @Sugar said in I will teach you to grow taller: Frankfurt plane Is it fun to be this crazy?? I kind of wish I would be like this when my mental health is down the drain.
  • suffice to say you are all brown dysgenic subhumans on this forum

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    alfredoolivasA
    @lykos [image: 1768243889124-bef2bc2c-a00c-44be-8445-2343e46a5a7a-image.png]
  • Nature of Estrogen/ Positive Ions

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  • Odd taste after milk

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    sunsunsunS
    @nothingclever oh then nvm
  • WW3 talk

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    sunsunsunS
    [image: 1767469972043-97b9c5b6-a428-41f0-b43c-f11f84306192-image.png] @ThinPicking
  • Head mirrin!

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    GardnerG
    @Norwegian-Mugabe It is a historical coincidence that Franz Kafka consumed large quantities of unpasteurized milk as part of his strict vegetarian diet, [image: 1767126158963-06b3c447-193a-4966-a8df-01ce6b3c4a46-image.png] which he adopted for general health purposes and to ease ailments like migraines and insomnia, long before his tuberculosis diagnosis. He consumed unpasteurized milk and believed it was a healthy choice, a common view before the understanding of bacterial transmission was widespread. Milk doesn't necessary causes hairloss but there migh be a connection between his tuberculosis and habit of drinking unpasteurized milk
  • Neuro-degeneration: A multi-factorial approach

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    LucHL
    Useful links *) Coenzyme et Cofacteur ne se lient pas par insuffisance de Thiamine (B1) (Coenzyme and cofactor do not bind due to thiamine (B1) deficiency) https://mirzoune-ciboulette.forumactif.org/t2015-vaut-le-detour-it-s-worth-the-detour#29416 *) B1 deficiency and Potassium Waste Thiamine Deficiency Causes Intracellular Potassium Wasting 04/23 By Elliot OVERTON, DIPCNM CFMP, author at “Hormones Matters” is a nutritional therapist and functional medicine practitioner based in the UK. https://www.hormonesmatter.com/thiamine-deficiency-causes-intracellular-potassium-wasting/ Thiamine deficiency causes intracellular potassium wasting. Excerpt: In short, the bioenergetic state of the cell governs its ability to retain potassium ions and structure water into a gel-like phase. A cell with plentiful ATP can maintain this ability, independent of the “sodium potassium pump”. On the other hand, cells lacking energy lose their capacity to retain potassium, intracellular water becomes “unstructured” and intracellular concentration of sodium ions increases and the electronic state of the cell is changed. This causes water to “leak” out of the cells into the extracellular space to produce a localized edema of sorts. Thiamine, playing a central role in energy metabolism, is partially responsible for maintaining healthy redox balance and a continuous supply of ATP. Hence, it is no wonder why a deficiency of this essential nutrient produces such drastic changes in the cellular electrolyte balance. *) Thyroïde B1 B2 B3 – Interaction entre les vitamines du groupe B et la thyroïde https://mirzoune-ciboulette.forumactif.org/t2018-comment-booster-votre-energie#29549 Thyroid hormone (thyroxine) regulates the enzymatic conversion of riboflavin into its active coenzyme forms. B2 is necessary for the regulation of thyroid enzymes: B2 helps to organify iodine (i.e. the incorporation of iodine for the production of thyroid hormones). *) Choline is a well-known methyl donor, but it cannot play a methyl-donor role until it is converted to betaine in the liver and kidneys. Avoid chronic high niacin exposure since it might induce a methyl pool depletion. Excessive nicotinic acid increases methyl consumption and hydrogen peroxide generation in rats https://www.tandfonline.com/doi/full/10.3109/13880209.2012.697175 https://www.nature.com/articles/hr2011133 *) Anti-Stress & Neuro-Protective Effects of Thiamine (B1) Mitochondrial Energy Uploaded thanks to Optimized Enzyme Communication https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1#29712 Neuroprotective Effects of Thiamine Impact on mitochondrial respiration – Link with ATP production Power plant (power station generating electricity) The role of thiamin deficiency in lower brain dysfunction (dysautonomia) Nutrient deficiency & interaction of vitamins B Understanding nutritional & functional deficiencies (enzymatic metabolic block) How much and which kind of thiamine? (video Elliot Overton) How to proceed to avoid / limit a paradoxical reaction.