What are you trying to do? Acetozalamide is a carbonic anhydrase inhibitor; so is thiamine.
The importance of thiamine (vitamin B1) in humans
" Carbonic anhydrase isoenzyme inhibitors (e.g. acetazolamide) are used to prevent pulmonary edema, altitude sickness, and increase oxygen levels. Thiamine also acts as an inhibitor of the isoenzyme of carbonic anhydrase. "
also:
New Developments in High-Dose Thiamine: The Legacy of Antonio Costantini
"The inhibition of carbonic anhydrase isoenzymes by high-dose thiamine and the resulting production of carbon dioxide could lead to reductions in fatigue and other symptomatic improvement through one or more of four potential pathways: (a) by reducing intracranial hypertension and/or ventral brainstem compression; (b) by increasing blood flow to the brain; (c) by facilitating aerobic cellular respiration and lactate clearance through the Bohr effect; or (d) by dampening the pro-inflammatory Th-17 pathway, again through the Bohr effect, potentially mediated by reductions in hypoxia-inducible factor 1."
Are you trying to resolve lactic acidosis with the baking soda? In order to have good oxidative metabolism, thiamine is needed because it acts as a co-factor for several enzymes in the process. In a thiamine deficiency, the final bi-product from the Krebs cycle is lactic acid; when thiamine is available, the final product is carbon dioxide.
Or are you working on something else entirely?