Posts made by Mulloch94

https://inlibrary.uz/index.php/science-research/article/view/28822

"In the world, hypovitaminosis A occurs in one third of children under the age of five. It kills 670,000 children under the age of five each year. An estimated 250,000-500,000 children in developing countries become blind each year due to vitamin A deficiency (mostly in Southeast Asia and Africa)."

Sobering fact that we live in such a privileged society here in the capitalist west that we get to explore these dumb fringe ideas like "poison A" while kids are literally dying from a A deficiency (and other deficiencies most likely).

@yerrag Interesting, I'm wondering if the use of the calcium-channel blocker is increasing parathyroid hormone (R) which is causing a higher demand for magnesium.

Oysters - A good brand, they can be obtained on Amazon. I prefer the chili pepper ones. They also come smoked in just olive oil (no pepper) and traditionally packed in water.

Oatbran - Best company hands down. They also sell the best powdered milk on the market too. These products can also be found at Amazon.

Cheese - This is my main one, although I will occasionally pick up some fresh raw cheeses as well. Only ingredients is the milk, culture, and rennet. You may be able to order it, but it's best to just have a Costco membership so you can pick it up.

https://www.youtube.com/watch?v=1bAQSqBacEk

I'm not sure what Agar powder is (something from seaweed I think, based on my preliminary google search) or it's safety profile, but you could obviously supplement with gelatin instead. Looks very tasty, and very Peatish.

I think I remember Haidut saying the ideal ratio was more like 1:5 of vitamin D : vitamin A. But I haven't seen that post in a few years so I might be misremembering. I think he cited a study though.

@NotShanalotte said in Kidney general:

I've since moved to 20,000 IU vitamin D a day which includes non-kidney improvements such as T3 response as well.

Yeah when I was hypothyroid I was also deficient in vitamin D. No matter how much thyroid I took my temps would never budge. Once I corrected my D3 deficiency, I light up like a furnace when I take my thyroid now, lol. In my experiences whenever I'm not responding to thyroid it's usually a PTH issue, which I guess makes sense considering Peat called it the primary thyroid antagonist. 20,000 units is a lot though, especially year round. That might make vitamin A requirements go up. I'm still trying to determine what a good ratio of D3:A actually is. The Weston Price foundation said 1:10 of vitamin D : vitamin A, but I'm not sure I trust those recommendations. Very shoddy organization to say the least considering they recommend oxidized cancerous liver oil.

@NotShanalotte That sucks, I'm sorry about your dad.

@S-Holmes No I've never read his book. Don't see the purpose, even if it does work I've found my own way through my problems. Also the last person I've seen to take up arms against the CICO school of thought was Cirion on the old forum, and one of his very last posts were him flipping out on Ray for supporting calorie reduction, and then he suddenly disappears. Rage quit the forum I guess, lol. I don't think he was being very truthful about his weight loss journey either. Just my opinion, so I can't prove anything.

I just found it weird he was gaining weight then a couple months later summed up his posting time on the forum by saying "Ray wrong, I keep getting better...bye bye now." I don't wanna be that guy that says "post pics or it never happened," but when someone claims they can defy CICO and eat 5,000-7,000 calories a day and lose weight I'd like to see more than just their words on a thread. Because I equate that statement to some astronaut going into space and tweeting "Wow, the earth really is flat." without sending picture evidence.

@S-Holmes said in BIOHACKING by Nathan Hatch, "F*** Portion Control":

I've been using Nathan's very "Peaty" recommendations for more than 2 months and my temperature has never been better.

I can't speak for why that individual said you weren't "peaty," but I think the general issue is Nathan's advice itself. At least this is how I see it. Ray Peat has NEVER been against portion control, or more specifically, calorie restriction. This issue came up on another thread here, and it's came up again, and again, and again, and again, and again, and again on the RPF. And for whatever reason, people can't seem to wrap their head around this idea, despite the words leaving Peat's mouth on video/audio recording. The idea that Ray has said excessive calories make people fat isn't an idea "pulled out of the ethos," it's from Ray Peat's mouth.

In fact, in nearly every scenario where I've seen someone critique CICO, it's usually been from low-carbers who espouse the insulin theory of fat gain. So basically the people furthest from Ray's ideas. I can't remember them all, but I know Gary Taubes and that guy that made the famous "Fat Head" documentary believed this. I'm not suggesting Nathan is as bad as these people. The mere fact he's supportive of sugar makes him a notch better. But he's still got some ketobro logic to weight gain, as do many others around these parts. Calories do in fact matter, which means portion control matters. Forgoing portion control is choosing to ignore Ray's views about weight loss in the context of euthyroid people (Obviously I'm not discussing hypo people, which Ray has discussed in detail as well. Severe hypothyroidism can make people maintain weight even in caloric deficits.)

@Kvirion said in Examination of survey data suggest T3 is positively associated with longevity, but not T4.:

@Mulloch94 Yeah, agreed. Moreover, IQ studies are also criticized from a statistical point of view.
https://medium.com/incerto/iq-is-largely-a-pseudoscientific-swindle-f131c101ba39

the most important marker here would've been the ratio of T4 to T3, as a more even one, 3:1

Interesting read, I agree with a good majority of it. I think in some respects we should take into account IQ tests, but people who suggest its a "gold standard" way of measuring human intelligence are wrong, or biased. At best it's a single marker.

@Kvirion said in Examination of survey data suggest T3 is positively associated with longevity, but not T4.:

@Mulloch94 Fascinating finding, thank you!

It seems to be another proof (besides things like learned helplessness) that poor(er) people aren't "just lazy", but the key ingredient to being more entrepreneurial may also be "the drive" i.e. healthy metabolic (bio)energy.

Obviously, the formulation of the study's conclusion isn't fully correct. The key issue isn't the level of T4 per se, but its lack of conversion into (free) T3 or even worse conversion of T4 into reverse T3 - which is not mentioned in this research paper together with other factors like low inflammation, low PUFAs, progesterone, and so on, that also influence fT3 levels...

No problem! Yeah I think personally it puts a lot of questions in doubt about standardized IQ measurements for analyzing intelligence too. So called "dumb people" are probably not actually dumb. The brain is a glucose burning organ, and is likely dependent on generous amounts of free T3 to keep running optimally. I mean, Ray has already been saying stuff like that for years, but I find it interesting other researchers are now exploring the relationship between thyroid and aging, drive, and other socioeconomic factors.

Yeah they didn't really get into the specifics I was interested in. I'm fairly certain T4 is rather indifferent in its effects to all of this, simply because free T3 is dependent on good T4 levels, glucose consumption, and liver function. I think probably the most important marker here would've been the ratio of T4 to T3, as a more even one, 3:1 (and under), would indicated good free T3 levels. Whereas higher ones (over 4:1) would indicate a greater amount of reverse T3. The latter may or may not being a factor of diseased livers (PUFA, endotoxin, alcohol use, etc.)

https://www.pnas.org/doi/abs/10.1073/pnas.2308652121

"The hypothalamic–pituitary–thyroid (HPT) axis is fundamental to human biology, exerting central control over energy expenditure and body temperature. However, the consequences of normal physiologic HPT-axis variation in populations without diagnosed thyroid disease are poorly understood. Using nationally representative data from the 2007 to 2012 National Health and Nutrition Examination Survey, we explore relationships with demographic characteristics, longevity, and socio-economic factors. We find much larger variation across age in free T3 than other HPT-axis hormones. T3 and T4 have opposite relationships to mortality: free T3 is inversely related and free T4 is positively related to the likelihood of death. Free T3 and household income are negatively related, particularly at lower incomes. Finally, free T3 among older adults is associated with labor both in terms of unemployment and hours worked. Physiologic TSH/T4 explain only 1.7% of T3 variation, and neither are appreciably correlated to socio-economic outcomes. Taken together, our data suggest an unappreciated complexity of the HPT-axis signaling cascade broadly such that TSH and T4 may not be accurate surrogates of free T3. Furthermore, we find that subclinical variation in the HPT-axis effector hormone T3 is an important and overlooked factor linking socio-economic forces, human biology, and aging."

I found this earlier today and thought it might fit for general kidney health. I have no idea if TRT helps foamy urine but I remember Haidut having a post on the old forum demonstrating aromatase inhibitors and/or DHT is effective in restoring kidney function. This is a recent review echoing the idea androgens have a positive effect on kidney health.

"Testosterone deficiency is a prevalent condition that frequently affects individuals with end-stage renal disease (ESRD) and those who have undergone renal transplantation. While the etiology of this condition is complex, its implications in this population are far-reaching, impacting various domains such as endocrine profile, sexual and erectile function, bone mineral density (BMD), anemia, and graft survival following renal transplantation. Herein, we review the most recent literature exploring the pathophysiology of testosterone deficiency in ESRD and renal transplant patients, examining its diverse effects on this demographic, and assessing the advantages of testosterone replacement therapy (TRT). Existing evidence suggests that TRT is a safe intervention in ESRD and renal transplant patients, demonstrating improvements across multiple domains. Despite valuable insights from numerous studies, a critical need persists for larger, high-quality prospective studies to comprehensively grasp the nuances of TRT, especially in this vulnerable population. Proactive screening and treatment of testosterone deficiency may prove beneficial, emphasizing the urgency for further research in this area."

It should be noted that foamy urine is still largely a mystery, as only like 30% of people with foamy urine actually have protein spilling over into it. The potassium and fatty acid theories all make sense to certain degrees, but there's still a lot up in the air with regards to this.

Best thing to do is keep your vitamin D, calcium, thyroid, androgens, and progesterone in optimal levels. And if you have preexisting disease perhaps look into kidney supportive substances like thiamine, niacinamide, TUDCA, pyrucet, and aspirin. Activate charcoal can help too by removing endotoxins.

It's possible you lowered serotonin too much with the antibiotics. Constipation is a sign of low serotonin. Maybe try some oatbran or carrot salad.

Because the body has an amazing ability to adapt. With the fortification of foods she's probably hitting her basic needs for survival. Most people do, at least in the developed world.

@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:

Thanks.
I was tryign low fat, low protein yesterday as well.
And I feel like restricting two macro-nutrients is too much. not sure if I could handle that long term. If almost all you eat is carbs, you probably run into satiety problems down the road. Carbs just arent that filling IME. But maybe it would get easier over time, as the animal studies show a shift in substrate utilization towards carbohaydrate oxidation, so maybe the cravings are transitory.

I have noticed I don''t crave fatty foods as much when I take pyrucet. I'm thinking the more you increase glucose oxidation, the less you fatty foods tasty. However I'm not sure the same can be said about protein.

I've been asked on occasions what are some good quality products when speaking about a specific substance. Considering the vitamin and supplement industry can be a bit shady this is understandable. We need to watch our supplements just as close as our diets so we don't put bad shit into our bodies. I thought I'd create this thread to give people some insights into good products. The list isn't exhaustive, but probably common items bioenergetic people would use. If you would like a more extensive list of products I highly recommend toxinless, which shouldn't be a stranger around these parts. Should go without saying, but I'm not affiliated with any companies mentioned here. Also If anyone else has good products worth mentioning feel free to post them as well.

Coconut oil - this is the coconut oil I use. I like it because it's pure, wholesale, and was recommended to me long ago by another Peater on the old forum. One 35lb bucket lasts me a whole year.

Vitamin D3 - A no brainer in my opinion. It's under 20 dollars (shipping not included) and it's basically pure, the only ingredients are D3, MCT oil, and tocopherol. 5,000 units daily (10 drops) will last 2 months.

Progest-E - Shouldn't need any introduction. It can be obtained either in the link provided or by email directly at Kenogen@gmail.com

Aspirin - The product in the link is fine, basically a generic GeriCare alternative. However, I recommend you actually buy it in the store instead of ordering. Last time I ordered aspirin it was already old and vinegary smelling. Every time I've bought it from the store it's been good. Keep it in the freezer for long shelf-life.

Vitamin E - Besides Georgi's product this is the only acceptable alternative I've found. Mixed tocopherols with only gelatin, glycerin, water as additives. Not cheap, but at 1 daily will last you 4 months.

Magnesium - Eating leafy greens would be my first choice, but if you wanted to turn to supplementation this is what I recommend. Highly absorbable and fast acting. Cost effective as well, even at 2x the recommended dose (12 sprays) the 8oz size lasts 4 months.

DHEA - There's probably a lot of comparable products just as good. But I'm loyal to this company. They ship fast and regularly give discounts. It's dissolves in Progest-E well. The 25 gram bag is cost effective and lasts a long time depending on your dosage.

BCAA - Best product I've been able to acquire. No funny business. Strictly the branch chain aminos and no other ingredients. Usually lasts a while, I buy 2 whenever I order it.

Casein - Unparalleled basically. This is pure casein, nothing else. Best protein on the market because it has low cysteine and a very good calcium to phosphorus ratio. Out of all the items mentioned here it's probably the least cost effective. i find myself having to order it basically monthly. Only downside in my opinion.

I will add to the list as time goes on. Keep in mind Idealabs is also great for any specialty items. I think Health Natura has the most pure micronized pregnenolone on the market I believe.

@GreekDemiGod said in Any peaters using squash as their main (or a regular) source of carbs? If so, how's it going?:

Watch out for carotene toxicity. I don’t think it’s wise to have it as a daily staple.

Yeah, if you're low thyroid carotene can be problematic (which is why I wouldn't consider any squash to be "ideal"). But if your thyroid is good a modest amount won't hurt you.

@CO3 said in Any peaters using squash as their main (or a regular) source of carbs? If so, how's it going?:

@Mulloch94 said in Any peaters using squash as their main (or a regular) source of carbs? If so, how's it going?:

zucchinis are too low in calories

eat... more? like i don't get it. i eat like 5 at a time

How many do you eat? 3.5 pounds (1,600 grams) of zucchini only has 33 grams of net carbohydrate. I prefer to treat zucchini as a vegetable than a fuel source.