@CO3
many people refuse to take it in conservative doses.
I personally settled into taking quite big doses (many mgs), after a few months of experimentation. Hundreds of micrograms were noticeable, but far cry from even 2 mgs.
That said, I've since stepped down from the peak of 8 mg to now 5. Really depends on what you are taking it for, whether you are taking anything else. My MB needs, to keep symptoms at bay go down when I take Aspirin, for ex.
So, for me, comparatively big doses are rational. Can't speak for others