@Kvirion Coffee, caffeine and milk are each complicated topics. No one size fits all answer for any of them. And i still mean to follow up on some of the interesting info that @LucH brought up previously, the website and maybe even skimming the book since i can see that it's available elsewhere.

@ZeroTron That's a great question. Many years ago I was reading a study about guys in the military. Couldn't get their wives pregnant despite great health markers. Now it's been awhile but IIRC they needed 15-20 nanograms/deciliter progesterone. The tail motor of sperm doesn't work without progesterone. So without further context, and the joke that's modern lab range of 0, that's my best guess. Couldn't hurt to use pubmed and search around a bit, use sci-hub.st to try to find full papers.

Thanks for all the great information you all provided. Culture turned out to be positive for a relatively common and most often benign skin bacteria, so it was most likely a false positive/contaminated sample. But, this is all useful information nonetheless.

@happycat You're welcome!

@LucyJ said in Gastro paresis: @SummerPeach I think my issue is cortisol. Things that up regulate my glutamate and cause head agitation and tension = slow my gut. Now that's calmed down my gut is better but I will try the enzymes as I am prone to constipation (currently K2 seems to be causing some issues), thank you You might consider looking into the effects of estrogen on cortisol. go here: https://raypeat.com/articles/articles/estrogen-age-stress.shtml search for Cortisol. "People have spoken of "cascades" in relation to the adrenal glucocorticoids (e.g., cortisol) and estrogen, leading to cell damage, but really both of these hormonal cascades have to be seen as part of a more general collapse of adaptive systems, as a result of both chronic and immediate inadequacies of energy production." also "Estradiol stimulates cortisol production by adrenal cells in estrogen-dependent primary adrenocortical nodular dysplasia." (from the References below the article)

Maybe drop the B and K2 for a couple of weeks just to see if anything changes.

@revenant 1.5L doesn't seem too much, especially if you don't drink water, but could try to go lower as a "therapeutic intervention".

Vitamine E et peroxydation des membranes https://mirzoune-ciboulette.forumactif.org/t642-vitamine-e-et-peroxydation-des-membranes#5645

@PeatPioneer I work outside everyday and I was looking for a sunscreen alternative for a while. Diet is important and you have to build up your resistance to sunlight starting with the morning light. I use idealabs solban on my face every morning if I have to work under the sun all day, last week I forgot it once and got a minor sunburn.

@LiamGraves said in Horrific Nausea from Seizure Medication: A friend of mine was recently prescribed a medication called Keppra (Levetiracetam) to deal with seizures. As a result, she started experiencing mood swings, and more importantly, terrible nausea and headaches whenever eating anything, leading her to sometimes go days without eating, and almost never feeling hungry. I recommended progesterone and thyroid, and that's done a lot to elevate her mood, but the nausea symptoms from food persist. Does anyone have any advice? I typed the word "Levetiracetam" into the search bar at the Ray Peat forum and came up with these threads and posts: https://raypeatforum.com/community/threads/after-effects-of-serotonin-syndrome-advice-please.4330/ https://raypeatforum.com/community/threads/hdac-inhibitors-affect-every-function-of-the-cell-and-may-extend-lifespan.10924/#post-334386 https://raypeatforum.com/community/threads/advancing-widespread-nerve-damage-and-pain-severe-insomnia-suicidal-every-day.49591/ https://raypeatforum.com/community/threads/brain-damage.23810/ https://raypeatforum.com/community/threads/vitamin-c-protects-against-seizures.27339/ https://raypeatforum.com/community/threads/please-help-my-3-year-old-son-who-his-suffering-from-epilepsy.21368/page-2#post-859621 Personally i would skim over it for useful ideas, a common theme seems to be Magnesium but the form is often important. Wishing your friend the best, and luck for you in your research.

@diamond BTW this thread may give you some additional insights... https://bioenergetic.forum/topic/2132/thyroxine-rt3-troubleshooting-what-worked-for-you/5

@HyperTorless Thanks man!

@diamond generally speaking you have to subtract one degree Fahrenheit to arrive at the core temperature. I don't think it's perfect so don't get too frustrated if your ear temperature seems too low from subtracting the degree.

@Solrig you're welcome.

@holyshineball I need to add a few things: When someone has a thiamine deficiency/functional blockage, they cannot convert make ATP (cellular energy) via oxidative metabolism properly. Normally, the process of oxidative metabolism burns glucose in the presence of oxygen and the end product is carbon dioxide. Thiamine acts as a cofactor for several enzymes in the process. If Thiamine is not available, then the process is derailed and lactic acid is the end product instead of carbon dioxide. Lactic acid build up is known as lactic acidosis, which is extremely painful. Thiamine supplementation is known to resolve (quickly) lactic acidosis. This is how thiamine supplementation resolves the pain. As people age, their ability to absorb thiamine through the intestinal wall doesn't work as well as when they were younger. This is why older people are more likely to run into trouble with thiamine deficiency. Thiamine deficiency is implicated in many chronic diseases seen in old age, including all the dementias. I hope you find this information helpful. Here are additional links for your consideration: https://www.mercuryfreekids.org/mercury101/2018/1/21/thiamine-saves also: https://awaken.com/2021/02/the-overlooked-vitamin-that-improves-autoimmune-disease-and-autonomic-dysfunction/

@Ismail said in Dealing with Fatigue: @mostlylurking will def check it out, thank you as always, much appreciated Have ordered some HCL version of thiamine, meant to arrive today. Good deal! Continue researching thiamine, especially about things that deplete it/interfere with it such as: sugar, high carbs, coffee, black tea, sulfites, foods containing thiaminases. see here: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/thiaminase Lots of prescription drugs, including antibiotics, block thiamine function. Mine got blocked by Bactrim antibiotic. Things did not go back to normal after stopping the antibiotic and I got into real trouble; it took months to recover via high dose thiamine hcl.

@Mulloch94 Yes I did, even though it has been a long time since. It's not really a supplement, I agree. The weird thing is that I feel like I'm getting leaner now that I'm reducing my intake and upping salt. I don't force anything down my throat anymore, but I still consume 2800-3000 kcal a day I would think. I consumed 3400-3600 a few months ago. When I did, I felt like I overdid it a little bit. All the craze about eating more made me want to try eating more in combination with more thyroid. I'm about 6 ft (182 cm) and weigh 175 lbs (79.5 kg). I am active, I walk around 10.000-14.000 steps every day and do some moderate weight lifting. I still feel very warm all day and don't have cold fingers any more. The NDT might have supressed my own thyroid production, because I had cold fingers more often. It was winter time, but still. I had some muscle cramps when introducing high salt, but since I downed my ndt it went away... I really want to include some form of thyroid in my diet, like Ray suggested, but I'm just not sure on how to do it.