[image: 1719053868238-8d7146a6-b34a-4921-a4e5-3c228cb759f4-image.png] New Perspectives on the Use of Niacin in the Treatment of Lipid Disorders

@Galaroc Thanks for the links, I will have a read. Currently I've stopped taking T3 and am going to try and improve my diet before I try again.

Oh Kuinone would be marvelous. And keep working on him eating ripe fruit, more salt and gelatin.

My LDL is hovering around 150 mg/dL. I was hoping that taking thyroid would lower it, but so far it hasn't been the case, and I've been on thyroid for more than 2 months. Last blood test was 140 mg/dL, a bit lower. It seems like in some people, eating Saturated Fats abruptly increases LDL cholesterol, and in others, to a lesser degree.

I remember discussing this issue with our rodent. To be conservative, you'd have to find the maximum permitted level for a given food to contain after its addition (varies between countries), but 1% would be a generous value. 50 grams as a food serving with lecithin at 1% yields 0.5 g of lecithin. If this was pure linoleic acid, we would have 500 mg linoleic acid/serving. The phospholipid research center: current research in phospholipids and their use in drug delivery [image: 1718929724133-c4be1291-03e9-4989-a44a-cbcbca5034e2-image.png] Lecithin is processed and the product may have a higher concentration of phosphatidylcholine. The use of natural and synthetic phospholipids as pharmaceutical excipients [image: 1718929767580-9076602c-4de0-473d-8569-e2d2293b2ded-image.png] To keep it simple, we can treat other phospholipids of lecithin that may be present as phosphatidylcholine and assume that the only fatty acid occurring is linoleic acid. Fatty acid (linoleic acid): R-COOH Fatty acyl (linoleoyl): R-CO- Dilinoleoyl-phosphatidylcholine – glycerophosphocholine (whole molecule minus the non-fatty fraction) ⠀ 782 g/mol – 257 g/mol = 525 g/mol (corresponding to the 2 'linoleoyls') ⠀ 782 g/mol → 100% 525 g/mol → ~70% 500 mg PC/serving × 70% = ~350 mg LA/serving The values above were inflated. As an example of how low it can be, I contacted a large company to ask how much soy lecithin they add to their whey protein, and they replied that it contains 0.1 g lecithin/kg whey protein (0.01%). Lecithin per serving: 15 g × 0.01 = 0.0015 g = 1.5 mg lecithin/serving Discounting the non-fatty fraction: 1.5 mg × 70% → ~1 mg fatty acids/serving Discounting the other fatty acids: 1 mg × 70% → ~0.7 mg linoleic acid/serving (~0.0007 g/serving) Nutrient Ranking Tool | MyFoodData Phospholipids are remodeled during digestion. Potential Roles of Fatty Acids and Lipids in Postharvest Needle Abscission Physiology [image: 1718929791450-2159dc7f-4c36-445b-957c-233b26572706-image.png] Individual Phosphatidylcholine Species Analysis by RP-HPLC ELSD for Determination of Polyenylphosphatidylcholine in Lecithins [image: 1718929807261-352ed625-861b-4b75-b09c-6503d637a8c3-image.png] The abbreviation is in order (sns: 1, 2, 3). Example: LLPC is Linoleoyl, Linoleoyl and Phosphorylcholine. The sn-2 position is known as the susceptible to remodeling during digestion (after the action of phospholipase A2). In contrast, the sn-1 position might remain intact. It would be preferable for linoleoyl not to occur at the sn-1 position because of this, but at least linoleoyl in the middle (sn-2) is a common pattern in these phospholipids and can be substituted for other fatty acyls. The released fatty acid can be absorbed in free form, but not incorporated in the phospholipid.

@Energia said in Rapid Deterioration?: Desperate for any kind of help. Myriad of health issues. History of chronically increased cortisol levels ( stress related, no cushings). Many signs typically associated with cushings, with the worst being skin thinness followed by muscle and joint/bone weakness. Very underweight, difficulty putting on and maintaining weight bordering cachexic looking. Sensitivity to most foods, so that doesn't help. Indigestion/ GERD elicit arrythmias (SVT), so I must be careful with food intake. Sudden movements also can trigger this rhythm. Issues have been going on for years, but have hit breaking point and progressing rapidly. Skin rapidly becoming too thin to the point where almost every blood vessel is visible, new fine line wrinkles popping up seemingly every day (and this is no exaggeration). Can't even smile slightly without getting pretty severe redness in face and visible veins due to the thin skin. Petechiae everywhere, new moles popping up. Extremely dry hair and skin, regardless of hydration. I thought it was all attributed to cortisol issues, but recently I have a strong suspicion of ehlers danlos. Joints extremely unstable/ pop extremely loudly when manipulated. Internal organs feel like they're hanging on by a thread (possible hiatal hernia?) Severe social anxiety/uneasiness which causes a cortisol/adrenaline response. Took beta blocker for many years but weaned off few years ago. Thinking about restarting it to help mitigate some tissue/muscle damage from adrenaline. Neurological issues. I could go on further, but basically every organ system seems to be wasting away and quite rapidly at this point. Don't know what to do as I've become extremely sensitive to almost every food and even just eating causes fatigue. Don't know how fixable any of this is at this point, especially the collagen/ thin skin issues, as I've read that once skin has thinned out it can't really be regrown. Although maybe the bioenergetic theory says otherwise? Anyone have any knowledge on this or any of the other issues I mentioned? Any advice would be greatly appreciated. Thanks in advance. Magnesium lowers cortisol. see here: Magnesium Status and Stress: The Vicious Circle Concept Revisited Your description above sounds like thiamine deficiency/beriberi. see here: https://www.hormonesmatter.com/thiamine-deficiency-in-modern-medical-practice/ also: Hiding in Plain Sight: Modern Thiamine Deficiency Thiamine and magnesium work together in the body. Supplementing thiamine improves tolerance for magnesium. see also: https://www.multibriefs.com/briefs/icim/thiamin.pdf Hypothyroidism symptoms and thiamine deficiency symptoms have some similarities because each of these block oxidative metabolism. It can get confusing. Also, the thyroid needs thiamine to do its job. Ray Peat explained that adrenaline is released when blood sugar gets too low which is supposed to signal to the liver to release stored sugar into the blood stream. If the liver is unable to store sugar it won't be able to release any. If that happens, then cortisol is released to dissolve body tissues to provide glucose to the heart and brain. The liver needs thiamine to work properly. If there's a thiamine deficiency, the liver can't do a good job of storing sugar etc. In addition, the mitochondria need thiamine to burn glucose for cellular energy. If this process is blocked (from no thiamine), then from the body's perspective there is a lack of glucose getting turned into energy. This can cause the release of adrenaline, then cortisol, resulting in tissue wasting.

Every time I listen to this thyroid wav my heart rate increases and blood flow increases. https://youtu.be/31q6hGK9i08?si=kVLFsPwTGECYqlOs Interesting about that binaural nutrition channel as it seems to be pretty peaty in its frame work. With videos like "estrogen Blocker" and "serotonin reducer". Also some funny ones like trenbelone.

@Cearrson was the blood bright or dark? dark would be cause for concern because it's higher up in your digestive tract. bright probably means something on the way out got hurt. i've had the latter for years due to hemorrhoids, which usually flares up if i'm dealing with inflammation or constipation, but it's very noticeable for me.

@Polar334 I don’t personally feel like I know enough to say one way or another. All I can say is that I had a separated shoulder for about two years heal after about a month on BPC. I couldn’t sleep, train, or hold my newborn without literal excruciating pain. Pain that at times was so severe it caused instant spontaneous weakness, (like almost a total loss of use of my arm). That pain translocated to my wrist because I was constantly overcompensating for the weak/painful shoulder. So now I have an arm from shoulder to hand that is essentially useless, and in one month, it was like I didn’t spend two years like that. It’s been almost 6 years since it healed and I have to really think about it to remember it ever happened, I have zero pain. I say all this just to say, maybe sometimes in life we have choices to make, and maybe there isn’t going to be a clear best choice? I tell everyone I know about my experience because living with chronic pain for years has got to be worse holistically for the mind, body, and spirit than a round of BPC. I am not a doctor, and this is not medical advice. I’m just an n=1.

@NotShanalotte yeah I’d love to hear the theories behind it and see it discussed and picked apart in a thread. I don’t know enough to say it can’t happen. After all, Ray has shown some convincing theories that its electron transferring (layman’s terms), that is the specific “thing” that nutrients and hormones etc, carry to the target that yields the actual measured response/result of said nutrient. I would not doubt that vibrations can do something wonky we don’t see yet. Thanks for the heads up.

How much riboflavin? The gut can only absorb a limited amount of riboflavin at one time, and an excess is quickly excreted in the urine. Therefore, No Upper Intake Level for riboflavin has not been established. => Light yellow urine = excretion of unused B2. However, riboflavin does not cause any side effects. No need to take B2 every day. Every other day for maximal intake. But I take it twice a week when I make a cure with thiamine (B1). When consumption exceeds the ability to absorb (37 mg), riboflavin passes into the large intestine, where it is catabolized by bacteria to various metabolites that can be detected in feces.[5] There is speculation that unabsorbed riboflavin could affect the large intestine microbiome.[42] But taking into account that riboflavin is used immediately, thus not stored in the body, excess amounts would be excreted, mainly in the urine (90% in 24H). The biological half-life of riboflavin in the liver of rats was 6.5 days. I use Swanson riboflavin 100 mg 2x/wk. 50 mg would be enough if no worrying excipient. (Here: rice four, gelatin, magnesium stearate). Not every day Mg stearate and not too much. I didn’t find a better form. But it’s OK for me. 42. https://en.wikipedia.org/wiki/Riboflavin#cite_note-42

@Kvirion Yes! I read the same too about methylation from another forum and that if one was to start B vitamins, they would need to start low and slow also. But high doses are advertised everywhere.

Thank you very much to all for responding. I resorted to supplements because sleep has been really challenging for a period of time. With the information you all have provided above and from listening to Jay Feldman and Mike Fave's podcast re sleep, I'm back to the drawing board to tweak my food intake specially in the evenings going for more carbs. Thanks a lot everyone! The experimentation continues....

Hopefully your relationship survives her coming off BC, I’ve heard many horror stories.

@yerrag said in Why does only starch raise my temp well? (and sugar not): yerrag yerrag a day ago @neverever sweet potato has a higher yeah potato was no good need to eat too much and doesnt last me long as you said. thanks for the advices anyway now is finally summer and can get hours of sun so i should be fine healing with that advices

@Sippy Topical iodine should help greatly