@visalibero said in Periodontitis as the latest manifestation of an underlying unexplained problem: @yerrag it's absurd because he doesn't do much sport at all, he smokes! and he eats random things.... I am convinced that it could also have been that 7 years ago I broke a tooth due to a blow to the face and I had to extract it (the only tooth I am missing) I have never placed an implant thinking I will place it later.... the right one got twisted and the gum also left a bloody crack in it... I think they entered from there and over time it started to develop! So the current strategy would be impeccable oral hygiene, low production of toxins and fixing the metabolism to strengthen the immune system? And to provide a healthy terrain that brings about a state of balance in your oral microbiome. If your salivary secretions are alkaline as a natural consequence of having optimal metabolism that produces CO2 that does its job of providing for a healthy terrain, it favors the presence of microbes that are regulatory and commensal, and your oral health would be optimal as well. That is just the way our body should be free from the corrupting influence of a society where we are influenced by dental associations that need us to have poor oral health to derive royalties from treating them. here in Italy in my opinion we are ahead on some things but behind on others. there are no doctors who look at things with this holistic philosophy! and if there are any, they are unrealistic or scammers who were selling sofas until the day before. They are trained by their association to keep us returning to them. It makes no sense for them to cure us and have no returning patients.

@Lizb Schnaubert gives plenty of useful information which I have to take time to understand before I begin to use the information to make my own blend. I hope you give it enough time for the information to sink in before you begin to apply it. I wasn't rushing but I managed to put myself in a hole wrongly applying what I learned in a moment of clumsy oversight. And that was what caused me a year of dealing with the issue of the ensuing bronchitis that eventually led to my nadir of heart failure. I learned that lesson and subsequently used the book to heel myself of my bronchitis. So, I cannot stress enough the need for caution, especially in making sure all T's are crossed and I's dotted before proceeding. I consider myself thorough but despite that I still fell through the cracks. But overall, because I learned a lot from personally having a lung issue and how it relates to developing edema leading to my heart failure, the insight it gave me was an education I value. I especially relish the part where I overcame hopelessness in fearing I would not get my lungs back to turning the tide back to healing and recovery to my former robust lung state. My lungs have always been strong and I have high endurance and can swim underwater for long stretches, and I back where I used to be. With the right technique, many things that appear insurmountable just simply are easy to overcome. I have gotten used to doctors saying it's genetic and impossible like it's written in stone, and dismissing their loser attitude and training in favor of Ray Peat's belief in the wisdom of the body. I hope you can be hopeful and positive in a way that isn't shaped by Jewish aphorisms so predominant in the western culture. Yes, I'm talking real hope instead of false pallative hope.

@The-New-Sun You're welcome! You can use other forms of magnesium when you're in maintenance mode. Neutral ones like mag oxide will do.

When people are hypothyroid they run high on adrenaline. Cortisol too but cortisol is more like a mediator of sorts, or a facilitator. Most of the unpleasant symptoms are related to adrenaline. Caffeine can also raise adrenaline. In someone who's already adrenaline dominant (due to hypothyroidism) caffeine may be problematic. I recommend the following 1) con leche from now on. Coffee, with equal parts of milk (preferably whole milk), will always make the caffeine slightly more tolerable. For one milk has a little carbohydrate in it, but it also come with saturated fat, which will slow the absorption. 2) have some salty gelatinous soup. Oxtail soup is a good and classic choice for a peater. I in fact have it for dinner most nights of the week. The combination of gelatin and salt will powerfully lower adrenaline. 3) carrot salad and/or lots of cooked white mushrooms. Stimulating bowel transit and introducing antiseptic fibers to the intestine will reduce endotoxin which powerfully burns through the liver's glycogen holding abilities. More glycogen = steady stream of glucose = less free fatty acids and adrenaline. 4) Consider a liver "defatting" protocol. This can be expensive, but it will do wonders for your health if you actually need it. High dose K2 (>45mgs), glycine, TUDCA, and choline. Not to mention the caffeine helps too. I'd run it daily for about 60 days. 5) Supplemental progesterone can be an excellent tool to crush adrenaline when you're in a pinch or if you're about to sleep. Usually 12-14 drops of Progest-E will kill adrenaline in it's track. 6) Magnesium can be helpful against adrenaline, also just in general for hypothyroid people who lose it easily. Boiled leafy greens like kale is a good choice. 7) Last but not least, getting on thyroid replacement will modulate adrenaline back into a healthy range. But this can take a while, because finding the right dose of thyroid is tricky for a lot of people. It can also initially sensitize yourself to adrenaline even more, making the above suggestions all the more important.

Is he still raw primal?

@LiftWaffe88 I was chronic fasting and on keto for around 2 years. Got off of it and trying to slowly build back up . I lifting regularly and trying to up my carbs alot more. It's weird because I thought my cortisol would be sky high, because of the crazy looking stretch marks on my abdominal area.

@Starcrossed Doesnt necessarily suggest hypothyroidism, but with other stuff mentioned i guess u might be mildly hypothyroid (you have good high pulse, oral temp range, t4 and t3 not obviously skewed maybe slightly depends, tsh only a bit elevated, but blood loss adrenaline cold if u still are etc - so maybe but not obviously hypo) More salt can be helpful for the fight or flight thing as if you do have some level of hypothyroidism , sodium gets wasted more easily so isnt countering adrenaline well without replenishing often, (taking thyroid can increase adrenaline sensitivity too so more need for salt, but also lowers cortisol). some people move up doses every 2 weeks until desired effect or hit a total of 25mcg - 50mcg t3 in multiple doses depending on severity Theres some positive studies using vit A or vit D for abnormal menstrual bleeding. and vitamin b1 vit b1 https://pubmed.ncbi.nlm.nih.gov/24738933/ vit d https://www.jcdronline.org/admin/Uploads/Files/6564af6091d0d1.39699188.pdf vit a (if fixing low levels) (these are extreme doses i wouldnt take but looks very helpful in potential, high doses get toxic so i would like to keep it under 5000iu, as even 10,000iu has some inflammatory / toxic potential) https://journals.co.za/doi/pdf/10.10520/AJA20785135_24314 Might be worth eating beef or sheep liver (in balance) if you dont, which gives Vit A, and copper, and a little iron. . And if those 3 arent enough 2 targets may be 1. things that help mature blood vessels / stop leakiness. and 2. things that lower eNOS & nitric oxide , shown here to relate to the endometrial breakdown https://pubmed.ncbi.nlm.nih.gov/9915994/ and mentioned lower in this post too (need vasoconstriction in a specific place to stop bleeds which nitric oxide counters) Some idea of mechanism (failure of vessels to mature so theyre more permable?) (or failure of spiral arterioles to constrict because of too much nitric oxide?) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320491/ This review supports existing evidence that increased proangiogenic and decreased antiangiogenic factors cause impaired vessel maturation, resulting in more fragile and permeable vessels. Conceivably, the genesis of AUB in patients with AUB-E and AUB-I is caused by a different combination of abnormalities in angiogenic factors. In general, VEGF expression increased and Ang-I decreased in patients with objectively defined AUB-E: this could suggest decreased vessel maturation in these patients. In patients with AUB-I, angiogenic factors were increased after short-term exposure and unchanged after long-term exposure to exogenous hormones. This could be in agreement with the fact that spotting complaints with exogenous hormone use gradually disappear over time (Hillard, 2014) and, hypothetically, angiogenesis in the endometrium will normalize. However, these findings should be interpreted with caution and do not imply causation. Vasoconstriction of spiral arterioles is essential to limit menstrual blood flow, as a small increase in diameter will lead to an extensive increase in blood flow. For instance, if the diameter is increased 2-fold this will lead to a 16-fold decrease in flow resistance (Jain et al., 2022). Blumenthal et al. (2002) found an increase in eNOS in both the secretory and proliferative phase in patients with AUB-E (Blumenthal et al., 2002). As eNOS produces NO and NO increases vasodilatation, HMB could hypothetically be caused by an increase in spiral arteriole diameter under the influence of increased NO levels (Jeremy et al., 1999; Valdes et al., 2008). This could indicate that, apart from angiogenesis, several other mechanisms are involved in AUB. . It is likely that in patients with AUB-E and AUB-I, a combination of different angiogenic mechanisms may play a role. This could be one of the explanations for why increased angiogenesis is not always associated with a change in MVD but could lead to vessels of insufficient quality or unstable vessels with an impaired function. Cessation of menses requires (i) vasoconstriction of specialised endometrial spiral arterioles, (ii) an effective haemostatic response, including repair of damaged vasculature and (iii) timely reepithelialisation of the remaining denuded basal endometrium. This unique, scarless repair process is essential to maintain fertility and limit menstrual blood loss

The amount of studies producing EFA deficiency with fat-free or Hydrogenated Coconut Oil-added diets are the majority, but apparently not the fastest to deplete EFAs. I posted a few days ago how Oleic acid (MUFA) accelerates EFA deficiency, in the simplest study below 0.8% linoleic and a 20:1 Oleic:Linoleic ratio accelerated depletion. Apart from macadamias, I don't know of anything that has a good OA:LA ratio and little PUFA or is pure Oleic, so I think supplementing with Stearic Acid may be even better, since it is well known and used and has no PUFA, it is also widely converted into Oleic Acid within the body (Rats on a diet rich in Oleic vs Stearic have basically the same amount of Oleic in the tissues). It would be nice to do an OmegaQuant to see if the depletion is working.

@Galaroc i tried it but didnt notice benefits (maybe other problems meaning benefits couldnt be gained or maybe my coq10 synthesis is good and not a limiting factor for energy production for me?). apparently its good with heart failure sounds like there is some "programmed in" thinking mixed into that? like theres some sort of counter for atp that when it hits mitochondria stop or something? as speculation. but mitochondria repair / replace in right conditions, co2/atp production clearly dynamic, older age people sill respond positively to supplements that influence mitochondria etc but haidut posted this http://haidut.me/?p=2144 highlighting the type of metabolism increase is important . someone can have high metabolism but be excessively uncoupled (i.e low functioning of the last part of the Electron Transport Chain in mitochondria), so lacking atp production, or someone can have high metabolism but atp produced from glycolysis without the co2 benefits u get from mitochondria linked metabolism so worsen longevity. or another factor could be ramping up the ETC too much for what the cell can handle with current factors (too much ROS production in the process), where milder increase could be protective increased co2 production in cells from increased metabolic rate is an important factor in aging / longevity ray mentioned some stuff on that in https://raypeat.com/articles/articles/salt.shtml

@ThinPicking I used to benefit a lot from green tea actually. Maybe I need to start drinking it again... Its the dose that is difficult. Sometimes I would put 4 teabags in a cup and drink it and feel good. Sometimes does nothing Im also looking into functional B2 deficiency and molybdenum supplements which I am taking currently. That is related to GABA because of weird cascades in the body and all sorts. I read about how molybdenum is needed to transport iron around the body. People with adhd have low brain iron and apparently amphetamine somehow fixes that????? But that seems like using a sledgehammer to put in tent pins modern medicine is very forceful. peat is gentle. better for the body? im going to keep doing what im doing for a week or two and come back. this may be it.

@AR04 https://www.sciencedirect.com/science/article/pii/S2214426921001300 megadose UMP stopped epileptic seizures in 2 days and stayed free https://www.degruyter.com/document/doi/10.1515/tnsci-2018-0031/html?lang=en orally nobelitin protects against seizures in mice , restores gaba/glutamate balance, ~250mg heq 7,8 DHF has profound preventative effect but the dose is extremely important, high dose just 2x makes them worse than controls, where 1/2 the dose as low dose improved a lot. i would be cautious and go low, it was administered i.p so idk dose orally but being cautious matching as oral dose ~50mg-60mg human equivalent. and i would start with less. from my experience it felt like it lowered cortisol potently at 12.5mg - 25mg still https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723075/ The lower dose of 7,8-DHF almost completely prevented the occurrence of SRSs in the observation period of 21 days. Whereas, as noted above, 14 of 17 vehicle-treated rats displayed spontaneous motor seizures, only 2 of 18 rats treated with 5 mg/kg 7,8-DHF experienced each a single motor seizure, and this happened much later than in the vehicle group @Peatful said in All things seizure disorders: https://raypeat.com/articles/articles/epilepsy-progesterone.shtml progesterone, thyroid / fixing hypothyroidism, vit E protection from PUFA, lowering pufa intake, carbon dioxide, good carb intake, foundation of protein intake to prevent edema, sodium, adenosine (& probably being cautious with caffeine) {UMP uridine study i posted is another nucleic acid like adenosine}, (peats article worth full read) & not drinking too much water It has been known for a long time that hyperhydration can produce seizures; at one time, neurologists would test for epilepsy by having the patient drink a pint of water. Although there are many reasons to think that the hyperhydration produced by hypothyroidism is a factor in epilepsy, physicians have been very reluctant to consider the possibility, because they generally think of thyroid hormone as a stimulant, and believe that "stimulants" are necessarily inappropriate for people with epilepsy. Pre-eclampsia and pregnancy toxemia have been corrected (Shanklin and Hodin, 1979) by both increased dietary protein and increased salt, which improve circulation, lower blood pressure, and prevent seizures, while reducing vascular leakiness.

@StreamOfWater said in High DHEA, Cortisol, Lactate, Prolactin, Progesteron but low PTH: Hi, I just received (29, male) bloodwork results. Here they are: DHEA: 30 nmol/l Cortisol: 615 nmol/l Lactate: 2.10 mmol/l Prolactin: 21 μg/l Progesterone: 3.3 nmol/l PTH: 2.0 pmol/l LDL Cholesterol: 3.90 mmol/l TSH: 2.5 I have been following Ray Peat's approach for 2 years, but was already eating low in PUFA and avoiding most processed foods for years. I mostly eat dark vegetables, potatoes, cheese, eggs, meat, honey, some citrus fruits, some seafood and drink a lot of milk. This is what I mostly eat in winter. In summer, definitely more carbs (fruits). I had more blood markers tested, but the ones I mentioned are the most concerning. I did not take any supplements for 2 months prior to the blood test. What is the best course of action for me in this situation? It would be helpful if you would please provide the test ranges in addition to the numbers of your own results. Your TSH is high. A full thyroid panel including free T4, free T3, and reverse T3 would be helpful. The goal is to have a low PTH; it means your parathyroid is quiet and happy and not pumping out PTH. Without the ranges for the lab tests, evaluation of your results is difficult if not possible. Look on your lab tests and see if you can find them.

@himblondemaxxing & more [image: 1719304131327-396d464d-7fcd-4c48-aa8f-d07a577a659f-image.png] https://www.youtube.com/watch?v=R8fpVNhiqKQ https://www.youtube.com/watch?v=Dy4HA3vUv2c

@fucker I know you mentioned it already, but porn will do this. If you get erections from edging to porn but not a real woman, then you know its PIED. If you don't get erections from porn either, then it may also still be PIED. If you have no desire or interest altogether (asexual) then it could be a low dopamine problem, as you likely are lacking zest for living altogether.

@VehmicJuryman schizophrenia is Peaty, read Kazantzakis

@constipated It's a joke