@jhp said in Question about Cyproheptadine: i'd be interested in hearing more about this. I have no info in the form of a book or PDF for sophrology. But well to introduce the practice to people who do not really know EFT (Emotional Freedom Technique). For breathing technique see beneath but I’m not sure it’s going to help in asthma, except this pathology is quite bound to the nervous system. Without speaking about the inflamed lungs (selenium in nebulizer, not in a spray, could help, according to Dr. Klinghardt). When your immune system reacts inappropriately, in front of an intruder (allergen, badly or indigestive macromolecule, for example) it sends the big artillery to neutralize the intruder, often accompanied by an inflammatory response, if so that there is an intruder to locate / to fight. Then we apply conventional techniques: medical imaging and painkillers, for example. (I simplify excessively for the clarity of the presentation). You do not learn anything when I’m telling you that traditional European medicine and across the Atlantic, they focus mainly on symptoms. However, this medicine is especially effective in the event of a pathology with acute crisis (heart attack, fractured member, etc.). In the case of a PR or SPA "the conventional therapists" are often disarmed ... "Chinese medicine" is more efficient when it comes to rebalancing energy flows, homeostasis... SPA = Syndrome de polyarthrite ankylosante: PR = polyarthrite rhumatismale. *) Concrete example: Take an image to view the problem: 1 ° Cause of the problem (causing pain or problem) 2 ° Zzzz… (=> disturbed energy system). => Image of a blurred TV making Zzzz (bad reception: fog). 3 ° Pathology (pain for example) Traditional medicine will try to relieve pathology by "treating" the cause (stress for example). It will work quite often, but the evil will not be eradicated in a structural / deep way. It tapped / hided itself, will put itself on the backstil, until the next episode where you will have pulled too much on the rope ... As long as you do not change the behavior and especially evacuate the Zzzz, a disturbing element, the problem will often persist ... Otherwise expressed, if you only care about the phase 1 of the process (cause) and the phase 3 (pathology), you will not progress or not very well because the disturbing element will be still present (Zzzz). *) Chinese medicine “More than 5,000 years ago, the Chinese “people” discovered a system of energy circuits that crosses the body. Oriental medicine and acupuncture, acupressure and several other healing techniques are based on these energetically fluxes, or meridian circuits. This energy circulates in the body and is invisible to the naked eye. We cannot see it without a high-tech equipment. By analogy, you do not see the energy broadcast in a television either. You know, however, that it exists, thanks to its effects. Sounds and images are proof that this energy flow exists”. Source : Emotional Freedom Techniques TM (Technique de libération émotionnelle). Manuel de Gary Craig, en PDF. EFT – traitement énergétique de la douleur https://mirzoune-ciboulette.forumactif.org/t550-eft-kes-ca-ko Understand how and why EFT can help you (in French, translator needed) https://mirzoune-ciboulette.forumactif.org/t347-comprendre-comment-et-pourquoi-l-eft-peut-vous-aider => Cardiac coherence - Relaxation session We inspire on 5", rather slowly. Then we expire on 5". Inspire by the nose and expires complete by the mouth. We do not inspire too quickly otherwise we will block / pause at the 4th time (1 - 2 - 3 - 4 - 5) (we do not count because we follow the sinusoidal graph). We expire well, thoroughly! If the head turns, you shorten the session and start again 3 hours later. 3 x 5’ a day. So it's a rhythm to take and it can be learned, it's like everything... Examples of video if you need / if you want visual assistance: https://youtu.be/fujdW6M3zcU (waterfall, with a ball that goes up and down). https://youtu.be/6WV3BaOjoUo (seaside, waves on the beach, at sunset) https://youtu.be/W3OVCOekcSk (full ocean) Etc.

Fuck ton of sugar, caffeine, salt, a little bit of T3, b-vits (especially 1-3,6), inosine Personally, too much protein slows me down a lot.

I used to drink two cups a day, in the morning and after lunch. But after my son was born I started drinking another cup after work, sometimes between 5-6 PM to help me stay up a bit for evenings to help my wife out with the baby. I found that I can still sleep well enough even with that late coffee, so sometimes I'll make a cup if I feel like it. I think it really varies from person to person though and I just generally go by feel, if I have work the next day and need to get up early I might skip out on it but if it's the weekend why not? My morning and evening cups are usually with milk while my lunch coffees are usually espresso with a bit of sugar. If that makes a difference.

@DavidPS Your argument is well noted. I don't diminish the causality involved with those factors. But I fail to see why those factors mentioned are made at the exclusion of others. Except that the authors want to frame PD as predominantly environmental. I take exception to their mix of omission of other factors and their concentration of focus on the factors they call environmental. I also can't be sure of your reassurance that these folks won't frame CO² as part of the pollutants in their study. Their kind has for decades been blaming CO² with nary a mention of CO (carbon monoxide), and would obfuscate the distinction by simply calling us to lower our "carbon footprint." These are the same people who banned the use of carbogen in hospitals, and excoriate progesterone while praising estrogen. I also want to add that I don't see the increases in PD as being unmistakably caused by the rise in incidences of wild fires. It is probably, not possibly, rooted in iatrogenic causes, particularly with the penchant for doctors to prescribe neurotoxin antibiotics of the fluroquinolone classes, and their m.o. is to tell patients that it is the only oralantibiotic that the dominant pathogen in a culture (urine or sputum) is sensitive to. There are alternatives such as essential oils that will do as good a job, but of course that is woo to the medical priestly class. I am living proof of that.

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia: @mostlylurking said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia: @yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia: @mostlylurking I got to read the article on efferocytosis. It is a good read, though like most of these articles we get, they're a hard read as it's hard to keep up the different names of enzymes and proteins and what not involved. They get too detailed beyond what is practical for us to use. I get to wonder often if doctors actually read to such detail as they hardly find them to read and rather go to Hawaiian resorts for all+expenses paid symposiums. And they get a nice spiel and summary from their med reps. I would prefer they present these things in a black box way, without too much detail. Honestly, I just brush thru these articles because I feel the law of diminishing returns at work when I have to be thorough finishing such articles. Still, I'm disappointed the article leaves out mention of hemolyzed red blood cells and how they are disposed. You noticed. I agree with you. But once in a while I stumble upon a gem of an article that is actually insightful and helpful. This happens mainly in articles written for veterinary research, including for the fishing industry. Here's an example: Fatty acid signatures connect thiamine deficiency with the diet of the Atlantic salmon (Salmo salar) feeding in the Baltic Sea Go down to the Conclusions: "As Keinänen et al. (2017) suggested, fatty young sprat specimens, when abundantly preyed on by salmon, easily overload them, particularly with highly unsaturated DHA, thereby predisposing them to oxidative stress, which results in the depletion of thiamine." That right there made it worth it to me to slog through the article. The fisheries solved the die off problem by adding thiamine to the water for the salmon hatchlings. Yes! I think, with the exception of false rabies shots, vets have been better care of animals than doctors have been taking care of humans. I've found that vets (at least the ones I've gotten to know) are decent people who like animals. Modern day doctors, on the other hand, seem to consider people to be something like a commodity to extract money from. Research for humans is really horrible. I get sent notifications for new papers released about hypothyroidism; about 99% of them are bought and paid for papers that try to shore up the American Thyroid Association's position that T3 isn't needed (except for very rare occasions) and synthetic T4 alone is the "proper" treatment. The ATA should be RICOed. It is really a racket. But racketeers are our overlords, so such evident rackets become accepted as the norm. But once you see it, you cannot unsee it. If you see it, you can take steps to defend yourself via learning (for free on the internet). One nit I have with such publications is that they talk too much unnecessary detail that they lose the forest for the trees. They are heavy on the ABC's and light on the why's and wherefore's that forms a cause and effect narrative on disease. It is mainly useless circumlocution that gets the reader no nowhere. Perhaps that is the intent- to make us go around in an endless circle of meaningless twiddling and twaddling. I've noticed that they also consistently make erroneous assumptions and then base the rest of the paper on those assumptions. It's really terrible. Also why in the world do they insist on using thousands of initials for thousands of technical words/things? It makes reading the paper impossible. But I think that's the point. To keep us second-guessing and paralyzed in such a way we become so reliant on their "experts" to save us. Once you see the game and "get it" then the wise saying comes into play: "Fool me once, shame on you; fool me twice, shame on me." Perhaps I have been spoiled by Peat, as he cuts through that wasteland and skims it of its gems and summarizes the studies for us. And I still find it more rewarding to read the articles and books that I have not read. And there's a lot of material left of his I have to read up on. Peat's papers were a godsend for me. Although they aren't easy to read, multiple readings made for better understanding. Peat actually had things to say, truths you can sink your teeth into. I'm much better able to discern if someone else's paper is worth struggling through now after studying Ray Peat's work. I feel as guided as you are by having read and understood his writing. I am not as blind and less given to be led by the pied pipers. Knowledge is power. Thanks for the effort compiling the supplements you take, though I have to admit I have moved on from taking a lot of supplements as it was my intent to seek nutrients from food when I go back to my country. As the nice thing about backward countries is the diversity of the food supply chain which still allows me to get nutrients from food that is typically missing in the US. That's good about your country's food supply; I hope you can return to it so that you may benefit from it. I have been back to my country for 16 years already. The control of pharma is much much less even if the Philippines is a total tributary state of the Evil Empire. It is much poorer but being poorer makes it less a fertile ground to be fleeced by the racketeers. I misunderstood you before; I thought you had traveled out of the Philippines. The B-vitamins and Vitamin E and C are the only exceptions. And I have benefited from this strategy. Like you, my eyesight has improved within a 5-yr span from starting to eat beef liver weekly. The retinol it provides is what I consider real vitamin A as opposed to the beta-carotene almost always pushed by supplement companies. A sister of mine who sells and also uses supplements for a well-known supplement marketing company, Shaklee, has been faithfully using its products yet her eyesight is no better that in fact her eye doctor is telling her she would be due for cataract surgery in the near future. No wonder, Shaklee considers beta-carotene to be the only vitamin A in their supplements. I was overloaded with beta-carotene when I found Peat's work in 2014. I'm very sensitive to it, not in a good way. But me, I am no longer required to wear glasses to drive and I still easily read the small type from my cellphone. And this is coming from where I had been prescribed bifocals 15 years back. My vision history is very similar. I no longer have to wear glasses to drive. but I do need to grab my readers to read small print; I'm 74, after all. It may be that you are sufficient in retinol, but need more endogenous CO2 production. Just a guess. As CO2 abundance is needed for good vision as well. With optimal sugar metabolism, CO2 abundance is assured. Yes about the need for CO2. If you are deficient in thiamine you cannot make CO2 via sugar metabolism; the end product is lactic acid instead of CO2. Thiamine acts as an enzyme cofactor in the process. Supplementing with thiamine hcl has corrected my inefficient oxidative metabolism and thus has restored my level of CO2. Two proxies I use to ensure I am optimal metabolically is acid-base balance and good blood sugar requisition. IMHO, all other testing is just superfluous. Testing for those two can be done at home, at a miniscule fraction of the cost. Which is why I consider the medical system a Rube Goldberg system that I always seek to find an alternate and simpler for. In many ways, health forums such as ours are unavoidably thus infected with the creep from our games medical system. This makes me decide to limit digging to deep into the medical literature wasteland, as it is designed to make us go in circles for a solution. To me, a Rube Goldberg system implies a lack of sinister purpose and more a cobbling things together in ignorant bliss. The business of still filling people's teeth with mercury in this day and age is inexcusable. Likewise the intentional destruction of treatment for hypothyroidism with desiccated thyroid while banishing food sources of thyroid. Likewise the promotion of PUFA as "heart healthy". I could go on, but I'm sure you get the point. We're not witnessing innocent stupidity. Rackets sprockets. I'm more focused on connecting the dots from reading and benefiting from disinterested medical tomes from Peat, Long, St Gyorgi et all than from commercially vetted and supported research works that form a larger part of the wasteland. I agree; it's a much better way to use your time. I sigh with dismay when we continue to talk of cell membranes, and accept the use of HbA1c as a valid marker for blood sugar health when Ray has pointed out how poorly it represent our blood sugar health. And we are so close-minded that we are tribal in the sense that this forum has never wanted to consider the use of urine pH and saliva pH as a proxy marker for metabolic health, still following the beat of the pied piper of mainstream medicine. Just because the pied piper says so. I'm hoping that we will get to witness the destruction of Rockefeller medicine, the medical industrial complex, and most especially the pharmaceutical industry. Sooner rather than later would be good. Before the total decimation of the human race is an accomplished fact. Here's a video about our medical complex's problem; set to start at the Rockefeller chapter. That will only happen when the US military is swallowed by the Red Sea. I suspect the situation is on a positive tract; we just are not told all the details. It's a war, after all. An unconventional war with no news coverage. This week should prove interesting.

@DavidPS I learned something new! No wonder a lot of people have poor eyesight. Mainstream keeps pushing beta-carotene as Vitamin A at the expense of retinol. While our doctors keep interpreting thyroid panels wrongly and giving people false negatives on whether or not they are hypothyroid. Eat beef liver to be sure. And eat carrots for the gut antibacterial effect.

@basebolt Thanks! Wow 150mcg I'm only at a sip and im on my second week and this morning I experienced a stress response. Woke up with a beating heart and sweating. I already have high heart beats from estrogen and adrenaline. I can't imagine getting to 150mcg from the get go. Will staying on T3 deplete T4 too much or should that not be an issue since my liver is dysfunctional and overburdened? I am on high dose progesterone for 6 months, so its certain the T3 caused the stress response. What does my reaction to T3 tell you about my situation?

@bigdeuce I had the same issue when I was eating solid foods with liquids. For example my routine was to keep a balanced calcium to phosphate ratio, so whenever I ate meat, I would drink milk afterwords. This made me bloated and I was switching from constipation to diarrhea frequently. Now everytime I drink something, I wait 1 hour at least and then eat solids. I upped my bowels to 2 a day more quantity and no bloating. I feel way better this way I believe water dilutes gastric acid Soup in an exception since it warms the body

Thank you. I'll be back. Still look around, don't stop.

@visalibero said in Periodontitis as the latest manifestation of an underlying unexplained problem: @yerrag it's absurd because he doesn't do much sport at all, he smokes! and he eats random things.... I am convinced that it could also have been that 7 years ago I broke a tooth due to a blow to the face and I had to extract it (the only tooth I am missing) I have never placed an implant thinking I will place it later.... the right one got twisted and the gum also left a bloody crack in it... I think they entered from there and over time it started to develop! So the current strategy would be impeccable oral hygiene, low production of toxins and fixing the metabolism to strengthen the immune system? And to provide a healthy terrain that brings about a state of balance in your oral microbiome. If your salivary secretions are alkaline as a natural consequence of having optimal metabolism that produces CO2 that does its job of providing for a healthy terrain, it favors the presence of microbes that are regulatory and commensal, and your oral health would be optimal as well. That is just the way our body should be free from the corrupting influence of a society where we are influenced by dental associations that need us to have poor oral health to derive royalties from treating them. here in Italy in my opinion we are ahead on some things but behind on others. there are no doctors who look at things with this holistic philosophy! and if there are any, they are unrealistic or scammers who were selling sofas until the day before. They are trained by their association to keep us returning to them. It makes no sense for them to cure us and have no returning patients.

@Lizb Schnaubert gives plenty of useful information which I have to take time to understand before I begin to use the information to make my own blend. I hope you give it enough time for the information to sink in before you begin to apply it. I wasn't rushing but I managed to put myself in a hole wrongly applying what I learned in a moment of clumsy oversight. And that was what caused me a year of dealing with the issue of the ensuing bronchitis that eventually led to my nadir of heart failure. I learned that lesson and subsequently used the book to heel myself of my bronchitis. So, I cannot stress enough the need for caution, especially in making sure all T's are crossed and I's dotted before proceeding. I consider myself thorough but despite that I still fell through the cracks. But overall, because I learned a lot from personally having a lung issue and how it relates to developing edema leading to my heart failure, the insight it gave me was an education I value. I especially relish the part where I overcame hopelessness in fearing I would not get my lungs back to turning the tide back to healing and recovery to my former robust lung state. My lungs have always been strong and I have high endurance and can swim underwater for long stretches, and I back where I used to be. With the right technique, many things that appear insurmountable just simply are easy to overcome. I have gotten used to doctors saying it's genetic and impossible like it's written in stone, and dismissing their loser attitude and training in favor of Ray Peat's belief in the wisdom of the body. I hope you can be hopeful and positive in a way that isn't shaped by Jewish aphorisms so predominant in the western culture. Yes, I'm talking real hope instead of false pallative hope.

@The-New-Sun You're welcome! You can use other forms of magnesium when you're in maintenance mode. Neutral ones like mag oxide will do.

When people are hypothyroid they run high on adrenaline. Cortisol too but cortisol is more like a mediator of sorts, or a facilitator. Most of the unpleasant symptoms are related to adrenaline. Caffeine can also raise adrenaline. In someone who's already adrenaline dominant (due to hypothyroidism) caffeine may be problematic. I recommend the following 1) con leche from now on. Coffee, with equal parts of milk (preferably whole milk), will always make the caffeine slightly more tolerable. For one milk has a little carbohydrate in it, but it also come with saturated fat, which will slow the absorption. 2) have some salty gelatinous soup. Oxtail soup is a good and classic choice for a peater. I in fact have it for dinner most nights of the week. The combination of gelatin and salt will powerfully lower adrenaline. 3) carrot salad and/or lots of cooked white mushrooms. Stimulating bowel transit and introducing antiseptic fibers to the intestine will reduce endotoxin which powerfully burns through the liver's glycogen holding abilities. More glycogen = steady stream of glucose = less free fatty acids and adrenaline. 4) Consider a liver "defatting" protocol. This can be expensive, but it will do wonders for your health if you actually need it. High dose K2 (>45mgs), glycine, TUDCA, and choline. Not to mention the caffeine helps too. I'd run it daily for about 60 days. 5) Supplemental progesterone can be an excellent tool to crush adrenaline when you're in a pinch or if you're about to sleep. Usually 12-14 drops of Progest-E will kill adrenaline in it's track. 6) Magnesium can be helpful against adrenaline, also just in general for hypothyroid people who lose it easily. Boiled leafy greens like kale is a good choice. 7) Last but not least, getting on thyroid replacement will modulate adrenaline back into a healthy range. But this can take a while, because finding the right dose of thyroid is tricky for a lot of people. It can also initially sensitize yourself to adrenaline even more, making the above suggestions all the more important.

Is he still raw primal?

@LiftWaffe88 I was chronic fasting and on keto for around 2 years. Got off of it and trying to slowly build back up . I lifting regularly and trying to up my carbs alot more. It's weird because I thought my cortisol would be sky high, because of the crazy looking stretch marks on my abdominal area.

@Starcrossed Doesnt necessarily suggest hypothyroidism, but with other stuff mentioned i guess u might be mildly hypothyroid (you have good high pulse, oral temp range, t4 and t3 not obviously skewed maybe slightly depends, tsh only a bit elevated, but blood loss adrenaline cold if u still are etc - so maybe but not obviously hypo) More salt can be helpful for the fight or flight thing as if you do have some level of hypothyroidism , sodium gets wasted more easily so isnt countering adrenaline well without replenishing often, (taking thyroid can increase adrenaline sensitivity too so more need for salt, but also lowers cortisol). some people move up doses every 2 weeks until desired effect or hit a total of 25mcg - 50mcg t3 in multiple doses depending on severity Theres some positive studies using vit A or vit D for abnormal menstrual bleeding. and vitamin b1 vit b1 https://pubmed.ncbi.nlm.nih.gov/24738933/ vit d https://www.jcdronline.org/admin/Uploads/Files/6564af6091d0d1.39699188.pdf vit a (if fixing low levels) (these are extreme doses i wouldnt take but looks very helpful in potential, high doses get toxic so i would like to keep it under 5000iu, as even 10,000iu has some inflammatory / toxic potential) https://journals.co.za/doi/pdf/10.10520/AJA20785135_24314 Might be worth eating beef or sheep liver (in balance) if you dont, which gives Vit A, and copper, and a little iron. . And if those 3 arent enough 2 targets may be 1. things that help mature blood vessels / stop leakiness. and 2. things that lower eNOS & nitric oxide , shown here to relate to the endometrial breakdown https://pubmed.ncbi.nlm.nih.gov/9915994/ and mentioned lower in this post too (need vasoconstriction in a specific place to stop bleeds which nitric oxide counters) Some idea of mechanism (failure of vessels to mature so theyre more permable?) (or failure of spiral arterioles to constrict because of too much nitric oxide?) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320491/ This review supports existing evidence that increased proangiogenic and decreased antiangiogenic factors cause impaired vessel maturation, resulting in more fragile and permeable vessels. Conceivably, the genesis of AUB in patients with AUB-E and AUB-I is caused by a different combination of abnormalities in angiogenic factors. In general, VEGF expression increased and Ang-I decreased in patients with objectively defined AUB-E: this could suggest decreased vessel maturation in these patients. In patients with AUB-I, angiogenic factors were increased after short-term exposure and unchanged after long-term exposure to exogenous hormones. This could be in agreement with the fact that spotting complaints with exogenous hormone use gradually disappear over time (Hillard, 2014) and, hypothetically, angiogenesis in the endometrium will normalize. However, these findings should be interpreted with caution and do not imply causation. Vasoconstriction of spiral arterioles is essential to limit menstrual blood flow, as a small increase in diameter will lead to an extensive increase in blood flow. For instance, if the diameter is increased 2-fold this will lead to a 16-fold decrease in flow resistance (Jain et al., 2022). Blumenthal et al. (2002) found an increase in eNOS in both the secretory and proliferative phase in patients with AUB-E (Blumenthal et al., 2002). As eNOS produces NO and NO increases vasodilatation, HMB could hypothetically be caused by an increase in spiral arteriole diameter under the influence of increased NO levels (Jeremy et al., 1999; Valdes et al., 2008). This could indicate that, apart from angiogenesis, several other mechanisms are involved in AUB. . It is likely that in patients with AUB-E and AUB-I, a combination of different angiogenic mechanisms may play a role. This could be one of the explanations for why increased angiogenesis is not always associated with a change in MVD but could lead to vessels of insufficient quality or unstable vessels with an impaired function. Cessation of menses requires (i) vasoconstriction of specialised endometrial spiral arterioles, (ii) an effective haemostatic response, including repair of damaged vasculature and (iii) timely reepithelialisation of the remaining denuded basal endometrium. This unique, scarless repair process is essential to maintain fertility and limit menstrual blood loss

The amount of studies producing EFA deficiency with fat-free or Hydrogenated Coconut Oil-added diets are the majority, but apparently not the fastest to deplete EFAs. I posted a few days ago how Oleic acid (MUFA) accelerates EFA deficiency, in the simplest study below 0.8% linoleic and a 20:1 Oleic:Linoleic ratio accelerated depletion. Apart from macadamias, I don't know of anything that has a good OA:LA ratio and little PUFA or is pure Oleic, so I think supplementing with Stearic Acid may be even better, since it is well known and used and has no PUFA, it is also widely converted into Oleic Acid within the body (Rats on a diet rich in Oleic vs Stearic have basically the same amount of Oleic in the tissues). It would be nice to do an OmegaQuant to see if the depletion is working.