@Cynomel maybe a bit spicier. Go in jars and inspect each time, might be different each time

@RandomUser is there any good way to help the liver? Taurine maybe

Can't wait to print this off and read it. Looks very detailed!

@DavidPS very informative, thank you

@risingfire said in The Testosterone/DHT Conspiracy: @yerrag beyond albumin I would suggest estrone, prolactin and dht Might be low dht, but less likely high estrone or prolactin. As my good metabolism (supported by good sugar regulation and good acid base balance, no allergies, great immune resistance, normal weighted essential despite not having an active sports or workout lifestyle while eating 3 full carb loaded meals a day) precludes having high estrone or prolactin. But my high blood pressure condition also points toward my body adapting my blood pressure to provide just enough pressure to provide adequate perfusion to my organs to protect them from degeneration. This pressure is not enough though, to fully feed the capillaries of my scalp adequately to maintain a lush hair cover. There is still enough hair though to not be bald. The body simply know having lush hair is not as important as keeping my organs. It probably thinks keeping my virility at its highest is not as important as well. I may have enough androgens but not enough microcirculstion for my hair to be as full.

its unbelievably castrating for me LOL

Find dopaminergic activities that you enjoy or go to the gym and exert yourself. Most times I was smoking weed I was straight up just bored or didn't have any goals set that I was trying to amount to. Weed is also serotonigenic so I would def recommend staying away.

Well temps are still at 37.8 (100 F). Should I take a cold shower?

@otto - Thanks for the study. There is more than one way to skin a cat (deal with depression). Pharmaceutical SSRIs, which increase the 'happiness hormone', have their issues. Especially when a person stops taking them. At one time there was talk about many of the mass shootings were done by people who recently stopped their SSRIs. Now it seems that the medical privacy of the deceased shooter is more important than the discovering the root cause. SSRI drugs, not depression, destroy empathy http://haidut.me/?p=1053

@Andrewㅤ What did you change to eating?

@DkJoe2 I haven't used either regularly enough to compare. The main difference would be the acetyl group in aspirin which permanently inhibits the COX enzyme, and aspirins acidic ph (can be buffered with sodium bicarbonate). Wintergreen is potentially more similar to sodium salicylate I'd say? Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme

@Peatful Yeah ikr all that raw undigestible plant fiber did a number on me. And ofc i would love to share my experience on here.

@StreamOfWater said in High DHEA, Cortisol, Prolactin and Cholesterol: and I feel like it's damaging my body as a whole. Yep, low thyroid / high cortisol may cause muscle wasting, fat accumulation, etc. also looks like that my liver has a problem storing glycogen RAY PEAT: “Thyroid acting partly through the liver helps to lower prolactin production" https://raypeat.com/articles/articles/hot-flashes-energy-aging.shtml "One of the things progesterone does is to stabilize blood sugar. In one experiment, hot flashes were found to be increased by lowering blood sugar and decreased by moderately increasing blood sugar (Dormire and Reame, 2003). Hypoglycemia increases brain hormones, corticotropin releases hormones, CRH (Widmaier, et al., 1988), which increases ACTH and cortisol. CRH causes vasodilation (Clifton, et al., 2005), and is more active in the presence of estrogen. Menopausal women are more responsive to its effects, and those with the most severe hot flushes are the most responsive (Yakubo, et al., 1990). | The first reaction to a decrease of blood glucose, at least in healthy individuals, is to increase the activity of the sympathetic nervous system, with an increase of adrenaline, which causes the liver to release glucose from its glycogen stores. The effect of adrenaline on the liver is very quick, but adrenaline also acts on the brain, stimulating CRH, which causes the pituitary to secrete ACTH, which stimulates the adrenal cortex to release cortisol, which by various means causes blood sugar to increase, consequently causing the sympathetic nervous activity to decrease. Even when the liver's glycogen stores are adequate, the system cycles rhythmically, usually repeating about every 90 minutes throughout the day." Haidut: The methods for increasing glycogen storage depend very much on the specific organism/person, but if you are interested in trying some new things the first option I would suggest is to get some pure fructose (or fruit juices like apples that contain mostly fructose) and use that as your primary source of sugar for several days. Fructose is supposed to be particularly good at building up glycogen storage. | On the supplement side, taurine is supposed to help with that, but the dose varies wildly from person to person for optimal effects. So, you have to try to find out what works for you. Typically, effective doses are 2g-5g a day. | Another supplement that Peat wrote about is uridine. Read The Problem of Alzheimer's Disease as a clue to Immortality Part 1 | Finally, if you are interested in trying drugs (after consulting with your doctor of course) an older antihistamine and anti-acid drug famotidine (Pepcid) is exceptionally good at inhibiting glycogen breakdown and promoting the synthesis of new glycogen. It is worth noting that famotidine is unique in its glycogen effects among the anti-acid drugs and unlike other drugs it has no known interaction with any other drug or any known effects on liver health or metabolizing abilities. So, you could use that while loading up on sugar. Famotidine is helpful for several conditions completely unrelated to stomach acid such as schizophrenia and PTSD. A probable explanation of those benefits would be due to the drug improving glycogen storage/usage and thus improving brain energetic profile. I'm very happy for you that you are doing better. Did you dig yourself out of it? I spent a lot of time researching and healing my soul/psyche and body. I'm almost at the right spot, but the legal availability of some drugs (prescription only) is the thing I still need to overcome...

@Lothric take T3, that cured my constipation

@mikeyd by this increasing ghrelin has effect, (or serotonin but many downsides) or motilin has effect https://www.nature.com/articles/nrgastro.2012.57 induce phase III which is the peak phase for movements (maybe the main reason why we get this activity between meals, ghrelin) was thinking maybe taking frequent amino acids https://pubmed.ncbi.nlm.nih.gov/14520028/ but here (through IV) reduced the MMC cycle duration https://gut.bmj.com/content/44/2/240 , maybe them going through digestive system matters, or using only essential if the second study didnt, or idea doesnt land https://www.ncbi.nlm.nih.gov/pmc/articles/PMC372329/ , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833301/ fixing hypothyroidism / getting good thyroid hormone function as everything slows down, reptile mode (effect independent of ghrelin, didnt measure small intestine but did here https://pubmed.ncbi.nlm.nih.gov/2777044/) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113274/ With hypothyroidism, time of phase I of interdigestive migrating contractions (IMC) was longer, time of phase II and phase III was significantly shortened, and both the continuous time of strong tetanic contraction at antrum and 10-h frequency of phase III counted from the first IMC after meal significantly decreased. Whereas, hyperthyroidism caused the opposite events to those with hypothyroidism. Furthermore, We found giant migrating contractions (GMC) occurred from the upper gastrointestinal tract when we administrated high dose of thyroid hormone. [image: 1721994205119-9e12ca07-db32-4ee8-b744-da55ecf32978-image.png]