@Ilias-Ant said in Glucose metabolism - Free Fatty Acids: actually now i m in low fat high carb diet.... but the most important thing for me is low energy.... that's why i m trying to lift weights etc for workout... i also grounding and I'm out in the sun (shade) for about 2.5-3 hours per day... Sun helps a lot i can feel the difference... Fine. As long you consume minimum 20 % fat and optimal protein ratio to weight, it's OK. For fats: 45 % SFA (coconut, butter, meat preferable free range) 45 % MUFA: e.g. avocado, olive oil (only for veggies), free range poultry, duck, etc. 10 % PUFA, but no need to target 10 gr every day. I target 1.5 w3 et 6 gr w6. original, not processed. See Kate Deering for useful info on energy metabolism.

Also, I wanted to thank everyone for sharing different experiences, resources, exercises and insights to improve this issue!

@Amethyst said in What Did Dr. Pete Say The K-2 To Calcium Ratio Was?: So how much to take if I am taking in at least 1,200 mgs. of calcium? How much vitamin K? I’ve had a discussion on RPF about the dosage of vitamin K2. How much is too much? Details are given beneath (last part). I won’t recommend taking more than 2 mg / day, given the fact that the menaquinones (K2 family) are broken down into menadiones, which can be "toxic" If repeated. http://ajplung.physiology.org/content/ajplung/262/5/L637.full.pdf Here are the main points Haidut said: “Does it mean that more than 2mg K2 at a time will lead to toxic levels of K3?” LucH answered: Well, we don't know exactly. This is a supposed by-side effect. I explain. Conversion of excess menaquinones in menadiones We know menadione is a metabolite of oral vitamin K supplement. Phylloquinone (K1) is converted into menaquinone-4 and accumulates in extrahepatic tissues. Neither the route nor the function of the conversion is totally known. One supposed metabolic route is the conversion of 5 – 25 % of menadione from phylloquinone by catabolic activity. 10 – 15 % is most likely converted. But this is aleatory (due to intestinal absorption) and not equally distributed. We can only measure the presence of menadione in urine and make deductions when excreted. (1) When taking excess menadiones, through conversion / excretion it would be quite advisable to take some NAC to get enough selenium to neutralize ROS. Adaptive response. (2) Menadione generates ROS through redox cycling, and high concentrations trigger cell death. If lack of glutathione. (3 – 4) Edit: No NAC if supplementing B3 vitamin. Correction form Haidut: Haidut said: I think selenium is a much safer option then NAC. The cysteine has a lot of bad effects on the organism. LucH answers: => Yes, cysteine could depress thyroid function in case of insufficient iodine. Conversation following, by LuH: Menadione in excess clearly affects the mitochondrial function. (5) However there is no reported health risk when taking K2. Excess K2 is excreted through urine and feces (through bile). No direct adverse effect doesn’t mean there is no impact on energy level. This is a personal comment. It depends on the way the body neutralizes an excess oral supplement. Mind excess alpha-tocopherols too (vitamin E) because it may interfere with synthesis of K2. (6- 7) Also if you take phytonutrients as AINS (curcumine or aspirin) because it affects cytochrome P450 (detox pathway). You need a recovery period between 2 cures. https://www.researchgate.net/publication/7305589_Menadione_is_a_metabolite_of_oral_vitamin_K http://www.jbc.org/content/281/52/40485.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005834/ Oxidative Stress-Induced Apoptosis by Menadione at high concentration. https://www.ncbi.nlm.nih.gov/pubmed/20937380 + http://www.sciencedirect.com/science/article/pii/S1521661601951290 http://jcs.biologists.org/content/106/1/309 http://health.oregonstate.edu/biblio/vitamin-e-decreases-extra-hepatic-menaquinone-4-concentrations-rats-fed-menadione-or http://www.pubpdf.com/pub/22707266/Vitamin-E-decreases-extra-hepatic-menaquinone-4-concentrations-in-rats-fed-menadione-or-phylloquinon α-Toco may interfere with the side chain removal of phylloquinone (PK) to form menadione (MN) as an intermediate for synthesis of tissue-specific menaquinone-4 (MK-4). Paymanz said: “you didnt meant to say alpha tocopherol inhibit its conversion ,right?” LucH answers: => Tocopherols neutralize oxidant molecules. If excess menaquinone leaves quinones, if menadione generates ROS, yes, alpha tocopherols would serve as firemen. Thus tocopherols could inhibit K2 when taken at the same time. Only a supposition but it’s logical. More info to optimize Ca and phosphorus (between 2.2/1) Bone metabolism and joints: Dependent on vitamin K2 To absorb Ca (via osteoblasts), the body is dependent on vitamin K2. The synthesis of osteocalcin depends on vitamin K2. If we schematize: osteocalcin allows the body to use calcium for bone metabolism. In the absence of vitamin K, osteocalcin cannot function. Vitamin K2 is necessary to carboxylate/activate K2-dependent proteins so that they perform their functions. For example, the matrix Gla protein (MGP protein or osteocalcin), it prevents calcium from being deposited on blood vessels and other soft tissues. The more vitamin K2 you lack, the less MGP will be activated, so calcium will lodge in the arteries, creating stasis and then blockage... NB: the matrix Gla protein is not specific to bone: it is also found in the wall of vessels where it plays a role in inhibiting vascular calcification. See animation on this link (bone remodelling): http://www.random42.com/bone-biology-osteoblasts-and-osteoclasts-animation Info on absorption, target and dosage of vitamin K (and links from Chris Masterjohn and Kate Rheaume-blue) (in French, with English links) https://mirzoune-ciboulette.forumactif.org/t1704-vit-k-mk4-vs-mk7-update-02-2020#21497 Momado965 said: Do you think a dose of 45mg of mk4 spread throughout is toxic? Luch answered: Toxic, no. K1= 45 mcg. Enough to improve the level of artery calcification and cardiac mortality. It depends on the interaction between A D K vitamins. K2 type MK4: 45 mg (45.000 mcg). Recommended to decarboxylate the Osteocalcin level. K2 type MK7: 240 mcg for diabetics and obese people. Level recommended in the prevention of atherosclerosis, diabetes, osteoporosis, obesity, etc. From « Dosage optimum » on this link (in French): http://mirzoune-ciboulette.forumactif.org/t706-vitamine-k2-achat-exemples-de-produits#6433

@himblondemaxxing said in When peating fails: Feel like I am getting worse and more hypothyroid which is discouraging... can anyone else relate? Hi, I’d have a look at these points to deal with anti-energy problem (part of the whole point) Estrogen imbalance Thyroid saturation by heavy metals See Kate Deering too to optimize the metabolism. Note: It’s not because RP said sth was good in general that you don’t have to manage according to your ground and the level of you energy (the way you metabolize). Useful info: *) The link between thyroid, energy and excess estrogen. Statistics show that one in eight women between the ages of 35 and 65 and one in five women over the age of 65 have some form of thyroid disease. If T3 is impaired, the neurotransmitter will fail to transmit the right impulse to regulate the action of serotonin, norepinephrine, and GABA (gamma aminobutyric acid). If you don’t have enough T3, or if its action is blocked, an entire cascade of neurotransmitter abnormalities may ensue and can lead to mood and energy changes, including depression. Source: Effects of estrogen on thyroid function http://www.drnorthrup.com/thyroid-disease/ *) Iodine deficiency is also very common in women. See Thyroid Toxicity, By Philip L. Roberts, MD What intoxicates the thyroid? -- Watch out fluorine and bromine: they saturate the receptors of the thyroid and prevent iodine from fixing / to reach the target. Useful nutrients for the thyroid. Les vitamines liposolubles : A, D, E, K. Les vitamines C B-2 B9 et B12 Les oligo-éléments : Magnésium – Sélénium – Zinc – Iode More info in the book « Stop the thyroid madness II, chapter 10. How Thyroid Experts are Challenging Ineffective Treatments and Improving the Lives of Patients JANIE A. BOWTHORPE, M.ED. EDITOR. Or a summary of the book on my forum: http://mirzoune-ciboulette.forumactif.org/t119-the-thyroid-madness#817 *) Brain protection from aluminum, cadmium, lead, mercury and nickel. Magnesium protects the brain from the onslaught of toxic minerals like aluminum, cadmium, lead, mercury and nickel. Low levels of brain magnesium allow the toxic metals to enter brain cells, and could be the harbinger of conditions like Alzheimer’s and Parkinson’s We recommend combining ionized magnesium with choline citrate to enhance magnesium uptake and chaperone its delivery to cells. Regular magnesium is often not absorbed efficiently, especially in people with compromised digestion and chronic conditions; these are the people who most need the support that magnesium provides. The cellular uptake of magnesium entails an energy-dependent step that is bypassed by the addition of choline. Source: Three Safe & Simple Ways to Detox Note: If you suffer from mercury toxicity, any recovery can’t take place. There is a strict protocol to follow. And mind current mistakes: too long with the same product. No recovery stage allowed for energy. Get informed on the health crisis before detoxifying. Useful info: Book: How to heal your metabolism. http://mirzoune-ciboulette.forumactif.org/t1347-comment-guerir-votre-metabolisme-livre => Large excerpts on my forum (in French). Top 3 of the read posts. Mind ratio Hg/ Se in fish and seafood. Selenium (Se) must be higher than mercury (Hg) Ratio Hg / Se mg / 100 gr fish Espadon 0,89 / 0,062 mg / 100 gr de poisson (swordfish) Maquereau espagnol 0,44 / 0,36 (Spanish mackerel) Saumon d'élevage atlantique 0,06 / 0,041 Saumon sockeye d'Alaska 0.03 / 0,030

@DavidPS it also solves heart disease in the Linus Pauling protocol it's an interesting substance

Found the whole graph @yerrag @PrinceTrebata [image: 1723163589662-gueq65uwiaqvumx.jpg]

@Lothric sounds like a mast cell reaction, allergen or foreign body -> IL-4 cytokine causing differentiation to Th2 cells -> Th2 cells producing IL-4 or IL-13 -> B cells production of IgE -> mast cells activating which release a bunch of irritating stuff (histamine + serotonin + leukotrines) -> Further IgE production https://www.ncbi.nlm.nih.gov/books/NBK27117/ 1 path to itching is histamine & serotonin activating TRPa1 TRPv1 receptors . PUFA metabolites can activate these too (maybe more susceptible if losing weight with pufa stored in fat cells being oxidised?) there's another path signalled in the brain alternatively If it gets really bad (mast cell activation syndrome) cortisol works for a bit but not a good long term solution. idk would be useful to know how to prevent the cycle happening rather than trying to lessen the reaction. finding the triggers can be complex co2 can help a bit with symptoms https://www.researchgate.net/publication/49801580_Treatment_of_mast_cells_with_carbon_dioxide_suppresses_degranulation_via_a_novel_mechanism_involving_repression_of_increased_intracellular_calcium_levels https://www.researchgate.net/publication/238230244_Intranasal_Non-Inhaled_CO2_Provides_Rapid_Relief_of_Seasonal_Allergic_Rhinitis_SAR_Nasal_Symptoms

@Galaroc wow thanks a ton. Very appreciated. I need to dive into that research.

@hwisdom said in Share Your Grocery Hauls: @Jennifer peppermint reduces DHT️️️️ I sure hope so! Prevent hairs from sprouting up on my chinny chin chin. I love peppermint. I find it to be useful for nausea, digestion, gallstones, toothaches, respiratory congestion, as an anti-spasmodic and headache reliever. Good stuff!

@RaypEagle I know how you feel sadly I am still living in mine despite the numerus conversations about cutting my contract well actually almost an year. So what helps me cope in that shit situation is Ketotifen. In the winter was 1gr twice a day, now is the summer bc of the heat and the humidity I do 2gr twice a day. Also I use sometimes Lapodin.

I asked Chat and it gave me these 4 reasons Ill skip the actual explanations. Vasoconstriction and Vasodilation:, Histamine Release, Autonomic Nervous System: Bromocriptine's effect on the autonomic nervous system can disrupt the normal regulation of nasal blood vessels, leading to congestion, and prolactin suppression.

@ThinPicking thanks.

@Stinky-bill-19 before you start taking exogenous thyroid it might be worth it to try eating things which have zinc and copper and selenium like liver and oysters, and eating coconut oil and more carbohydrate, maybe also vitamin D and more calcium to see if you can get some endogenous thyroid going and lower the TSH. I haven’t tried Tyromix but I hear that alcohol is not the best delivery vehicle for thyroid hormone. The Mexican stuff is what I’ve tried and most swear by it.