Pro progesterone effects... These data suggest that cinnamaldehyde selectively induced progesterone production and inhibited production of testosterone and dehydroepiandrosterone in human adrenal cells. https://www.sciencedirect.com/science/article/abs/pii/S0024320510001803 Also, to bypass any possible heavy metal contaminants maybe the use of cinnamon essential oil could work. Eg, 1 drop in food/drink etc. Cinnamaldehyde is an aldehyde found in cinnamon bark in high concentrations. It's used as a flavor and medicine. Cinnamon bark is usually used medicinally in doses of 1-6 grams orally. 6 grams of cinnamon can contain from to 42 to 189 mg cinnamaldehyde. Cinnamon contains approximately 1 to 3.5 percent essential oil. The essential oil is approximately 70 to 90 percent cinnamaldehyde. — http://herbpedia.wikidot.com/cinnamaldehyde

@Alomongerpete said in Glucose Loading Protocol: What's the purpose of this protocol? Expected benefits? Reply This protocol gets glucose to the brain, even for insulin resistant or metabolically challenged people, and gets the brain functioning better. This can result in the healing of brain fog, mental illness, and even other physical challenges that might be present because of less than optimal brain function.

@slow-learner wow that is a interesting phenomenon Ive heard of ssris , accutane and lions mane having permanent changes on peoples gene expression but I doubt methylblue could do that. Also finasteride. i.e PSSD, PFAS.

@A-Former-User said in Metabolism: sloth to a dopaminergic child: Holy shit I think I'm about to make it to a healthy metabolism... I'm almost there... Just waiting for my grass fed livers next week I never noticed much energy surplus from liver, though I like it. Maybe the organic is better. I think good seafood and shellfish is 100% energizing; citrus and other fruits, potatoes. Frozen shrimp is probably one of the best and cheapest shellfish even with whatever heavy metals and contamination is present. It usually instantly gives me energy. Spanish Shrimp: fry garlic in butter, add shrimp, salt and pepper. add parsley, add lemon juice. top with paprika when finished.

Ray Peat’s response to my question (https://www.bioenergetic.life/clips/16348?t=3962&c=74) may be helpful for anyone looking for an answer in the future. In summary, he said that yes, pregnenolone can be beneficial, but recommended keeping progesterone supplementation low because high or long-term doses can suppress testosterone. This also suggests that one should keep pregnenolone doses relatively low and use it for a shorter period, since pregnenolone and progesterone levels tend to rise in tandem.

@pannacottas Any luck on DHTE? Ex-athlete trying to figure things out as I transition to next part of life...particularly interested in the mental and lifestyle benefits. Think this is where the real benefits are and the research looks promising

@jonnil yep. Eat robustly and balanced macros as much as you can. Huge help usually.

@mexican_coke_fan said in DNP Powder: @Alexander99 You should put them in capsules. I did some research a while back, and it would be best to buy a capping device, such as a "Cap M Quik" to make your pills. Go to body building forums and look at how to do this, I recall it was recommended to mix corn starch with the DNP, but I don't recall how many mg of each you need. I do recall that you're going to want to dry your powder, DNP ships wet because it is flammable. You can lay out your powder for like a day in the sun and it should be enough. I ended up encapsulating using a milligram scale, gelatin capsules and a mg spoon to pack the capsules. Let them dry too before consumption, went from dirty salty brown to bright yellow in 24h. Was good as I did in bulk and dosed to 150mg - a low(er) dose I felt comfortable at, while the pills bought online tend to be 200mg (with a vast margin of error) as standard. Lost a couple kg in a week then stopped cycle 1. On a second longer cycle now.

@Serotoninskeptic ooops I can't read. I'm doing honey diet + using gelatin as primary protein source to get lean. Non-dietary just blast DNP

@foxgelb said in DAO Deficiency: If you decide to do copper supplement, what other vitamins/minerals should you be sure to have enough of, do you know? I gave the two most required but if you lack other ones, it's not going to turn round: Zn 10-15 mg / Cu 1.5 mg => Meat for Zinc. Vit C (not high level, mind the kind too), D3 2000 UI. B6 PLP (not PNP), 5 days a week, for 3 weeks. then stop one week. Repeat once. Make a search with "mastocytes and histamine" and which supplement.

@DavidPS Hmm. Seems to be many possible causes. I did consume too much to drink on New Year evening and its been happening since then. Possibly a vitamin or mineral deficiency from too much alcohol

@LucH said in Agar agar: "Locust bean gum, HPMC, guar gum, and kappa carrageenan impacted various parameters in a reversible manner, while xantham gum, sorbitan monostearate, glyceryl stearate, maltodextrin, and P80 impacted various microbiota parameters, both compositionally and/or functionally, in a non-reversible manner https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986288/ Happy New Year! This is part of your perfect answer.

@smelllikacowshit That feeling but through carbon dioxide would be ideal

@peatolish with cream and sugar is the right way is the peat way. Any one, hypo or not, having black coffee with out any thing sweet is asking for trouble.

@Serotoninskeptic said in Low dose naltrexone: He recommends starting with 1.5mg, and increasing to 4.5mg. Any experiences eith this protocol? I've felt mild benefits, as in a tiny bit more stable physically and mentally from 4mg naltrexone daily. I felt like the 4mg were too much. Ultimately it wasn't worth continueing for me after I had used it up. Also, if I were to give it another try I'd argue against increased doses but instead go for 1mg or even less. As in ULDN (ultra low dose naltrexone). The way it's reported to act through the opiod recepters in incrementally smaller doses is funnily kind of reminiscient of homeopathy.