@dapose said in ROS (elevated by fat oxidation) drive immune dysfunction in cancer; vitamin E may help:
Does anyone think molecular hydrogen would be the better route
No, I don't think so.
H₂O₂ exhibits selectivity, modifying certain proteins and thereby influencing enzyme activities and transcription factors.
Hydrogen peroxide (H₂O₂) selectively modifies proteins by oxidizing redox-sensitive cysteine residues, which alters their activity and influences cellular processes like enzyme function and gene transcription. This modification acts as a redox signaling mechanism, enabling cells to respond to environmental cues and regulate important biological functions such as cell division, differentiation, migration, and survival. The selectivity arises from the specific oxidation of these cysteine residues, with the reversibility of this process, often mediated by glutathione, allowing for dynamic regulation of cellular responses.
Reversible Modification:
The oxidation of these cysteine residues is often a reversible process, allowing for a dynamic on/off switch in protein function. For example, the reducing agent glutathione (GSH) can reverse the oxidation of cysteine residues, restoring the protein to its reduced state.
Note’s editor: Do not stimulate GSH (in order to form glutathione) since cancer cells use GSH to protect themselves from the immune system (thanks the use of ROS by the body).
Target what’s going to protect telomere and mitochondria: In terms of remedies, aspirin, niacinamide, vitamin D, thyroid, progesterone, quinones, etc. would probably be the most directly accessible and helpful remedies for restoring/improving mitochondrial function. (RP)
NB: As a preventive action.
However, we have still to make the distinction between 2 phases:
Prevention and recovering phases;
Ionized or chemical “therapy”.
Most known antioxidants are counterproductive in case of established cancer since they weaken our immune system.
NB1: Mind Haidut’s the conclusion! Supplying antioxidants can help in prevention, but we have to be more specific during the “reverse” process.
H says: “Yes, “something as simple as vitamin E or one of the quinone-like molecules would be able to greatly reduce the growth rate of already existing tumors, as well as the aggressiveness of returning tumor after cancer treatments.”
=> Does CoQ10 and MK-4 counteract cancer ionized treatment?
DOI https://doi.org/10.1038/s41598-017-08659-7
CoQ10 is not recommended during ionizing radiation treatment because it can interfere with the therapy's effectiveness by acting as an antioxidant that protects cancer cells from damage. While some studies suggest potential benefits in protecting healthy tissues from radiation damage and reducing fatigue, its use is controversial and can compromise the therapeutic outcome.
You should not use MK-4 either nor other antioxidant supplements during or immediately after radiation treatment, as it can reduce the effectiveness of the therapy. While vitamin K has shown potential benefits as an adjuvant therapy for cancer due to its anti-inflammatory and anti-cancer properties, it's crucial to avoid antioxidant supplements during active radiation treatment.
NB2: I haven’t read sth that says Vit E could do the job, in the way it moderates the proliferation (tocotrienols gamma are very effective against inflammation and could protect one side of the membrane).
Vitamin E: This vitamin also acts as an antioxidant and plays a role in regulating hydrogen peroxide generation within the mitochondria.
Vitamin K2: Vitamin K2 protects against mitochondrial oxidative stress and cell damage by regulating mitochondrial quality control processes, such as the balance between mitochondrial fusion and fission, and promoting mitophagy (the removal of damaged mitochondria).
How long to wait before taking quinones to protect the mitochondria after an ionizing treatment (cancer)?
=> No consensus on posology & timing.
Restoration of mitochondria after an ionizing treatment (cancer)
Restoring mitochondria after ionizing radiation treatment in cancer focuses on clearing damaged mitochondria through mitophagy, potentially by using mitochondria-targeting antioxidants like Methylene Blue and MitoQ to manage ROS levels. In cancer cells, strategies like using dichloroacetate (DCA) to restore oxidative phosphorylation and targeting metabolic reprogramming (away from glycolysis) can also play a role in restoring mitochondrial function.
Modulating Metabolism:
• Dichloroacetate (DCA): This compound has been shown to restore mitochondrial function by promoting oxidative phosphorylation and reducing the Warburg effect (a reliance on glycolysis by cancer cells), thereby restoring a more normal metabolic state.
• Lactate dehydrogenase (LDH) inhibitors: Targeting LDHA, the enzyme responsible for converting pyruvate to lactate, can reduce the reliance on glycolysis, which is often increased in cancer cells after irradiation.
Important Considerations
Investigational Use: The use of Methylene Blue in cancer treatment is largely investigational and lacks broad clinical guidelines for safety and efficacy.
Dose-Dependent Effects: The effects of Methylene Blue are highly dose-dependent; high doses can have negative effects, while low doses may be beneficial. There is misinformation surrounding Methylene Blue. Mind the source (confirm).
In cancer therapy, the most important thing after an aggressive therapy is to relieve the liver's workload, prevent toxins from circulating, and anticipate cachexia.
