@Mauritio said:
I think those two things come down to the same conclusion.
Because if the fluoride atoms disassociated , should not that show up relatively quickly via systemic side effects, as in liver and kidney damage ?
Not necessarily as I think of fluorine/fluoride harboring quite some insidious effects on endrocrine and exocrine glands. If there was huge fluorine unloading we could expect kidney damage. E.g. if all 22mg fluorine of 200mg BAM15 dissociated.
But if it's only 5% or 10% dissociation and therefore 1.1 or 2.2mg fluorine/fluoride per day it won't be obvious but very obfuscated in a range of unspecificity. Would then require larger daily amounts of iodide and support of renal excretion to counteract.
For comparison, amiodarone also has its two halogens (iodine, 37% w/w) attached to its aromatic ring so just as with BAM15 we would expect little dissocation. It's been shown however to yield c. 10% dissociation of iodine and any dose above the very-low-dose 100mg/d is therefore an established possible cause for blood--testis barrier disruption and inflammatory degradation of the interstitial testicular tissue in humans.
Well if anyone's worried about F in BAM15 then 2-3mg of daily KI wouldn't be the worst to stack with it or in general.