There are few studies on PUFA deficiency in which the rats consume a good amount of food, most studies keep the nutrients below the requirement and the rats degenerate. I saw a study in which rats developed the symptoms of PUFA deficiency when placed on a fat-free diet ad libitum, the symptoms were cured spontaneously as long as the diet continued ad libitum, and it was even theorized that the rats produced the essential fatty acids. There's another study in which they didn't even develop symptoms even with a high amount of Mead's acid, but the diet was ad libitum from the start. [image: 1714352867130-9c664463-90fa-45a7-b23d-10b239ce616b-image.png] Without him talking about the symptoms, we can't be sure. The skin problems of PUFA deficiency seem to be caused by the replacement of linoleic acid(18:2n-6) by oleic acid(18:1n-9). You need a degree of unsaturation to control water permeability, there's a study that rats don't suffer many symptoms of deficiency because they kept the humidity high, it seems to take a while for mead acid(20:3n-9) to take over WHE = 90% humidty [image: 1714353865798-694c784e-3324-4219-a170-6f4cf21f54e8-image.png] Bearing in mind that saturated and hydrogenated fats accelerate the depletion of DHA, I believe that the deficiency of DHA is real and there is no other that can replace its function. In rats, 0.26% of calories in ALA was enough to maintain the maximum concentration of DHA(in organs such as the brain) in adult rats, 0.4% in young rats(which means it's difficult to become deficient in DHA). I haven't looked to see if it can be translated to humans literally, as a few oysters would do the job. Tokelauans(max 7g PUFA/day) of the past seemed relatively depleted of omega-6 and were relatively free of the diseases of today, I don't remember reading about any particular problem [image: 1714354494268-62645e88-b569-4e77-9ebf-87e231f851f1-image.png]

@joshiepenis I think focusing on the basics is enough. Be outside in the sun, lift weights, get good sleep, and eat nutritious food. I think hiking in the sun is one of the best ways to improve androgen production which goes hand in hand with bigger testicles. I have seen marked increase in ball size since I started hiking for hours on most days.

@Mulloch94 said in Grant Genereux admits he "didn't do a whole lot a research" for his anti-vitamin A books: I think most people who get into that type of work will tell you their true intentions got perverted somewhere along the way. Yeah, I have just recently watched a compelling video about a story like that... https://www.youtube.com/watch?v=LKiBlGDfRU8

Maybe high dose fat solubles were crashing estrogen too low as you do need estrogen to function just in a good balance

I’ve been reading that it’s important for the thyroid and how people with too low ferritin don’t respond well to thyroid treatments.

Info continuation Main points in practice Support you own endogenous production of DAO with useful nutrients. ## Be sure to get enough of vitamin C B6 (P5P) and coper. Pay attention: Not a vitamin B complex. 50 mg B6 is OK. B6 must be co-enzymed (P5P), without additive preferably. • Swanson, P-5-P-pyridoxal-5-phosphate, 20 mg, 60 capsules. 3.51 € iherb.com, 0.18 €/gel. =>Advised choice for dosage if neuronal pathology (hypersensitivity). 1x/d. Pay attention: Too much of a good thing is bad. ## There is a threshold not to overload with B6 PLP, depending on your underlying degree of low grade inflammation and neuro-pathologies. pauses are required with PLP (effective form). • Thorne, Pyridoxal 5'-phosphate, 180 capsules. 33.8 mg. With dioxide Si. 47.28 € - 10% by iherb..com, 0.263 €/gel. • Nutrabio 100 mg, 60 capsules. 14.72 €, 0.25 €/ gel. My choice because without excipient. 1x/ every other day (every two days). Chelated Coper (bisglycinate coper 10-15 mg, twice a day if suffering from dysbiosis). Vitamin C must be identified with CAS N° 50-81-7 (or with Specific Optical Rotation, between +20.5°~+21.5°) (without HM => certificate). Otherwise it’s half not assimilated (rubbish). Mine comes from Scotland, organic source (not from China). Labelled acid ascorbic quali-c (nutrimuscle.com 125 gr 22.95 €). Surfine powdered vitamin so that it dimots well, without residue. Magnesium bisglycinate (mind the origin: well diluted and taste) we lack Mg. DAO enzyme. 1 000 000 units. I take NaturDAO 10-15’ before meal 3x/d. Gradually stop treatment (amazon.fr) I won’t eat liver more than once every 5 days. And from organic source or from poultry (young chicken). Support your methylation: For example with betaïne HCL (Now Food, with pepsin) or with TMG supplement (Now Food, TMG 1000 mg or 2x 500 mg). I take TMG (tri-methyl-glycine) 2250 mg from Super Smart (with a 30 % discount). No need to be so high. NDLR: Chris Masterjohn has recommended TMG when taking B3 (niacin). What is the difference between betaine HCl and trimethylglycine? Betaine HCl has an acidic taste whereas anhydrous TMG ("anhydrous betaine") tastes sweet with a metallic aftertaste and is usually produced from sugar beets (as is betaine hydrochloride). Both are active as methyl donors, as 'betaine' is retained in both forms. Mast cell control I take quercetin anhydride 500 mg (nutrixeal.com) once a day. With a meal because some fat is required. In cure. Or every other week (every two weeks). Mind some foods: We should not only worry about foods that contain large quantity histamine (H3 in the PDF list), but also foods that release histamine (L3 in the PDF list, in French) (L stands for liberation). For example, tuna is classified H3 (high contribution), the orange fruit is L3 (leads to a high reaction of histamine release). Histamine Diet See PDF list. Useful info (in French) https://mirzoune-ciboulette.forumactif.org/t1745-traiter-lintolerance-a-lhistamine?highlight=histamine => How to deal with histamine intolerance + short list of food high in histamine. See beneath for an English source. L3 (power 3/3) (L stand for liberator => set free) Walnut, lemon (lime), orange, grapefruit, wine and balsamic vinegar, alcohol, iodine. Other examples on this link (list of incompatibility for histamine, in French): Noix, citron vert (lime), orange, pamplemousse, vinaigre de vin et balsamique, alcool, iode. Autres exemples sur ce lien (Liste d’incompatibilité à l’histamine) : https://www.mastzellaktivierung.info/downloads/foodlist/31_FoodList_FR_alphab_avecCat.pdf It is not because a food brings little histamine that he does not cause a release of histamine. So be careful not to be based only on a single info source. It is above all the accumulation that must be avoided, and be careful in more sensitive times, of course. Traduction : Ce n’est pas parce qu’un aliment apporte peu d’histamine qu’il n’entraine pas une libération d’histamine. Donc, attention à ne pas se baser seulement sur une seule source d’info. C’est surtout le cumul qu’il faut éviter, et faire attention en période plus sensible, évidemment. Alcohol and other drugs Alcohol overburdens liver detox. There are many drugs with prohibited molecules. See link. I made a copy in a docx in order to make a search easily. By the way, I made 2 mistakes: curcumine and High dose thiamine (B1) before recovering. + pineapple (L2) in crisis. This group does extensive research on histamine and is quite reputable. They list Thiamine/B1 as being a liberator and DAO blocker with certain types of administration: *) Thiamin as histamin liberator and DAO inhibitor Sattler 1985 (PDF with reference on histamine active substance, in English) Sattler J, Hesterberg R, Lorenz W, Schmidt U, Crombach M, Stahlknecht CD.: "Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: relevance for clinical side effects?" Agents Actions. 1985 Apr;16(3-4):91-4. https://pubmed.ncbi.nlm.nih.gov/3925736 (Liste unverträglicher Medikamente (DAO-Hemmer)) *) Low histamine Diet Anit Tee factvsfitness.com (pdf with info I English) *) Liste de compatibilité alimentaire – Histamine Triée par ordre alphabétique, avec catégories. Communauté d'intérêts Suisse de l'intolérance à l'histamine (SIGHI) www.mastzellaktivierung.info | www.histaminintoleranz.ch => rubrique téléchargement / Liste détaillée de la compatibilité des aliments de base (rubrique : Régime alimentaire pour éliminer l'histamine > Téléchargement). Info en anglais / français / allemand. Liste PDF en français FoodList histamine, FR, alphabétique, avec catégories https://www.mastzellaktivierung.info/downloads/foodlist/31_FoodList_FR_alphab_avecCat.pdf Fix the gut => Dysbiosis – Probiotics? – Strengthen gut walls – Target diet if intolerant gut Sources and references 0. Useful Info Dr. Becky Campbell – Free Histamine Guide. https://lowhistamineeats.com/clear-histamine-naturally/ Reversing Histamine Intolerance Takes More Than a Low-Histamine Diet https://caplanhealthinstitute.com/reversing-histamine-intolerance-takes-more-than-a-low-histamine-diet/ https://drtaniadempsey.com/5-natural-antihistamines-to-combat-allergies/ Sources and references “Effect of dietary fatty acid and micronutrient intake/energy ratio on serum diamine oxidase activity in healthy women” https://pubmed.ncbi.nlm.nih.gov/28606572/ Results: Serum DAO activity in both phases was positively correlated with intake of long-chain fatty acids, saturated fatty acids, and monounsaturated fatty acids (P < 0.05). Intake of phosphorus, calcium, zinc, magnesium, iron, and vitamin B12 during the luteal phase was positively correlated with serum DAO activity (P < 0.05). “Nutrient-induced inflammation in the intestine – PMC –NCBI.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520304/ Understanding the relationship between nutrient absorption and intestinal inflammation is important. We need a better understanding of the interaction between enterocytes and the intestinal immune cells in nutrient absorption and the gut inflammatory responses. The increased release of histamine and DAO is specific to fat feeding and is not shared by carbohydrate or protein feeding. Wollin A, Wang XL, Tso P. Nutrients regulate diamine oxidase release from intestinal mucosa. Am J Physiol. 1998;275:R969–R975. [PubMed] [Google Scholar] Adopting a leaky gut protocol or a diet rich in anti-inflammatory foods and high in antioxidants, can be instrumental in addressing the root-problem. Improving gut health and taking DAO are pillars of histamine intolerance treatment. https://caplanhealthinstitute.com/reversing-histamine-intolerance-takes-more-than-a-low-histamine-diet/ Useful nutrients include vitamins B6, copper, iron, magnesium, phosphorus, zinc, and vitamin C. (a,b) Each of these nutrients both support and modulate immune function for the better. a. Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007;85(5):1185-1196. doi:10.1093/ajcn/85.5.1185 b. Miyoshi M, Ueno M, Matsuo M, et al. Effect of dietary fatty acid and micronutrient intake/energy ratio on serum diamine oxidase activity in healthy women. Nutrition. 2017;39-40:67-70. doi:10.1016/j.nut.2017.03.004 Le syndrome d'activation des mastocytes et l'activation inappropriée des mastocytes Les symptômes proviennent principalement de la libération de médiateurs et comprennent un prurit, des bouffées de chaleur et une dyspepsie due à une hypersécrétion gastrique. Mastocyte activation syndrome and inappropriate activation of mastocytes Symptoms come mainly from the release of mediators and include pruritus, hot flashes and dyspepsia due to gastric hypersecretion.

We really don’t have enough info about your diet to be that helpful. How much fat do you eat each meal? Do u snack between meals? Lots of liquid calories? Some people do better with starches, some better with sugars etc gotta find what works for you

A better oxidative metabolism actually has a slower burn of glucose while a more reduced glycolytic metabolism wastes glucose quicker. I used to crash between meals and feel that stress often. Or have intense cravings. After many years of pro metabolic eating and now taking thyroid I generally feel more stable between meals and rarely feel that hypoglycemic stress unless I workout hard and then skip a meal

My eyes run like crazy when I go outside in the cold, especially if it's windy. The Internet (which is never wrong) says this is a dry eye issue. All this time I thought it was caused by low estrogen.

@VehmicJuryman said in Countries with most bald men in the world: The west needs to start third-worldmaxxing. Take siestas, take vacations, be unemployed, be lazy at work. Why don’t you take a trip to a ‘third world’ country controlled by the West and saddled with debt by the world bank and watch your hair grow then? Most people in those countries cannot feed themselves let alone take vacations. I like a joke but this one is no laughing matter

@Peatly thank you so much

Half the time I want to throw my computer off of the desk so, yes, I can see it raising cortisol for a variety of reasons. One time I did one of those 4-sample saliva cortisol tests that you take throughout the day, and there was an upwards blip in cortisol just before bed. I did a gaming session just before taking the sample.

It should help Vitamin D for treatment of non-alcoholic fatty liver disease detected by transient elastography: A randomized, double-blind, placebo-controlled trial PDF