@Sattva Everything you said is not peaty. Meditation is bad and for losers just like psychedelics; it shrinks your amygdala as well. Your advice is good for people with bad metabolism who want to have even worse metabolism.

He hasn’t been Keto for years.

@pittybitty said in What helps improve executive function?: I've generally been fine in regards to energy since supplementing B vitamins, but the low executive function remains. Give details, please, because it's not with a B-50 multi you're going to have a game changer. You need to read these two links to understand why you lack B6 if you're inflamed or under-immune. Sure with dysbiosis. And to understand why you need more B1 thiamine (not HCl) if you eat carbs like most people. Potential roles of Vit B6 in inflammation and immunity. Preventive role of B6 against chronic diseases & downregulation of the inflammatory mediators https://mirzoune-ciboulette.forumactif.org/t2034-english-corner-potential-roles-of-vit-b6-in-inflammation-and-immunity#29633 Main ideas • Preventive role of B6 against chronic diseases. Several diseases are mediated, at least in part, by lower inflammation, possibly through modulation of several kinases. (1) • Vit B6 deficiency is associated with lower immune function and higher susceptibility to viral infection. (2) Megadoses do not produce additional benefits after repletion. (3-4) But elderly should benefit from cyclic supplement (with pauses and moderate amounts, aka 50 mg pyridoxamine). • Plasma PLP levels were inversely correlated with systemic inflammation markers such as CRP. (5) Vitamin B6 supplementation suppressed IL-6 and increased total lymphocytes in patients with chronic conditions. (6) • Vitamin B6 supplementation improved immune function in both human and animal studies. (7-8) It improves the immune response, causing increased antibody production, and enhances communicative interactions between cytokines and chemokines. (9-11) • The authors of this study (0) assume that vitamin B6 is possible to suppress hyperinflammation, at least in part, through NLRP3 inflammasome inhibition, limiting virus spread and cytokine storm. Together with the notion that NLRP3 inflammasome plays a central role in chronic diseases, including CVD, diabetes, and acute viral pneumonia (12–14), the anti-inflammasome effect of vitamin B6 suggest its therapeutic role in reducing the severity of COVID-19 and its complications. • Studies indicate that B6-vitamers can reduce superoxide radical and lipid peroxide levels induced by H2O2 in vascular endothelial cells (15). Too much sulfites (H2O2) exhaust B6 PLP. • Pyridoxamine has anti-glycation activity and inhibits the formation of AGEs. (16) • It was identified that high-dose vitamin B6 has a global anti-inflammatory effect on lipopolysaccharide-induced inflammation in monocyte/macrophage cells by downregulating the key broad-spectrum inflammatory mediators. (17-18) Sources and References (in English, on the link, my forum). See too: English Corner – Vit B6: How much is too much? Main ideas Too much of a good thing is bad. Especially bad for neuro-sensitive people. Vitamin B6 is well documented for its role as a modulator of steroid hormones. No problem with food intake if not supplemented. Maximum RDA target is 25 mg B6. But update RDA is given at 6-12 mg. There are 6 vitamers and a way-out form through the urine. If we want a pharmacological effect, we have to take into account the form of the vitamers. The active form is B6 PLP. And for B1 thiamin *) ## Thiamine Deficiency - A Potential Cause of SIBO and other Gut Dysfunction? https://mirzoune-ciboulette.forumactif.org/t1896-vit-b1-deficience-desordre-intestinal Version complète plus complète sur ce site (Vaut le détour) : Elliot Overton – Nutrition and Functional Medicine https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo – 01/2019 *) ## Thiamine and the Microbiome – Dr. Lonsdale https://www.hormonesmatter.com/thiamine-microbiome/ 03/23 Excerpt: The acquisition / bioavailability of thiamine is not only essential to the physiology of our organism and our good physical and mental condition, but thiamine is a cofactor for certain intestinal bacteria that change behavior depending on the variable availability of B1 .

@wester130 said in Natural antibiotic - Allicin, Neem and Oregano Oil,: Would this work for SIBO? Not enough. As said by Kviron, we need to deal with a better metabolism or the problem won't disappear, and even worsens. You're going to kill some / a lot of bacteria with these options but not all the bacteria. The strongest ones will remain and overgrowth. You must first get informed on how dealing with LPS when killing some bacteria (how to manage a saturated liver). Need to know how to avoid stagnation of starch in the second part of the colon (See MMC and SIBO / SIFO). Afterwards you need to help thyroid for the right amount of energy with adapted nutrients. And last but not the ultimate you have to balance the communication between the brain and the stomach (commensal bacteria). Excerpt: The lower regions of the brain responsible for coordinating the autonomic nervous system are particularly vulnerable to a deficiency of thiamine. Consequently, the metabolic derangement in these brain regions caused by deficiency produces dysfunctional autonomic outputs and misfiring, which goes on to exert detrimental effects on every bodily system – including the gastrointestinal organs. However, the severe gut dysfunction in this context is not only caused by faulty central mechanisms in the brain, but also by tissue specific changes which occur when cells lack thiamine. The primary neurotransmitter utilized by the vagus nerve is acetylcholine. Enteric neurons also use acetylcholine to initiate peristaltic contractions necessary for proper gut motility. Thiamine is necessary for the synthesis of acetylcholine and low levels produce an acetylcholine deficit, which leads to reduced vagal tone and impaired motility in the stomach and small intestine. In the stomach, thiamine deficiency inhibits the release of hydrochloric acid from gastric cells and leads to hypochlorydria (low stomach acid). The rate of gastric motility and emptying also grinds down to a halt, producing delayed emptying, upper GI bloating, GERD/reflux and nausea. This also reduces one’s ability to digest proteins. Due to its low pH, gastric acid is also a potent antimicrobial agent against acid-sensitive microorganisms. Hypochlorydria is considered a key risk factor for the development of bacterial overgrowth. Source: Dr Costantini SIBO and Thiamine Deficiency Dr Costantini and bacterial overgrowth SIBO, IBS, and Constipation: Unrecognized Thiamine Deficiency? – June 2020 https://www.hormonesmatter.com/sibo-ibs-constipation-thiamine-deficiency/ PS: You'll probably need to optimize bile and chlorhidric acid to optimize meat digestion if the digestion takes to long. Bile & SIBO (in French, but with links in English) Optimiser la bile & fluidifier le transit en cas de SIBO https://mirzoune-ciboulette.forumactif.org/t2005-impact-de-la-bile-sur-le-microbiote-et-le-transit#29365 La prolifération bactérienne est fréquemment rencontrée chez les personnes qui souffrent de colopathie (IBS).

On twitter, @haidut mentioned using vitamin K3 as a safer version of DNP to drop some weight. (This was back around ~Mar 15 2023.) In one of the reply streams, someone posted a link to this product: https://www.medixlife.com/shop/vicasol-buy-online-menadione/ I am not aware of a US source. I would love to find one and give it a try.

@hwisdom Np. Lmk if you need more info.

@SummerPeach that stuff is so expensive tho :/. Especially since Im not even sure I have The Hpylor. Doctor never even mentioned H pylori or any diagnosis for that fact lmao. Im gonna try get an appointment for gastroscopy in a week when im back there although idk if they can even see it ig at least they can tell if i need to take still this ppi shit due to ulcer or sth or no

@DukesBobby777 No, i didn't, because this drug eventually would be too expensive to keep doing it. Actually, i'm on Mirtazapine 30mg, an atypical antidepressant that it's a serotonin antagonist very similar to Metergoline bc it acts specifically of the 5-ht2 receptors and i'm getting good results (althought i'm thinking about increasing the dose to 45mg). If you have high serotonin symptoms i would give it a try, I get the prescription monthly from my psychiatrist and since I started it my symptoms have drastically reduced

@cs3000 I can bear witness to this. When I was suffering from a year long condition that started with bronchitis, my eyelids were drooping. The lack of the usual amount of oxygen easily translates into low energy. And my eyelids were a good tell.

@chudlord Great stuff thanks! For those who can get it, a nice hack is tomato sauce or sea salt with truffle extracts. Makes it very easy to add a tiny bit of it everyday. [image: 1715758068604-70992f33-7d09-4af6-b5fd-bf378491e7c3-20055_sel-truffe-guerande_328e5620-1ca7-49c8-be65-a4472113e4f6_600x.webp]

@hwisdom Jesus that's an enormous amount lmao. I guess 200g/week is enough.

@shedim interesting. Is there any risk of staining teeth? Are you saying you actually had bone regrowth doing this?