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Subcategories

  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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    LucHL
    @DavidPS said in Lipofuscin accumulation in aging and neurodegeneration: Dr. Peat has written about lipofuscin. Too many options (lazy). here I've got this info on my pC. *) How the Oils In Your Diet Are Aging Your Skin. Dr. Peat goes on to explain what this rancidity (oxidation process) does: "The free radicals produced in this process react with parts of cells, such as molecules of DNA and protein, and may become attached to those molecules, causing abnormalities of structure and function." https://raypeat.com/articles/articles/unsaturated-oils.shtml EGCG Inhibited Lipofuscin Formation Based on Intercepting Amyloidogenic β-Sheet-Rich Structure Conversion https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816542/ "Lipofuscin (LF) is formed during lipid peroxidation and sugar glycosylation by carbonyl-amino crosslinks with biomacrolecules, and accumulates slowly within postmitotic cells. The environmental pollution, modern dietary culture and lifestyle changes have been found to be the major sources of reactive carbonyl compounds in vivo. Irreversible carbonyl-amino crosslinks induced by carbonyl stress are essentially toxiferous for aging-related functional losses in modern society. Results show that (-)-epigallocatechin gallate (EGCG), the main polyphenol in green tea, can neutralize the carbonyl-amino cross-linking reaction and inhibit LF formation, but the underlying mechanism is unknown."
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    61 Topics
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    yerragY
    @what-about-bob Thanks. I like the summary. How everything all fits in from theae great minds and put together by Ray Peat into more practical lifestyle applicable ideas. I am appreciating how I see myself on the "applied technology" end of their contributions as I incorporate these ideas into my attempt to be my own doctor as I attempt to improve my health. I have been unable for the past 24 years to lower my blood pressure without using prescription medication. But I am seeing the light at the end of this tunnel. It is a long process of learning and I don't give up. Thanks to recent developments in science and technology, I may be able to lower my blood pressure finally using ideas from Peat and his predecessors. What has been helpful is my use of AI as an efficient research assistant and aggregator of concepts and minute details that my own limited human mind can't recall easily and utilize readily.
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    S
    ^^^^what he said. He’s always taking about his labs and dropping some numbers, but I’ve never seen them posted, especially not in a comprehensive fashion. Maybe they’re behind a paywall, I don’t know.
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    360 Topics
    3k Posts
    alfredoolivasA
    @engineer @engineer said in Separation in Pansterone bottle: Saw that, really interesting how 6 keto has had approximately 0 interest since that 50s study oh my, if what you're saying is true, then Georgi made a major oversight with how common precipitation seems to be judging by other reports on RPF. You are coming close to taking the Peat black pill. We welcome you
  • Recipes, food, meal prep, brands. Discuss them all here.

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    alfredoolivasA
    @heyman said in Euphoric foods: äggost Does it taste like cream cheese?
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    85 Topics
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    BioEclecticB
    @jamezb46 said in pre workout / intra / post workout: @BioEclectic Why do you think lactic acid produces DOMS? From what i had read at the old RPF forum, though i always hold open the possibility that i have either misconstrued or misremembered whatever i had read. Not sure if this applies but I do know it noticeably reduces work or shoe related foot soreness. Mag sulfate and Mag bicarbonate.
  • Didn't Ray bring up eating oat bran in the past?

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    hwisdomH
    Phytic acid in oats is anti cancer
  • Thyroid, cholesterol, muscle growth

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    DonkeyDudeD
    @temple-of-salt said in Thyroid, cholesterol, muscle growth: particularly through consumption of brain - the organ meat with the highest concentration of cholesterol Vince Gironda's "12 to 36 raw eggs a day" protocol was based on a similar notion (along with a belief that cholesterol degrades with heat). According to him it was the closest one can get to a steroid cycle without actually using drugs. I'm not sure how much validity it has; I haven't experienced any effects from trying it, but I am hypothyroid and I haven't taken thyroid along with the eggs.
  • Cenforce 200 Mg: Increase Intimacy Between two person

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    M
    The dosage is insane. Inhibiting the breakdown of second messengers like cAMP and cGMP can have vast benefits, including sexual benefits. But you generally should not need a dose so large. 1,500-2,000 milligrams of horny goat weed is good, quality varies. Something that's 20% Icariin or higher is best. Pharma cGMP facilitators are much much more potent. I can't remember the exact equivalence, but I'm pretty sure sildenafil is like 80x more potent than Icariin. So you wouldn't need that much, like 2.5-5mgs of tadalafil would work. But I generally fail to see how this will increase "emotional closeness." This will just improve erection quality. I think peptide research like PT-141 or Oxytocin is more up the alley you're looking for. I don't think any of these substances are "Peat approved" or even generically bioenergetic friendly, so do your research thoroughly and accordingly. I do have a more nuanced approach towards nitric oxide, and I think it's obviously useful in certain scenarios. But from a sexual standpoint it's only so useful before getting diminishing returns elsewhere (like dangerous hypotension). I see a lot of men striving to achieve that "teenage self" again. It's a valiant effort, but there's a reason few people ever succeed at this. Teenage sex drive isn't from nitric oxide or androgens. It's actually from an enhanced histaminergic tone with a lack of H3-H4 receptors. H2 (and to a slightly lesser extent H1)has a profoundly strong pro-libido effect, but in adults the autoreceptors (H3) and the H4 receptors prevent this from happening. The teenage brain still hasn't fully created all these networks yet. Dopaminergerc networks also form before serotonin. So a teenage brain is very high in pro-libido histamine receptors, dopamine receptors, and really low in anti-libido stuff like H3, H4, and serotonin.
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  • Dry mouth - need advice

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    CO3C
    @raytreats Awesome! I think more broadly it was stress hormones causing this, hence the spike when you drank espressos without milk or sugar. But this can have been caused by the deficiency! So not to say that isn't a perfect solution. Try to avoid additives in your supplements. Glad you solved it.
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  • if Estrogen is so bad, why does it direct fat towards feminine areas

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    D
    Estrogen, in sufficient quantities, just puts the breaks on testosterone production (through negative feedback loop). That's what causes feminising effects. Its not the estrogen itself that feminises. Transexuals often use anti-androgen compounds (like spironolactone) for the feminising effects. I don't think increasing estrogen to very high levels even has the capacity to fully feminise a male if his androgen are still high enough. Many men have very high estrogen but still look like men.
  • best way to take progesterone?

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    Milk DestroyerM
    Progest-E
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  • its time to gather dandelion greens

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    ?
    @Ray-Van-Winkle holy shit cheapest vegan diet ever
  • How do you define richness from a bioenergetic point of view?

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    onliestO
    @Norwegian-Mugabe said in How do you define richness from a bioenergetic point of view?: @Ray-Van-Winkle Only a few select people like myself are suited for luxury. This is incredibly real. Low frequency people given money will still live in filth and squalor, and waste their fortune on trivial distractions. The goal is to live a charmed life. The life you save could be your own.
  • Coffee absorbed through ballsack

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    M
    That's interesting, but wouldn't it make more sense to use pure topical caffeine on the scrotum for this effect? Seems like it would, because unlike coffee, the caffeine would not have to be digested first. It's basically following the same principle of using topical t4/t3 mixtures, and NOT topical desiccated thyroid.
  • Curing Parkinson's disease with B1

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    CO3C
    @basednigga2006 said in Curing Parkinson's disease with B1: Can you not get the enough doses of b1 by eating healthy.....? Theoretically, maybe. But we live in a real world. So in our current world: not even remotely. Stress depletes all kinds of vitamins and minerals, and our food is more devoid of them than it has ever been in the history of mankind... Starches contain no vitamin B1. Sugar, which is what starches are converted to, requires a lot of it. The advent of white rice (where the thiamine-rich husk is discarded) caused up to 90% of the Japanese military to become B1 deficient!!! [image: main-qimg-4af9ab3816e4e317228dce55b499552d-lq]
  • High fructose corn syrup ultra giga peaty?!?!?!

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  • Simplifying Bioenergetics for others

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    DonkeyDudeD
    @CO3 Where I live the topic is somewhat well known; for example, TV nutrition experts often promote a rule of thumb that the more liquid a dietary fat is in room temperature, the healthier it is. Confidently stating the opposite at least gets some attention, and if someone is unable to understand the solid fat/liquid oil distinction I'm not sure it's possible to simplify it even more.
  • T3 pooling from low cortisol?

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    R
    @BroJonas there has to be some truth because Ray suggested if you had cortisol issues to take t3 with pregnenolone. I'm not sure how prevelant it is or how much it related to low or high cortisol.
  • Aspirin recommendations?

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    DavidPSD
    Ray Peat email exchanges - Aspirin
  • Does mead acid form prostaglandins?

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    I
    @TexugoDoMel Great response, thank you!
  • Aspirin for uncoupling?

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    T
    @dan-dominic Thanks, dan-dominic, for posting that from him. I was mistaken in thinking he'd been banned years ago. I hope VoS considers putting in an appearance here at some point. If anyone has personal contact with VoS, please ask if he's still using his Co2 regulator/canula setup and/or if there are any other links where some of us who enjoyed following his experiments at RFP might read up on what he's been up to in terms of up-regulating metabolism since he left.