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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    713 Topics
    5k Posts
    yerragY
    @Ena said: Yes, statins possess antibacterial properties, so in principle they will introduce LPS by helping the white blood cells to kill bacteria. But it's a strange wording, so I don't understand what he means either. @Ena said: Yes, statins possess antibacterial properties, so in principle they will introduce LPS by helping the white blood cells to kill bacteria. But it's a strange wording, so I don't understand what he means either. I think so too. Stating are antibacterial though they are not marketed to be anything else but a cholesterol lowering drug. Otherwise why would they lead to increasing endotoxins.
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
    703 Posts
    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    W
    @ChroncStresChris yes generally speaking, because DHT dries you out and may actually reduce tesosterone testosterone is "wet" and is needed with dht, dht is "dry"
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    D
    Who knows if this Lead Safe Mama person is actually reliable or not? I continue to use Great Lakes because I don’t know any better brand.
  • Recipes, food, meal prep, brands. Discuss them all here.

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    JenniferJ
    @Mossy, do you mean the brand or type of French bread like the baguette? I was trying to think of popular French brands, but couldn’t come up with any. That’s great! My grandmother used red potatoes too for her potato salad. Aside from digestibility—baby potatoes typically being easier to digest—the best potato really depends on its growing conditions and less so the variety, IME. After spending months testing numerous varieties from different suppliers, I (happily) settled on the baby Yukons. They’re from a local supermarket chain and even better than the Upstate Abundance—they’re consistently so creamy and flavorful that they don’t need any added butter or salt, but they’re half the price and available year round. Alexandre is excellent, yes, but prior to caring for my dad, the majority of my dairy (and eggs) came from a local 100% grass-based, biodynamic, A2 certified (raw) dairy farm that practices Calf at Foot where the calf stays with its mother, something that’s important to me. I’ve known the owner for over 16 years now. I found his farm just after my spine collapsed and I was recovering from veganism. After hearing what happened to me, he started supplementing his herd’s diet with sea minerals to give me the most nutrient dense milk possible. The man is an earth angel. We geek out on health and science whenever I get the chance to visit the farm. He introduced me to the French scientist Louis Kervran and his controversial theory of biological transmutation and last time I saw him, he had started using a refractometer to test the Brix of his herd’s milk. Thank you for the heads-up on Vital Farms. I saw a YouTube video on it a month or so ago. I had always assumed their hens were fed supplemental feed containing soy as it’s a common practice in the industry, even for pastured. I don’t know of any brand on the market whose hens are fed entirely on pasture—Angel Acres Farm, owned by the ‘Strong Sistas’, sells eggs that are tested to be low in PUFA, though—or if it’s even possible to maintain the health of the hens and egg production to meet demands, while keeping the cost of eggs reasonable enough to not offend the consumer. With that said, I haven’t bought their eggs since maybe 2024. I buy a “humanely hatched” brand that uses the technology in-ovo sexing to end the practice of chick culling. It’s great that you’re tolerating bananas better. That’s another good indication your health has improved. Did cooked bananas also cause a serotonin response, previously? If I’m not mistaken, Ray recommended cooking them because of the raw starch. I used to only tolerate them raw when overripe. I haven’t had them in quite some time, though. My diet was further simplified because I’m having to prepare 6 meals a day, currently. Thankfully, I overcame the dysautonomia so the only effect protein has on me now is positive, but the majority of my fuel came from potatoes—I was averaging upwards of 4 lb daily. The concentrated carbs helped, but it was immersing myself in nature regularly on the trail that was most responsible for calming my nervous system and restoring my thyroid function so my adrenals weren’t having to compensate with adrenaline. I had this epiphany that it was not my body that needed convincing it was safe to relax, but me who needed it. I’ve heard it said that we should get out of our comfort zone, but it occurred to me that I’ve never had one. Figuratively speaking, I’ve been putting out fires since I was a child and always preparing for the next one. I knew I needed to take my healing beyond the cell back to the self, but it was challenging to do so when I felt so disconnected from myself, hollow even, since my mum’s passing and distracting myself with the demands of caring for my dad wasn’t going to reconnect me. I didn’t overcome the dysautonomia overnight, but I stayed committed to getting out on the trail at least 4 days a week, and one day, while on the last mile stretch of one of my hikes, I had a moment, a breakthrough, when there was what I can only describe as a lifting of the veil between this world and heaven. I thought I knew peace, but just like hell has no floor, the depths of it are endless, I discovered that day that heaven has no ceiling. To go from feeling completely disconnected to feeling connected to not just myself but everything, to know life’s tragic realities, intimately, and at the same time its miraculousness, was life-affirming. I was reminded that the source that created the mountains I’ve climbed is the same source that created me to be just as enduring, and whatever comes my way I can handle it because in hindsight I always have, and where, in the past, I would have gone into fire-extinguisher mode hearing the doctor say my dad had what killed my mum, I felt at ease, in the flow and have remained so. I’m not just drifting around the ocean on a surfboard, at the mercy of the water. I am the water. And thank you. ️ Yes, you can definitely relate. Being a caregiver is a lot, but I’m just so grateful to have more time with my dad that I didn’t have with my mum.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    C
    I thought aspirin and/or baking soda w water is good for afterwards? Gummy bears or fruit before and during lifting, no?
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    GreekDemiGodG
    He hasn’t been Keto for years.
  • What helps improve executive function?

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    LucHL
    @pittybitty said in What helps improve executive function?: I've generally been fine in regards to energy since supplementing B vitamins, but the low executive function remains. Give details, please, because it's not with a B-50 multi you're going to have a game changer. You need to read these two links to understand why you lack B6 if you're inflamed or under-immune. Sure with dysbiosis. And to understand why you need more B1 thiamine (not HCl) if you eat carbs like most people. Potential roles of Vit B6 in inflammation and immunity. Preventive role of B6 against chronic diseases & downregulation of the inflammatory mediators https://mirzoune-ciboulette.forumactif.org/t2034-english-corner-potential-roles-of-vit-b6-in-inflammation-and-immunity#29633 Main ideas • Preventive role of B6 against chronic diseases. Several diseases are mediated, at least in part, by lower inflammation, possibly through modulation of several kinases. (1) • Vit B6 deficiency is associated with lower immune function and higher susceptibility to viral infection. (2) Megadoses do not produce additional benefits after repletion. (3-4) But elderly should benefit from cyclic supplement (with pauses and moderate amounts, aka 50 mg pyridoxamine). • Plasma PLP levels were inversely correlated with systemic inflammation markers such as CRP. (5) Vitamin B6 supplementation suppressed IL-6 and increased total lymphocytes in patients with chronic conditions. (6) • Vitamin B6 supplementation improved immune function in both human and animal studies. (7-8) It improves the immune response, causing increased antibody production, and enhances communicative interactions between cytokines and chemokines. (9-11) • The authors of this study (0) assume that vitamin B6 is possible to suppress hyperinflammation, at least in part, through NLRP3 inflammasome inhibition, limiting virus spread and cytokine storm. Together with the notion that NLRP3 inflammasome plays a central role in chronic diseases, including CVD, diabetes, and acute viral pneumonia (12–14), the anti-inflammasome effect of vitamin B6 suggest its therapeutic role in reducing the severity of COVID-19 and its complications. • Studies indicate that B6-vitamers can reduce superoxide radical and lipid peroxide levels induced by H2O2 in vascular endothelial cells (15). Too much sulfites (H2O2) exhaust B6 PLP. • Pyridoxamine has anti-glycation activity and inhibits the formation of AGEs. (16) • It was identified that high-dose vitamin B6 has a global anti-inflammatory effect on lipopolysaccharide-induced inflammation in monocyte/macrophage cells by downregulating the key broad-spectrum inflammatory mediators. (17-18) Sources and References (in English, on the link, my forum). See too: English Corner – Vit B6: How much is too much? Main ideas Too much of a good thing is bad. Especially bad for neuro-sensitive people. Vitamin B6 is well documented for its role as a modulator of steroid hormones. No problem with food intake if not supplemented. Maximum RDA target is 25 mg B6. But update RDA is given at 6-12 mg. There are 6 vitamers and a way-out form through the urine. If we want a pharmacological effect, we have to take into account the form of the vitamers. The active form is B6 PLP. And for B1 thiamin *) ## Thiamine Deficiency - A Potential Cause of SIBO and other Gut Dysfunction? https://mirzoune-ciboulette.forumactif.org/t1896-vit-b1-deficience-desordre-intestinal Version complète plus complète sur ce site (Vaut le détour) : Elliot Overton – Nutrition and Functional Medicine https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo – 01/2019 *) ## Thiamine and the Microbiome – Dr. Lonsdale https://www.hormonesmatter.com/thiamine-microbiome/ 03/23 Excerpt: The acquisition / bioavailability of thiamine is not only essential to the physiology of our organism and our good physical and mental condition, but thiamine is a cofactor for certain intestinal bacteria that change behavior depending on the variable availability of B1 .
  • Vitamin C effects

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  • Natural antibiotic - Allicin, Neem and Oregano Oil,

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    LucHL
    @wester130 said in Natural antibiotic - Allicin, Neem and Oregano Oil,: Would this work for SIBO? Not enough. As said by Kviron, we need to deal with a better metabolism or the problem won't disappear, and even worsens. You're going to kill some / a lot of bacteria with these options but not all the bacteria. The strongest ones will remain and overgrowth. You must first get informed on how dealing with LPS when killing some bacteria (how to manage a saturated liver). Need to know how to avoid stagnation of starch in the second part of the colon (See MMC and SIBO / SIFO). Afterwards you need to help thyroid for the right amount of energy with adapted nutrients. And last but not the ultimate you have to balance the communication between the brain and the stomach (commensal bacteria). Excerpt: The lower regions of the brain responsible for coordinating the autonomic nervous system are particularly vulnerable to a deficiency of thiamine. Consequently, the metabolic derangement in these brain regions caused by deficiency produces dysfunctional autonomic outputs and misfiring, which goes on to exert detrimental effects on every bodily system – including the gastrointestinal organs. However, the severe gut dysfunction in this context is not only caused by faulty central mechanisms in the brain, but also by tissue specific changes which occur when cells lack thiamine. The primary neurotransmitter utilized by the vagus nerve is acetylcholine. Enteric neurons also use acetylcholine to initiate peristaltic contractions necessary for proper gut motility. Thiamine is necessary for the synthesis of acetylcholine and low levels produce an acetylcholine deficit, which leads to reduced vagal tone and impaired motility in the stomach and small intestine. In the stomach, thiamine deficiency inhibits the release of hydrochloric acid from gastric cells and leads to hypochlorydria (low stomach acid). The rate of gastric motility and emptying also grinds down to a halt, producing delayed emptying, upper GI bloating, GERD/reflux and nausea. This also reduces one’s ability to digest proteins. Due to its low pH, gastric acid is also a potent antimicrobial agent against acid-sensitive microorganisms. Hypochlorydria is considered a key risk factor for the development of bacterial overgrowth. Source: Dr Costantini SIBO and Thiamine Deficiency Dr Costantini and bacterial overgrowth SIBO, IBS, and Constipation: Unrecognized Thiamine Deficiency? – June 2020 https://www.hormonesmatter.com/sibo-ibs-constipation-thiamine-deficiency/ PS: You'll probably need to optimize bile and chlorhidric acid to optimize meat digestion if the digestion takes to long. Bile & SIBO (in French, but with links in English) Optimiser la bile & fluidifier le transit en cas de SIBO https://mirzoune-ciboulette.forumactif.org/t2005-impact-de-la-bile-sur-le-microbiote-et-le-transit#29365 La prolifération bactérienne est fréquemment rencontrée chez les personnes qui souffrent de colopathie (IBS).
  • Pufa depletion thread drop ur cures n shit

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    On twitter, @haidut mentioned using vitamin K3 as a safer version of DNP to drop some weight. (This was back around ~Mar 15 2023.) In one of the reply streams, someone posted a link to this product: https://www.medixlife.com/shop/vicasol-buy-online-menadione/ I am not aware of a US source. I would love to find one and give it a try.
  • Ray peats paper about William Blake

    william blake ray peat yung
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  • Cu-GHK peptide on my dick?

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    @hwisdom Np. Lmk if you need more info.
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  • COVID VACCINATION = CANCER

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  • High stomach acid? Should i keep taking ppi?

    question ppi famotidine
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    @SummerPeach that stuff is so expensive tho :/. Especially since Im not even sure I have The Hpylor. Doctor never even mentioned H pylori or any diagnosis for that fact lmao. Im gonna try get an appointment for gastroscopy in a week when im back there although idk if they can even see it ig at least they can tell if i need to take still this ppi shit due to ulcer or sth or no
  • Looking for experiences with metergoline

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    @DukesBobby777 No, i didn't, because this drug eventually would be too expensive to keep doing it. Actually, i'm on Mirtazapine 30mg, an atypical antidepressant that it's a serotonin antagonist very similar to Metergoline bc it acts specifically of the 5-ht2 receptors and i'm getting good results (althought i'm thinking about increasing the dose to 45mg). If you have high serotonin symptoms i would give it a try, I get the prescription monthly from my psychiatrist and since I started it my symptoms have drastically reduced
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    yerragY
    @cs3000 I can bear witness to this. When I was suffering from a year long condition that started with bronchitis, my eyelids were drooping. The lack of the usual amount of oxygen easily translates into low energy. And my eyelids were a good tell.
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  • Fragrances, scents, pheromones

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    HyperTorlessH
    @chudlord Great stuff thanks! For those who can get it, a nice hack is tomato sauce or sea salt with truffle extracts. Makes it very easy to add a tiny bit of it everyday. [image: 1715758068604-70992f33-7d09-4af6-b5fd-bf378491e7c3-20055_sel-truffe-guerande_328e5620-1ca7-49c8-be65-a4472113e4f6_600x.webp]
  • Why is my UPPER lip getting crusty?

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    HyperTorlessH
    @hwisdom Jesus that's an enormous amount lmao. I guess 200g/week is enough.
  • Regrowing enamel

    dental teeth enamel
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    @shedim interesting. Is there any risk of staining teeth? Are you saying you actually had bone regrowth doing this?
  • My stool smells like death

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    BioEclecticB
    Dietary and environmental toxins? Not ingesting or being exposed as much as reasonably possible. Then vitamins and minerals take over from there. The way i've understood it, you need just a bit more than what your body uses for itself, any excess will often move on to secondary duties like toxin removal or mitigation. Ideally it would be a steady supply also. Just a sample list but Zinc is good for certain toxins, Selenium and Copper for others, B1, Vit-C, Glycine etc etc. Be extremely careful with some of the detox protocols you may have stumbled upon, research them well before attempting.