Crohn disease
The main clinical signs are abdominal pain, prolonged diarrhea, the emission of bloody mucus, a possible palpable mass in the right iliac pit, moderate fever, asthenia and weight loss. Biologically, there is an accelerated ESR, increased CRP (reactive Protein-C), light anemia, leukocytosis with polynucleosis and hypo-albuminemia.
Note: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are two markers in the blood that measure levels of inflammation.
For JS, Crohn's disease has a mechanism similar to that of colitis. The severity of the Crohn’s would be due to a difference in the waste to be eliminated, perhaps a stronger quantity, often a more complex structure. The activation of several varieties of leukocytes and the secretion of multiple pro-inflammatory cytokines cause the release and activation of matrix metaloproteinases which degrade tissues, which can generate fistulas, cracks, large abscesses and fibrous strenosis (Shanahan 2002).
The proportion of various cells and cytokines in the infiltrate suggests a much more inflammatory than immune response (Mac Dermott et al. 1993), which is corroborated by the absence of association between Crohn and HLA and the ineffectiveness of the Ciclosporin which reduces the immune response in vain (Sandborn 1995). Crohn’s is related to the pathology of elimination and not to autoimmunity. Crohn’s is for Seignalet a giant colitis, a multifactorial pathology (bacteria and food).
In Crohn's disease, certain foods have awakened certain symptoms (diarrhea, pain), even a simple exclusion diet would have put these symptoms under the nod: it is interesting to note that cereals, milk and some cooked products appear frequently challenging for patients. And JS cites case studies carried out on his patients.
The results
The hypotoxic diet has been implemented in 99 cases of Crohn’s, but he will only retain the 72 patients for whom the decline is more than one year. The results are 62 frank success, with complete or almost complete remission, 9 more nuanced results and one single true failure. JS comment
Nutritional change can remove ulcers, micro-abscess and inflammatory granulomas; in short, the inflammatory process characteristic of the Crohn’s. But it can do nothing against certain definitive lesions, such as cracks, fistulas, macro-abscess and fibrous stenosis.
