Dietary and environmental toxins? Not ingesting or being exposed as much as reasonably possible. Then vitamins and minerals take over from there. The way i've understood it, you need just a bit more than what your body uses for itself, any excess will often move on to secondary duties like toxin removal or mitigation. Ideally it would be a steady supply also.

Just a sample list but Zinc is good for certain toxins, Selenium and Copper for others, B1, Vit-C, Glycine etc etc.

Be extremely careful with some of the detox protocols you may have stumbled upon, research them well before attempting.

Orally progesterone and thyroid help the most. But she should also check the skin care she’s using to make sure it doesn’t clog pores. Google pore clogging checker and there are a bunch of sites. It can take a few months to clear.

@wrl

Thank you! and from the point of view Ray Peat? I also read that it blocks histamine H2 receptors, helps with acid reflux and gastritis

Has this video been shared on their forum yet? I did a cursory examination of the first few pages and I don't see it. Bet you'd get banned for it, lol.

@scamp said in Help me choose supplements:

@Mulloch94 37 nmol/L

That's borderline. I think it's still technically "in the reference" because the bottom end is 30 nmol/L for most standard tests, but for me it would be too close for comfort.

If it were me, I would probably do 10,000 units daily for a couple weeks then reduce it to 5,000 units daily for maintenance. Check yourself again in about 12 weeks to reevaluate your situation.

@Verdad
Acne is a sign of your liver not being capable of getting rid of all the toxins that are in your body. So the toxins leave through your secondary detoxifying way which is your skin. So yeah having healthy amount of Vitamin A -> Increasing Liver Function will help you with that.

He just posted a video that goes through the dumpster fire that is Charlie and the Ray peat forum today.

Youtube Video

@wrl

I don't, but supplementation must be safer than in pregnancy.

The concentrations aren't increased to a worrying extent, can elevate the content to 5 mcg/L. An infant might consume up to 1 L a day and the inflated recommended intake for them is 10 mcg/d.

The excessive supplementation to enrich milk with vitamin D may induce deficiencies in the mother, than may manifest in milk.

@rosenstein if the liver can’t store glycogen then sleep will be affected, (no fuel during sleep-which ironically is a metabolically demanding process). Stress in the form of overtraining will raise cortisol which can lead to fatty liver and decreased glycogen storage/muscle catabolism. Some of us with favorable body composition might be able to skirt this for a time because muscles can store glycogen too, (my personal theory is that they do so when subjected to the stress of training as localized glycogen storage tanks to deal with stress more immediately-especially if liver function is impaired).

I don’t do the caffeine before bed, (sorry for any confusion there). I take my last dose around 3pm. My reasoning for the caffeine and vitamin K supplementation is due to a number of studies Haidut posted on the old forum regarding their leaning out the liver and assisting in glycogen storage. When I started “Peating” I couldn’t drink black coffee without cold hands and feet. Now I can drink a double espresso on an empty stomach with no stress response, (suggesting my glycogen storage is much improved).

In the studies, I believe glycogen storage was improved with a certain amount of caffeine mg/kg. In my initial experiments I used 1200mg split in three doses of 400mg each with lots of food for two weeks. Since then I’ve found I prefer 200mg twice a day for longer periods. This also assisted in improved metabolism as I dropped body fat while increasing calories and maintaining training regime. My weight went from about 235 to 205, (and the weight loss wasn’t instant, it continued after ceasing the caffeine over the course of the next few months).

K in studies was found to lower liver enzymes dramatically at 15mg over a few weeks, or 45mg over a few days.

There are few studies on PUFA deficiency in which the rats consume a good amount of food, most studies keep the nutrients below the requirement and the rats degenerate.

I saw a study in which rats developed the symptoms of PUFA deficiency when placed on a fat-free diet ad libitum, the symptoms were cured spontaneously as long as the diet continued ad libitum, and it was even theorized that the rats produced the essential fatty acids. There's another study in which they didn't even develop symptoms even with a high amount of Mead's acid, but the diet was ad libitum from the start.

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Without him talking about the symptoms, we can't be sure. The skin problems of PUFA deficiency seem to be caused by the replacement of linoleic acid(18:2n-6) by oleic acid(18:1n-9). You need a degree of unsaturation to control water permeability, there's a study that rats don't suffer many symptoms of deficiency because they kept the humidity high, it seems to take a while for mead acid(20:3n-9) to take over

WHE = 90% humidty
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Bearing in mind that saturated and hydrogenated fats accelerate the depletion of DHA, I believe that the deficiency of DHA is real and there is no other that can replace its function.

In rats, 0.26% of calories in ALA was enough to maintain the maximum concentration of DHA(in organs such as the brain) in adult rats, 0.4% in young rats(which means it's difficult to become deficient in DHA). I haven't looked to see if it can be translated to humans literally, as a few oysters would do the job.

Tokelauans(max 7g PUFA/day) of the past seemed relatively depleted of omega-6 and were relatively free of the diseases of today, I don't remember reading about any particular problem
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@joshiepenis I think focusing on the basics is enough. Be outside in the sun, lift weights, get good sleep, and eat nutritious food. I think hiking in the sun is one of the best ways to improve androgen production which goes hand in hand with bigger testicles. I have seen marked increase in ball size since I started hiking for hours on most days.

@Mulloch94 said in Grant Genereux admits he "didn't do a whole lot a research" for his anti-vitamin A books:

I think most people who get into that type of work will tell you their true intentions got perverted somewhere along the way.

Yeah, I have just recently watched a compelling video about a story like that... https://www.youtube.com/watch?v=LKiBlGDfRU8

Maybe high dose fat solubles were crashing estrogen too low as you do need estrogen to function just in a good balance