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Subcategories

  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    643 Topics
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    MauritioM
    @alfredoolivas said in Are microdoses of mifeprestone the ultimate receptor level anti-glucorticoid?: it would likely occupy all progesteorone receptors, it's birth control, you can get it through online pharmacies I think. Then I don't think it's really worth the hassle. Id still be curious to hear how something like this feels and affects a person...
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    C
    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    ThinPickingT
    https://bioenergetic.forum/post/53285 https://bioenergetic.forum/post/53271 I had fun reading these again, thank you sneedster. And no one can argue with you, they may as well argue with a bathroom mirror. @sunsunsun said in Avocado: Toxic but how much?: Even the authors of the liver collagen solubility study showing avocado tended to promote fibrosis say they are surprised at their result because their previous study in skin showed the opposite effect. Something's wrong with the controls in almost all of the literature and we all know it. There were at least 2 whole threads about this on rpf. This was also highly amusing btw. 9/9 spirited character. https://bioenergetic.forum/post/63157 @sunsunsun said in Avocado: Toxic but how much?: Danny Roddy who apparently is le Ray Peat expert never caught this or called him out on it. This is a guy who charges people money for his 'expertise' on bioenergetics. The hasty pursuit of practical application for chicken farming.
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    388 Topics
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    engineerE
    @heyman DHT is just a metabolite of T, and there are many differences between the two: DHT is way more androgenic T is a cortisol antagonist, while DHT is less so DHT depends on the 5ar enzyme which is the target of so-called "hair loss" medicines like finasteride and dutasteride
  • Recipes, food, meal prep, brands. Discuss them all here.

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    sunsunsunS
    @Gardner that post was after potato as starch meal so yor assumption is incorrect and secondly i take increased appetite as easy marker of increased vitality
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    engineerE
    @hawk1 I have similar concerns to you regarding suppression. So, despite that, I have also gone the nuclear route with 500mg a week of T isocaproate. Surprisingly, I haven't detected much suppression if any because vitamin E, pregnenolone/DHEA, and progesterone all work to oppose estrogen and prolactin which are the main underlying mechanisms behind endogenous shutdown. This is all because regular T aromatizes, unlike 11KT, which shockingly does NOT! So even if you're not already doing other Peaty things you are already in a low risk position.
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  • Thyroxine & RT3 troubleshooting - what worked for you?

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    @cs3000 heat production is good for the most of the time, but still rt3 is building up, ill figure it out sonner or later, being patient is hard and take slow aproach to thing plus memory is short, this cortisol Supps iv been there multiple times and had same conclusion lol
  • what are the most dopaminergic things you tried?

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    ChudC
    redbull low dose cypro+bromo suntan music walking
  • White sugar and white tounge

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    @Samyo said in White sugar and white tounge: @mostlylurking You said magnesium too, should i stop milk with its high calcium then? I was on b1 before with no response No, if you tolerate milk OK, there's no reason to stop. Your body needs both calcium and magnesium.
  • Medikinet drug, whats the main mechanism?

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    @FitnessMikey Seens it primarily increases dopamine, (and norepinephrine a bit also) which would lower prolactin and serotonin (two stress related substances iirc). Alternatives... boost metabolism (mitochondria repair etc) boost dopamine lower serotonin and prolactin lower cortisol/ACTH/(estrogen?) aka anti-stress Some quotes on Medikinet: Medikinet is an extended-release methylphenidate medication, while Ritalin is a short-acting methylphenidate medication Methylphenidate primarily acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). Methylphenidate is a psychostimulant and increases the activity of the central nervous system through inhibition on reuptake of the neurotransmitters norepinephrine and dopamine. Methylphenidate is most active at modulating levels of dopamine (DA) and to a lesser extent norepinephrine (NE). Methylphenidate binds to and blocks dopamine transporters (DAT) and norepinephrine transporters (NET).
  • Extremely hypothyroid after gluten/wheat?

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    @xand you're a young sprout. Find out what foods irritate your gut and avoid them just like wheat. I'm sure you'll be fine
  • The starch question

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    EmiliaE
    @CO3 "Volkheimer found that mice fed raw starch aged at an abnormally fast rate, and when he dissected the starch-fed mice, he found a multitude of blocked arterioles in every organ, each of which caused the death of the cells that depended on the blood supplied by that arteriole. It isn't hard to see how this would affect the functions of organs such as the brain and heart, even without considering the immunological and other implications...." "Around 1988 I read Gerhard Volkheimer's persorption article, and after doing some experiments with tortillas and masa, I stopped eating all starch except for those, then eventually I stopped those. Besides grains of starch entering the blood stream, lymph, and cerebral spinal fluid, starch feeds bacteria, increasing endotoxin and serotonin. For people with really sensitive intestines or bad bacteria, starch should be zero.” ~Ray Peat PhD
  • Questions

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    LucHL
    Hi, Or, you open a diary and name it: Papaya Diary. You find then the best appropriate category (main problem). Try to be sequential: Make the distinction between the facts and the sensation. Precise the delay and the intensity. µ See you later.
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    @LucH If you drink enough during the day light, you can’t be dehydrated because of sleep unless there is another problem. Well yes of course, that's true of every human, the issue is what constitutes enough? Why is it I went from consuming x amount of water and now need to consume several times that amount for the same result. This would treat the symptoms but not the cause. I'm not necessarily looking for treatment whether the root cause, or the symptoms but rather trying to find out what is causing this all to happen in the first place. Most fruits and vegetables are digested in less than half an hour. If you eat first starch and meat, fibers will remain longer (2-3 hours) in the first part of the colon than what is needed. Ok that is useful information if I decide to consume vegetables or more fruit again, thanks. Currently I'm consuming fruit juice and the juice from oranges only. But I'll note that with melons and such. Maybe I'll just separate the juices anyway to be sure. @LucH Check my list under diet above, more than adequate protein is being consumed. Well I consume 0.6-0.8 g per pound of body weight which is what Mike Fave and Jay Feldman recommend. Peat changed his stance on high protein towards the end and describes high protein as being anti metabolic. I would add: duck. Ok I don't understand that either, duck is full of pufas. You didn't explain that and it's not obvious. I suppose I should just take this for gospel otherwise I would be "arguing". @LucH You didn’t say how much and what type. It’s not with 50 mg Thiamine HCl you’re going to re-connect the brain and the microbiota through the vagus nerve. True, I take 200-300mg Thiamin HCL. Yes, you have if you bloat and have flatulence. Your digestion is problematic. True but I had that before this issue began with severe flatulence but no skin or dehydration issues. I won’t discuss any longer why and how. You’re not receptive enough and I need to see the person accessible to optimize my “time invest”. Ok you seem somewhat authoritarian in your advice and much of it seems anti peat. It's normal for me to ask for an explanation. You seem to be offended when anything you say is questioned so as you say it's probably best to leave it. You should have asked why or how if you didn’t perceive the reason instead of arguing. I did ask why. Quote from above: "You mean separate from other food types? Why would that help?" You even responded to that. Not sure what you want to say there. Sorry to be hard but … Ok hope you feel better soon. Thanks for the help anyway. Take care of you and stay open-minded. Normally you work with someone to find solve their problems instead of just telling them what will work for them without question. Problems are very individual and context dependent, there's no blanket advice that will work for all. Of course you have no obligation to help as you say, for what it's worth I did get some useful info from you.
  • Aiding sexual assault recovery with Peat principles

    trauma recovery healing
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    @shivaflow
  • Help I can't poop.

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    @monkey11 Hey bro if all else fails: Lie face down have fat friend belly flop on your back It is suggested to take off pants and whitey tighties for this. good luck OP
  • How to avoid being perscribed bad antibiotics (and get the ones you want)

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    @Evolutionarily a good way to get any drug is to basically say you were staying out of the country and were prescribed this drug at this dose and you are seeing if you can get a refill because your date for going back to the country you got it in is a little later and you are worried to run out. then once you have it prescribed one on your file you can go to another doctor and more easily get it. this works well in countries with tele-medicine consults and doctor shortages. minocycline is easy to get over the phone by saying you took it for acne many years ago and would like to go back on it
  • best place to live during northern hemisphere winter

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    @Norwegian-Mugabe chvd goes south. curious.
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    @yerrag said in Heart failure report showing t4 solo vs t4:t3 in action for full recovery (edema too): By the way, I have fully recovered from heart failure but thanks to the knowledge gained from the bioenergetic orientation of being immersed in a thought subculture revolving around Ray Peat's writings I am back to mybold healthy thriving self.
  • Causes of death in London in 1632

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    Crypt KeeperC
    So few murders back then.
  • Best ways to slow time perception

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    @Sattva Everything you said is not peaty. Meditation is bad and for losers just like psychedelics; it shrinks your amygdala as well. Your advice is good for people with bad metabolism who want to have even worse metabolism.
  • Why does my skin become dry when i starting pooping 1 or twice a day?

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    GreekDemiGodG
    He hasn’t been Keto for years.
  • What helps improve executive function?

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    LucHL
    @pittybitty said in What helps improve executive function?: I've generally been fine in regards to energy since supplementing B vitamins, but the low executive function remains. Give details, please, because it's not with a B-50 multi you're going to have a game changer. You need to read these two links to understand why you lack B6 if you're inflamed or under-immune. Sure with dysbiosis. And to understand why you need more B1 thiamine (not HCl) if you eat carbs like most people. Potential roles of Vit B6 in inflammation and immunity. Preventive role of B6 against chronic diseases & downregulation of the inflammatory mediators https://mirzoune-ciboulette.forumactif.org/t2034-english-corner-potential-roles-of-vit-b6-in-inflammation-and-immunity#29633 Main ideas • Preventive role of B6 against chronic diseases. Several diseases are mediated, at least in part, by lower inflammation, possibly through modulation of several kinases. (1) • Vit B6 deficiency is associated with lower immune function and higher susceptibility to viral infection. (2) Megadoses do not produce additional benefits after repletion. (3-4) But elderly should benefit from cyclic supplement (with pauses and moderate amounts, aka 50 mg pyridoxamine). • Plasma PLP levels were inversely correlated with systemic inflammation markers such as CRP. (5) Vitamin B6 supplementation suppressed IL-6 and increased total lymphocytes in patients with chronic conditions. (6) • Vitamin B6 supplementation improved immune function in both human and animal studies. (7-8) It improves the immune response, causing increased antibody production, and enhances communicative interactions between cytokines and chemokines. (9-11) • The authors of this study (0) assume that vitamin B6 is possible to suppress hyperinflammation, at least in part, through NLRP3 inflammasome inhibition, limiting virus spread and cytokine storm. Together with the notion that NLRP3 inflammasome plays a central role in chronic diseases, including CVD, diabetes, and acute viral pneumonia (12–14), the anti-inflammasome effect of vitamin B6 suggest its therapeutic role in reducing the severity of COVID-19 and its complications. • Studies indicate that B6-vitamers can reduce superoxide radical and lipid peroxide levels induced by H2O2 in vascular endothelial cells (15). Too much sulfites (H2O2) exhaust B6 PLP. • Pyridoxamine has anti-glycation activity and inhibits the formation of AGEs. (16) • It was identified that high-dose vitamin B6 has a global anti-inflammatory effect on lipopolysaccharide-induced inflammation in monocyte/macrophage cells by downregulating the key broad-spectrum inflammatory mediators. (17-18) Sources and References (in English, on the link, my forum). See too: English Corner – Vit B6: How much is too much? Main ideas Too much of a good thing is bad. Especially bad for neuro-sensitive people. Vitamin B6 is well documented for its role as a modulator of steroid hormones. No problem with food intake if not supplemented. Maximum RDA target is 25 mg B6. But update RDA is given at 6-12 mg. There are 6 vitamers and a way-out form through the urine. If we want a pharmacological effect, we have to take into account the form of the vitamers. The active form is B6 PLP. And for B1 thiamin *) ## Thiamine Deficiency - A Potential Cause of SIBO and other Gut Dysfunction? https://mirzoune-ciboulette.forumactif.org/t1896-vit-b1-deficience-desordre-intestinal Version complète plus complète sur ce site (Vaut le détour) : Elliot Overton – Nutrition and Functional Medicine https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo – 01/2019 *) ## Thiamine and the Microbiome – Dr. Lonsdale https://www.hormonesmatter.com/thiamine-microbiome/ 03/23 Excerpt: The acquisition / bioavailability of thiamine is not only essential to the physiology of our organism and our good physical and mental condition, but thiamine is a cofactor for certain intestinal bacteria that change behavior depending on the variable availability of B1 .