@Mauritio said in Thymus health:
@cs3000 said in Thymus health:
Looks like the main benefit of the Thymus could actually be from suppressing too much immune damage via t reg cells
That is such an interesting thought. Why wouldnt we have an organ whos purpose it is to dampen excessive inflammation, given chronic inflammation is a part of so many diseases.
@yerrag said in Thymus health:
The funny thing is that the elephant in the room was always being ignored, in the absence of mention of the T-cells, such that it's importance was relegated to that of a bit player, inconsequential to improving our body's response to the putative virus.
Seems to me that beefing up the thymus gland should be the main topic of the COVID response. The question of the day.
Looks like a big health unlock , neutrophils are big players in autoimmune problems maybe the biggest, you see them showing up causing big damage in a wide range of health issues covid cystic fibrosis ulcerative colitis heart failure etc
and theyre highly destructive with different weapons, cytokine release, then they have proteases that degrade the structure surrounding the cell (if u inhibit neutrophil proteases in arthritis they dont develop arthritis at all https://pmc.ncbi.nlm.nih.gov/articles/PMC150852/ ), and they can form wild traps where they basically gut themselves & spill out strands of dna laced with proteins to form damaging webs like some kind of arsehole spiderman in the autoimmune situation
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their benefit is mainly in the first 12 hours where theyre supposed to help kickstart the cleanup & repair process then back off (reversing their path back into bone marrow). but in the current state of health its common that they stay chronically activated for days weeks months years . regulatory t cells specifically T Reg cells look key to help resolve that
@yerrag I can't help but think of metabolic health being as impactful on our immunity, and this is is but just one example of Ray's dictum that metabolic health drives all other aspects of health in us.
something that fits with that & the rest, neutrophils dont use mitochondria for energy they basically just use glycolysis (& can create their own glucose in presence of glutamine too, and use fatty acids for some functions like ROS production or possibly switch over to fatty acid use to become more intense, in my experience eating more fat takes high neutrophil damage to an extreme),
BUT unlike neutrophils T Reg cells need mitochondria complexes functioning to enable their immune resolving function
