@pittybitty said in What helps improve executive function?:
I've generally been fine in regards to energy since supplementing B vitamins, but the low executive function remains.
Give details, please, because it's not with a B-50 multi you're going to have a game changer.
You need to read these two links to understand why you lack B6 if you're inflamed or under-immune. Sure with dysbiosis.
And to understand why you need more B1 thiamine (not HCl) if you eat carbs like most people.
Potential roles of Vit B6 in inflammation and immunity.
Preventive role of B6 against chronic diseases & downregulation of the inflammatory mediators
https://mirzoune-ciboulette.forumactif.org/t2034-english-corner-potential-roles-of-vit-b6-in-inflammation-and-immunity#29633
Main ideas
• Preventive role of B6 against chronic diseases. Several diseases are mediated, at least in part, by lower inflammation, possibly through modulation of several kinases. (1)
• Vit B6 deficiency is associated with lower immune function and higher susceptibility to viral infection. (2) Megadoses do not produce additional benefits after repletion. (3-4) But elderly should benefit from cyclic supplement (with pauses and moderate amounts, aka 50 mg pyridoxamine).
• Plasma PLP levels were inversely correlated with systemic inflammation markers such as CRP. (5) Vitamin B6 supplementation suppressed IL-6 and increased total lymphocytes in patients with chronic conditions. (6)
• Vitamin B6 supplementation improved immune function in both human and animal studies. (7-8) It improves the immune response, causing increased antibody production, and enhances communicative interactions between cytokines and chemokines. (9-11)
• The authors of this study (0) assume that vitamin B6 is possible to suppress hyperinflammation, at least in part, through NLRP3 inflammasome inhibition, limiting virus spread and cytokine storm. Together with the notion that NLRP3 inflammasome plays a central role in chronic diseases, including CVD, diabetes, and acute viral pneumonia (12–14), the anti-inflammasome effect of vitamin B6 suggest its therapeutic role in reducing the severity of COVID-19 and its complications.
• Studies indicate that B6-vitamers can reduce superoxide radical and lipid peroxide levels induced by H2O2 in vascular endothelial cells (15). Too much sulfites (H2O2) exhaust B6 PLP.
• Pyridoxamine has anti-glycation activity and inhibits the formation of AGEs. (16)
• It was identified that high-dose vitamin B6 has a global anti-inflammatory effect on lipopolysaccharide-induced inflammation in monocyte/macrophage cells by downregulating the key broad-spectrum inflammatory mediators. (17-18)
Sources and References (in English, on the link, my forum).
See too:
English Corner – Vit B6: How much is too much?
Main ideas
Too much of a good thing is bad.
Especially bad for neuro-sensitive people.
Vitamin B6 is well documented for its role as a modulator of steroid hormones.
No problem with food intake if not supplemented.
Maximum RDA target is 25 mg B6. But update RDA is given at 6-12 mg.
There are 6 vitamers and a way-out form through the urine.
If we want a pharmacological effect, we have to take into account the form of the vitamers.
The active form is B6 PLP.
And for B1 thiamin
*) ## Thiamine Deficiency - A Potential Cause of SIBO and other Gut Dysfunction?
https://mirzoune-ciboulette.forumactif.org/t1896-vit-b1-deficience-desordre-intestinal
Version complète plus complète sur ce site (Vaut le détour) : Elliot Overton – Nutrition and Functional Medicine
https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo – 01/2019
*) ## Thiamine and the Microbiome – Dr. Lonsdale
https://www.hormonesmatter.com/thiamine-microbiome/ 03/23
Excerpt:
The acquisition / bioavailability of thiamine is not only essential to the physiology of our organism and our good physical and mental condition, but thiamine is a cofactor for certain intestinal bacteria that change behavior depending on the variable availability of B1 .
