@Faceguy said in IPAM (indolepropionamide) extends lifespan of rotifers by 300%:

So it works better on rotifers but would presumably be less effective on mammals? I always knew knew being spineless, cold-blooded, and ciliated would pan out well for me.

The researchers in the linked study added that in the species of rotifier they tested on, IPAM caused the single greatest lifespan increase of any molecule tested in any study.

Obviously the equivalent dosage will likely not cause as potent effects in humans. However, it is an endogenous compound and quite small so it could be taken in larger doses at a small cost. Without as much concern for safety a synthetic drug would cause.

@Kruton very interesting. I may have read this before? I’ll read again if so. Thank you

You can make your own chocolate syrup with cacao powder, sugar, milk or water, and vanilla extract. Bringing this to a boil and reducing it allows it to become a syrup. The stearic acid in cacao butter can help a lot with your metabolism as it is dopaminergic (I think), increases mitochondrial fusion, and lowers cancer risk. +1 for the heavy metals as chocolate can be high in cadmium and aluminum. The polyphenols in chocolate can also help with digestion as it acts as a prebiotic (at least in pigs.)

@calx methylene blue can cause high blood pressure in high enough doses.

@alf to dumb it down big time: thyroid regulates metabolism. Hypothyroid people have less thyroid hormones than people with a well functioning thyroid. Less thyroid hormones, worse metabolism. More thyroid hormones, better metabolism.

I might delete, since some of my original statements are wrong

@Fructose ok I see

@aesthetic9 We literally can share energy, using concept of RESONANCE, to let the physical bodies of those who tooks the cov19 vax HEALS itself.

@izkrov said in Fructose - Resources:

Looking to pool resources on the effects of fructose, I've never felt any different from eating it but some people it upsets their tummies. Ray's mentioned that fructose is also mitochondrial uncoupler
e2803e53-7602-4f87-95b2-232c6dcd5cef-image.png
If someone knows a source for that or the reasoning behind it, please poast.
Anyway, here's some sources from his newsletters:

Fructose promotes sodium retention (https://pubmed.ncbi.nlm.nih.gov/6344611/)
Diabetics have increased vascular leakiness (https://pubmed.ncbi.nlm.nih.gov/12564648)
Fructose lowers blood vessel leakiness (https://pubmed.ncbi.nlm.nih.gov/14553836/)
And the "Sugar Issues" newsletter from 2011 talks about how you can use fructose when glucose isn't available, as well as eating more calories but retaining the same weight.

Some Haidut sources. He has a study that shows fructose didn't deplete liver atp which is a main argument against fructose
https://twitter.com/haidut/status/1751765657648038132

Perhaps fructose, as an insulin mimetic, has a similar effect to insulin on the oxidation of fatty acids, which may contribute to better oxidative phosphorylation.

@peatard haven’t had alcohol without Phenibut or Kratom in probably months they’re designed to go together

@pillsbury
What kind of exercises were you doing before getting injured?? Those are both injuries of over-use. I had the same time of cyst on my wrist from gymnastics but I didn't pop it. I stopped putting heavy loads on it and I took lots of aspirin, and it disappeared in a couple of months.

You should take aspirin, vitamin E mixed tocopherols, and get some selenium from shellfish 2x a week. Put a warm wet rag on it for 10 minutes every day. Never use icy hot at the same time as the skin is wet, but icy hot or a similar menthol+camphor+methyl salicylate rub helps too.

@API-Beast I’m unsure. I know for myself, cooking rice pilaf well in bone broth was great for quick, digestible starches with no blood sugar “crash” feel. Same with jasmine rice and sweet potatoes.

@StrongestPeater The soul isnt real. This is all just a chemical reaction.

@AndrewPeatMatrix I had exercise intolerance after a brain injury, dysautonomia was a big part of the problem and sounds similar to what you're describing.

I've been focusing on increasing my heart rate variability, doing resonant breathing in between sets (kneeling or sitting on the ground and doing deep 4 second breaths in and out) and it seemed to help. Having said that, it took quite a while to get to that point. I wear a whoop strap which tracks my HRV though and have measured an increase over the past few months and don't feel terrible afterward.

Related to that, I've been laying on a biomat post-workout, doing Wim Hof breathing either pre or post workout, and also increasing my Vitamin B intake (thiamine deficiency can be implicated in dysautonomia)