@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:
On top of that im not comfortable with NAC's role in cancer.
I won't take HD NAC with HD B3
When Niacin (or vitamin B3) and NAC (N-acetyl cysteine) are combined, especially under specific pH and concentration conditions, a chemical reaction may occur that forms pyrazinic acid (pyrazine).
Most sources specify that no interaction has been found between NAC and niacinamide (or nicotinamide). This is incorrect when there is prolonged concomitant use with a high dosage of NAC.
The toxic effects of pyrazinic acid may include cellular damage and oxidative stress, which is of particular concern for people with predispositions to oxidative stress-related diseases.
Source:
Hepatotoxicity related to anti-tuberculosis drugs: mechanisms and management
https://doi.org/10.1016/j.jceh.2012.12.001 2013.
The toxicity of pyrazinamide is both dose dependent with a higher dose at 40–50 mg/kg, with NAC combination. (2 800 to 3 500 mg NAC for 70 Kg/weight, or +/ 170 Lb).
Moreover NAC may not be safe for people who bleed easily. NAC may raise your odds of bleeding problems if you have a bleeding disorder such as hemophilia or you take blood-thinning drugs (aspirin, some essential oils or curcumin, which have some impact on platelet aggregation).
=> Prolonged dose NAC interfere with platelet aggregation.
